Preise und Auszeichnungen

2004

Heckmann L, Fiedler J, Brenner R
1st poster award of the "Annual Meeting of the German Connective Tissue Society". Title: Tissue Engineering of Tendon: Cultivation of Human Mesenchymal Progenitor Cells in a 3D-Collagen System.

2002

Brenner R, Röderer G, Fiedler J
1st poster award of the "Joint Annual Meeting of the German Connective Tissue Society and Southern Scandinavian Universities". Title: Chemotactic migration of primary human mesenchymal progenitor cells.

2000

Mayr-Wohlfart U, Kessler S, Brenner R, Günther KP
1st poster award of the German Society for Traumatology for the presentation“. Title: Migration of primary human osteoblasts under stimulation with growth factors.

Literatur

2011

Schneider EM, Du W, Fiedler J, Högel J, Günther KP, Brenner H, Brenner RE. The (-765 G>C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis. Ann Rheum Dis. 2011 Aug;70(8):1458-60. PMID: 20378913.

Joos H, Hogrefe C, Rieger L, Dürselen L, Ignatius A, Brenner RE. Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1ß on cell survival. Int J Mol Med. 2011 Aug;28(2):271-7. PMID: 21567074

Fiedler J, Kolitsch A, Kleffner B, Henke D, Stenger S, Brenner RE. Copper and silver ion implantation of aluminium oxide-blasted titanium surfaces: proliferative response of osteoblasts and antibacterial effects. Int J Artif Organs. 2011 Sep;34(9):882-8. PMID: 22094570.

Fiedler J, Groll J, Engelhardt E, Gasteier P, Dahmen C, Kessler H, Moeller M, Brenner RE. NCO-sP(EO-stat-PO) surface coatings preserve biochemical properties of RGD peptides. Int J Mol Med. 2011 Jan;27(1):139-45.PMID: 21069259

2010

Joos H, Albrecht W, Laufer S, Brenner RE. Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes. Br J Pharmacol. 2010 Jul;160(5):1252-62.PMID: 20590617

Habisch HJ, Schmid B, von Arnim CA, Ludolph AC, Brenner R, Storch A. Efficient processing of Alzheimer's disease amyloid-Beta peptides by neuroectodermally converted mesenchymal stem cells. Stem Cells Dev. 2010 May;19(5):629-33.PMID: 19469700

Schneider EM, Du W, Fiedler J, Högel J, Günther KP, Brenner H, Brenner RE. The (-765 G->C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis. Ann Rheum Dis. 2010 Apr 8. [Epub ahead of print]PMID: 20378913

Kreja L, Brenner RE, Tautzenberger A, Liedert A, Friemert B, Ehrnthaller C, Huber-Lang M, Ignatius A. Non-resorbing osteoclasts induce migration and osteogenic differentiation of mesenchymal stem cells. J Cell Biochem. 2010 Feb 1;109(2):347-55.PMID: 19950208

Hinrichs T, Superti-Furga A, Scheiderer WD, Bonafe L, Brenner RE, Mattes T. Recessive multiple epiphyseal dysplasia (rMED) with homozygosity for C653S mutation in the DTDST gene - Phenotype, molecular diagnosis and surgical treatment of habitual dislocation of double-layered patella: Case report. BMC Musculoskelet Disord. 2010 Jun 3;11(1):110. PMID: 20525296

Habisch HJ, Liebau S, Lenk T, Ludolph AC, Brenner R, Storch A. Neuroectodermally converted human mesenchymal stromal cells provide cytoprotective effects on neural stem cells and inhibit their glial differentiation. Cytotherapy. 2010 Mar 24. PMID: 20331410

2009

Perl M, Brenner RE, Lippacher S, Nelitz M. Dysplasia epiphysealis hemimelica: a case report with novel pathophysiologic aspects. Clin Orthop Relat Res. 2009 Sep;467(9):2472-8. Epub 2009 Jun 13.PMID: 19526273

Groll J, Fiedler J, Bruellhoff K, Moeller M, Brenner RE. Novel surface coatings modulating eukaryotic cell adhesion and preventing implant infection. Int J Artif Organs. 2009 Sep;32(9):655-62. Review.

Hess K, Ushmorov A, Fiedler J, Brenner RE, Wirth T. TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway. Bone. 2009 May 1. PMID: 19414075

Joos H, Albrecht W, Laufer S, Brenner RE. Influence of p38MAPK inhibition on IL-1beta-stimulated human chondrocytes: A microarray approach. Int J Mol Med. 2009 May;23(5):685-93. PubMed PMID: 19360329.

