Research groups2013
Original publications
Grotek B*, Wehner D* and Weidinger G (2013) Notch signaling coordinates cellular proilferation with differentiation during zebrafish fin regeneration, Development, 140, 1414-1423, * equal contribution
Thieme S, Gyárfás T, Richter C, Ozhan G, Fu J, Alexopulou D, Muders MH, Michalk I, Jakob C, Dahl A, Klink B, Bandola J, Bachmann M, Schröck E, Buchholz F, Stewart AF, Weidinger G, Anastassiadis K, Brenner S (2013) The histone demythylase UTX regulates stem cell migration and hematopoiesis, Blood, in press
Reviews
Kühl SJ and Kühl M ( 2013) The role of Wnt/b-catenin signaling in stem cells, BBA general subjects, 1820, 2297-306
Pandur P, Sirbu IO, Kühl SJ, Philipp M, Kühl M (2013) Islet1 expressing cardiac progenitor cells: A comparison across species, Dev. Genes Evol., 223, 117-29
2012
Original publications
Philipp M*, Niederkofler V*, Debrunner M, AltherT, Kunz Beat, Stoeckli ET (2012) RabGDI conrols axonal midline crossing by regulating Robo1 surface expression, Neural Dev., in press, *equal contribution
Herrmann F*, Groß A*, Zhou D, Kestler HA, Kühl M (2012) A boolean model of the cardiac regulatory network determining first and second heart field identity, PLOS one, 10, 1-10, *equal contribution
Julier A, Goll C, Korte B, Knöchel W, Wacker S (2012) The Pou-V factor regulates early morphogenesis in Xenopus laevis, Development, Growth and Differentiation, 54,702-16
Moro E, Ozhan-Kizil G, Mongera A, Beis D, Wierzbicki C, Young RM, Bournele D, Domenichini A, Valdivia LE, Lum L, Chen C, Amatruda JF, Tiso N, Weidinger G, Argenton F (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains, Dev. Biol., 366, 327-40
Shin D, Weidinger G, Moon RT, Stainier DY (2012) Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver, Mech. Dev. 128, 525-35
Murugan S, Shan J, Kühl SJ, Tata A, Pietulä I, Kühl M and Vainio SJ (2012) WT1 and Sox11 regulate synergistically the promotor of Wnt4 gene that encodes a critical signal for nephrogenesis, Exp. Cell Res., 318, 1134-45
Tauc HM*, Mann T*, Werner K, Pandur P (2012) A role for Drosophila Wnt-4 in heart development, Genesis, 50, 466-81, *equal contribution, cover image
Schuff M*, Siegel D*, Philipp M, Bundschu K, Heymann N, Donow C, Knöchel W (2012) Danio rerio nanog promotes proliferation and inhibits differentiation in mouse ES cells, Stem Cells and Development, 21:1225-38, *equal contribution
Hopfensitz M, Müssel C, Wawra C, Maucher M, Kühl M, Neumann H, Kestler HA (2012) Multiscale binarization of gene expression data for reconstructing Boolean networks, IEEE/ACM, in press
Comments
Kühl S und Kühl M (2012) Nobelpreise 2012, Physiologie oder Medizin, Naturwissenschaftliche Rundschau, 12, 5-7
Text books
Kühl S und Kühl M (2012) Stammzellbiologie, UTB, Eugen Ulmer Verlag, Stuttgart
2011
Original publications
Herrmann F*, Bundschu K*, Kühl SJ, Kühl M (2011) Tbx5 overexpression favours a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos, Dev. Dyn., 240, 2634-45, * both contributed equally
Tao S, Kühl M, Kühl SJ (2011) Expression of periostin during Xenopus laevis embryogenesis, Dev. Genes Evol., 221, 247-54
Tecza A, Bugner V, Kühl M, Kühl SJ (2011) Pes1 and ppan function during Xenopus laevis pronephros development, Biol. Cell, 103, 483-98, cover image
Bugner V, Aurhammer T and Kühl M (2011) Xenopus laevis insulin receptor substrate IRS-1 is important for eye development, Dev. Dyn., 240, 17-15
Guo Y, Christine KS, Conlon F, Gessert S, Kühl M (2011) Expression analysis of epb41l4a during Xenopus laevis embryogenesis, Dev. Genes Evol., 221, 118-9
Maucher M*, Kracher B*, Kühl M, Kestler H (2011) Inferring Boolean network structure via correlation, Bioinformatics, 27, 1529-36, * both contributed equally
Bugner V, Tecza A, Gessert S, Kühl M (2011) Peter Pan functions independent of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis, Development, 138, 2369-78
