Publikationen

Osseointegration of photodynamic active biomaterials for bone regeneration in an animal bone model over a period of 12 months.

Kranz S, Heyder M, Rabe U, Liu P, Mrozinska A, Guellmar A, Berg A, Steen D, Tuckermann J, Watts DC, Sigusch B, Reise M. Dent Mater. 2023 Sep 12:S0109-5641(23)00374-3. doi: 10.1016/j.dental.2023.09.001. Online ahead of print. PMID: 37709590 Free article.

Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome.

Stifel U, Vogel F, Caratti G, Reincke M, Tuckermann J. Hypertension. 2023 Aug 30. doi: 10.1161/HYPERTENSIONAHA.123.21185. Online ahead of print. PMID: 37646167 Free article.

ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection.

Engler M, Albers D, Von Maltitz P, Groß R, Münch J, Cirstea IC. Life Sci Alliance. 2023 Jul 4;6(9):e202201880. doi: 10.26508/lsa.202201880. Print 2023 Sep. PMID: 37402592 Free PMC article.

Signalling by senescent melanocytes hyperactivates hair growth.

Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV. Nature. 2023 Jun;618(7966):808-817. doi: 10.1038/s41586-023-06172-8. Epub 2023 Jun 21. PMID: 37344645 Free PMC article.

Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues.

Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger M, Kutschka I, Cyganek L, Zenker M, Kensah G, Ahmadian MR. Commun Biol. 2023 Jun 21;6(1):657. doi: 10.1038/s42003-023-05013-8. PMID: 37344639 Free PMC article.

Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society.

Stein M, Elefteriou F, Busse B, Fiedler IA, Kwon RY, Farrell E, Ahmad M, Ignatius A, Grover L, Geris L, Tuckermann J. J Bone Miner Res. 2023 Aug;38(8):1045-1061. doi: 10.1002/jbmr.4868. Epub 2023 Jul 4. PMID: 37314012 Free article. Review.

Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism.

Knoop P, Yilmaz D, Paganoni R, Steele-Perkins P, Gruber A, Akdogan B, Zischka H, Leopold K, Vujić Spasić M. Int J Mol Sci. 2023 May 18;24(10):8948. doi: 10.3390/ijms24108948. PMID: 37240294 Free PMC article.

Intact GR dimerization is critical for restraining plasma ACTH levels during chronic psychosocial stress.

Langgartner D, Koenen M, Kupfer S, Glogger L, Kurz L, Perez-Rivas LG, Theodoropoulou M, Noll-Hussong M, Vettorazzi S, Tuckermann J, Reber SO. Neurobiol Stress. 2023 May 2;24:100541. doi: 10.1016/j.ynstr.2023.100541. eCollection 2023 May. PMID: 37215522 Free PMC article.

The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1.

Robinson LJ, Soboloff J, Tourkova IL, Larrouture QC, Onwuka KM, Papachristou DJ, Gross S, Hooper R, Samakai E, Worley PF, Liu P, Tuckermann J, Witt MR, Blair HC. PLoS One. 2023 May 11;18(5):e0264596. doi: 10.1371/journal.pone.0264596. eCollection 2023. PMID: 37167218 Free PMC article.

Energy saver: Monocytes hibernate in bone marrow upon fasting.

Tuckermann J, Fischer-Posovszky P. Cell Metab. 2023 May 2;35(5):734-736. doi: 10.1016/j.cmet.2023.04.008. PMID: 37137288

Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis.

Macfarlane E, Cavanagh L, Fong-Yee C, Tuckermann J, Chen D, Little CB, Seibel MJ, Zhou H. Osteoarthritis Cartilage. 2023 Sep;31(9):1189-1201. doi: 10.1016/j.joca.2023.04.009. Epub 2023 Apr 25. PMID: 37105394

Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance.

Caratti G, Stifel U, Caratti B, Jamil AJM, Chung KJ, Kiehntopf M, Gräler MH, Blüher M, Rauch A, Tuckermann JP. Nat Commun. 2023 Apr 20;14(1):2271. doi: 10.1038/s41467-023-37831-z. PMID: 37080971 Free PMC article.

Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1.

