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Publications at the Institute of General Zoology and Endocrinology (since 2010)

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2014

Opens external link in new windowReichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM. Glucocorticoids induce gastroparesis in mice through depletion of L-arginine. Endocrinology. 2014 Jul 24:en20141246. [Epub ahead of print]

Opens external link in new windowWeitnauer M, Schmidt L, Ng Kuet Leong N, Muenchau S, Lasitschka F, Eckstein V, Hübner S, Tuckermann J, Dalpke AH. Bronchial epithelial cells induce alternatively activated dendritic cells dependent on glucocorticoid receptor signaling. J Immunol. 2014 Aug 1;193(3):1475-84. doi: 10.4049/jimmunol.1400446. Epub 2014 Jun 25.

Opens external link in new windowZhao B, Choi JP, Jaehne M, Gao YR, Desai R, Tuckermann J, Zhou H, Handelsman DJ, Simanainen U. Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. Prostate. 2014 Jul;74(10):1068-78. doi: 10.1002/pros.22825. Epub 2014 May 23.

Opens external link in new windowAsfar P, Tuckermann J, Radermacher P.(2014). Steroids and vasopressin in septic shock-brother and sister or just distant cousins? Crit Care Med. 2014 Jun;42(6):1531-2. doi: 10.1097/CCM.0000000000000262.

Opens external link in new windowWeitnauer M, Schmidt L, Ng Kuet Leong N, Muenchau S, Lasitschka F, Eckstein V, Hübner S, Tuckermann J, Dalpke AH.(2014). Bronchial Epithelial Cells Induce Alternatively Activated Dendritic Cells Dependent on Glucocorticoid Receptor Signaling. J Immunol. 2014 Jun 25. pii: 1400446. [Epub ahead of print]

Opens external link in new windowZhao B, Choi JP, Jaehne M, Gao YR, Desai R, Tuckermann J, Zhou H, Handelsman DJ, Simanainen U. (2014). Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. Prostate. 2014 Jul;74(10):1068-78. doi: 10.1002/pros.22825. Epub 2014 May 23. PMID: 24862220 [PubMed - in process]

Opens external link in new windowSchweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM. (2014). Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses. Acta Neuropathol. 2014 Feb 1. [Epub ahead of print] PMID: 24488308 [PubMed - as supplied by publisher]

2013

Opens external link in new windowVujić Spasić M, Sparla R, Mleczko-Sanecka K, Migas MC, Breitkopf-Heinlein K, Dooley S, Vaulont S, Fleming RE, Muckenthaler MU. (2013). Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload. Biochim Biophys Acta. 2013 Jan;1832(1):76-84. doi: 10.1016/j.bbadis.2012.08.013. Epub 2012 Aug 31.

Opens external link in new windowRauner M, Thiele S, Sinningen K, Winzer M, Salbach-Hirsch J, Gloe I, Peschke K, Haegeman G, Tuckermann JP, Hofbauer LC. (2013). Effects of the selective glucocorticoid receptor modulator compound A on bone metabolism and inflammation in male mice with collagen-induced arthritis. Endocrinology. 2013 Jul 24. [Epub ahead of print]

Opens external link in new windowBaschant U, Culemann S, Tuckermann J. (2013). Molecular determinants of glucocorticoid actions in inflammatory joint diseases. Mol Cell Endocrinol. 2013 Jun 13. pii: S0303-7207(13)00247-5. doi: 10.1016/j.mce.2013.06.009. [Epub ahead of print]

Opens external link in new windowSeeling M, Hillenhoff U, David JP, Schett G, Tuckermann J, Lux A, Nimmerjahn F. (2013). Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice. Proc Natl Acad Sci U S A. 2013 Jun 10. [Epub ahead of print]

Opens external link in new windowLi A, Hardy R, Stoner S, Tuckermann J, Seibel M, Zhou H. (2013). Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PLoS One. 2013 May 16;8(5):e63578. doi: 10.1371/journal.pone.0063578. Print 2013.