Gessert S, Schmeisser MJ, Tao S, Böckers TM, Kühl M (2011) The spatio-temporal expression of ProSAP/Shank family members and their interaction partner LAPSER1 during Xenopus laevis development, Dev. Dyn., 240, 1528-36
Tata RP, Tata NR, Kühl M, Sirbu IO (2011) Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC, Nucleic Acids Res., 39, 3574-81
Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W and Caron MG (2011) Growth arrest specific 8 (Gas8) and GPCR kinase 2 (GRK2) cooperate in the control of smoothenend signaling, JBC, 286, 27676-86
Soderblom EJ, Philipp M, Thompson JW, Caron MG and Moseley MA (2011) A quantitative label-free phosphoproteomics strategy for mulitfaceted experimental designs, Anal. Chem., 83,3758-64
Ullrich M, Bundschu K, Benz PM, Abesser M, Freudinger R, Fischer T, Ullrich J, Renne T, Walter U, Schuh K (2011) Identification of Sprouty-related protein with EVH-1 domain (SPRED) 2 as a negative regulator of the Hypothalamic-Pituitary-Adrenal (HPA) axis, J Biol Chem, 286, 9477-88
Wacker SA, Alvarado C, von Wichert G, Knippschild U, Wiedenmann J, Clauss K, Nienhaus GU, Hameister H, Baumann B, Borggrefe T, Knöchel W and Oswald F (2011) RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J. 30, 43-56
Schmidt J, Schuff M, Olsson L (2011) A role for FoxN3 in the development of cranial cartilages and muscles in Xenopus laevis, J. Anat. 218, 226-42
Klein C, Mikutta J, Krueger J, Scholz K, Brinkmann J, Liu D, Veerkamp J, Siegel D, Abdelila-Seyfried S, le Noble F (2011) Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis, Development 138, 1935-45
Reviews
Kühl SJ and Kühl M (2011) Improving cardiac function after injury: are we a step closer? BioEssays, 33, 669-73
Kestler HA and Kühl M (2011) Generating a Wnt switch: it´s all about the right dosage, JCB, 193, 431-3
2010
Original publications
Gessert S, Bugner V, Tecza A, Pinker M, Kühl M (2010) FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development, Dev. Biol., 341, 222-35
Tuduce I, Schuh K, Bundschu K (2010) SPRED2 expression during mouse development, Dev. Dyn., 239, 3072-85
Cao Y, Oswald F, Wacker S, Bundschu K, Knöchel W (2010) Reversal of xenopus OCT25 function by disruption of the pou doman structure, J Biol Chem, 285, 8408-21
Schuff M, Siegel D, Bardine N, Oswald F, Donow C and Knöchel W (2010) FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis. Dev. Biol. 337, 259-273
Reviews
Gessert S and Kühl M (2010) The multiple phases and faces of Wnt signaling during cardiac differentiation and development, Circ. Res., 107, 186-99
Rao TP and Kühl M (2010) An updated overview of Wnt signaling pathways: a prelude for more, Circ. Res., 106, 1798-806
Durston AJ, Jansen HJ and Wacker SA (2010) Time-space translation: a developmental principle. ScientificWorldJournal. 10, 2207-2214
Durston AJ, Jansen HJ and Wacker SA (2010) Review: Time-space translation regulates trunk axial patterning in the early vertebrate embryo. Genomics 95(5), 250-255
Text books
Kühl M und Gessert S (2010) Entwicklungsbiologie, UTB Basics, Eugen Ulmer Verlag, Stuttgart
2009
Original publications
Gessert S and Kühl M (2009) Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis, Dev. Biol. 334, 395-408
Mann T, Bodmer R, Pandur P (2009) The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis, Development, 136, 317-26
Zhao X, Sirbu IO, Mic FA, Molotkov A, Kumar S, Duester G (2009) Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning. Curr. Biol., 19,1050-7
Woltering JM, Vonk FJ, Müller H, Bardine N, Tuduce IL, de Bakker MA, Knöchel WP, Sirbu IO, Durston AJ, Richardson MK (2009) Axial patterning in snakes and caecilians: Evidence for alternative interpretation of the Hox code. Dev. Biol., 332,82-9
Siegel D, Schuff M, Oswald F, Cao Y and Knöchel W (2009) Functional dissection of XDppa2/4 structural domains in Xenopus development. Mech. Dev. 126, 974-989
