Publications at the Institute of General Zoology and Endocrinology (since 2010)
2013
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G. (2013). PPARβ/δ governs Wnt signaling and bone turnover. Nat Med. 2013 Mar 31. doi: 10.1038/nm.3146. [Epub ahead of print]
Zee T, Boller S, Györy I, Makinistoglu MP, Tuckermann JP, Grosschedl R, Karsenty G. (2013). The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner. FEBS Lett. 2013 Feb 5. pii: S0014-5793(13)00094-X. doi: 10.1016/j.febslet.2013.01.049. [Epub ahead of print]
Vandevyver S, Dejager L, Tuckermann J, Libert C. (2013). New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation. Endocrinology. 2013 Feb 5. [Epub ahead of print]
2012
Seitz S, Keller J, Schilling AF, Jeschke A, Marshall RP, Stride BD, Wintermantel T, Beil FT, Amling M, Schütz G, Tuckermann J, Schinke T. (2012). Pharmacological Estrogen Administration Causes a FSH-Independent Osteo-Anabolic Effect Requiring ER Alpha in Osteoblasts. PLoS One. 2012;7(11) (Epub 2012 Nov 27)
Baschant U, Lane NE, Tuckermann J. (2012). The multiple facets of glucocorticoid action in rheumatoid arthritis. Nat Rev Rheumatol. 2012 Oct 9. doi: 10.1038/nrrheum.2012.166. (Epub ahead of print)
Thiele S, Ziegler N, Tsourdi E, De Bosscher K, Tuckermann JP, Hofbauer LC, Rauner M. (2012). Selective glucocorticoid receptor modulation maintains bone mineral density in mice. J Bone Miner Res. 2012 Jun 19. doi: 10.1002/jbmr.1688. (epub ahead of print)
Vandevyver S, Dejager L, Van Bogaert T, Kleyman A, Liu Y, Tuckermann J, Libert C. (2012). Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation. J Clin Invest. 2012 May 15. pii: 60006. doi: 10.1172/JCI60006. (epub ahead of print)
Mueller KM, Themanns M, Friedbichler K, Kornfeld JW, Esterbauer H, Tuckermann JP, Moriggl R. (2012). Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol. 2012 Apr 30. (epub ahead of print)
Laschak M, Spindler KD, Schrader AJ, Hessenauer A, Streicher W, Schrader M, Cronauer MV (2012). JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells. BMC Cancer. 12 (epub ahead of print)
Jain G, Voogdt C, Tobias A, Spindler KD, Möller P, Cronauer MV, Marienfeld RB (2012). IκB Kinases Modulate the Activity of the Androgen Receptor in Prostate Carcinoma Cell Lines. Neoplasia 14, 178-189
Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD (2012). A CELL AUTONOMOUS ROLE FOR THE GLUCOCORTICOID RECEPTOR IN SKELETAL MUSCLE ATROPHY INDUCED BY SYSTEMIC GLUCOCORTICOID EXPOSURE. Am J Physiol Endocrinol Metab. (epub ahead of print)
Illing A, Liu P, Ostermay S, Schilling A, de Haan G, Krust A, Amling M, Chambon P, Schinke T, Tuckermann JP (2012). Estradiol increases hematopoietic stem and progenitor cells independent on its actions on bone. Haematologica. (epub ahead of print)
Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP (2012). RSK2 protects mice against TNF-induced bone loss. J Cell Sci. (epub ahead of print)
Reichardt SD, Föller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann JP, Lang F, Reichardt HM (2012). Glucocorticoids enhance intestinal glucose uptake via the dimerized glucocorticoid receptor in enterocytes. Endocrinology. (epub ahead of print)
Kleiman A, Hübner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schütz G, Libert C, Reichardt HM, Tuckermann JP (2012). Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J. 26, 722-729
2011
Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP (2011). Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci USA. 108, 19317-19322
Evaluated by "Faculty of 1000"
Schweingruber N, Haine A, Tiede K, Karabinskaja A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F (2011). Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis. J Immunol. 187, 4310-4318
Rose AJ, Díaz MB, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S (2011). Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor. Cell Metab. 14, 123-130
Conaway HH, Pirhayati A, Persson E, Pettersson U, Svensson O, Lindholm C, Henning P, Tuckermann J, Lerner UH (2011). Retinoids stimulate periosteal bone resorption by enhancing RANKL, a response inhibited by monomeric glucocorticoid receptor. J Biol Chem. 286, 31425-31436
Van Bogaert T, Vandevyver S, Dejager L, Van Hauwermeiren F, Pinheiro I, Petta I, Engblom D, Kleyman A, Schutz G, Tuckermann J, Libert C (2011). TNF inhibits glucocorticoid receptor function in mice: A strong signal towards lethal shock. J Biol Chem. 286, 26555-26567
