Dr. Alexander Karabatsiakis

Alexander Karabatsiakis studied biology at the University of Münster.
He received his Ph.D at the Center for Systems Neuroscience (ZSN), located at the University of Veterinary Medicine in Hanover, for the investigation of biological and electrophysiological correlates of aging in major depression. For this, he worked at the Clinic for Psychiatry, Social Psychiatry and Psychotherapie at the Hanover Medical School (MHH).

In July 2011 he established the first of currently three biological laboratory units at the department of Clinical & Biological Psychology where he is working as a supervisor and lab Manager.



Alexander Karabatsiakis

Alexander Karabatsiakis
☎ +49-(0)731/5015475
℻  +49-(0)731/50 26599
Π 47.1.208

Consultation hours
on appointment

Research interests

  • Psychoneuroimmunological consequences of stress and trauma on health
  • Metabolite- and lipid-fingerprinting for the identification of molecular and metabolic alterations in trauma-associated disorders
  • Consequences of chronic and traumatic stress on biological aging mechanisms and cellular integrity
  • Characterization of mitochondrial physiology in immune cells in healthy and (psycho)pathological aging.

Research cooperations

Own talk and poster contributions at international conferences

“Combined metabolite and lipid fingerprinting in women with childhood maltreatment reveals biomarkers linked to inflammation and oxidative stress”. ISPNE 2018, Irvine, California, USA.

“Biochemical fingerprinting: An innovative technological approach to identify serum biomarker signatures of childhood maltreatment”. German Society of Biological Psychiatry (DGBP 2018), Heidelberg, Germany.

“Combined metabolite and lipid fingerprinting in women with childhood maltreatmentreveals biomarkers linked to inflammation and oxidative stress”. Annual meeting of the German-speeking Society of Psychotraumatology (DeGPT 2018), Dresden, Germany.

”The involvement of mitochondria in chronic low-grade inflammation associated with matreatment experiences in childhood”. Mitochondrial Physiology (MIP) 2017, Hradec Kralove, Tschechische Republik/Czech Republic.

“Combined metabolite and lipid fingerprinting in women with childhood maltreatment reveals biomarkers linked to inflammation and oxidative stress“. 6th Symposium of the Göttinger Proteomics Forum (23.11.2017), Göttingen, Germany.

"Metabolite fingerprinting reveals new serum metabolites and associated pathways in posttraumatic stress disorder". PNIRS 2017, Galveston, USA.

"Metabolite fingerprinting reveals new serum metabolites and associated pathways in posttraumatic stress disorder". GEBIN 2017, Münster, Germany.

"Mitochondrial respiration in peripheral blood mononuclear cells of individuals with borderline personality disorder". PNIRS 2016, Brighton, United Kingdom.

“The effects of child maltreatment on the stress hormones cortisol and dehydroepiandrosterone in hair of mother-infant pairs“, 4th German Health Research meeting 2015, Berlin, Germany.

"Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder", MIP2015, Pez pod Snezkou, Czech Republic.

"Consequences of depression on respiratory activity in peripheral blood mononuclear cells" Mitochondr Physiol Network 19.11. 96th OROBOROS O2k-Workshop on HRR and O2k-Fluorometry, Schroecken, Austria.

“Telomerverkürzungen in adaptiven Immunzellen bei Major Depression“, Psychologie und Gehirn 2014, Lübeck.

“Alterations of Endocannabinoids and Related Primary Fatty Acid Amides in trauma and post-traumatic stress disorders“, Psychologie und Gehirn 2012, Jena.

“Depression is associated with accelerated telomere shortening as identified in selected lymphocyte subpopulations“, ISNIM 2011, Dresden.

Publikationen / Publications

Karabatsiakis, A., Schoenfeldt-Lecuona, C. (2018). Depressionen als Stoffwechselstörung: Die Rolle der Mitochondrien. Nervenheilkunde 37(12): 873-879. DOI: 10.1055/s-0038-1677359.

