Project Title Principal Investigator
Project Group A Experimental leukemia models  
A1 The contribution of mechanisms of aging of HSCs to leukemia initiation and progression

H. Geiger

A3 Notch signaling as a novel target of AML1/ETO F. Oswald
H. Geiger
A4 Dissecting of the function of the “Lymphoid enhancer-binding factor 1” (Lef1) in acute myeloid leukemia C. Buske
A6 The role of homeobox genes in erythroid leukemia M. Feuring-Buske
A9 Role of B cell receptor signaling and acquired immunoglobulin gene changes in the development of chronic lymphocytic leukemia (CLL) E. Hobeika
H. Jumaa
A10 Investigating the crosstalk between pre-BCR and IL7-R signaling in B-cell precursor acute lymphoblastic leukemia H. Jumaa
Project Group B Clinical translations  
B1 Genomic instability, disease evolution and rational treatment development in CLL mouse models A. Müller
S. Stilgenbauer
B2 Mechanisms of CLL progression and Richter transformation in patients with CLL treated with agents targeting BTK and BCL2

D. Mertens
H. Döhner
S. Stilgenbauer

B3 Molecular and functional characterization of cooperating events in acute myeloid leukemia with NPM1 mutation K. Döhner
L. Bullinger
B6 Multi-targeting and identification of synergistic activities to overcome therapy resistance in ALL L.-H. Meyer
K.-M. Debatin
B8 The role of deubiquitinating enzyme USP7 in the pathogenesis and treatment of acute myeloid leukemia J. Krönke
B9 Causes and consequences of the epigenetic disturbances in T-pro-lymphocytic leukemia L. Wiehle
R. Siebert
B10 (new) Genetic and epigenetic charaterization of chronic lymphocytic leukemia with translocations involving the immunoglobulin loci A. Mottok
R. Siebert
B11 (new) Novel oncogenes in complex karyotype acute lyeloid leukemia C. Plass
B12 (new) Disscting AML treatment response to FLT3 inhibitors by single-cell sequencing K. Rippe
K. Döhner
  Central Projects  
Z1 Bioinformatics core: semantic knowledge fusion and non-standard optimization
Single-cell sequencing core
H. Kestler
K. Rippe
Z2 Central Project Management H. Döhner
Z3 The core unit mass spectrometry and proteomics S. Wiese