2008

Heckmann L, Fiedler J, Mattes T, Dauner M, Brenner RE. Interactive effects of growth factors and three-dimensional scaffolds on multipotent mesenchymal stromal cells. Biotechnol Appl Biochem. 2008 Mar;49(Pt 3):185-94. PubMed PMID: 17640172.

Joos H, Albrecht W, Laufer S, Reichel H, Brenner RE. IL-1beta regulates FHL2 and other cytoskeleton-related genes in human chondrocytes. Mol Med. 2008 Mar-Apr;14(3-4):150-9. PubMed PMID: 18224250; PubMed Central PMCID: PMC2213891.

Habisch HJ, Fiedler J, Ludolph AC, Storch A, Brenner RE. Altered migration and adhesion potential of pro-neurally converted human bone marrow stromal cells. Cytotherapy. 2008;10(8):824-33. PubMed PMID: 19016370.

2007

Schütze N, Schenk R, Fiedler J, Mattes T, Jakob F, Brenner RE. CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells. BMC Cell Biol. 2007 Oct 31;8:45. PubMed PMID: 17973995; PubMed Central PMCID: PMC2211300.

Maisel M, Herr A, Milosevic J, Hermann A, Habisch HJ, Schwarz S, Kirsch M, Antoniadis G, Brenner R, Hallmeyer-Elgner S, Lerche H, Schwarz J, Storch A. Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state. Stem Cells. 2007 May;25(5):1231-40. Epub 2007 Jan 11. PubMed PMID: 17218394.

Habisch HJ, Janowski M, Binder D, Kuzma-Kozakiewicz M, Widmann A, Habich A, Schwalenstöcker B, Hermann A, Brenner R, Lukomska B, Domanska-Janik K, Ludolph AC, Storch A. Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm. 2007;114(11):1395-406. Epub 2007 May 18. PubMed PMID: 17510731.

Hausser HJ, Ruegg MA, Brenner RE, Ksiazek I Agrin is highly expressed by chondrocytes and is required for normal growth. Histochem Cell Biol 2007, 127:363-374.

Heckmann L, Schlenker HJ, Fiedler J, Brenner R, Dauner M, Bergenthal G, Mattes T, Claes L, Ignatius A Human mesenchymal progenitor cell responses to a novel textured poly(L-lactide) scaffold for ligament tissue engineering. J Biomed Mater Res B Appl Biomater 2007, 81:82-90.

Heckmann L, Fiedler J, Mattes T, Dauner M, Brenner RE Interactive effects of growth factors and 3D-scaffolds on multipotent mesenchymal stromal cells. Biotechnol Appl Biochem 2007.

Stove J, Lehmann L, Fickert S, Aigner T, Brenner R Artificial organs: a new option for treating osteoarthritis. Curr Drug Deliv 2007, 4:77-88.

2006

Fiedler J, Brill C, Blum WF, Brenner RE IGF-I and IGF-II stimulate directed cell migration of bone-marrow-derived human mesenchymal progenitor cells. Biochem Biophys Res Commun 2006 May 12; [Epub ahead of print]

Heckmann L, Fiedler J, Mattes T, Brenner RE Mesenchymal progenitor cells communicate via alpha and beta integrins with a three-dimensional collagen type I matrix Cells Tissues Organs. 2006;182(3-4):143-154.

Heckmann L, Schlenker H-J, Fiedler J, Brenner R, Dauner M, Bergenthal G, Mattes T, Claes L, Ignatius A Human mesenchymal progenitor cell responses to a novel textured poly(L-lactide) scaffold for ligament tissue engineering J Biomed Mater Res B 2006 (in press)

Hermann A, Liebau S, Gastl R, Fickert S, Habisch HJ, Fiedler J, Schwarz J, Brenner R, Storch A. Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocols.J Neurosci Res. 2006 Jun 1;83(8):1502-14. PMID: 16612831

2005

Groll J, Fiedler J, Engelhard E, Ameringer T, Tugulu S, Klok HA, Brenner RE, Moeller M. A novel star PEG-derived surface coating for specific cell adhesion.J Biomed Mater Res A. 2005 Sep 15;74(4):607-17. PMID: 16035061

Fiedler J. Gene symbol: SEDL. Disease: spondyloephiphyseal dysplasia, late.Hum Genet. 2005 Feb;116(3):233. No abstract available. PMID: 15818804

