For most recent publications, please see:



Kreiner G, Sönmez A, Liss B, Parlato R (2019): Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Disease. Front. Mol. Neurosci., doi: 10.3389/fnmol.2019.00106. PDF


1. Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B, Parlato R (2017): Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models. Dis Model Mech. 2017 Mar 30. pii: dmm.028092. doi: 10.1242/dmm.028092. PDF.

2. Parlato R, Liss B (2017): Selective degeneration of dopamine neurons in Parkinson's disease: emerging roles of altered calcium homeostasis and nucleolar function. De Gruyter. 2017 Dec 23. doi: 10.1515/nf-2017-A006. PDF.


1. DJ Klionsky et al (multiple Authors in alphabetical orders, R. Parlato). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 2016; 12(1): 1-222. PDF-download

2. R. Parlato and P.G. Mastroberardino. Editorial on "Neuronal self-defense: compensatory mechanism in neurodegenerative disorders". Frontiers in Cellular Neuroscience, 2016; 9:499 eCollection 2015. PDF-download


1. R. Parlato, H. Bierhoff. Role of nucleolar dysfunction in neurodegenerative disorders: a game of genes? AIMS Molecular Science, 2015; 2(3): 211-224. (Special Issue: Molecular Mechanisms of Neurodegenerative Diseases)

2. R. Parlato, C. Mandl, G. Hölzl-Wenig, B. Liss, KL.Tucker, F. Ciccolini. Epigenetic regulation of embryonic neural precursor proliferation by CREB/CREM signaling. Neurogenesis, 2015; 1(1):1-13.

1F. Shamsi, R. Parlato, P. Collombat, A. Mansouri. A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells. Cell Cycle, 2014; 13(24):3948-57.

2. LH. Lehmann, J. Rostosky, SJ Buss, MM. Kreusser, J. Krebs, W. Mier, F. Enseleit, K. Spiger, S. Hardt, T. Wieland, M. Haass, TF. Lüscher, MD. Schneider, R. Parlato, HJ. Gröne, U. Haberkorn, M. Yanagisawa, HA. Katus, J. Backs. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci USA, 2014; 111(37):13499-504.

3. S. Wieland, D. Dan, M. Oswald, R. Parlato, G. Köhr, W. Kelsch. Dopaminergic neurons evoke acute cholinergic interneuron firing by sequential activation of NMDA, D1 and D2 receptors. J Neurosci, 2014; 34(35):11549-59. (Featured Article)

4. A. Bilbao, C. Rieker, N. Cannella, R. Parlato, S. Golda, M. Piechota, M. Korostynski, D. Engblom, R. Przewlocki, G. Schütz, R. Spanagel, J. Rodriguez Parkitna. CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects. Front Behav Neurosci, 2014; 8:212.

5. R. Parlato* and B. Liss. How Parkinson´s disease meets nucleolar stress. BBA-Molecular basis of disease, 2014; 1842(6):791-97.
(* Corresponding author)

1. A. Kiryk, K. Sowodniok, G. Kreiner, J. Rodriguez-Parkitna, A. Sönmez, T. Gorkiewicz, H. Bierhoff, M. Wawrzyniak, A. Janusz, B. Liss, W. Konopka, G. Schütz, L. Kaczmarek, R. Parlato*. Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons. Frontiers in Cellular Neuroscience, 2013; 7:207 (* Corresponding author)

2. P. Chmielarz, J. Kuśmierczyk, R. Parlato, G. Schütz, I. Nalepa, G. Kreiner. Inactivation of glucocorticoid receptor in noradrenergic system influences anxiety- and depressive-like behavior in mice. PLoS ONE 2013, 8(8):e72632.

