|Prof. Dr. med. Christian Beltinger|
Department of Pediatrics
University of Ulm
We have first-time preliminary evidence that attenuated vaccination measles virus of the Edmonston strain (MV-Edm) can selectively kill pediatric ALL cells in vitro and in vivo. We now want to investigate in detail the efficacy of plain MV-Edm and of MV-Edm protected in leukemia-searching human endothelial progenitor cells against primary pediatric ALL xenotransplanted into mice that are naive to or have been passively immunized against measles. This proof-of-principle study, combined with an analysis of the selectivity of MV-Edm, may provide the basis for a novel treatment strategy against ALL.
Attenuated oncolytic measles virus against ALL of childhood: preclinical proof-of-principle and molecular mechanisms
Back C, Knauß H, Ludwig WD, Schrappe M, Debatin KM, Beltinger C. Mitochondrial genome variants in non-remitting ALL of childhood. Br J Haematol. 2011;155:626-29.
Debatin KM, Wei J, Beltinger C. Endothelial progenitor cells for cancer gene therapy. Gene Ther. 2008;15:780-86.
Wei J, Wahl J, Nakamura T, Stiller D, Mertens T, Debatin KM, Beltinger C. Targeted release of oncolytic measles virus by blood outgrowth endothelial cells in situ inhibits orthotopic gliomas. Gene Ther. 2007b;14:1573-86.
Wei J, Jarmy G, Genuneit J, Debatin KM, Beltinger C. Human blood late outgrowth endothelial cells for gene therapy of cancer: determinants of efficacy. Gene Ther. 2007a;14:344-56.
Wei J, Zhou S, Bachem G, Debatin KM, Beltinger C. Infiltration of blood outgrowth endothelial cells into tumor spheroids: role of matrix metalloproteinases and irradiation. Anticancer Res. 2007c;27:1415-21.
Wei J, Blum S, Unger M, Jarmy G, Lamparter M, Geishauser A, Vlastos GA, Chan G, Fischer KD, Rattat D, Debatin KM, Hatzopoulos AK, Beltinger C. Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell. 2004;5:477-88.
Eggermann J, Kliche S, Jarmy G, Hoffmann K, Mayr-Beyerle U, Debatin KM, Waltenberger J, Beltinger C. Endothelial progenitor cell culture and differentiation in vitro: A methodological comparison using human umbilical cord blood. Cardiovasc Res. 2003;58:478-86.