Bardine N, Donow C, Korte B, Durston AJ, Knöchel W and Wacker SA (2009) Two Hoxc6 transcripts are differentially expressed and regulate primary neurogenesis in Xenopus laevis. Dev. Dyn. 238, 755-765
Reviews
Sirbu IO and Pandur P (2009) Saving hearts through basic research. Birth Defects Res C Embryo Today 87, 273-283
2008
Original publications
Gessert S, Maurus D, Brade T, Walther P, Pandur P, Kühl M (2008) DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells, Dev. Biol. 321, 150-61
Gessert S, Maurus D, Kühl M (2008) Repulsive guidance molecule A (RGM A) and its receptor Neogenin during neural and neural crest development of Xenopus laevis, Biol. Cell, 100, 659-73, cover image
Sirbu IO, Zhao X, Duester G (2008) Retinoic acid controls heart anteriorposterior patterning by downregulating Isl1 through the Fgf8 pathway. Dev. Dyn., 237,1627-35
Cao Y, Siegel D, Oswald F and Knöchel W (2008) Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. J. Biol. Chem. 283, 34168-34177
Luu O, Nagel M, Wacker S, Lemaire P and Winklbauer R (2008) Control of gastrula cell motility by the Goosecoid/Mix.1/ Siamois network: basic patterns and paradoxical effects. Dev. Dyn. 237, 1307-1320
Yuan L, Cao Y, Oswald F and Knöchel W (2008) IRE1beta is required for mesoderm formation in Xenopus embryos. Mech. Dev. 125, 207-222
Reviews
Kestler HA, Wawra C, Kracher B, Kühl M (2008) Network modeling of signal transduction: establishing of a global view, BioEssays, 30, 1110-25
Kestler HA, Kühl M (2008) From individual Wnt pathways towards a Wnt signalling network, Phil. Trans. R. Soc. B, 363, 1333-47
Book chapters
Kühl M, Pandur P (2008) Dorsal axis duplication as a functional read-out for Wnt acitivity, Ed: Vincan E. Humana Press Inc., New Jersey, USA
Kühl M, Pandur P (2008) Measuring CamKII activity in Xenopus embryos as a read-out for non-canonical Wnt signaling, Ed: Vincan E. Humana Press Inc., New Jersey, USA
2007
Original publications
Anton R, Kestler HA, Kühl M (2007) β-catenin signalling contributes to stemness and regulates differentiation in murine embryonic stem cells, FEBS Letters 581, 5247-5254
Gessert S*, Maurus D*, Rössner A, Kühl M (2007) Pescadillo is required for Xenopus laevis eye and neural crest development, Dev. Biol. 310, 99-112, * both contributed equally
Brade T, Gessert S, Kühl M, Pandur P (2007) The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development, Dev. Biol. 311, 297-310
Wawra C, Kühl M, Kestler HA (2007) Extended analyses of the Wnt/beta-catenin pathway: robustness and oscillatory behavior, FEBS Lett, 581, 4043-8
Giamas G, Shoshiashvili L, Hirner H, Grithey A, Gessert S, Kühl M, Henne-Bruns D, Vorgias CE, Knippschild U (2007) Phosphorylation of CKIδ by PKA, Akt, CLK2 and PKC: Identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo, Biochem. J. 406, 389-398
Schuff M, Rössner A, Wacker SA, Donow C, Gessert S, Knöchel W (2007) FoxN3 is required for craniofacial and eye development of Xenopus laevis, Dev. Dyn. 236, 226-39
Yuan L, Cao Y and Knöchel W (2007) Endoplasmic reticulum stress induced by tunicamycin disables germ layer formation in Xenopus laevis embryos. Dev. Dyn. 236, 2844-2851
Jansen HJ, Wacker SA, Bardine N and Durston AJ (2007) The role of the Spemann organizer in anterior-posterior patterning of the trunk. Mech. Dev. 124, 668-681
Cao Y, Siegel D, Donow C, Knöchel S, Yuan L and Knöchel W (2007) POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J. 26, 2942-2954
Wacker SA, Oswald F, Wiedenmann J and Knöchel W (2007) A green to red photoconvertible protein as an analyzing tool for early vertebrate development. Dev. Dyn. 236, 473-480
Reviews
Anton R, Kühl M, Pandur P (2007) A molecular signature of the master heart cell, BioEssays, 29,422-26
Bundschu K, Walter U, Schuh K (2007) Getting a first clue about SPRED functions, BioEssays 29, 897-907
2006