Seeling M, Pöhnl M, Kara S, Horstmann N, Riemer C, Wöhner M, Liang C, Brückner C, Eiring P, Werner A, Biburger M, Altmann L, Schneider M, Amon L, Lehmann CHK, Lee S, Kunz M, Dudziak D, Schett G, Bäuerle T, Lux A, Tuckermann J, Vögtle T, Nieswandt B, Sauer M, Böckmann RA, Nimmerjahn F. Immunity. 2023 May 9;56(5):1046-1063.e7. doi: 10.1016/j.immuni.2023.02.019. Epub 2023 Mar 21. PMID: 36948194 Free article.

Downregulation of the Autism Spectrum Disorder Gene Shank2 Decreases Bone Mass in Male Mice.

Ahmad M, Stirmlinger N, Jan I, Stifel U, Lee S, Weingandt M, Kelp U, Bockmann J, Ignatius A, Böckers TM, Tuckermann J. JBMR Plus. 2022 Dec 15;7(2):e10711. doi: 10.1002/jbm4.10711. eCollection 2023 Feb. PMID: 36751416 Free PMC article.

Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids.

Caratti G, Desgeorges T, Juban G, Stifel U, Fessard A, Koenen M, Caratti B, Théret M, Skurk C, Chazaud B, Tuckermann JP, Mounier R. EMBO Rep. 2023 Feb 6;24(2):e55363. doi: 10.15252/embr.202255363. Epub 2022 Dec 15. PMID: 36520372 Free PMC article.

Glucocorticoid receptor and RAS: an unexpected couple in cancer.

Cirstea IC, Moll HP, Tuckermann J. Trends Cell Biol. 2023 Jul;33(7):594-604. doi: 10.1016/j.tcb.2022.11.002. Epub 2022 Nov 22. PMID: 36428174 Review.

Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model.

Nandi S, Chennappan S, Andrasch Y, Fidan M, Engler M, Ahmad M, Tuckermann JP, Zenker M, Cirstea IC. Front Cell Dev Biol. 2022 Oct 18;10:1000575. doi: 10.3389/fcell.2022.1000575. eCollection 2022. PMID: 36330334 Free PMC article.

Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.

Maity-Kumar G, Ständer L, DeAngelis M, Lee S, Molenaar A, Becker L, Garrett L, Amerie OV, Hoelter SM, Wurst W, Fuchs H, Feuchtinger A, Gailus-Durner V, Garcia-Caceres C, Othman AE, Brockmann C, Schöffling VI, Beiser K, Krude H, Mroz PA, Hofmann S, Tuckermann J, DiMarchi RD, Hrabe de Angelis M, Tschöp MH, Pfluger PT, Müller TD. Mol Metab. 2022 Dec;66:101616. doi: 10.1016/j.molmet.2022.101616. Epub 2022 Oct 18. PMID: 36270613 Free PMC article.

Could a phase model help to improve translational animal research?

Mayer B, Tuckermann J, Muche R. Animal Model Exp Med. 2022 Dec;5(6):550-556. doi: 10.1002/ame2.12284. Epub 2022 Oct 20. PMID: 36266781 Free PMC article.

Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis.

Bülow JM, Renz N, Haffner-Luntzer M, Fischer V, Schoppa A, Tuckermann J, Köhl J, Huber-Lang M, Ignatius A. Front Endocrinol (Lausanne). 2022 Sep 30;13:1016057. doi: 10.3389/fendo.2022.1016057. eCollection 2022. PMID: 36246887 Free PMC article.

Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function.

Wepler M, Preuss JM, Tilp C, Keck M, Blender J, Wachter U, Merz T, Vogt J, Kress S, Gröger M, Hoffmann A, Fink M, Calzia E, Burret U, Radermacher P, Tuckermann JP, Vettorazzi S. Front Immunol. 2022 Sep 12;13:980707. doi: 10.3389/fimmu.2022.980707. eCollection 2022. PMID: 36172380 Free PMC article.

Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors.

Stifel U, Caratti G, Tuckermann J. FEBS Lett. 2022 Oct;596(20):2617-2629. doi: 10.1002/1873-3468.14474. Epub 2022 Sep 4. PMID: 35997656 Review.

