Completed Theses

Bachelor of Science

  • 2013-2020

    2020

    • Direct modeling of tumor growth and time to event data**/ Young Statisticians Session 2020
    • Operating Characteristics of Surrogate Endpoint Methods for Normally Distributed Data**/ Young Statisticians Session 2020
    • Bayesian Continued Process Verification for Biopharmaceuticals**
    • Multiple imputation under not-at-random missingness with application in prediction with qPCR data*

    2019

    • Qualitätsauswertung der Krankenhausversorgung mit Hilfe von Martingal-Methoden für konkurrierende Risiken*
    • Circular statistics in a study connecting dentofacial data and wind instrument positioning*
    • Modeling of Dose-Exposure Relationships and Model-Based Extrapolation During Early Clinical Development**

    2018

    2016

    • Sample Size Reassessment in Equivalence Trials with Binary Data**
    • A Causal Analysis of Ventilator-Associated Pneumonia in Intensive Care/ Bernd-Streitberg Award

    2015

    • Time-dependent Covariates in the Proportional Subdistribution Hazards Modell
    • Zur Varianzschätzung des Mantel-Haenszel-Schätzers des Odds Ratios in stratifizierten Studien

    2014

    • Incidence rates and competing risks in the history of hospital epidemiology
    • Nichtparametrische Schätzung einer Übergangswahrscheinlichkeit in einem Nicht-Markov illness-death-Modell mit Hilfe von konkurrierenden Risiken
    • Comparison of Different Estimators regarding the Intra-Individual Correlation in Phase I Trials and their Usage for Trial Design**

    2013

    • The predicitive distribution of the residual variability in the linear model for clinical cross-over rials**/ Bernd Streitberg Award
    • Interaktion von Membranpermeabilität und zugrunde liegendem Mortalitätsrisiko bei inzidenten Dialyse Patienten der MPO Studie*

    Cooperations with

    Academic Partners*    Industry Partners**    International Cooperations***

Master of Science

  • 2014-2020

    2020

    • Zusammenhang von Schmerz und Funktionalität im prä- und postoperativen Verlauf bei Patienten mit Osteoarthrose und deren Bedeutung für die Sterblichkeit*
    • General Independent Censoring in Event-Driven Trials with Staggered Entry*
    • Absolute risk prediction for nested exposure case-control sampling
    • Landmarking for left-truncated competing risk data with applications to pregnancy outcome registries*/ Young Statisticians Session 2020

    2019

    2018

    • Evaluating potential post-treatment preditive and prognostic markers with time-to-event data**
    • The statistical analysis if the DEcompressive surgery Plus hypoTHermia for Space Occupying Stroke (DEPTH-SOS) trial, with a view towards mortality and safety*
    • Joint Models, Landmarking and the Ulm Osteoarthritis Study*

    2017

    2016

    • Nested Case-Control Designs and Exposure Density Sampling
    • Joint Modelling of Overall Survival and Progression-free Survival**/*** Bernd Streitberg Award.
    • Joint modelling of left-truncated observational studies: unmeasured 
      baseline covariates as a consequence of delayed study entry/ 
      Bernd Streitberg Award
    • Pseudo-Value Regression for the Excess Length-of-Stay and subsequent Quality-of-Life associated with hospital-acquired Infections

    2015

    • Bayesian decision criteria in clinical development**
    • Estimation of pregnancy outcome probabilities in the presence of heavy left-truncation/ "Young Statisticians Session 2015"
    • Nelson-Aalen and Aalen-Johansen estimators for randomly left-truncated and right-censored non-Markov multistate models with application to hospital epidemiology/ Student Award 2015 of the German Association for Medical Informatics, Biometry and Epidemiology
    • Analysis of time-dynamic oncological data - in the presence of a non-occurring event of interest*/***
    • Schätzung altersbedingter Herzkreislaufrisiken basierend auf Routinedaten*
    • Evaluation of the impact of a clinical hold in survival studies under different assumptions regarding the true effect**
    • Handling missing data using longitudinal or time-to-event techniques - Simulation studies and practical implementation in the Ulm Birth Cohort Study (UBCS)*
    • Bayesian Phase II Optimization for Time-To-Event Data Based on Historical Information**
    • Nonparametric estimation of cumulative incidence functions in the presence of dependent left-truncation with application to pregnancy outcome data

    2014

    • Planning of clinical survival studies in the presence of competing risks
    • Wild bootstrapping Nelson-Aalen estimates with application in health services research*/ Bernd Streitberg Award
    • Sample size calculations for overall survival in oncology trials incorporating a biomarker using multistate models**
    • Investigating the performance of EWOC designs compared to 3+3 in early oncology trials based on historical data**
    • Confidence intervals for the difference of proportions adjusted for covariates**
    • Robustification of state space models*/***

    Cooperations with

    Academic Partners*    Industry Partners**    International Cooperations***

PhD

  • 2018-2020

    2018

    • Statistical Evaluation of Non-Standard Time-to-Event Outcomes in Biomedical Research: cumulative PhD where one paper has received the Gustav-Adolf-Lienert-Award