Fiedler J, Leucht F, Waltenberger J, Dehio C, Brenner RE. VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells.Biochem Biophys Res Commun. 2005 Aug 26;334(2):561-8. PMID: 16005848

Hausser HJ, Brenner RE. Phenotypic instability of Saos-2 cells in long-term culture.Biochem Biophys Res Commun. 2005 Jul 22;333(1):216-22 PMID: 15939397 [PubMed - in process]

Lieb E, Hacker M, Tessmar J, Kunz-Schughart LA, Fiedler J, Dahmen C, Hersel U, Kessler H, Schulz MB, Gopferich A Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides. Biomaterials. 2005 May;26(15):2333-41. PMID: 15585236

2004

Hausser HJ, Decking R, Brenner RE Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage. Osteoarthritis Cartilage. 2004 Nov;12(11):870-7

Koepp HE, Schorlemmer S, Kessler S, Brenner RE, Claes L, Gunther KP, Ignatius AA Biocompatibility and osseointegration of beta-TCP: histomorphological and biomechanical studies in a weight-bearing sheep model. J Biomed Mater Res. 2004 Aug 15;70B(2):209-17

Fickert S, Fiedler J, Brenner R Identification of Subpopulations with Characteristics of Mesenchymal Progenitor Cells from Human Osteoarthritic Cartilage using Triple Staining for Cell Surface Markers Arthritis Research Therapy 2004, 6:R422-R432

Fiedler J, Etzel N, Brenner RE To Go or not to Go: Migration of Human Mesenchymal Progenitor Cells stimulated by isoforms of PDGF J Cell Biochem. 2004 Dec 1;93(5):990-8

Fiedler J, Le Merrer M, Mortier G, Heuertz S, Faivre L, Brenner RE X-linked Spondyloepiphyseal Dysplasia Tarda: Novel and Recurrent Mutations in 13 European Families. Hum Mut 2004 , Jul;24(1):103.

Hausser HJ, Brenner RE Low doses and high doses of heparin have different effects on osteoblast-like Saos-2 cells in vitro J Cell Biochem. 2004 Apr 1;91(5):1062-73

Hermann A, Gastl R, Liebau S, Popa MO, Fiedler J, Boehm BO, Maisel M, Lerche H, Schwarz J, Brenner R, and Storch A Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells J Cell Science 2004, Aug 10;Pt. [Epub ahead of print]

2003

Fickert S, Fiedler J, Brenner R Identification, Quantification and Isolation of Mesenchymal Progenitor Cells from Osteoarthritic Synovium by Fluorescence Automated Cell Sorting Osteoarthritis Cartilage 2003 Nov;11(11):790-800

Fiedler J, Bergmann, C, Brenner, R X-linked spondyloepiphyseal dysplasia tarda: Molecular cause of a heritable disorder associated with early degenerative joint disease 2003 Acta Orthopaedica Scandinavica, Vol. 74, No. 6, 737-741

Fiedler J, LeMerrer M, Frances AM, Richter M, Brenner R X-linked spondyloepiphyseal dysplasia tarda: Molecular cause of a heritable platyspondyly 2003 SPINE Volume 28, Number 22, pp E478

Huch K, Kleffner S, Stove J, Puhl W, Gunther KP, Brenner RE PTHrP, PTHr, and FGFR3 are involved in the process of endochondral ossification in human osteophytes. Histochem Cell Biol. 2003 Apr;119(4):281-7. Epub 2003 Apr 12

2002

Fiedler, J, Röderer, G, Günther, KP, Brenner, R BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells 2002 Journal of Cellular Biochemistry 87 3 305-12

Fiedler, J, Bittner, M, Puhl, W, Brenner R Mutations in the spondyloepiphyseal dysplasia tarda (SEDL) coding sequence are not a common cause of early primary osteoarthritis in men 2002 Clin Genet 62 1 94-95

Fiedler, J, Stöve, J, Heber, F, Brenner R Clinical Phenotype and Molecular Diagnosis of Multiple Epiphyseal Dysplasia With Relative Hip Sparing During Childhood (EDM2) 2002 American Journal of Medical Genetics; 112 2 144-153

Huch K, Mordstein V, Stöve J, Nerlich A, Arnholdt H, Delling G, Puhl W, Günther KP, Brenner RE Expression of Collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage 2002 European Journal of Histochemistry 46 249-258