Correction: Steppe et al. Bone Mass and Osteoblast Activity Are Sex-Dependent in Mice Lacking the Estrogen Receptor α in Chondrocytes and Osteoblast Progenitor Cells. Int. J. Mol. Sci. 2022, 23, 2902.

Steppe L, Bülow J, Tuckermann J, Ignatius A, Haffner-Luntzer M. Int J Mol Sci. 2022 May 27;23(11):6020. doi: 10.3390/ijms23116020. PMID: 35683036 Free PMC article.

Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice.

Schoppa AM, Chen X, Ramge JM, Vikman A, Fischer V, Haffner-Luntzer M, Riegger J, Tuckermann J, Scharffetter-Kochanek K, Ignatius A. Dis Model Mech. 2022 May 1;15(5):dmm049392. doi: 10.1242/dmm.049392. Epub 2022 May 13. PMID: 35394023 Free PMC article.

Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing.

Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J. Bone Res. 2022 Apr 6;10(1):33. doi: 10.1038/s41413-022-00195-z. PMID: 35383146 Free PMC article.

The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth.

Caratti B, Fidan M, Caratti G, Breitenecker K, Engler M, Kazemitash N, Traut R, Wittig R, Casanova E, Ahmadian MR, Tuckermann JP, Moll HP, Cirstea IC. Sci Signal. 2022 Mar 22;15(726):eabm4452. doi: 10.1126/scisignal.abm4452. Epub 2022 Mar 22. PMID: 35316097

Bone Mass and Osteoblast Activity Are Sex-Dependent in Mice Lacking the Estrogen Receptor α in Chondrocytes and Osteoblast Progenitor Cells.

Steppe L, Bülow J, Tuckermann J, Ignatius A, Haffner-Luntzer M. Int J Mol Sci. 2022 Mar 7;23(5):2902. doi: 10.3390/ijms23052902. PMID: 35270044 Free PMC article.

Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice.

Krüger BT, Steppe L, Vettorazzi S, Haffner-Luntzer M, Lee S, Dorn AK, Ignatius A, Tuckermann J, Ahmad M. Biomedicines. 2022 Feb 8;10(2):404. doi: 10.3390/biomedicines10020404. PMID: 35203613 Free PMC article.

Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury.

Meyer Zu Reckendorf S, Moser D, Blechschmidt A, Joga VN, Sinske D, Hegler J, Deininger S, Catanese A, Vettorazzi S, Antoniadis G, Boeckers T, Knöll B. J Neurosci. 2022 Mar 23;42(12):2474-2491. doi: 10.1523/JNEUROSCI.1305-21.2022. Epub 2022 Feb 11. PMID: 35149515 Free PMC article.

A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.

Loft A, Schmidt SF, Caratti G, Stifel U, Havelund J, Sekar R, Kwon Y, Sulaj A, Chow KK, Alfaro AJ, Schwarzmayr T, Rittig N, Svart M, Tsokanos FF, Maida A, Blutke A, Feuchtinger A, Møller N, Blüher M, Nawroth P, Szendrödi J, Færgeman NJ, Zeigerer A, Tuckermann J, Herzig S. Cell Metab. 2022 Mar 1;34(3):473-486.e9. doi: 10.1016/j.cmet.2022.01.004. Epub 2022 Feb 3. PMID: 35120589 Free article.

Distinct Glucocorticoid Receptor Actions in Bone Homeostasis and Bone Diseases.

Lee S, Krüger BT, Ignatius A, Tuckermann J. Front Endocrinol (Lausanne). 2022 Jan 10;12:815386. doi: 10.3389/fendo.2021.815386. eCollection 2021. PMID: 35082759 Free PMC article. Review.

Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other.

Nilsson KH, Wu J, Gustafsson KL, El Shahawy M, Koskela A, Tuukkanen J, Tuckermann J, Henning P, Lerner UH, Ohlsson C, Movérare-Skrtic S. Am J Physiol Endocrinol Metab. 2022 Mar 1;322(3):E211-E218. doi: 10.1152/ajpendo.00383.2021. Epub 2022 Jan 24. PMID: 35068191 Free PMC article.

