Publikationen

2011

• Mellert K, Uhl M, Högel J, Lamla M, Kemkemer R, Kaufmann D (2011) Aberrant single exon skipping is not altered by age in exons of NF1, RABAC1, AATF or PCGF2 in human blood cells and fibroblasts. Genes
• Zobor D, Kaufmann DH, Weckerle P, Sauer A, Wissinger B ,Wilhelm H, Kohl S (2011) Cone-rod dystrophy associated with amelogenesis imperfecta in a child with neurofibromatosis type 1. Ophthalmic Genet. Jul 5.
• Kaufmann D, Su Y, Biela S, Jungbauer S, Spatz JP, Kemkemer R (2011) Soft lithography detects partial mechano-sensoric blindness to micrometre topography in cultured aged and diseased cells. IJMR; 102(7): 896-902
• Zahl JT, Louban I, Jungbauer S, Bissinger M, Kaufmann D, Kemkemer R, Spatz JP (2011) Age-dependent changes in micro-scale stiffness and mechano-responses of cells. Small; 23;7(10):1480-1487
• Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek (2011) Structural and Biochemical Consequences of NF1 Associated Non-Truncating Mutations in the Sec14-PH Module of Neurofibromin. Hum Mutat; 32(2):191-197

2010

• Harder A, Titze S, Herbst L, Harder T, Guse K, Tinschert S, Kaufmann D, Rosenbaum T, Mautner VF, Windt E, Wahlländer-Danek U, Wimmer K, Mundlos S, Peters H (2010) Monozygotic twins with neurofibromatosis type 1 (NF1) display differences in methylation of NF1 gene promoter elements, 5' untranslated region, exon and intron 1. Twin Res Hum Genet; 13(6):582-594
• Lamla M, Seliger H, Kaufmann D (2010) Differences in uptake of PNAs modified by COX VIII presequence peptide or by triphenylphoshonium cation into mitochondria of tumour cells. Drug Deliv; 17(4):263-271
• Kilian HG, Kazda M, Kaufmann D, Kemkemer R, Bartkowiak D (2010) Symmetries of the Structure-bounded Growth Process in Plant populations. Cell Biochem Biophys; 57(2-3):87-100

2009

• Bartelt-Kirbach B, Wuepping M, Dodrimont-Lattke M, Kaufmann D (2009) Expression analysis of genes lying in the NF1 microdeletion interval points to four candidate modifiers for neurofibroma formation. Neurogenetics; 10(1):79-85
• Wuepping M, Kenner O, Hegele H, Schwandt S, Kaufmann D (2009) Higher efficiency of TA-clamp modified single stranded oligonucleotides in targeted nucleotide sequence correction is not correlated to a lower intracellular degradation. Hum Gene Ther; 20(3):283-287

2008

• Kilian HG, Bartkowiak D, Kaufmann D, Kemkemer R (2008) The General Growth Logistics of Cell Populations. Cell Biochem Biophys. 2008 May 21
• Hegele H, Wuepping M, Ref C, Kenner O, Kaufmann D (2008) Simultaneous targeted exchange of two nucleotides by single-stranded oligonucleotides clusters within a region of about fourteen nucleotides. BMC Mol Biol. 2008 Jan 28;9(1):14

2007

• Hanemann CO, Diebold R, Kaufmann D. (2007) Role of NF2 haploinsufficiency in NF2-associated polyneuropathy. Brain Pathol. 2007 Oct;17(4):371-6
• Detjen AK, Tinschert S, Kaufmann D, Algermissen B, Nurnberg P, Schuelke M. (2007) Analysis of mitochondrial DNA in discordant monozygotic twins with neurofibromatosis type 1. Twin Res Hum Genet;10(3):486-95

2006

• Kemkemer R, Jungbauer S, Kaufmann D, Gruler H. (2006) Cell orientation by a microgrooved substrate can be predicted by automatic control theory. Biophys J; 90(12):4701-11.

2005

• Diebold R, Bartelt-Kirbach B, Evans DG, Kaufmann D, Hanemann CO (2005) Sensitive detection of deletions of one or more exons in the neurofibromatosis type 2 (NF2) gene by multiplexed gene dosage polymerase chain reaction. J Mol Diagn. 7(1):97-104
• Hanemann CO, Kaempchen KE, Kaufmann D, Krause BJ (2005) Fludeoxyglucose F 18 positron emission tomography and computed tomography of a giant retroperitoneal schwannoma occurring in a patient with neurofibromatosis type 2. Arch Neurol. 62(4):674-675
• Kilian HG, Gruler H, Bartkowiak D, Kaufmann D (2005) Stationary cell size distributions of Archaea, Bacteria and Eukaryotes described with an increment model in terms of irreversible thermodynamics. Eur Phys E, DOI 1011.40/epje/12004-10143-8
• Kemkemer R, Estrada GG, Kaufmann D, Ulrich D, Gruler, H (2005) Feature extraction of non-stained melanocyte cells. Image Processing, 3, 605-688