3. G. Kreiner, H. Bierhoff, M. Armentano, J. Rodriguez Parkitna, K. Sowodniok, L. Bonfanti, B. Liss, G. Schütz, I. Grummt, R. Parlato*. A neuroprotective phase precedes striatal degeneration upon nucleolar stress. Cell Death Differ, 2013; 20:1455-1464. (* Corresponding author; see also Editorial by JD Erickson and NG Bazan in Cell Death Differ, 2013; 20:1435-1437)

4. C. J. Straub, H. Lau, R. Parlato, G. Schütz, J.-M. Fritschy, U. Rudolph. Bidirectional regulation of intravenous general anesthetic actions by alpha3-containing GABAA receptors. Anesthesiology 2013, 118(3):562-76.

5. R. Parlato* and G. Kreiner. Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle? J Mol Med, 2013; 91:541-7. (* Corresponding author; Featured online under the “Key Scientific Articles” section of Global Medical Discovery [ISSN1929-8536])

6. A. Schober, R. Parlato, K. Huber, R. Kinscherf, G. Schütz, K. Unsicker. Cell loss and autophagy in the extra-adrenal chromaffin organ Zuckerkandl are regulated by glucocorticoid signalling. Journal of Neuroendocrinology 2013; 25(1):34-47.


1.  J. Rodriguez Parkitna, W. Solecki, K. Golembiowska, K. Tokarski, J. Kubik, S. Gołda, M. Novak, R. Parlato, G. Hess, R. Sprengel, R. Przewlocki. Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. Int J Neuropsychopharmacol 2012; 10:1457-71.


1. F. Luzzati, S. De Marchis, R. Parlato, S. Gribaudo, G. Schütz, A. Fasolo, P. Peretto. New striatal neurons in a mouse model of progressive striatal degeneration are generated in both the subventricular zone and the striatal parenchyma. PLoS ONE 2011; 6(9):e25088.

2. A. Domanskyi, C. Geißler, I. Vinnikov, H. Alter, A. Schober, M. Vogt, P. Gass, R. Parlato and G. Schütz. Pten ablation in adult dopaminergic neurons is neuroprotective in mouse models of Parkinson's disease. FASEB J 2011; 25:2898-2910.

3. C. Rieker, D. Engblom, G. Kreiner, A. Domanskyi, A. Schober, S. Stotz, M. Neumann, X. Yuan, I. Grummt, G. Schütz and R. Parlato. Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mTOR signaling. J Neurosci, 2011; 31:453-60. (, rating 8)


1. K. Tsarovina, T. Reiff, J. Stubbusch, D. Kurek, F.G. Grosveld, R. Parlato, G. Schütz, H. Rohrer. The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. J Neurosci. 2010; 30:10833-43.

2. R. Parlato*, H. Cruz, C. Otto, P. Murtra, J. Rodriguez Parkitna, M. Martin, S.A. Bura, Y. Begus, O. von Bohlen und Halbach, R. Maldonado, G. Schütz and C. Lüscher. Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine. J Neurochem. 2010; 115: 563-573. (* Corresponding author; cover page)


1. F. Aquado, C. Diaz, R. Parlato, A. Martinez, M. Angels Carmona, S. Bleckmann, J. Ureña, F. Burgaya, J. A. Del Río, G. Schütz, and E. Soriano. The CREB/CREM transcription factors regulate negatively early synaptogenesis and spontaneous network activity. J Neurosci. 2009; 29: 328-33.

2. R. Parlato, C. Otto, J. Tuckermann, S. Stotz, S. Kaden, H-J. Gröne, K. Unsicker, G. Schütz. Conditional inactivation of glucocorticoid receptor gene in dopamine-Beta-hydroxylase cells impairs chromaffin cell survival. Endocrinology. 2009; 150: 1775-81.


1. R. Parlato, G. Kreiner, G. Erdmann, C. Rieker, S. Stotz, E. Savenkova, S. Berger, I. Grummt and G. Schütz. Activation of an endogenous suicide response due to perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci. 2008; 28: 12759-64.

2. C. Diaz, R. Parlato, F. Aquado, J. Ureña, F. Burgaya, A. Martinez, M. Angels Carmona, G. Kreiner, S. Bleckmann, J. A. Del Río, G. Schütz, and E. Soriano. Regulation of neural migration and DAB1 levels by the CREB/CREM transcription factors. Mol Cell Neurosci. 2008; 39: 519-28.