Impaired Glucocorticoid Receptor Signaling Aggravates Lung Injury after Hemorrhagic Shock.

Preuss JM, Burret U, Gröger M, Kress S, Scheuerle A, Möller P, Tuckermann JP, Wepler M, Vettorazzi S. Cells. 2021 Dec 30;11(1):112. doi: 10.3390/cells11010112. PMID: 35011674 Free PMC article.

Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle.

Stifel U, Wolfschmitt EM, Vogt J, Wachter U, Vettorazzi S, Tews D, Hogg M, Zink F, Koll NM, Winning S, Mounier R, Chazaud B, Radermacher P, Fischer-Posovszky P, Caratti G, Tuckermann J. Mol Metab. 2022 Mar;57:101424. doi: 10.1016/j.molmet.2021.101424. Epub 2021 Dec 22. PMID: 34954109 Free PMC article.

Estrogen Receptor α Signaling in Osteoblasts is Required for Mechanotransduction in Bone Fracture Healing.

Steppe L, Krüger BT, Tschaffon MEA, Fischer V, Tuckermann J, Ignatius A, Haffner-Luntzer M. Front Bioeng Biotechnol. 2021 Dec 7;9:782355. doi: 10.3389/fbioe.2021.782355. eCollection 2021. PMID: 34950644 Free PMC article.

The Role of Glucocorticoids in Inflammatory Diseases.

Reichardt SD, Amouret A, Muzzi C, Vettorazzi S, Tuckermann JP, Lühder F, Reichardt HM. Cells. 2021 Oct 28;10(11):2921. doi: 10.3390/cells10112921. PMID: 34831143 Free PMC article. Review.

Osteoblast-specific inactivation of p53 results in locally increased bone formation.

Liao N, Koehne T, Tuckermann J, Triviai I, Amling M, David JP, Schinke T, Luther J. PLoS One. 2021 Nov 18;16(11):e0249894. doi: 10.1371/journal.pone.0249894. eCollection 2021. PMID: 34793446 Free PMC article.

Dexamethasone-mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells.

Ahmed HMM, Nimmagadda SC, Al-Matary YS, Fiori M, May T, Frank D, Patnana PK, Récher C, Schliemann C, Mikesch JH, Koenig T, Rosenbauer F, Hartmann W, Tuckermann J, Dührsen U, Lanying W, Dugas M, Opalka B, Lenz G, Khandanpour C. Br J Haematol. 2022 Feb;196(4):995-1006. doi: 10.1111/bjh.17940. Epub 2021 Nov 18. PMID: 34792186

A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation.

Tschaffon MEA, Reber SO, Schoppa A, Nandi S, Cirstea IC, Aszodi A, Ignatius A, Haffner-Luntzer M. Endocrine. 2022 Jan;75(1):266-275. doi: 10.1007/s12020-021-02853-4. Epub 2021 Sep 16. PMID: 34529238 Free PMC article.

Deletion of Cdk5 in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10.

Pfänder P, Eiers AK, Burret U, Vettorazzi S. Int J Mol Sci. 2021 Sep 6;22(17):9648. doi: 10.3390/ijms22179648. PMID: 34502552 Free PMC article.

The endothelium-bone axis in development, homeostasis and bone and joint disease.

Tuckermann J, Adams RH. Nat Rev Rheumatol. 2021 Oct;17(10):608-620. doi: 10.1038/s41584-021-00682-3. Epub 2021 Sep 3. PMID: 34480164 Free PMC article. Review.

RSPO3 is important for trabecular bone and fracture risk in mice and humans.

Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C. Nat Commun. 2021 Aug 13;12(1):4923. doi: 10.1038/s41467-021-25124-2. PMID: 34389713 Free PMC article.

Shaping the bone through iron and iron-related proteins.

Ledesma-Colunga MG, Weidner H, Vujic Spasic M, Hofbauer LC, Baschant U, Rauner M. Semin Hematol. 2021 Jul;58(3):188-200. doi: 10.1053/j.seminhematol.2021.06.002. Epub 2021 Jun 27. PMID: 34389111 Free article. Review.