Original publications
Cus R, Maurus D, Kühl M (2006) Cloning and developmental expression of WSTF during Xenopus laevis embryogenesis, Gen Expr. Patt 6, 340-346
Schön C, Wochnik A, Rössner A, Donow C and Knöchel W (2006) The FoxP subclass in Xenopus laevis development. Dev. Genes Evol. 216, 641-646
Cao Y, Siegel D and Knöchel W (2006) Xenopus POU factors of subclass V inhibit activin/nodal signaling during gastrulation. Mech. Dev. 123, 614-625
Schuff M, Rössner A, Donow C and Knöchel W (2006) Temporal and spatial expression patterns of FoxN genes in Xenopus laevis embryos. Int. J. Dev. Biol. 50, 429-434
Cao Y, Knöchel S, Oswald F, Donow C, Zhao H and Knöchel W (2006) XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos. Mech. Dev. 123, 84-96
Reviews
Brade T, Männer J, Kühl M (2006) Wnt signaling during cardiac development and remodelling. Cardiovasc. Res., 72, 198-209
Quaiser T, Anton R, Kühl M (2006) Kinases and G proteins join the Wnt receptor complex. BioEssays, 128, 339-343
Bundschu K, Walter U, Schuh K (2006) The VASP-Spred-Sprouty domain puzzle, J Biol Chem 281, 36477-36481
Book chapters
Kühl M, Moon RT (2006) How to assay non-canonical Wnt signaling: A critical analysis, in: Analysis of growth factor signaling in embryos, pp 29-35, Ed.: Whitman M, Sater AK. CRC press, Francis & Taylor, Boca Raton, FL, USA
2005
Original publications
Maurus D, Heligon C, Bürger-Schwärzler A, Brändli A, Kühl M (2005) Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis, EMBO J. 24, 1181-1181
Koyanagi M, Haendeler J, Badorff C, Brandes RP, Hoffmann J, Pandur P, Zeiher A, Kühl M, Dimmeler S (2005) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells, J. Biol. Chem. 290, 16838-16842
Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knöchel W and Borggrefe T (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell Biol. 25, 10379-10390
Pohl BS, Rössner A and Knöchel W (2005) The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development. Int. J. Dev. Biol. 49, 53-58
Reviews
Pandur P (2005) What does it take to make a heart. Biol. Cell 97, 1-14
Pohl BS and Knöchel W (2005) Of Fox and Frogs: Fox (fork head/winged helix) transcription factors in Xenopus development. Gene. 344, 21-32.
Book chapters
Pandur P (2005) Recent discoveries in vertebrate non-canonical Wnt signaling: towards a Wnt signaling network. In: Mlodzik, M. (Ed.), Adv. Dev. Biol. Biochem. Elsevier, Vol.14
2004
Original publications
Pandur PD, Dirksen ML, Moore KB, Moody SA (2004) Xenopus flotillin1, a novel gene highly expressed in the dorsal nervous system. Dev Dyn. 231, 881-887
Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA (2004) Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development 131, 5871-5881
Schön C, Köster M and Knöchel W (2004) A downstream enhancer is essential for Xenopus FoxD5 transcription. Biochem. Biophys. Res. Commun. 325, 1360-1366
Pohl BS, Schön C, Rossner A and Knöchel W (2004) The FoxO-subclass in Xenopus laevis development. Gene Expr. Patterns. 5, 187-192
Cao Y, Knöchel S, Donow C, Miethe J, Kaufmann E and Knöchel W (2004) The POU factor Oct-25 regulates the Xvent-2B gene and counteracts terminal differentiation in Xenopus embryos. J. Biol. Chem. 279, 43735-43743
Wacker SA, Jansen HJ, McNulty CL, Houtzager E and Durston AJ (2004) Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation. Dev. Biol. 268, 207-219
Pohl BS and Knöchel W (2004) Isolation and developmental expression of Xenopus FoxJ1 and FoxK1. Dev. Genes Evol. 214, 200-205
Durr U, Henningfeld KA, Hollemann, T, Knöchel W and Pieler T (2004) Isolation and characterization of the Xenopus HIVEP gene family. Eur. J. Biochem. 271, 1135-1144
Karaulanov E, Knöchel W and Niehrs C (2004) Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J. 23, 844-856
Wacker SA, McNulty CL and Durston AJ (2004) The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4. Dev. Biol. 266, 123-137
