Principal investigators

Dr. med. Lüder Hinrich Meyer
Department of Pediatrics
University of Ulm
Eythstrasse 24
89075 Ulm
Phone: 0731-500-57254
lueder-hinrich.meyer(at)uniklinik-ulm.de

 

Prof. Dr. med. Klaus-Michael Debatin
Department of Pediatrics
University of Ulm
Eythstrasse 24
89075 Ulm
Phone: 0731-500-57000
klaus-michael.debatin(at)uniklinik-ulm.de

Curriculum Vitae


Summary

Based on our previous finding that distinct engraftment phenotypes of leukemic blasts from pediatric patients with acute lymphoblastic leukemia (ALL) xenotransplanted in NOD/SCID/huALL mice are closely associated with patient survival, the following main issues will be addressed: (1) characterization of the engraftment phenotype on genomic and miRNA levels, functional investigation of previously identified genes and attributed pathways such as apoptosis; (2) utility of the previously identified gene signature as diagnostic classifier for (early) relapse; and (3) pre-clinical testing of novel, directed treatment strategies targeting signaling molecules or pathways identified under aims (1) and (2).

B6

The NOD/SCID/huALL xenotransplant model: characterization and prognostic impact of distinct engraftment properties (time to leukemia, TTL) of primary ALL cells

Publications

Meyer LH, Eckhoff SM, Queudeville M, Kraus JM, Giordan M, Stursberg J, Zangrando A, Vendramini E, Moricke A, Zimmermann M, Schrauder A, Lahr G, Holzmann K, Schrappe M, Basso G, Stahnke K, Kestler HA, Te Kronnie G, Debatin KM. Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways. Cancer Cell. 2011;19:206-17.

Meyer LH, Debatin KM. Diversity of Human Leukemia Xenograft Mouse Models: Implications for Disease Biology. Cancer Res. 2011;71: Published Online First November 16, 2011.

Meyer LH, Queudeville M, Eckhoff SM, Creutzig U, Reinhardt D, Karawajew L, Ludwig WD, Stahnke K, Debatin KM. Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML. Blood. 2008;111:2899-903.

Meyer LH, Karawajew L, Schrappe M, Ludwig WD, Debatin KM, Stahnke K. Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL. Blood. 2006;107:4524-31.