A guide to changing paradigms of glucocorticoid receptor function-a model system for genome regulation and physiology.

Vettorazzi S, Nalbantoglu D, Gebhardt JCM, Tuckermann J. FEBS J. 2022 Oct;289(19):5718-5743. doi: 10.1111/febs.16100. Epub 2021 Jul 18. PMID: 34213830 Review.

Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis.

Cherifi C, Latourte A, Vettorazzi S, Tuckermann J, Provot S, Ea HK, Ledoux A, Casas J, Cuvillier O, Richette P, Ostertag A, Hay E, Cohen-Solal M. Osteoarthritis Cartilage. 2021 Sep;29(9):1335-1345. doi: 10.1016/j.joca.2021.06.001. Epub 2021 Jun 16. PMID: 34144150 Free article.

Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis.

Elson A, Stein M, Rabie G, Barnea-Zohar M, Winograd-Katz S, Reuven N, Shalev M, Sekeres J, Kanaan M, Tuckermann J, Geiger B. Front Cell Dev Biol. 2021 May 20;9:671210. doi: 10.3389/fcell.2021.671210. eCollection 2021. PMID: 34095139 Free PMC article.

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.

Giroud M, Tsokanos FF, Caratti G, Kotschi S, Khani S, Jouffe C, Vogl ES, Irmler M, Glantschnig C, Gil-Lozano M, Hass D, Khan AA, Garcia MR, Mattijssen F, Maida A, Tews D, Fischer-Posovszky P, Feuchtinger A, Virtanen KA, Beckers J, Wabitsch M, Uhlenhaut H, Blüher M, Tuckermann J, Scheideler M, Bartelt A, Herzig S. Diabetologia. 2021 Aug;64(8):1850-1865. doi: 10.1007/s00125-021-05470-y. Epub 2021 May 20. PMID: 34014371 Free PMC article.

Studying Metabolic Abnormalities in the Costello Syndrome HRAS G12V Mouse Model: Isolation of Mouse Embryonic Fibroblasts and Their In Vitro Adipocyte Differentiation.

Fidan M, Chennappan S, Cirstea IC. Methods Mol Biol. 2021;2262:397-409. doi: 10.1007/978-1-0716-1190-6_24. PMID: 33977491

An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.

Barnea-Zohar M, Winograd-Katz SE, Shalev M, Arman E, Reuven N, Roth L, Golani O, Stein M, Thalji F, Kanaan M, Tuckermann J, Geiger B, Elson A. J Cell Sci. 2021 May 1;134(9):jcs254979. doi: 10.1242/jcs.254979. Epub 2021 May 11. PMID: 33975343 Free PMC article.

Iron at the Interface of Hepatocellular Carcinoma.

Paganoni R, Lechel A, Vujic Spasic M. Int J Mol Sci. 2021 Apr 15;22(8):4097. doi: 10.3390/ijms22084097. PMID: 33921027 Free PMC article. Review.

Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing.

Hachemi Y, Rapp AE, Lee S, Dorn AK, Krüger BT, Kaiser K, Ignatius A, Tuckermann J. Front Immunol. 2021 Feb 17;11:628287. doi: 10.3389/fimmu.2020.628287. eCollection 2020. PMID: 33679723 Free PMC article.

PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis.

Shalev M, Arman E, Stein M, Cohen-Sharir Y, Brumfeld V, Kapishnikov S, Royal I, Tuckermann J, Elson A. FEBS J. 2021 Aug;288(15):4702-4723. doi: 10.1111/febs.15778. Epub 2021 Mar 5. PMID: 33605542 Free article.

A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function.

Kroon J, Schilperoort M, In Het Panhuis W, van den Berg R, van Doeselaar L, Verzijl CRC, van Trigt N, Mol IM, Sips HHCM, van den Heuvel JK, Koorneef LL, van der Sluis RJ, Fenzl A, Kiefer FW, Vettorazzi S, Tuckermann JP, Biermasz NR, Meijer OC, Rensen PCN, Kooijman S. Mol Metab. 2021 May;47:101179. doi: 10.1016/j.molmet.2021.101179. Epub 2021 Feb 3. PMID: 33548499 Free PMC article.