2004

• Kenner O, Lutomska A, Speit G, Vogel W, Kaufmann D (2004) Concurrent targeted exchange of three bases in mammalian hprt by oligonucleotides. Biochem Biophys Res Commun; 321(4):1017-1023
• Kaufmann D, Kenner O, Nurnberg P, Vogel W, Bartelt B. (2004) In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons. Eur J Hum Genet.  12(2):139-149
• Jungbauer S, Kemkemer R, Gruler H, Kaufmann D, Spatz JP (2004) Cell shape normalization , dendrite orientation, and melanin production of normal and genetically altered (haploinsufficient NF1) melanocytes by microstructured interactions. Chem. Phys. Chem. 5: 85-92

2002

• Kemkemer R, Schrank S, Vogel W, Gruler H, Kaufmann D. Increased noise as an effect of haploinsufficiency of the tumor suppressor gene Neurofibromatosis type 1 in vitro. Proc Natl Acad Sci USA, 99(21): 13783-13788
• Kenner O, Kneisel A, Klingler J, Bartelt B, Speit G, Vogel W, Kaufmann D (2002) Targeted gene correction of hprt mutations by 45 base single stranded oligonucleotides. Biochem Biophys Res Comm 299(5): 787-792
• Schultz ES, Kaufmann D, Tinschert S, Schell H, Von Den Driesch P, Schuler G. Segmental neurofibromatosis. Dermatology. 2002;204(4):296-7
• Kaufmann D, Muller R, Kenner O, Leistner W, Hein C, Vogel W, Bartelt B. The N-terminal splice product NF1-10a-2 of the NF1 gene odes for a transmembrane segment. Biochem Biophys Res Commun. 2002 Jun 7;294(2):496-503.
• Kaufmann D, Leistner W, Kruse P, Kenner O, Hoffmeyer S, Hein C, Vogel W, Messiaen L, Bartelt B. Aberrant splicing in several human tumors in the tumor suppressor genesneurofibromatosis type 1, neurofibromatosis type 2, and tuberous sclerosis 2. Cancer Res. 2002 Mar 1;62(5):1503-9.
• Kemkemer R, Csete M, Schrank S, Kaufmann D, Spatz J (2002) The determination of the morphology of melanocytes by laser-generated periodic surface structures. Materials Science and Engineering; C 1064, 1-4 

2001

• Kaufmann D, Muller R, Bartelt B, Wolf M, Kunzi-Rapp K, Hanemann CO, Fahsold R, Hein C, Vogel W, Assum G. Spinal neurofibromatosis without cafe-au-lait macules in two families with null mutations of the NF1 gene. Am J Hum Genet. 2001 Dec;69(6):1395-400.
• Kaufmann D, Tinschert S, Algermissen B. Is the distribution of dermal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature? Eur J Dermatol. 2001 Nov-Dec;11(6):521-6.

2000

• Tinschert S, Naumann I, Stegmann E, Buske A, Kaufmann D, Thiel G, Jenne DE. Segmental neurofibromatosis is caused by somatic mutation of the neurofibromatosis type 1 (NF1) gene. Eur J Hum Genet. 2000 Jun;8(6):455-9.
• Fahsold R, Hoffmeyer S, Mischung C, Gille C, Ehlers C, Kucukceylan N, Abdel-Nour M, Gewies A, Peters H, Kaufmann D, Buske A, Tinschert S, Nurnberg P. Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain. Am J Hum Genet. 2000 Mar;66(3):790-818.
• Kemkemer R, Kling D, Kaufmann D, Gruhler H (2000) Elastic properties of nematoid arrangements formed by amoeboid cells. Eur Phys J E 1: 215-225
• Kemkemer R, Teichgräber V, Schrank-Kaufmann S, Kaufmann D, Gruler H (2000) Nematic order-disorder state transition in a liquid crystal analogue formed by oriented and migrating amoeboid cells. Eur Phys J E 3: 101-110

1999

• Kaufmann D, Junge I, Bartelt B, Lattke H, Muller R. On the lysosomal degradation of neurofibromin and its phosphorylation in cultured melanocytes. Biol Chem. 1999 Sep;380(9):1071-8.
• Kaufmann D, Bartelt B, Hoffmeyer S, Muller R. Posttranslational regulation of neurofibromin content in melanocytes of neurofibromatosis type 1 patients. Arch Dermatol Res. 1999 Jun;291(6):312-7.
• Kaufmann D, Gruener S, Braun F, Stark M, Griesser J, Hoffmeyer S, Bartelt B. EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. DNA Cell Biol. 1999 May;18(5):345-56.

