Adult stem cells are a powerful source in tissue regeneration as well as in cancer.
How adult stem cells are regulated in health, disease and aging is still not very well understood.
What contribution has the stem cell itself to changes in its phenotype, or is the niche the driving force?
How do normal stem cell become malignant stem cells?
Is aging of stem cells a common theme, and can we develop, based on our knowledge, pathways that revert aging?
Can we attenuate the steps that lead from a normal to a malignant stem cell?
Where reside stem cells and why?
These are questions we would like to find answers for in the Geiger lab.