Leukemia inhibitory factor treatment attenuates the detrimental effects of glucocorticoids on bone in mice.

Lee S, Liu P, Ahmad M, Tuckermann JP. Bone. 2021 Apr;145:115843. doi: 10.1016/j.bone.2021.115843. Epub 2021 Jan 9. PMID: 33429108

Multiplex Fluorescent Bead-Based Immunoassay for the Detection of Cytokines, Chemokines, and Growth Factors.

Preuss JM, Burret U, Vettorazzi S. Methods Mol Biol. 2021;2261:247-262. doi: 10.1007/978-1-0716-1186-9_15. PMID: 33420994

Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation.

Wepler M, Preuss JM, Merz T, McCook O, Radermacher P, Tuckermann JP, Vettorazzi S. Intensive Care Med Exp. 2020 Dec 18;8(Suppl 1):37. doi: 10.1186/s40635-020-00325-z. PMID: 33336296 Free PMC article. Review.

Senescence in RASopathies, a possible novel contributor to a complex pathophenoype.

Engler M, Fidan M, Nandi S, Cirstea IC. Mech Ageing Dev. 2021 Mar;194:111411. doi: 10.1016/j.mad.2020.111411. Epub 2020 Dec 9. PMID: 33309600 Free article. Review.

Inhibition of 11β-HSD1 Expression by Insulin in Skin: Impact for Diabetic Wound Healing.

Brazel CB, Simon JC, Tuckermann JP, Saalbach A. J Clin Med. 2020 Nov 28;9(12):3878. doi: 10.3390/jcm9123878. PMID: 33260645 Free PMC article.

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice.

Nairz M, Metzendorf C, Vujic-Spasic M, Mitterstiller AM, Schroll A, Haschka D, Hoffmann A, Von Raffay L, Sparla R, Huck CW, Talasz H, Moser PL, Muckenthaler MU, Weiss G. Haematologica. 2021 Dec 1;106(12):3149-3161. doi: 10.3324/haematol.2019.241745. PMID: 33054105 Free PMC article.

RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk.

Najafova Z, Liu P, Wegwitz F, Ahmad M, Tamon L, Kosinsky RL, Xie W, Johnsen SA, Tuckermann J. Cell Death Differ. 2021 Feb;28(2):700-714. doi: 10.1038/s41418-020-00614-w. Epub 2020 Sep 8. PMID: 32901120 Free PMC article.

Author Correction: Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.

Hildebrandt S, Baschant U, Thiele S, Tuckermann J, Hofbauer LC, Rauner M. Sci Rep. 2020 Jun 4;10(1):9344. doi: 10.1038/s41598-020-65962-6. PMID: 32494045 Free PMC article.

The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis.

Merz T, Denoix N, Wigger D, Waller C, Wepler M, Vettorazzi S, Tuckermann J, Radermacher P, McCook O. Front Endocrinol (Lausanne). 2020 May 14;11:299. doi: 10.3389/fendo.2020.00299. eCollection 2020. PMID: 32477273 Free PMC article.

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass.

Müller DIH, Stoll C, Palumbo-Zerr K, Böhm C, Krishnacoumar B, Ipseiz N, Taubmann J, Zimmermann M, Böttcher M, Mougiakakos D, Tuckermann J, Djouad F, Schett G, Scholtysek C, Krönke G. Sci Rep. 2020 May 21;10(1):8428. doi: 10.1038/s41598-020-65305-5. PMID: 32439961 Free PMC article.

Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.

Stein M, Barnea-Zohar M, Shalev M, Arman E, Brenner O, Winograd-Katz S, Gerstung J, Thalji F, Kanaan M, Elinav H, Stepensky P, Geiger B, Tuckermann J, Elson A. Bone. 2020 Jul;136:115360. doi: 10.1016/j.bone.2020.115360. Epub 2020 Apr 8. PMID: 32278070

CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow.

