AG Molekulare Psychotraumatologie

Projektleitung

  • Prof. Dr. Iris-Tatjana Kolassa

Team

  • Dr. Alexander Karabatsiakis
  • Dr. Hannah Gola
  • Dipl.-Psych. Gilava Hamuni
  • Dipl.-Psych. Sarah Wilker
  • Traudl Hiller (MTA)
  • M. Sc. Christina Böck
  • Laura Ramo
  • Manuela Rappel
  • Benjamin Weber
  • Alexandra König
  • Dipl.-Psych. Anna Schneider
  • M.Sc. Daniela Conrad
  • Verena Nold
Copyright © 2014 • Heiko Grandel • Universitätsklinikum Ulm

Forschungsthemen

  • Genetik der Posttraumatischen Belastungsstörung (PTBS) mehr
  • Psychoneuroimmunologische Konsequenzen bei Stress und Trauma
  • Neuroplastische Veränderungen durch Stress
  • Biologische Korrelate der Behandlung traumatischer Störungen mit Narrativer Expositionstherapie (NET)
  • Psychologische und biologische Auswirkungen von Missbrauchs-, Misshandlungs- & Vernachlässigungserfahrungen in der Kindheit mehr
  • Transdisziplinäre Traumaforschung (pdf)

Drittmittel

  • 04/2009-03/2014 DFG Emmy Noether-Nachwuchsgruppe innerhalb der DFG-Forschergruppe Science of Social Stress zum Thema Stress- und Trauma-assoziierte immunologische Veränderungen und ihre Auswirkungen auf die Gesundheit.
  • 05/2013-04/2016 DFG-Antrag im D-CH-Programm: Gen-Umwelt-Interaktionen bei der Ätiologie, Symptomatologie und Therapie der Posttraumatischen Belastungsstörung: I.-T. Kolassa (DFG), D. de Quervain, A. Papassotiropoulos (SNF)

  • 01/2013-12/2016 BMBF: Stress resilience in the transgenerational transmission of childhood maltreatment. J. Fegert (Koordinator), H. Gündel, I.-T. Kolassa

Ausgewählte Publikationen

  • Karabatsiakis, A., Hamuni, G., Wilker, S., Kolassa, S., Renu, D., Kadereit, S., Schauer, M., Hennessy, T. & Kolassa, I.-T. (2015). Metabolite profiling in posttraumatic stress disorder. Journal of Molecular Psychiatry 3(1):2. 

  • Karabatsiakis, A., Böck, C., Manrique, J.S., Kolassa, S., Calzia, E., Dietrich, D.E., Kolassa, I.-T. (2014). Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Translational Psychiatry, 4:e397. [pdf]

  • Morath, J.*, Moreno-Villanueva, M.*, Hamuni, G., Kolassa, S., Ruf, M., Schauer, M., Bürkle, A., Elbert, T., Kolassa, I.-T. (2014). Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress. Psychotherapy and Psychosomatics, 83:e289-297. [pdf]

  • Papassotiropoulos, A., Gerhards, C., Heck, A., Ackermann, S., Aerni, A., Demougin, P., Elbert, T., Ertl, V., Gschwind, L., Hanser, E., Huynh, K.-D., Jessen, F., Kolassa, I.-T., Muhs, A., Paganetti, P., Spalek, K., Vogler, C., Pfeifer, A., de Quervain, D. (2013). Human genome-guided identification of memory-modulating drugs. PNAS, 110(46):e4369-74. [pdf]

  • Moreno-Villanueva, M.*, Morath, J.*, Vanhooren, V., Elbert, T., Kolassa, S., Libert, C., Bürkle, A., Kolassa, I.-T. (2013). N-Glycosylation profiling of plasma provides evidence for accelerated physiological aging in Posttraumatic Stress Disorder. Translational Psychiatry, 3:e320. *equally contributing [pdf]

  • Wilker, S., Kolassa, S., Vogler, C., Lingenfelder, B., Elbert, T., Papassotiropoulos, A., De Quervain, D. J.-F., et al. (2013). The Role of Memory-related Gene WWC1 (KIBRA) in Lifetime Posttraumatic Stress Disorder: Evidence from Two Independent Samples from African Conflict Regions. Biological Psychiatry, 74(9):664-671 [Abstract]

  • Wilker, S. & Kolassa, I.-T. (2013). The formation of a neural fear network in Posttraumatic Stress Disorder: Insights from molecular genetics. Clinical Psychological Science, 1(4), 452-469. [Abstract]

  • de Quervain, D. J.-F., Kolassa, I.-T., Ackermann, S., Aerni, A., Boesiger, P., Demougin, P., Elbert, T., Ertl, V., Gschwind, L., Hadziselimovic, N.,Hanser, E., Heck, E., Hieber, P., Huynh, K.-D., Klarhöfer, M., Luechinger, R., Rasch, B., Scheffler, K., Spalek, K., Stippich, C., Vogler, C., Vukojevic, V., Stetak, A. Papassotiropoulos, A.(2012). PKCα is genetically linked to emotional memory in healthy Europeans and to the risk for PTSD in heavily traumatized Rwandese. PNAS, 109(22):8746-51. [pdf]

  • Kolassa, I.-T., Ertl., V., Eckart, C., Thurm, F., Kolassa, S., Papassotiropoulos, A., de Quervain, D. J.-F., Elbert, T. (2010). Association study of trauma load and SLC6A4 promoter polymorphism in PTSD: evidence from survivors of the Rwandan genocide. Journal of Clinical Psychiatry, 71(5):543-547.

  • Kolassa, I.-T., Kolassa, S., Ertl, V., Papassotiropoulos, A., & de Quervain, D. J.-F. (2010). The risk of Posttraumatic Stress Disorder after trauma depends on trauma load and the COMT Val158Met polymorphism. Biological Psychiatry, 67(4), 304-308.

  • Sommershof, A.1, Aichinger, H.1, Adenauer, H., Catani, C., Boneberg, E., Engler, H., Elbert, T., Groettrup, M., Kolassa, I.-T. (2009). Substantial reduction of naïve and regulatory T cells following traumatic stress. Brain, Behavior, and Immunity, 23, 1117-1124. [pdf]

  • de Quervain, D. J.-F., Kolassa, I.-T., Ertl, V. Onyut, P. L., Neuner, F., Elbert, T., & Papassotiropoulos, A. (2007). A deletion variant of the α2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience, 10(9), 1137-1139.

  • Kolassa, I.-T., & Elbert, T. (2007). Structural and functional neuroplasticity in relation to traumatic stress. Current Directions in Psychological Science, 16(6), 321-325.