3. D. Engblom, A. Bilbao, C. Sanchis-Segura, L. Dahan, S. Perreau-Lenz, B. Balland, J. Rodriguez Parkitna, R. Lujan, B. Halbout, M. Mameli, R. Parlato, R. Sprengel, C. Lüscher, G. Schütz, R. Spanagel. Glutamate receptors on dopamine neurons control the persistence of cocaine-seeking. Neuron 2008; 59: 497-50.

4. S. Reiprich, C. Stolt, S. Schreiner, R. Parlato, M. Wegner. SoxE proteins are differentially required in mouse adrenal gland development. Mol Biol Cell. 2008; 19: 1575-86.

5. N. Gakhar-Koppole, CP. Bengston, R. Parlato, K. Horsch, V. Eckstein and F.Ciccolini. Depolarization promotes GAD 65-mediated GABA synthesis by a post-translational mechanism in neural stem cell-derived neurons. Eur J Neurosci. 2008; 27: 269-83.


1. M. Turiault, S. Parnaudeau, A. Milet, R. Parlato, J. Rouzeau, M. Lazar and F. Tronche. Analysis of dopamine transporter gene expression pattern − generation of DAT-iCre transgenic mice. FEBS J. 2007; 274:3568-77.

2. R. Parlato, C. Otto, Y. Begus, S. Stotz, G. Schütz. Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Development, 2007, 134: 1663-70.

3. T. Lemberger, R. Parlato, D. Dassesse, M. Westphal, E. Casanova, M., Turiault, F. Tronche, S. N. Schiffmann, G. Schütz. Expression of Cre recombinase in dopaminoceptive neurons. BMC Neuroscience, 2007,8:4.


1. R. Parlato, C. Rieker, M. Turiault, F. Tronche, G. Schütz. Survival of DA neurons is independent of CREM upregulation in absence of CREB. Genesis, 2006; 44:454-64.

2. M. Stanke, C. V. Duong, M. Pape, M. Geissen, G. Burbach, T. Deller, H. Gascan, R. Parlato, G. Schütz and H. Rohrer. Target-dependent specification of the neurotransmitter phenotype: Cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling. Development, 2006; 133:141-50.


1. C. Giachino, S. De Marchis, C. Giampietro, R. Parlato, I. Perroteau, G. Schütz, A. Fasolo and P.Peretto. cAMP response element-binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb. J Neurosci. 2005; 25: 10105-18.


1. R. Parlato, A. Rosica, A. Rodriguez-Mallon, A. Affuso, MP. Postiglione, C. Arra, A. Mansouri, S. Kimura, R. Di Lauro and M. De Felice. An integrated regulatory network controlling survival and migration in thyroid organogenesis. Developmental Biology, 2004; 276: 464-75.

2. A. Brancaccio, A. Minichiello, M. Grachtchouk, D. Antonini, H. Shen, R. Parlato, N. Dathan, AA. Dlugosz and C. Missero. Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis. Hum Mol Genet. 2004; 13: 2595-606.


1. MP. Postiglione, R. Parlato, A. Rodriguez-Mallon, A. Rosica, P. Mithbaokar, M. Maresca, RC. Marians, TF. Davies, MS. Zannini, M. De Felice and R. Di Lauro. Role of the thyroid stimulating hormone receptor signalling in development and differentiation of the thyroid gland. Proc Natl Acad Sci USA. 2002; 99: 15462-7.

2. N. Dathan, R. Parlato, A. Rosica, M. De Felice and R. Di Lauro. Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate and hair. Dev Dyn. 2002; 224: 450-456.

3. R. Parlato, A. Rosica, V. Cuccurullo, L. Mansi, P. E. Macchia, M. De Felice, J. D. Owens, J. F. Mushinski, R. F.Bonner and R. Di Lauro. A method that allows recovery of intact RNA from tissues dissected by Laser Capture Microdissection. Anal Biochem. 2002; 300: 139-45.