Ulm Lectures: Mechanisms of Malignant Progression of Carcinoma Cells

Zeit : Freitag , 19.05.2017, 18:00 Uhr
Ort : Stadthaus, Münsterplatz 50,

Dozent: Dr. Robert A. Weinberg

Abstract:
The phenotype of carcinoma cells is dictated in part by the somatic mutations that they have acquired en route to tumor formation.  However, epigenetic programs, such as the epithelial-mesenchymal transition (EMT), may impose strong phenotypic effects on cancer cells, including imparting of motility, invasiveness, an ability to disseminate, to form tumor-initiating cells, and to resist various types of therapy.  Recent data also implicates the responsiveness of epithelial vs. mesenchymal carcinoma cells to checkpoint immunotherapy, revealing yet another dimension of heterogeneity within tumor cells populations that share a common genome.