C06 – Hyperpolarized peptide-coated nanodiamonds for magnetic resonance imaging (Martin Plenio, Fedor Jelezko, Christian Buske)

Hyperpolarized 13C magnetic resonance imaging (MRI) is a promising tool to monitor the success of cancer treatment but currently requires extremely low temperatures and hour-long polarisation times. This project will use nitrogen-vacancy (NV) centers in nanodiamonds functionalized e.g. with cancer cell targeting peptides, to achieve a ~10,000-fold increase of the 13C nuclear spin polarisation at room temperature. Attachment of peptides to nanodiamonds might also allow to specifically target and detect cancer cells. Thus, this methodology greatly expands the possibilities for in vivo monitoring of molecular processes and holds great promise for biomedical research as well as cancer diagnostics and staging.

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Principal Investigators

Buske, Christian, Prof. Dr. med.

Institute of Exp. Cancer Research
Ulm University
James-Franck-Ring (N27)
89081 Ulm
Tel: 0731 50065800

Jelezko, Fedor, Prof. Dr.

Institute of Quantum Optics
Ulm University
Albert Einstein Allee 11
89081 Ulm
0731 50 23750

Plenio, Martin, Prof. Dr.

Institute of Theoretical Physics
Ulm University
Albert-Einstein-Str. 11
89069 Ulm
Tel: 0731 5022911