Opens external link in new windowScholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G. (2013). PPARβ/δ governs Wnt signaling and bone turnover. Nat Med. 2013 Mar 31. doi: 10.1038/nm.3146. [Epub ahead of print]

Opens external link in new windowZee T, Boller S, Györy I, Makinistoglu MP, Tuckermann JP, Grosschedl R, Karsenty G. (2013). The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner. FEBS Lett. 2013 Feb 5. pii: S0014-5793(13)00094-X. doi: 10.1016/j.febslet.2013.01.049. [Epub ahead of print]

Opens external link in new windowVandevyver S, Dejager L, Tuckermann J, Libert C. (2013). New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation. Endocrinology. 2013 Feb 5. [Epub ahead of print]

2012

Opens external link in new windowSeitz SKeller JSchilling AFJeschke AMarshall RPStride BDWintermantel TBeil FTAmling MSchütz GTuckermann JSchinke T. (2012). Pharmacological Estrogen Administration Causes a FSH-Independent Osteo-Anabolic Effect Requiring ER Alpha in Osteoblasts. PLoS One. 2012;7(11) (Epub 2012 Nov 27)

Opens external link in new windowBaschant U, Lane NE, Tuckermann J. (2012). The multiple facets of glucocorticoid action in rheumatoid arthritis. Nat Rev Rheumatol. 2012 Oct 9. doi: 10.1038/nrrheum.2012.166. (Epub ahead of print)

Opens external link in new windowThiele S, Ziegler N, Tsourdi E, De Bosscher K, Tuckermann JP, Hofbauer LC, Rauner M. (2012). Selective glucocorticoid receptor modulation maintains bone mineral density in mice.  J Bone Miner Res. 2012 Jun 19. doi: 10.1002/jbmr.1688. (epub ahead of print)

Opens external link in new windowVandevyver S, Dejager L, Van Bogaert T, Kleyman A, Liu Y, Tuckermann J, Libert C. (2012). Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation. J Clin Invest. 2012 May 15. pii: 60006. doi: 10.1172/JCI60006. (epub ahead of print)

Opens external link in new windowMueller KM, Themanns M, Friedbichler K, Kornfeld JW, Esterbauer H, Tuckermann JP, Moriggl R. (2012). Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol. 2012 Apr 30. (epub ahead of print)

Opens external link in new windowLaschak M, Spindler KD, Schrader AJ, Hessenauer A, Streicher W, Schrader M, Cronauer MV (2012).  JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells. BMC Cancer. 12 (epub ahead of print) 

Opens external link in new windowJain G, Voogdt C, Tobias A, Spindler KD, Möller P, Cronauer MV, Marienfeld RB (2012). IκB Kinases Modulate the Activity of the Androgen Receptor in Prostate Carcinoma Cell Lines. Neoplasia 14, 178-189

Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD (2012). A CELL AUTONOMOUS ROLE FOR THE GLUCOCORTICOID RECEPTOR IN SKELETAL MUSCLE ATROPHY INDUCED BY SYSTEMIC GLUCOCORTICOID EXPOSURE. Am J Physiol Endocrinol Metab. (epub ahead of print)

Illing A, Liu P, Ostermay S, Schilling A, de Haan G, Krust A, Amling M, Chambon P, Schinke T, Tuckermann JP (2012). Estradiol increases hematopoietic stem and progenitor cells independent on its actions on bone. Haematologica. (epub ahead of print)

Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP (2012). RSK2 protects mice against TNF-induced bone loss. J Cell Sci. (epub ahead of print) 

Opens external link in new windowReichardt SD, Föller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann JP, Lang F, Reichardt HM (2012). Glucocorticoids enhance intestinal glucose uptake via the dimerized glucocorticoid receptor in enterocytes. Endocrinology. (epub ahead of print) 

Opens external link in new windowKleiman A, Hübner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schütz G, Libert C, Reichardt HM, Tuckermann JP (2012). Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J. 26, 722-729

 

2011

Opens external link in new windowBaschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP (2011). Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci USA. 108, 19317-19322
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Opens external link in new windowSchweingruber N, Haine A, Tiede K, Karabinskaja A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F (2011). Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis. J Immunol. 187, 4310-4318 

Opens external link in new windowRose AJ, Díaz MB, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S (2011). Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor. Cell Metab. 14, 123-130 

Opens external link in new windowConaway HH, Pirhayati A, Persson E, Pettersson U, Svensson O, Lindholm C, Henning P, Tuckermann J, Lerner UH (2011). Retinoids stimulate periosteal bone resorption by enhancing RANKL, a response inhibited by monomeric glucocorticoid receptor. J Biol Chem. 286, 31425-31436 

Opens external link in new windowVan Bogaert T, Vandevyver S, Dejager L, Van Hauwermeiren F, Pinheiro I, Petta I, Engblom D, Kleyman A, Schutz G, Tuckermann J, Libert C (2011). TNF inhibits glucocorticoid receptor function in mice: A strong signal towards lethal shock. J Biol Chem. 286, 26555-26567 

Opens external link in new windowRauner M, Goettsch C, Stein N, Thiele S, Bornhaeuser M, De Bosscher K, Haegeman G, Tuckermann J, Hofbauer LC (2011). Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells. Endocrinology. 152, 103-112 