Reviews
Maurus D, Kühl M (2004) Getting an embryo into shape. BioEssays, 26, 1272-1275
Kühl M (2004) The Wnt/calcium pathway: biochemical mediators, tools and future requirements. Front. Biosci. 9, 967-974
Text books
Linnemann M, Kühl M (2004) Biochemie für Mediziner, Springer Verlag Heidelberg, 7. Auflage (vorherige Auflagen: 2002, 1999, 1995, 1993, 1992, 1992)
2003
Original publications
Sheldahl LC, Slusarski D, Pandur P, Miller J, Kühl M, Moon RT (2003) Dishevelled activates Ca2+ flux, PKC and CamKII signaling in vertebrate embryos, J. Cell Biol. 161, 769-777
Book chapters
Kühl M, ” Entwicklung und Altern” (2003) in: Lehrbuch Vorklinik (GK1), Hrsg: Unsicker, Schmidt, Fachhrsg: Birnbaumer, Kurtz, Schartl, Unsicker, Deutscher Ärzteverlag, C 575- 596
Hollemann T, Chen Y, Sölter M, Kühl M, Pieler T (2003) Embryonic explants from Xenopus laevis as an assay system to study differentiation of multipotent precursor cells, in: Cell biology: A Laboratory handbook, 3rd Ed., Ed: J.E. Celis, Elsevier Science, San Diego, USA
Behrens J, Kühl M (2003) Wnt signal transduction pathways: An overview. In: Kühl M (Editor): Wnt signalling in development, Landes Bioscience, Georgetown (Texas, USA), pp 1-14
Pandur P, Kühl M (2003) Wnt signalling in heart development. In: Kühl M (Editor): Wnt signalling in development, Landes Bioscience, Georgetown (Texas, USA), pp 170-183
Kaufmann E and Knöchel W (2003) Forkhead Domains. In: Cooper DN (ed.) Nature Encyclopedia of the Human Genome, vol. 2, pp. 519-523. London: Nature Publishing Group
2002
Original publications
Schwarz-Romond T, Asbrand C, Bakkers J, Kühl M, Schaeffer HJ, Huelsken J, Behrens J, Hammerschmidt M, Birchmeier W (2002) The ankyrin repeat protein Diversin recruits Casein kinase l epsilon to the beta-catenin degradation complex and acts in both canonical Wnt and non-canonical Wnt/JNK signaling, Genes Dev. 15, 2073-84
Pandur P, Läsche M, Eisenberg L, Kühl M (2002) Wnt-11 stimulation of a non-canonical Wnt-pathway is required for cardiogenesis, Nature 418, 636-641
Hitz MP, Pandur P, Brand T, Kühl M (2002) Cardiac specific expression of Xenopus Popeye-1 (Pop-1). Mech. Dev. 115, 123-126
Martin B, Schneider R, Janetzky S, Waibler Z, Pandur P, Kühl M, Behrens J, von der Mark K, Starzinski-Powitz A, Wixler V (2002) The LIM-only protein FHL2 interacts with β-catenin and promotes differentiaion of mouse myoblasts. J. Cell Biol. 159, 113-122
Pandur PD, Sullivan SA, Moody SA (2002) Multiple maternal influences on dorsal-ventral fate of Xenopus animal blastomeres. Dev Dyn 225, 581-587
Oswald F, Kostezka U, Astrahantseff K, Bourteele S, Dillinger K, Zechner U, Ludwig L, Wilda M, Hameister H, Knöchel W, Liptay S and Schmid RM (2002) SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. EMBO J. 21, 5417-5426
Pohl BS, Knöchel S, Dillinger K and Knöchel W (2002) Sequence and expression of FoxB2 (XFD-5) and FoxI1c (XFD-10) in Xenopus embryogenesis. Mech. Dev. 117, 283-287
Friedle H and Knöchel W (2002) Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B. J. Biol. Chem. 277, 23872-23881
Braun M, Wunderlin M, Spieth K, Knöchel W, Gierschik P and Moepps B (2002) Xenopus laevis Stromal cell-derived factor 1: conservation of structure and function during vertebrate development. J. Immunol. 168, 2340-2347
Pohl BS and Knöchel W (2002) Temporal and spatial expression patterns of FoxD2 during the early development of Xenopus laevis. Mech. Dev. 111, 181-184
Henningfeld KA, Friedle H, Rastegar S and Knöchel W (2002) Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1. J. Biol. Chem. 277, 2097-2103
Reviews
Kühl M (2002) Non-canonical Wnt signaling in Xenopus: regulation of axis formation and gastrulation. Sem. Cell Dev. Biol., 13, 243-249
Pandur P, Maurus D, Kühl M (2002) Increasingly complex: New players enter the Wnt signaling network. BioEssays 24, 881-885