B04 – Targeting CXCR4 signaling to eliminate metastatic cancer stem cells in pancreatic cancer (Patrick Hermann)

Cancer stem cells (CSCs) propagate pancreatic cancer growth and are often resistant against chemotherapy. The applicant identified a CXCR4-expressing subpopulation of these CSCs forming the invasive front in metastases. Thus, the present project will determine whether the CXCR4 antagonist EPI-X4 suppresses metastatic growth of pancreatic CSCs. Furthermore, it will examine the role of the antimicrobial peptides LL-37 and granulysin in the metastatic growth of pancreatic cancer because preliminary data suggest that secretion of these peptides by macrophages may enhance tumorigenicity and invasiveness of pancreatic cancer cells.

 

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Principal Investigator

Hermann, Patrick, Priv-Doz. Dr. Dr.

Department of Internal Medicine I
Ulm University Medical Center
Albert-Einstein-Allee 23
89081 Ulm
Tel: 0731 50044501
patrick.hermann(at)uni-ulm.de