Publications

Structural basis for CRISPR RNA-guided DNA recognition by Cascade.
Jore MM, Lundgren M, van Duijn E, Bultema JB, Westra ER, Waghmare SP, Wiedenheft B, Pul U, Wurm R, Wagner R, Beijer MR, Barendregt A, Zhou K, Snijders AP, Dickman MJ, Doudna JA, Boekema EJ, Heck AJ, van der Oost J, Brouns SJ.
Nat Struct Mol Biol. 2011 May;18(5):529-36.

H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO.
Westra ER, Pul U, Heidrich N, Jore MM, Lundgren M, Stratmann T, Wurm R, Raine A, Mescher M, Van Heereveld L, Mastop M, Wagner EG, Schnetz K, Van Der Oost J, Wagner R, Brouns SJ.
Mol Microbiol. 2010; 77:1380-93

Identification and characterization of E. coli CRISPR-cas promoters and their silencing by H-NS.
Pul U, Wurm R, Arslan Z, Geissen R, Hofmann N, Wagner R.
Mol Microbiol. 2010; 75:1495-512.

NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO.
Westra ER, Pul U, Heidrich N, Jore MM, Lundgren M, Stratmann T, Wurm R, Raine A, Mescher M, Van Heereveld L, Mastop M, Wagner EG, Schnetz K, Van Der Oost J, Wagner R, Brouns SJ.
Mol Microbiol. 2010;77:1380-93.

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III.
Deltcheva E, Chylinski K, Sharma CM, Gonzales K, Chao Y, Pirzada ZA, Eckert MR, Vogel J, Charpentier E.
Nature. 2011; 471:602-7.

Archaeal CRISPR-based immune systems: exchangeable functional modules.
Garrett RA, Vestergaard G, Shah SA.
Trends Microbiol. 2011; 19:549-56.

CRISPR-based immune systems of the Sulfolobales: complexity and diversity.
Garrett RA, Shah SA, Vestergaard G, Deng L, Gudbergsdottir S, Kenchappa CS, Erdmann S, She Q.
Biochem Soc Trans. 2011; 39:51-7.

Dynamic properties of the Sulfolobus CRISPR/Cas and CRISPR/Cmr systems when challenged with vector-borne viral and plasmid genes and protospacers.
Gudbergsdottir S, Deng L, Chen Z, Jensen JV, Jensen LR, She Q, Garrett RA.
Mol Microbiol. 2011; 79:35-49.

CRISPR/Cas and Cmr modules, mobility and evolution of adaptive immune systems.
Shah SA, Garrett RA.
Res Microbiol. 2011;162:27-38.

Distribution of CRISPR spacer matches in viruses and plasmids of crenarchaeal acidothermophiles and implications for their inhibitory mechanism.
Shah SA, Hansen NR, Garrett RA.
Biochem Soc Trans. 2009; 37:23-8.

CRISPR families of the crenarchaeal genus Sulfolobus: bidirectional transcription and dynamic properties.
Lillestøl RK, Shah SA, Brügger K, Redder P, Phan H, Christiansen J, Garrett RA.
Mol Microbiol. 2009; 72:259-72.

Stygiolobus rod-shaped virus and the interplay of crenarchaeal rudiviruses with the CRISPR antiviral system.
Vestergaard G, Shah SA, Bize A, Reitberger W, Reuter M, Phan H, Briegel A, Rachel R, Garrett RA, Prangishvili D.
J Bacteriol. 2008; 190:6837-45.