Rauner M, Goettsch C, Stein N, Thiele S, Bornhaeuser M, De Bosscher K, Haegeman G, Tuckermann J, Hofbauer LC (2011). Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells. Endocrinology. 152, 103-112
Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David J-P (2011). Elevated Fra-1 expression causes severe lipodystrophy. J Cell Sci. 124, 1465-1476
Rauch A*, Gossye V*, Bracke D, Gevaert E, Jacques P, Van Beneden K, Vandooren B, Rauner M, Hofbauer LC, Haegeman G, Elewaut D, Tuckermann JP**, De Bosscher K** (2011). An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation. FASEB J. 25, 1323-1332. (*,**equal contribution)
Schmieder A, Schledzewski K, Michel J, Tuckermann JP, Tome L, Sticht C, Gkaniatsou C, Nicolay JP, Demory A, Faulhaber J, Kzhyshkowska J, Géraud C, Goerdt S (2011). Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A. Int J Cancer. 129, 122-132
Asada M*, Rauch A*, Shimizu H, Maruyama H, Miyaki S, Shibamori M, Kawasome H, Ishiyama H, Tuckermann JP**, Asahara H** (2011). DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression. Lab Invest. 91, 203-215 (*, **equal contribution)
Kayser, H., Eilinger, P., Piechon, P., Wagner, T. (2011). C-26 vs. C-27 hydroxylation of insect steroid hormones: regioselectivity of a microsomal cytochrome P450 from a hormone-resistant cell line. Arch. Biochem. Biophys. 513, 27-25
Schauer, S., Callender, J., Henrich, V.C., Spindler-Barth, M. (2011). The N-terminus of ecdysteroid receptor isoforms and ultraspiracle interacts with different ecdysteroid response elements in a sequence specific manner to modulate transcriptional activity. J Steroid Biochem Mol Biol. 124:84-92
Tremmel, Ch., Azoitei, A., Schaefer, M., Hollmann, H., Spindler-Barth, M. (2011). Influence of helix 12 of Ultraspiracle on Drosophila melanogaster ecdysone receptor function. Insect Mol. 20(4):417-28
Laschak, M., Bechtel, M., Spindler, K.-D., Hessenauer, A. (2011). Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. Int. J. Mol. Med. 28, 645-651
Betanska K., Hönl C., Spindler-Barth M., Spindler K.D. (2011). The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor. Arch Insect Biochem Physiol. 76(1):12-21
Tremmel Ch., Schaefer M., Azoitei A., Ruff H., Spindler-Barth M. (2011). Interaction of the N-terminus of ecdysone receptor isoforms with the ligand-binding domain. Mol Cell Endocrinol. 332(1-2):293-300
2010
Chen Y, Qiao S, Tuckermann J, Okret S, Jondal M (2010). Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis. FASEB J. 24, 5043-5051
Shalapour S, Deiser K, Sercan O, Tuckermann J, Minnich K, Willimsky G, Blankenstein T, Hämmerling GJ, Arnold B, Schüler T (2010). Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo. Eur J Immunol. 40, 2391-2400
Tuckermann J, Bourguet W, Mandrup S (2010). Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine. Mol Endocrinol. 24, 1311-1321
Rauch A, Seitz S, Baschant, U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss M, Angel PE, Lerner UH, David JP, Reichard HM, Amling M, Schütz G, Tuckermann J (2010). Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 11, 517-531
Frijters R, Fleuren W, Toonen EJ, Tuckermann JP, Reichardt HM, Van der Maaden H, Van Elsas A, Van Lierop MJ, Dokter W, De Vlieg J, Alkema W (2010). Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor. BMC Genomics 11, 359
Baschant U, Tuckermann J (2010). The role of the glucocorticoid receptor in inflammation and immunity. J Steroid Biochem Mol Biol. 120, 69-75
Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K , Nyabi O, Haigh K , Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David J-P, Behrens A, Nagy A, Carmeliet G, Haigh JJ (2010). Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones. EMBO J. 29, 424-441
Schneider C.C., Hessenauer A., Montenarh M., Götz C. (2010). p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2. Prostate. 70(2):126-34
Reich M., Spindler K.D., Burret M., Kalbacher H., Boehm B.O., Burster T. (2010). Cathepsin A is expressed in primary human antigen-presenting cells. Immunol Lett. 128(2):143-7
Schütz S.V., Cronauer M.V., Rinnab L. (2010). Inhibition of glycogen synthase kinase-3beta promotes nuclear export of the androgen receptor through a CRM1-dependent mechanism in prostate cancer cell lines. J Cell Biochem. 109(6):1192-200
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