Fischer-Riepe L, Daber N, Schulte-Schrepping J, Véras De Carvalho BC, Russo A, Pohlen M, Fischer J, Chasan AI, Wolf M, Ulas T, Glander S, Schulz C, Skryabin B, Wollbrink Dipl-Ing A, Steingraeber N, Stremmel C, Koehle M, Gärtner F, Vettorazzi S, Holzinger D, Gross J, Rosenbauer F, Stoll M, Niemann S, Tuckermann J, Schultze JL, Roth J, Barczyk-Kahlert K. J Allergy Clin Immunol. 2020 Nov;146(5):1137-1151. doi: 10.1016/j.jaci.2020.02.034. Epub 2020 Mar 19. PMID: 32199911

Macrophage-HFE controls iron metabolism and immune responses in aged mice.

Tangudu NK, Yilmaz D, Wörle K, Gruber A, Colucci S, Leopold K, Muckenthaler MU, Vujic Spasic M. Haematologica. 2021 Jan 1;106(1):259-263. doi: 10.3324/haematol.2019.235630. PMID: 32079697 Free PMC article. No abstract available.

Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction.

Wepler M, Preuss JM, Merz T, Hartmann C, Wachter U, McCook O, Vogt J, Kress S, Gröger M, Fink M, Scheuerle A, Möller P, Calzia E, Burret U, Radermacher P, Tuckermann JP, Vettorazzi S. Front Immunol. 2020 Jan 23;10:3152. doi: 10.3389/fimmu.2019.03152. eCollection 2019. PMID: 32038649 Free PMC article.

Effects of sodium thiosulfate (Na₂S₂O₃) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis.

Datzmann T, Hoffmann A, McCook O, Merz T, Wachter U, Preuss J, Vettorazzi S, Calzia E, Gröger M, Kohn F, Schmid A, Denoix N, Radermacher P, Wepler M. Pharmacol Res. 2020 Jan;151:104536. doi: 10.1016/j.phrs.2019.104536. Epub 2019 Nov 14. PMID: 31734346

A Jack of All Trades: Impact of Glucocorticoids on Cellular Cross-Talk in Osteoimmunology.

Ahmad M, Hachemi Y, Paxian K, Mengele F, Koenen M, Tuckermann J. Front Immunol. 2019 Oct 17;10:2460. doi: 10.3389/fimmu.2019.02460. eCollection 2019. PMID: 31681333 Free PMC article. Review.

Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D₃ and parathyroid hormone-induced osteoclastogenesis.

Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. FASEB J. 2019 Dec;33(12):14394-14409. doi: 10.1096/fj.201802729RRR. Epub 2019 Nov 14. PMID: 31675485 Free PMC article.

Despite Genetic Iron Overload, Hfe-Hemochromatosis Mice Do Not Show Bone Loss.

Wagner A, Alan B, Yilmaz D, Ahmad M, Liu P, Tangudu NK, Tuckermann JP, Vujic Spasic M. JBMR Plus. 2019 Jul 26;3(9):e10206. doi: 10.1002/jbm4.10206. eCollection 2019 Sep. PMID: 31667458 Free PMC article.

mir-124-5p Regulates Phagocytosis of Human Macrophages by Targeting the Actin Cytoskeleton via the ARP2/3 Complex.

Herdoiza Padilla E, Crauwels P, Bergner T, Wiederspohn N, Förstner S, Rinas R, Ruf A, Kleemann M, Handrick R, Tuckermann J, Otte K, Walther P, Riedel CU. Front Immunol. 2019 Oct 4;10:2210. doi: 10.3389/fimmu.2019.02210. eCollection 2019. PMID: 31636629 Free PMC article.

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor.

Escoter-Torres L, Caratti G, Mechtidou A, Tuckermann J, Uhlenhaut NH, Vettorazzi S. Front Immunol. 2019 Aug 7;10:1859. doi: 10.3389/fimmu.2019.01859. eCollection 2019. PMID: 31440248 Free PMC article. Review.

Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

Javaheri T, Kazemi Z, Pencik J, Pham HTT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DNT, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R. Cell Death Dis. 2019 Aug 13;10(8):605. doi: 10.1038/s41419-019-1853-1. PMID: 31406155 Free PMC article.

Glucocorticoids Shape Macrophage Phenotype for Tissue Repair.