Boeck, C., Gumpp, A.M., Koenig, A.M., Radermacher, P., Karabatsiakis, A., and Kolassa, I.-T. (2019). The Association of Childhood Maltreatment With Lipid Peroxidation and DNA Damage in Postpartum Women. Front. Psychiatry 10:23. doi: 10.3389/fpsyt.2019.00023.

Ramo-Fernandez, L., Boeck, C., Koenig, A., Schury, K., Binder, E.B., Gündel, H., Fegert, J.M., Karabatsiakis, A., Kolassa, I.-T. (in press). The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach. Scientific Reports.

Koenig, A. M., Alexandra M., Ramo-Fernández, L., Boeck, C., Umlauft, M., Pauly, M., Binder, E.B., Kirschbaum, C., Gündel, H., Karabatsiakis, A., Kolassa, I.-T. (2018). Intergenerational gene × environment interaction of FKBP5 and childhood maltreatment on hair steroids. Psychoneuroendocrinology, 92, 103-112.

Geiger, M. L., Boeck, C., Koenig, A. M., Schury, K., Waller, C., Kolassa, S., Karabatsiakis, A., Kolassa, I.-T. (2018). Investigating the effects of child maltreatment experiences on inflammation: The influence of cortisol and DHEA on cytokine secretion ex vivo. Mental Health and Prevention. Early online.

Conrad, D., Wilker, S., Schneider, A., Karabatsiakis, A., Pfeiffer, A., Kolassa, S., Freytag, V., Vukojevic, V., Vogler, C., Milnik, A., Papassotiropoulos, A., de Quervain, D. J.-F., Elbert, T., Kolassa, I.-T. (2018). Integrated genetic, epigenetic and gene set enrichment analyses identify NOTCH as a potential mediator for PTSD risk after trauma: Preliminary results from two independent African cohorts. Psychophysiology, e13288. Early online.

Boeck, C., Gumpp, A.M., Calzia, E., Radermacher, P., Waller, C., Karabatsiakis, A., Kolassa, I.-T. (2018). The association between cortisol, oxytocin and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment. Psychoneuroendocrinology. 96, 69-77.

Krause, S., Boeck, C., Gumpp, A.M., Rottler, E., Schury, K., Karabatsiakis, A., Buchheim, A., Guendel, H., Kolassa, I-T., Waller, C. (2018). Child maltreatment is associated with a reduction of the oxytocin repector in peripheral blood mononuclear cells. Frontiers in Psychology 9:173.

Karabatsiakis, A., Koenig, A.M., Stoll, T., Wilker, S., Hennessy, T., Hill, M.M., Kolassa, I.T. (2018). Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study. Scientific Reports (8):3468.

Koenig, A.M., Gao, W., Umlauft, M., Schury, K., Reister, F., Kirschbaum, C., Karabatsiakis, A., Kolassa, I.T. (2018). Altered hair endocannabinoid levels in mothers with childhood maltreatment and their newborns. Biological Psychology 135:93-101.

Boeck, C., Pfister, S., Bürkle, A., Vanhooren, V., Libert, C., Salinas-Manrique, J., Dietrich, D.E., Kolassa, I.T., Karabatsiakis, A. (2018). Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder. Journal of Affective Disorders (234):139-147.

Kuester, O.C., Laptinskaya, D., Fissler, P., Schnack, P., Zuegel, M., Nold, V., Thurm, F., Pleiner, S., Karabatsiakis, A., von Einem, B., Weydt, P., Liesener, A., Borta, A., Woll, A., Hengerer, B., Kolassa, I.T., von Arnim, C.A.F. (2017).  Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway. Journal of Alzheimer’s Disease, 59(3):1097-1111.

Boeck, C., Krause, S., Karabatsiakis, A., Schury, K., Gündel, H., Waller, C., Kolassa, I.T. (2017). History of child maltreatment and telomere lenght in immune cells subsets: Associations with stress- and attachment-related hormones. Development and Psychopathology, 1-13.

Schury, K., Koenig, A.M., Isele, D., Hulbert, A.L., Krause, S., Umlauft, M., Kolassa, S., Ziegenhain, U., Karabatsiakis, A., Reister, F., Guendel, H., Fegert, J.M. and Kolassa, I.-T. (2017). Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment. BMC Psychiatry, 17:213.

