ProjectTitlePrincipal Investigator
Project Group AExperimental leukemia models
A1Checkpoint control in hematopoietic stem cells - contribution to genetic and epigenetic instability in leukemia

H. Geiger,
M.C. Florian

A2Dissecting the role of Mixed-Lineage-Leukemia 5 (MLL5) in the DNA dam-age response and its potential ef-fects on leukemogenesisH. J. Fehling
A3Notch signaling as a novel target of AML1/ETOF. Oswald, H. Geiger
A4Dissecting of the function of the “Lymphoid enhancer-binding factor 1” (Lef1) in acute myeloid leukemiaC. Buske
A5Characterization of regulatory and target pathways of microRNAs downstream of the leukemogenic Hoxa9/Meis1 axisA. Rouhi,
F. Kuchenbauer
A6VENTX and its role in acute erythroid leukemiaM. Feuring-Buske
A8Mechanistic basis of CLL resistance to targeted tumor therapy in patho-physiologically relevant cellular con-text: role of Rho GTPases and phospholipase C gamma2P. Gierschik
A9 (new)Role of BCR signaling in chronic lymphocytic leukemiaE. Hobeika
A10 (new)Investigating the crosstalk between pre-BCR and IL7-R signaling in B-cell precursor acute lymphoblastic leu-kemiaH. Jumaa
Project Group BClinical translations
B1Genomic instability, disease evolu-tion and rational treatment develop-ment in CLL mouse modelsS. Stilgenbauer
B2Genomic and epigenetic mechanisms of resistance and Richter transfor-mation in CLL patients treated with novel compounds

D. Mertens,
H. Döhner,
S. Stilgenbauer

B3Molecular and functional characteri-zation of cooperating events in acute myeloid leukemia with NPM1 mutationK. Döhner,
L. Bullinger
B6Genomic and signalomic characterization of pre- and post-therapy ALL modeled in vivoL.-H. Meyer,
K.-M. Debatin
B8 (new)Role of BRCC36 in the pathogenesis of myelodysplastic syndromeJ. Krönke
B9 (new)Causes and consequences of the epigenetic perturbances in T-prolymphocytic leukemiaR. Siebert,
R. Wagener
Central Projects
Z1Bioinformatics core - semantic knowledge fusion and non-standard optimization --
Next-generation sequencing core
H. Kestler,
C. Buske
Z2Central Project ManagementH. Döhner
Z3 (new)Mass spectrometry and proteomics core unitS. Wiese