Stöve J, Schöniger, R, Huch, K, Brenner, R, Günther, KP, Puhl, W, Scharf, HP Effects of dexamethasone on proteoglycan content and gene expression of IL-1B stimulated osteoarthrotic chondrocytes in vitro 2002 Acta Orthopaedica Scandinavica 73 5 562-7

Mayr-Wohlfart, U, Waltenberger, J, Hausser, H, Kessler, S, Gunther, KP, Dehio, C, Puhl, W and Brenner, RE Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts 2002 Bone 30 3 472-477

Stove, J, Fiedler, J, Huch, K, Gunther, KP, Puhl, W and Brenner, R Lipofection of rabbit chondrocytes and long lasting expression of a lacZ reporter system in alginate beads 2002 Osteoarthritis Cartilage 10 3 212-217

2001

Stöve J, Gerlach, C, Huch, K, Günther, KP, Brenner, R, Puhl, W, Scharf, HP Gene expression of stromelysin and aggrecan in osteoarthritic cartilage 2001 Pathobiology 69k 333-338

Brenner, RE, Felger, D, Winter, C, Christiansen, A, Hofmann, D and Bartmann, P Effects of dexamethasone on proliferation, chemotaxis, collagen I, and fibronectin-metabolism of human fetal lung fibroblasts 2001 Pediatr Pulmonol 32 1 1-7

Dame, C, Hausser, I, Geukens, J and Brenner, RE Special feature: pathological case of the month 2001 Arch Pediatr Adolesc Med 155 11 1275-1276

Sturmer, T, Brenner, H, Brenner, RE and Gunther, KP Non-insulin dependent diabetes mellitus (NIDDM) and patterns of osteoarthritis. The Ulm osteoarthritis study 2001 Scand J Rheumatol 30 3 169-171

Tiecke, F, Katzke, S, Booms, P, Robinson, PN, Neumann, L, Godfrey, M, Mathews, KR, Scheuner, M, Hinkel, GK, Brenner, RE, Hovels-Gurich, HH, Hagemeier, C, Fuchs, J, Skovby, F and Rosenberg, T Classic, atypically severe and neonatal Marfan syndrome: twelve mutations and genotype-phenotype correlations in FBN1 exons 24-40 2001 Eur J Hum Genet 9 1 13-21

Trummer, T, Brenner, R, Just, W, Vogel, W and Kennerknecht, I Recurrent mutations in the COL1A2 gene in patients with osteogenesis imperfecta 2001 Clin Genet 59 5 338-343

Wabitsch, M, Brenner, RE, Melzner, I, Braun, M, Moller, P, Heinze, E, Debatin, KM and Hauner, H Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation 2001 Int J Obes Relat Metab Disord 25 1 8-15

2000

Gebken, J, Brenner, R, Feydt, A, Notbohm, H, Brinckmann, J, Muller, PK and Batge, B Increased Cell Surface Expression of Receptors for Transforming Growth Factor-beta on Osteoblasts from Patients with Osteogenesis imperfecta 2000 Pathobiology 68 3 106-112.

Günther, KP, Brenner, R, Wörsdörfer, O Modified telescopic nailing for long bone fractures in children with osteogenesis imperfecta 2000Techniques in Orthopaedics 15(1) 54 - 57

Karbowski, A, Schwitalle, M, Brenner, R, Lehmann, H, Pontz, B and Worsdorfer, O Experience with Bailey-Dubow rodding in children with osteogenesis imperfecta 2000 Eur J Pediatr Surg 10 2 119-124

Taillandier, A, Cozien, E, Muller, F, Merrien, Y, Bonnin, E, Fribourg, C, Simon-Bouy, B, Serre, JL, Bieth, E, Brenner, R, Cordier, MP, De Bie, S, Fellmann, F, Freisinger, P, Hesse, V, Hennekam, RC, Josifova, D, Kerzin-Storrar, L, Leporrier, N, Zabot, MT and Mornet, E Fifteen new mutations (-195C>T, L-12X, 298-2A>G, T117N, A159T, R229S, 997+2T>A, E274X, A331T, H364R, D389G, 1256delC, R433H, N461I, C472S) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in patients with hypophosphatasia 2000 Hum Mutat 15 3 293

Walch, E, Schmidt, M, Brenner, RE, Emons, D, Dame, C, Pontz, B, Wiestler, OD and Bartmann, P Yunis-Varon syndrome: evidence for a lysosomal storage disease 2000 Am J Med Genet 95 2 157-160


Literatur vor 2000