Krause, S., Pokorny, D., Schury, K., Doyen-Waldecker, C., Hulbert, A-L., Karabatsiakis, A., Kolassa. I-T., Guendel, H., Waller, C., Buchheim, A. (2016). Effects oft he Adult Attachment Projective Picture System on Oxytoxin and Cortisol Blood Levels in Mothers. Frontiers in Human Neuroscience, 10:627.

Boeck, C., Koenig, A.M., Schury, K., Geiger, M.L., Karabatsiakis, A., Wilker, S., Waller, C., Gündel, H., Fegert, J.M., Calzia, E., Kolassa, I.T (2016). Inflammation in adult women with a history of child maltreatment: The involvment of mitochondrial alterations and oxidative stress. Mitochondrion, 30:197-207.

Wilker, S., Pfeiffer, A., Elbert, T., Ovuga, E., Karabatsiakis, A., Krumbholz, A., Thieme, D., Schelling, G., Kolassa, IT. (2016). Endocannabinoid concentrations in hair are associated with PTSD symptom severity. Psychoneuroendocrinology, 67:198-206.

Linkus, B. Wiesner, D., Meßmer, M., Karabatsiakis, A., Scheffold, A., Rudolph, K.L., Thal, D., Weishaupt J.H, Ludolph, A.C., Danzer, K.M. (2016). Telomere shortening leads to earlier age of onset in ALS mice. Aging, 8(2):282-393.

Gradual Activation of the Binding System leads to increased Release of Oxytocin in Mothers: What Role an early Binding Traumatization plays? (2016), Zeitschrift für Psychosomatische Medizin und Psychotherapie 61(1):74.

Brunner, R., Reichl, C., Bermpohl, F., Bertsch, K., Bock, J., Bödeker, K., Firk, C., Fuchs, A., Führer, D., Gröger, N., Heinz, A., Herpertz-Dahlmann, B., Herpertz, S. C., Dahmen, B., Hindi, Attar, C., Kluczniok, D., Konrad, K., Lehmkuhl, U., Möhler, E., Neukel, C., Reck, C., Resch, F., Rether, K., Zietlow, A.-L., Ziegenhain, U., Schury, K., Karabatsiakis, A., Braun, K., Gündel, H., Kindler, H., Buchheim, A., Meysen, T., Kolassa, I.T., Fegert, J. M. (2015). Mechanismen der transgenerationsübergreifenden Transmission belastender Kindheitserfahrungen. Trauma und Gewalt, Theoretischer Hintergrund, Forschungsdesigns und erste Ergebnisse zweier multizentrischer Studien in Deutschland, 2(9), 134-147.

Karabatsiakis, A.1, Hamuni, G.1, Wilker, S.1, Kolassa, S., Renu, D., Kadereit, S., Schauer, M., Hennessy, T., & Kolassa, I.-T. (2015). Metabolite profiling in posttraumatic stress disorder. Journal of Molecular Psychiatry, 3(1):2.

Böck, C., Karabatsiakis, A., Kolassa, I.-T. (2014). Biologische Grundlagen der Depression – Mitochondriale Funktionalität als Ansatzpunkt. Zeitschrift für Medizin-Ethik-Recht, 2, Jg.5.

Karabatsiakis, A.1, Böck, C.1, Manrique, J.S., Kolassa, S., Calzia, E., Dietrich, D.E., & Kolassa, I.-T. (2014). Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Translational Psychiatry, 4, e397.

Karabatsiakis, A., Kolassa, I.-T., Kolassa, S., Rudolph, K.L., & Dietrich D.E. (2014). Telomere shortening in leukocyte subpopulations in depression. BMC Psychiatry, 14:192.

Hauer, D., Schelling, G., Gola, H., Campolongo, P., Morath, J., Roozendaal, B., Hamuni, G., Karabatsiakis, A., Atsak, P., Vogeser, M., Kolassa, I.T. (2013). Plasma Concentrations of Endocannabinoids and Related Fatty Acid Amides in Patients with Post-Traumatic Stress Disorder. PLOS One, 8(5), e62741.