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My research is focused on the cognitive
psychology and the cognitive
neuroscience of memory and executive function.
Besides of behavioral experiments, my colleagues and I use
high-resolution event-related
potentials (ERPs) and functional magnetic resonance imaging
(fMRI) in order to investigate the temporal and spatial orchestration
of brain activity subserving these cognitive functions.
Within
this field I am working on the following four topics:
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Semantic Memory Structure
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In this part of my research, my
coworkers and I investigate according to which general principles
conceptual object knowledge is stored in human long-term memory. Hereby
we test the assumption that conceptual knowledge is not abstract, but
modality-specific that is it is essentially derived from our perceptual
and motor interactions with the outside world. More information
regarding this research project is found on the home page
of the Semantic
Memory Research Group.
Selected
publications:
"Brain-friendly
learning in vocational education"
This flyer describes evidence-based
guidelines for optimized learning in vocational education. It has been
developed in cooperation with vocational instructors at Bosch und
Siemens Hausgeräte GmbH in Gingen, Germany.
Kiefer, M. (2001). Perceptual and semantic
sources of category-specific
effects in
object categorization:
Event-related potentials during
picture and word
categorization. Memory & Cognition, 29, 100-116.
Kiefer, M. (2005). Repetition priming
modulates category-related
effects on
event-related potentials: Further evidence for multiple
cortical semantic systems.
Journal of Cognitive Neuroscience, 17, 199-211.
Kiefer,
M., Sim, E.-J., Liebich,
S., Hauk, O. & Tanaka, J. (2007).
Experience-dependent
plasticity of conceptual representations in human
sensory-motor areas.
Journal of Cognitive Neuroscience, 19, 525-542.
Kiefer, M., & Spitzer, M. (2001).
The limits of a distributed
account of conceptual
knowledge. Trends in Cognitive Sciences, 5,
469-471.
Sim,
E.-J. & Kiefer, M. (2005). Category-related brain
activity to natural categories
is associated with the retrieval of
visual features: Evidence from repetition effects
during visual and
functional judgments. Cognitive Brain
Research, 24, 260-273.
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Visual Masking and Semantic Priming
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How is semantic knowledge accessed
during word recognition? What are the electrophysiological correlates
of automatic vs. controlled access to semantic memory? In order to
study automatic semantic priming in isolation, we used a visual masking
procedure, which rendered the prime words unavailable to conscious
experience. Nevertheless, although not consciously perceived, these
prime words modulated behavioral reactions as well as the N400 ERP
component. We were able to show that conscious and unconscious semantic
priming exhibit in principle the same brain areas, but show different
time courses. More
information
is found on the home page
of the Unconscious Visual
Perception Research Group. This research is conducted within the
research network "Neuro-cognitive Mechanisms of Conscious
and Unconscious Visual Perception" funded by the German Research
Foundation.
Selected publications:
Kiefer, M.
(2002). The N400 is modulated by unconsciously perceived
masked words:
Further evidence for a spreading activation account of
N400 priming effects.
Cognitive Brain Research, 13, 27-39.
Kiefer, M.
(2002). Bewußtsein (Consciousness). In Müsseler, J., &
Prinz,
W. (Hrsg.), Lehrbuch der Allgemeinen Psychologie (pp. 178-222).
Heidelberg:
Spektrum, Akademischer Verlag.
Kiefer,
M. (2007). Top-down modulation of unconscious 'automatic'
processes:
A gating framework. Advances in Cognitive Psychology, 3, 289-306.
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Kiefer,
M. &
Brendel, D. (2006). Attentional modulation of
unconscious 'automatic'
processes: Evidence from event-related
potentials
in a masked priming paradigm.
Journal of
Cognitive Neuroscience, 18, 184-198.
Kiefer,
M. &
Spitzer, M. (2000). Time course of conscious and
unconscious semantic
brain activation. NeuroReport, 11, 2401-2407.
Martens,
E.U., Schweinberger, S.R., Kiefer, M., Burton, A.M.
(2006). Masked and
unmasked electrophysiological repetition
effects of famous faces. Brain
Research,
1109, 146-157.
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Working memory/Executive Function
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The
coordination of processes underlying cognition and action is an
important prerequisite for goal-directed behavior. It is assumed
that some of the working memory systems are mainly dedicated for
holding relevant information on line while others (executive function)
are involved in manipulating this information and in the goal-directed
orchestration of information processing. My colleagues and I
investigate the functional neuroanatomy of working memory systems and
their dysfunction in psychiatric disorders.
Selected publications:
Kiefer, M., Marzinzik, F., Weisbrod, M., Scherg, M. &
Spitzer, M.
(1998). The time
course of brain activations during response
inhibition: Evidence from event-related
potentials in a Go/Nogo task.
NeuroReport, 9, 765-770.
Weisbrod, M.,
Kiefer, M., Marzinzik, F. & Spitzer, M. (2000).
Executive control is
disturbed in schizophrenia: Evidence from
event-related potentials in a Go/Nogo
task. Biological Psychiatry, 47,
51-60.
Kiefer, M. Apel,
A., & Weisbrod, M. (2002). Arithmetic fact
retrieval and working
memory in schizophrenia. Schizophrenia Research,
53, 219-227.
Kiefer, M.,
Ahlegian, M. & Spitzer, M. (2005). Working memory
capacity, indirect
semantic priming and Stroop interference: Pattern of
interindividual prefrontal
performance differences in healthy
volunteers. Neuropsychology, 19, 332-344.
Kessler, K.
& Kiefer, M. (2005). Disturbing visual working memory:
Electrophysiological evidence for a role of prefrontal cortex in
recovery from
interference. Cerebral Cortex, 15, 1075-1087.
Emotions
have important modulatory influences on cognitive processes such as
memory and executive functions. It is assumed that emotions configure
the cognitive system thereby improving human adaptation to enviromental
challenges. Meanwhile it
is well accepted that emotional mood states
trigger different cognitive styles and -
as a consequence - influence memory
processes. However, the precise neuro-cognitive mechanisms underlying
the emotion/cognition interface are unclear. To address this issue, we
investigate the influences of positive
and negative mood states on episodic memory encoding.
Selected publications:
Erk, S.,
Kiefer, M., Grothe, J., Wunderlich, A., Spitzer, M. &
Walter, H. (2003).
Emotional context modulates subsequent memory
effect. NeuroImage,18, 439-447.
Kiefer,
M.,
Schuch, S., Schenck, W. & Fiedler, K. (2007). Mood states
modulate
activity in semantic brain areas during
emotional word encoding. Cerebral Cortex, 17, 1560-1530.
Kiefer,
M., Schuch, S., Schenck, W. & Fiedler, K. (2007).
Emotion and memory:
Event-related potential indices predictive for
subsequent successful memory depend
on the emotional mood state.
Advances in Cognitive
Psychology, 3, 363-373.
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