Kontakt
Institut für Angewandte Physiologie
Albert-Einstein-Allee 11, N27
89081 Ulm
N27, Raum 433
Telefon: +49 (0)731 500 33-770
E-mail: dennis.kaetzel(at)uni-ulm.de
Kontakt
Institut für Angewandte Physiologie
Albert-Einstein-Allee 11, N27
89081 Ulm
N27, Raum 433
Telefon: +49 (0)731 500 33-770
E-mail: dennis.kaetzel(at)uni-ulm.de
Jun.-Prof. Dr. Kätzel wird in Ulm von der "Else Kröner-Fresenius-Förderinitiative zur Berufung medizinischer Spitzenforscher aus dem Ausland" großzügig unterstützt.
We focus on the understanding of the neural mechanisms that lead to schizophrenia. Schizophrenia is a psychiatric disease affecting close to 1 % of the population and accounting for 25 % of psychiatric hospital beds. It is characterized by "positive" symptoms such as halluzinations and delusions, but also by "cognitive" and "negative" symptoms like deficits in working memory, attention, cognitive flexibility, social interaction and motivation. It is such cognitive and negative symptoms that hardly respond to currently available drug therapy and therefore represent the focus of our translational research efforts.
Kätzel D, Wolff AR, Bygrave AM, Bannermann DM. (2020): Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia. 2020 October 16; 11:486811; doi: 10.3389/fphar.2020.486811
Bygrave AM, Kilonzo K, Kullmann DM, Mannermann DM, Kätzel D (2019): Can N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Be Localized to an Individual Cell Type? Reviev Front. Psychiatry. 2019 November 21; 10:835. doi: 10.3389/fpsyt.2019.00835
Teutsch J, Kätzel D (2019): Operant Assessment of DMTP Spatial Working Memory in Mice. Front Behav Neurosci. 2019 Aug 27;13:193. doi: 10.3389/fnbeh.2019.00193.
Bygrave AM, Jahans-Price T, Wolff AR, Sprengel R, Kullmann DM, Bannerman DM, Kätzel D. (2019): Hippocampal-prefrontal coherence mediates working memory and selective attention at distinct frequency bands and provides a causal link between schizophrenia and its risk gene GRIA1., Transl Psychiatry. 2019 Apr 18;9(1):142. doi: 10.1038/s41398-019-0471-0.
Liss B, Kätzel D (2019): Kleinhirn, in Brandes R, Lang F, Schmidt RF: Physiologie des Menschen: mit Pathophysiologie, Springer-Verlag. ISBN 978-3-662-56467-7 Link
Jendryka M, Palchaudhuri M, Ursu D, van der Veen B, Liss B, Kätzel D, Nissen W, Pekcec A (2019): Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice. Scientific Reports 9:4522. doi: 10.1038/s41598-019-41088-2.
Bygrave AM, Masiulis S, Kullmann DM, Bannerman DM, Kätzel D (2018): Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia. Front Behav Neurosci. doi: 10.3389/fnbeh.2018.00332.
Grimm CM, Aksamaz S, Schulz S, Teutsch J, Sicinski P, Liss B and Kätzel D (2018): Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity. Translational Psychiatry 8:212. doi:10.1038/s41398-018-0268-6.
Wolff AR, Bygrave AM, Sanderson DJ, Boyden DS, Bannerman DM, Kullmann DM, Kätzel D (2018): Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms; Sci Rep. 2018 Aug 27;8(1):12871. doi: 10.1038/s41598-018-31163-5.
De Bruyckere E, Simon R, Nestel S, Heimrich B, Kätzel D, Egorov AV, Liu P, Jenkins NA, Copeland NG, Schwegler H, Draguhn A, Britsch S (2018): Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2; Front Mol Neurosci. 2018 Apr 5;11:103. doi: 10.3389/fnmol.2018.00103
Kohl MM, Kätzel D (2017): Optogenetic mapping of neuronal connections and their plasticity, in Appasani K (ed.): Optogenetics: from neuronal function to mapping and disease biology, Cambridge University Press, 2017. Link
Bygrave AM, Masiulis S, Nicholson E, Berkemann M, Barkus C, Sprengel R, Harrison P, Kullmann DM, Bannermann DM, Kätzel D (2016): Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801; Translational Psychiatry (2016) 6, e778; doi: 10-1038/tp.2016.44; published online: 12 April 2016.
Anastasiades PG, Marques-Smith A, Lyngholm D, Lickiss T, Raffiq S, Kätzel D, Miesenböck G, Butt SJ (2016): GABAergic interneurons form transient, layer-specific circuits in early postnatal neocortex; Nature Communications February 04; doi:10.1038/ncomms10584.
Kätzel D, Kullmann D (2015): Optogenetic and chemogenetic tools for drug discovery in schizophrenia. Book chapter in: Drug discovery for schizophrenia. RSC Publishing. Lipina T, Roder J (eds.). ISBN 978-1-78262-026-6.
Kätzel D, Nicholson E, Schorge S, Walker MC, Kullmann DM (2014): Chemical-genetic attenuation of focal neocortical seizures; Nature Communications May 27; doi: 10.1038/ncomms4847.
Kätzel D, Miesenböck G (2014): Experience-dependent rewiring of specific inhibitory connections in adult neocortex. PLoS Biol, February 25; 12(2): e1001798. doi: 10.1371/journal.pbio.1001798.
Kätzel D, Zemelman BV, Buetfering C, Wölfel M, Miesenböck G (2011): The columnar and laminar organization of inhibitory connections to neocortical excitatory cells; Nat Neurosci. 2011 Jan, 14(1): 100-107. doi: 10.1038/nn2687. PDF.
Nachname | Vorname | Titel | Tel. | Fax. | Büro | Labor | Geb. | Funktion |
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Kätzel | Dennis | Jun.-Prof. Dr. | 33770 | 33779 | 453 | 4401-7 | N26 | Head of the Group |
Bühner | Lukas | cand.Med | 33775 | 33779 | 454 | 4401-7 | N26 | MD-Student |
Kapanaiah | Sampath | M.Sc. | 33775 | 33779 | 4405 | 4401-7 | N26 | PhD-Student |
Kilonzo | Kasyoka | M.Sc. | 33775 | 33779 | 454 | 4401-7 | N26 | PhD-Student |
Jendryka | Martin | M. Sc. | 33775 | 33779 | 4405 | 4401-7 | N26 | PhD-Student |
Schmid | Mark | B.Sc. | 33775 | 33779 | 4405 | 4401-7 | N26 | Wiss. Hilfskraft |
Schulz | Stefanie | BTA | 15248 | 33779 | 454 | 4401-7 | N26 | Techn. Assistant |
Strahnen | Daniel | cand.Med | 33775 | 33779 | 4405 | 4401-7 | N26 | MD-Student Research Assistant |
van der Veen | Bastiaan | M. Sc. | 33775 | 33779 | 454 | 4401-7 | N26 | PhD-Student |