1998

• Klose A, Ahmadian MR, Schuelke M, Scheffzek K, Hoffmeyer S, Gewies A, Schmitz F, Kaufmann D, Peters H, Wittinghofer A, Nurnberg P. Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1. Hum Mol Genet. 1998 Aug;7(8):1261-8.]
• Hoffmeyer S, Nurnberg P, Ritter H, Fahsold R, Leistner W, Kaufmann D, Krone W. Nearby stop codons in exons of the neurofibromatosis type 1 gene are disparate splice effectors. Am J Hum Genet. 1998 Feb;62(2):269-77.

1997

• Eisenbarth I, Assum G, Kaufmann D, Krone W. Evidence for the presence of the second allele of the neurofibromatosis type 1 gene in melanocytes derived from cafe au laitmacules of NF1 patients. Biochem Biophys Res Commun. 1997 Aug 8;237(1):138-41.
• Griesser J, Kaufmann D, Maier B, Mailhammer R, Kuehl P, Krone W. Post-transcriptional regulation of neurofibromin level in cultured human melanocytes in response to growth factors. J Invest Dermatol. 1997 Mar;108(3):275-80.

Älteres

• Kaufmann D, Krone W, Hochsattel R, Martin R (1989) A cell culture study on melanocytes from patients with neurofibromatosis 1. Arch Dermatol Res 281: 510-513
• Klein EC, Steinmayer T, Kaufmann D, Weber L, Bröcker EB (1990) Identification of a melanoma progression antigen as integrin VLA-2. J Invest Dermatol 96:281-284
• Kaufmann D, Wiandt S, Veser J, Krone W (1991): Increased melanogenesis in melanocytes from patients with neurofibromatosis 1. Hum Genet 87:144-150
• Stark M, Assum G, Kaufmann D, Kehrer H, Krone W (1992) Analysis of segregation and expression of an identified mutation at the neurofibromatosis type 1 locus. Hum Genet 90:356-359
• Kaufmann D, Eisenbarth I, Wiandt S, Veser J (1993): Cultured epidermal melanocytes from patients with Neurofibromatosis 1 (M. Recklinghausen): a cell culture model for Neurofibromatosis 1. in: A. Bernd, J. Bereiter-Hahn, F. Hevert, H. Holzmann: Cell and Tissue Culture Models in Dermatological Research. Springer 1993: 148-154
• Hoffmeyer S, Assum G, Kaufmann D, Schwenk K, Krone W (1994) A deletion in the 5-region of the neurofibromatosis type 1 (NF1) gene. Hum Genet 94:97-100
• Hoffmeyer S, Assum G, Kaufmann D, Krone W (1994) Unequal expression of NF1 alleles. Nature Genetics 6:331
• Eisenbarth I, Hoffmeyer S, Kaufmann D, Assum G, Krone W (1995) Analysis of an alternatively spliced exon of the neurofibromatosis type 1 gene in cultured melanocytes from patients with neurofibromatosis. Arch Dermatol Res 287:413-416
• Griesser J, Kaufmann D, Eisenbarth I, Bäuerle C, Krone W (1995) Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1). Biol Chem Hoppe-Seyler 376:91-101
• Mautner VF, Lindenau M, Kaufmann D (1995) Klinik und Genetik der Neurofibromatosen: Neurofibromatose ist mehr als M. Recklinghausen. Deutsches Ärzteblatt 92: 1758-1764
• Hoffmeyer S, Assum G, Griesser J, Kaufmann D, Nürnberg P, Krone W (1995) On unequal allelic expression of the neurofibromin gene in neurofibromatosis type 1. Hum Mol Genet 4:1267-1272
• Robinson PN, Böddrich A, Peters H, Tinschert S, Buske A, Kaufmann D, Nürnberg P (1995) Two recurrent nonsense mutations and a 4bp deletion in a quasi-symmetric element in Exon 37 of the NF1-Gene. Hum Genet 96:95-98
• Böddrich A, Griesser J, Horn D, Kaufmann D, Krone W, Nürnberg P (1995) Reduced neurofibromin content but normal GAP activity in a patient with neurofibromatosis type 1 caused by a five base pair duplication in exon 12b of the NF1-Gene. Biochim Biophys Res Comm 214: 895-904
• Goebeler M, Kaufmann D, Bröcker EB, Klein CE (1996) Migration of highly agressive melanoma cells on hyaluronic acid is associated with functional changes, increased turn-over and shedding of CD44 receptors. Journal of Cell Science 109:1957-1964

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