1.The search for candidate genes involved in the signalling of germ layer differentiation is a prerequisite to study the early cell fate determination in stem cells.

2. We have demonstrated that small and intermediate conductance, calcium activated potassium channels (SK channels) are involved in early steps of murine stem cell differentiation and cardiac pacemaker cell fate determination, a preliminary work to study the role of SK channels during human embryonic development and their impact on the generation and maturation of other tissues

3. The signals involved in the differentiation and maintenance of numerous neuro-ectoderm derived cell types during embryonic development remains unknown, therefore the generation and characterization of purified human induced pluripotent stem cell derived neuronal subtypes in different pathogenetic settings is a the crucial basics to study defects in neurogenesis and neurodegeneration