Dozent: M.D. Ricardo Grieshaber Bouyer, Universitätsklinikum Heidelberg
Ricardo Grieshaber Bouyer studied Medicine at Heidelberg University, Harvard Medical School, Duke University School of Medicine and Universitätsspital Zurich, supported by the German National Academic Foundation (Studienstiftung) and the Boehringer Ingelheim Fonds MD Fellowship.
He is currently a medical resident in the physician scientist track at Heidelberg University Hospital, Department of Hematology, Oncology and Rheumatology. He has been in the Division of Rheumatology, Inflammation and Immunity of Brigham and Women's Hospital / Harvard Medical School since February 2016, performing his experimental thesis in neutrophil biology, and later postdoctoral research. He is a member of the Immunological Genome Project since 2017, where he has lead the assembly of a single cell gene expression atlas for neutrophils.
“Neutrophil Heterogeneity in Health and Inflammation – Opportunities for therapeutic intervention”
Neutrophils are critical components of the innate immune defense with an increasingly appreciated contribution to a myriad of immune-mediated diseases.
These heterogeneous functions are paralleled by a variety of phenotypes. However, in comparison to other immune lineages, the ontogeny of neutrophils remains poorly understood. In particular, the question if neutrophils encompass true sub-populations or rather different polarization forms, is highly debated. Neutrophils are currently not targeted therapeutically, in part because of safety concerns. However, this gap in knowledge passes on the opportunity to develop effective means to hinder their inflammatory capacity. Understanding the heterogeneity and developmental organization of neutrophils in health and inflamed scenarios is thus critical to identify safe and effective ways to manipulate them therapeutically.
In this seminar, we will explore the phenotypic, transcriptional and functional heterogeneity of neutrophils and expose potential features for therapeutic intervention.
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