Dr. habil. Tamás Röszer

Research

Immune surveillance and metabolism are two principles sustaining life. Immune cells support the organism's growth and metabolism. Dysfunctional interplay between the immune system and metabolism drives the development of metabolic diseases such as insulin resistance, metabolic syndrome and  diabetes mellitus. Our research aim is to better understand how the neuroendocrine system governs the interaction between immune cells and metabolic tissues. We use adipose tissue as a model system, in which we have explored non-canonical mechanisms, such as neuropeptide signaling, and breast milk mediated mother-to-child signaling, which control the number and behavior of adipose tissue macrophages (ATMs). ATMS are metabolically important immune cells. We have found that ATMs develop before birth, and ATMs in infancy maintain heat-generating  ("fat-burning") beige adipose tissue. Interestingly, neuropeptide signals guide the ability of ATMs to fulfill this task. Infants not fully breast-fed have impaired ATM functions and are more prone to premature loss of their beige adipose tissue, which might lead to the development of obesity and metabolic diseases in later life.  Video summaries of our recent research are available on the website of The Journal of Clinical Investigation (NPFF effects on ATMs, Breast-milk lipid signaling and adipose tissue development), in Science  and on the webpage of the European Commission CORDIS. Currently, we explore further how the nervous system orchestrates signaling between ATMs and adipocytes to keep the adipose tissue metabolically fit. Our work is supported by the German Research Fund (DFG), the European Foundation for the Study of Diabetes (EFSD), and a PRC Fellowhip Program. 

Recent publications

Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A, Harauma  A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuróczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB and Röszer T (2019) Breast milk alkylglyerols sustain beige adipocytes through adipose tissue macrophages. J Clin Invest 129(6) DOI 1172/JCI125646

Röszer, T (2018) Understanding the Biology of Self-Renewing Macrophages. Cells 2018, 7(8):103

Waqas SFH, Noble A, Hoang AC, Ampem G, Popp M, Strauß S, Guille M. Röszer T (2017) Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse. J Leukoc Biol 102(3): 845-855

Waqas SFG, Hoang AC, Lin Y, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen J, Gerling IC, Nam S, Lim J, Martinez-Ibanez J, Real JT, Paschke S, Quillet R, Ayachi S, Simonin F, Schneider M, Brinkman J, Lamming DW, Seroogy CM, Röszer T (2017) Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest 127(7): 2842-2854

Menendez-Guiterrez MP, Röszer T, Fuentes L, Nunez V, Escolano A, Redondo JM, DeClerck N, Metzger D, Valledor AF, Ricote M (2015) Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest 125(2): 809-823

 

Contact

  • Dr. habil. Tamás Röszer
  • Room: M25/5404; 5406
  • Phone: +49 (0) 731-50- 22695
    Fax: +49 (0) 731-50-22629
    E-mail: tamas.roeszer(at)uni-ulm.de
     
  • Lab members:
  • Haidong Yu, PhD student
  • Anh Cuong Hoang, PhD student
  • Katharina Schormair, Bachelor candidate
    Burak Yildiz, Bachelor candidate