Wissenschaftliche Interessen

• Regulation and function of telomerase in stem cells, during tissue regeneration and tumorigenesis
• Identification of novel telomere factors

Referenzen

1. Günes, C., Rudolph, K.L. The role of telomeres in stem cells and cancer. Cell. 2013 Jan 31;152(3):390-3. doi: 10.1016/j.cell.2013.01.010.

2. Kumar, M., Wittek B., Knippschild, U., Koch, S., Meena, J.K., Heinlein, C., Weise, J.M., Krepulat, F., Kuchenbauer, F., Iben, S., Rudoplh, K.L., Deppert, W.  and  Günes, C. CEBP factors regulate TERT promoter activity in WAP-T mice during mammary carcinogenesis. Int J Cancer. 2012 Oct 1. doi: 10.1002/ijc.27880. [Epub ahead of print]
3. Günes, C., and Rudolph K.L., Telomere dysfunction puts brakes on oncogene induced tumors. EMBO J. 2012 May 29;31(13):2833-4.
4. Hirner H, Günes C, Bischof J, Wolff S, Grothey A, Kühl M, Oswald F, Wegwitz F, Bösl MR, Trauzold A, Henne-Bruns D, Peifer C, Leithäuser F, Deppert W, Knippschild U Impaired CK1 Delta Activity Attenuates SV40-Induced Cellular Transformation In Vitro and Mouse Mammary Carcinogenesis In Vivo. PLoS One. 2012;7(1):e29709. Epub 2012 Jan 3.
5. Sirma H, Kumar M, Meena JK, Witt B, Weise JM, Lechel A, Ande S, Sakk V, Guguen-Guillouzo C, Zender L, Rudolph KL, Günes C. The Promoter of Human Telomerase Reverse Transcriptase is Activated during Liver Regeneration and Hepatocyte Proliferation. Gastroenterology. 2011 Jul;141(1):326-37, 337.e1-3.
6. Hartmann, D., Srivastava, U., Thaler, M., Kleinhans, K., Bauer, K., Kratzer, R.,Scheffold, A., Kloos, N., Katz, S.F., Song, Z., Begus-Nahrmann, Y., Kleger, A., von Figura, G., Lechel, A., Günes, C., N’Kontchou, G., Brecht, M., Potthoff, A., Deterding, K., Wedemeyer, H.H., Ju, Z., Song, G., Xiao, F., Gillen, S., Schrezenmeier, H., Mertens, T., Friess, T., Blöcker, H., Manns, M.P., Beaugrand, M., and Rudolph, K.L. Telomerase gene mutations are associated with cirrhosis formation. Hepatology. 2011 May; 53:1608-1617.
7. Schriefer, P., Günes, C., Wege, H. Rapid Quantification of Telomerase Activity Employing an Improved Real-time Telomeric Repeat Amplification Protocol in Clinical Tissue Samples Eliminates Interference by PCR Inhibitors. Journal of Cancer Science & Therapy. Volume 3(8): 176-180 (2011) – 177
8. Bagis H, Aktoprakligil D, Gunes C, Arat S, Akkoc T, Cetinkaya G, Kankavi O, Taskin AC, Arslan K, Dundar M, Tsoncheva VL, Ivanov IG.
   Expression of Biologically Active Human Interferon Gamma in the Milk of Transgenic Mice Under the Control of the Murine Whey Acidic Protein Gene Promoter. Biochem. Genet. 2011 Apr;49(3-4):251-7. Epub 2010 Dec 18.
9. Brassat U, Balabanov S, Bali D, Dierlamm J, Braig M, Hartmann U, Sirma H, Günes C, Wege H, Fehse B, Gontarewicz A, Dikomey E, Borgmann K, Brümmendorf TH. Functional p53 is required for effective execution of telomerase inhibition in BCR-ABL-positive CML cells. Exp. Hematol. 2011 Jan39(1):66-76.e2.Epub 2010 Oct 30.
10. Weise JM, Günes Ç. Differential Regulation of Human and Mouse Telomerase Reverse Transcriptase Gene Promoter Activity during Testis Development. Mol Reprod Dev. 2009; Mar; 76(3):309-17.
11. Zafrakas M, Tarlatzis B, Streichert T, Pournaropoulos F, Wölfle U, Wittek B, Grimbizis G, Papadimas J, Pantel K, Bontis J, Günes Ç.  Genome-wide microarray expression, absence of telomerase activity and array-CGH analysis in advanced ovarian endometriosis suggest high degree of differentiation rather than malignant potential. Int J Mol Med. 2008; 21(3):335-44.
12. Ritz JM, Günes Ç.  Telomeres and Telomerase: A survey about methods and recent advances in cancer diagnostic and therapy. Histol Histopathol 2006; 21: 1249-1261.
13. Ritz JM, Kühle O, Riethdorf  S, Sipos B, Deppert W, Englert C, Günes Ç. A Novel Transgenic Mouse Model Reveals Humanlike Regulation of an 8-kbp Human TERT Gene Promoter Fragment in Normal and Tumor Tissues. Cancer Res. 2005; 65 (4), 1187-1196.
14. Zhang B, Georgiev O, Hagmann M, Günes Ç, Cramer M, Faller P, Vasak M, Schaffner W. Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein. Mol Cell Biol. 2003; Dec; 23(23):8471-85.
15. Günes Ç, Lichtsteiner S, Vasserot AP, Englert C. Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res. 2000; 60, 2116-2121.
16. Auf der Maur A, Belser T, Wang Y, Günes Ç, Lichtlen P, Georgiev O, Schaffner W. Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1. Cell Stress and Chaperones 2000; 5 (3), 196-206.
17. Günes Ç, Heuchel R, Georgiev O, Müller K-H, Marino S, Bluthmann H, Aguzzi A, Schaffner W. Embryonic lethality and liver degeneration in mice lacking the metal responsive transcriptional activator MTF-1. EMBO J 1998; 17(10): 2846-2854.
18. Günes Ç, Müller-Hill B. Mutants in position 69 of Trp repressor of Escherichia coli K-12 with altered DNA-binding specificities. Mol. Gen. Genet. 1996; 251: 338-346.
19. Günes Ç, Staacke D, von Wilcken-Bergmann B, Müller-Hill B. Cooperative binding of two Trp repressor dimers to alpha or beta centered trp operators. Mol. Microbiol. 1996; 20(2) 375-384.
20. Günes Ç, Staacke D, von Wilcken-Bergmann B, Müller-Hill B. The possible roles of residues 79 and 80 of Trp repressor from Escherichia coli K-12 in trp operator recognition. Mol. Gen. Genet. 1995; 246: 180-195.