Buske, Christian, Prof. Dr. med.
Institute of Exp. Cancer Research
Tel: 0731 50065800
The function of leukemic stem cells (LSC), which play a key role in acute myeloid leukemia (AML), is critically dependent on their micro-environmental niche and CXCL12-CXCR4 signaling. The present project will determine whether improved derivatives of the CXCR4 antagonist EPI-X4 will suppress LSC growth and may thus have prospects for the treatment of AML. Furthermore, comprehensive peptide libraries generated from human blood and bone marrow will be examined for other endogenous peptides suppressing LSC growth or function.