Opens external link in new windowLuther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David J-P (2011). Elevated Fra-1 expression causes severe lipodystrophy. J Cell Sci. 124, 1465-1476 

Opens external link in new windowRauch A*, Gossye V*, Bracke D, Gevaert E, Jacques P, Van Beneden K, Vandooren B, Rauner M, Hofbauer LC, Haegeman G, Elewaut D, Tuckermann JP**, De Bosscher K** (2011). An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation. FASEB J. 25, 1323-1332. (*,**equal contribution)

Opens external link in new windowSchmieder A, Schledzewski K, Michel J, Tuckermann JP, Tome L, Sticht C, Gkaniatsou C, Nicolay JP, Demory A, Faulhaber J, Kzhyshkowska J, Géraud C, Goerdt S (2011). Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A. Int J Cancer. 129, 122-132 

Opens external link in new windowAsada M*, Rauch A*, Shimizu H, Maruyama H, Miyaki S, Shibamori M, Kawasome H, Ishiyama H, Tuckermann JP**, Asahara H** (2011). DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression. Lab Invest. 91, 203-215 (*, **equal contribution)

Kayser, H., Eilinger, P., Piechon, P., Wagner, T. (2011). C-26 vs. C-27 hydroxylation of insect steroid hormones: regioselectivity of a microsomal cytochrome P450 from a hormone-resistant cell line.  Arch. Biochem. Biophys. 513, 27-25

Schauer, S., Callender, J., Henrich, V.C., Spindler-Barth, M. (2011). The N-terminus of ecdysteroid receptor isoforms and ultraspiracle interacts with different ecdysteroid response elements in a sequence specific manner to modulate transcriptional activity. J Steroid Biochem Mol Biol. 124:84-92

Tremmel, Ch., Azoitei, A., Schaefer, M., Hollmann, H., Spindler-Barth, M. (2011). Influence of helix 12 of Ultraspiracle on Drosophila melanogaster ecdysone receptor function.  Insect Mol. 20(4):417-28

Laschak, M., Bechtel, M., Spindler, K.-D., Hessenauer, A. (2011). Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. Int. J. Mol. Med. 28, 645-651

Betanska K., Hönl C., Spindler-Barth M., Spindler K.D. (2011). The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor. Arch Insect Biochem Physiol. 76(1):12-21

Tremmel Ch., Schaefer M., Azoitei A., Ruff H., Spindler-Barth M. (2011). Interaction of the N-terminus of ecdysone receptor isoforms with the ligand-binding domain. Mol Cell Endocrinol. 332(1-2):293-300

 

2010

Opens external link in new windowChen Y, Qiao S, Tuckermann J, Okret S, Jondal M (2010). Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis. FASEB J. 24, 5043-5051

Opens external link in new windowShalapour S, Deiser K, Sercan O, Tuckermann J, Minnich K, Willimsky G, Blankenstein T, Hämmerling GJ, Arnold B, Schüler T (2010). Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo. Eur J Immunol. 40, 2391-2400

Opens external link in new windowTuckermann J, Bourguet W, Mandrup S (2010). Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine. Mol Endocrinol. 24, 1311-1321 

Opens external link in new windowRauch A, Seitz S, Baschant, U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss M, Angel PE, Lerner UH, David JP, Reichard HM, Amling M, Schütz G, Tuckermann J (2010). Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 11, 517-531

Opens external link in new windowFrijters R, Fleuren W, Toonen EJ, Tuckermann JP, Reichardt HM, Van der Maaden H, Van Elsas A, Van Lierop MJ, Dokter W, De Vlieg J, Alkema W (2010). Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor. BMC Genomics 11, 359 

Opens external link in new windowBaschant U, Tuckermann J (2010). The role of the glucocorticoid receptor in inflammation and immunity. J Steroid Biochem Mol Biol. 120, 69-75 

Opens external link in new windowMaes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K , Nyabi O, Haigh K , Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David J-P, Behrens A, Nagy A, Carmeliet G, Haigh JJ (2010). Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones. EMBO J. 29, 424-441

Opens external link in new windowSchneider C.C., Hessenauer A., Montenarh M., Götz C. (2010). p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2. Prostate. 70(2):126-34 

Reich M., Spindler K.D., Burret M., Kalbacher H., Boehm B.O., Burster T. (2010). Cathepsin A is expressed in primary human antigen-presenting cells. Immunol Lett. 128(2):143-7

Schütz S.V., Cronauer M.V., Rinnab L. (2010). Inhibition of glycogen synthase kinase-3beta promotes nuclear export of the androgen receptor through a CRM1-dependent mechanism in prostate cancer cell lines. J Cell Biochem. 109(6):1192-200