23rd INTERNATIONAL SUMMER SCHOOL OF EPIDEMIOLOGY

 

INTRODUCTION TO SYSTEMATIC REVIEWS AND META-ANALYSES

 

 

Dietrich Rothenbacher

 

This course will provide an introduction to the conduct of systematic reviews and meta-analysis of mainly observational data. It will describe the principal differences between systematic reviews and meta-analysis and will help to understand the different stages involved in the conduct of such research work: formulation of an adequate research question, identification of relevant studies, definition of eligibility criteria, extraction of data and quality assessment of included studies. Participants will further learn how to analyse, present and interpret results. Choice of models (fixed-effect or random effects) and approaches to quantify heterogeneity will be discussed. The generation and interpretation of forest plots including methods to assess the potential of bias (e. g. by means of funnel plots) will also be discussed. Further we will look on several tools and software programs that can help to critically evaluate and conduct a meta-analysis.