Dr. rer. nat. Darja Andreev
Research group leader
Center for Regenerative Therapies
Dresden, Germany

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovial inflammation, joint damage, and disability. Although Th1 and Th17 cells are well-established in RA, the role of type-2 immune responses, common in asthma and helminth infections, is less understood. My research reveals that type-2 immune responses play a protective role in RA, primarily through the accumulation of pro-resolving eosinophils in the synovium. These eosinophils help reduce inflammation through the polarization of alternatively activated macrophages and also prevent bone loss by inhibiting excessive osteoclast activity.

Students and colleagues are all welcome!