Desgeorges T, Caratti G, Mounier R, Tuckermann J, Chazaud B. Front Immunol. 2019 Jul 9;10:1591. doi: 10.3389/fimmu.2019.01591. eCollection 2019. PMID: 31354730 Free PMC article. Review.

Cdk5 Deletion Enhances the Anti-inflammatory Potential of GC-Mediated GR Activation During Inflammation.

Pfänder P, Fidan M, Burret U, Lipinski L, Vettorazzi S. Front Immunol. 2019 Jul 10;10:1554. doi: 10.3389/fimmu.2019.01554. eCollection 2019. PMID: 31354714 Free PMC article.

Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans.

Movérare-Skrtic S, Nilsson KH, Henning P, Funck-Brentano T, Nethander M, Rivadeneira F, Coletto Nunes G, Koskela A, Tuukkanen J, Tuckermann J, Perret C, Souza PPC, Lerner UH, Ohlsson C. FASEB J. 2019 Oct;33(10):11163-11179. doi: 10.1096/fj.201900707R. Epub 2019 Jul 15. PMID: 31307226 Free PMC article.

Identification of mineralocorticoid receptor target genes in the mouse hippocampus.

van Weert LTCM, Buurstede JC, Sips HCM, Vettorazzi S, Mol IM, Hartmann J, Prekovic S, Zwart W, Schmidt MV, Roozendaal B, Tuckermann JP, Sarabdjitsingh RA, Meijer OC. J Neuroendocrinol. 2019 Aug;31(8):e12735. doi: 10.1111/jne.12735. Epub 2019 Jun 14. PMID: 31121060 Free PMC article.

Deregulation of Hepatic Mek1/2⁻Erk1/2 Signaling Module in Iron Overload Conditions.

Tangudu NK, Buth N, Strnad P, Cirstea IC, Spasić MV. Pharmaceuticals (Basel). 2019 May 7;12(2):70. doi: 10.3390/ph12020070. PMID: 31067696 Free PMC article.

A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling.

Glantschnig C, Koenen M, Gil-Lozano M, Karbiener M, Pickrahn I, Williams-Dautovich J, Patel R, Cummins CL, Giroud M, Hartleben G, Vogl E, Blüher M, Tuckermann J, Uhlenhaut H, Herzig S, Scheideler M. FASEB J. 2019 May;33(5):5924-5941. doi: 10.1096/fj.201801385RR. Epub 2019 Feb 11. PMID: 30742779

Phosphorylation of the phosphatase PTPROt at Tyr³⁹⁹ is a molecular switch that controls osteoclast activity and bone mass in vivo.

Roth L, Wakim J, Wasserman E, Shalev M, Arman E, Stein M, Brumfeld V, Sagum CA, Bedford MT, Tuckermann J, Elson A. Sci Signal. 2019 Jan 8;12(563):eaau0240. doi: 10.1126/scisignal.aau0240. PMID: 30622194

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.

Kalvisa A, Siersbæk MS, Præstholm SM, Christensen LJL, Nielsen R, Stohr O, Vettorazzi S, Tuckermann J, White M, Mandrup S, Grøntved L. PLoS Biol. 2018 Dec 10;16(12):e2006249. doi: 10.1371/journal.pbio.2006249. eCollection 2018 Dec. PMID: 30532187 Free PMC article.

Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling.

Motta M, Fidan M, Bellacchio E, Pantaleoni F, Schneider-Heieck K, Coppola S, Borck G, Salviati L, Zenker M, Cirstea IC, Tartaglia M. Hum Mol Genet. 2019 Mar 15;28(6):1007-1022. doi: 10.1093/hmg/ddy412. PMID: 30481304

Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.

Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T. J Clin Invest. 2018 Nov 1;128(11):5056-5072. doi: 10.1172/JCI97912. Epub 2018 Oct 15. PMID: 30320600 Free PMC article.

Cell-based RNAi screening and high-content analysis in primary calvarian osteoblasts applied to identification of osteoblast differentiation regulators.

Ahmad M, Kroll T, Jakob J, Rauch A, Ploubidou A, Tuckermann J. Sci Rep. 2018 Sep 19;8(1):14045. doi: 10.1038/s41598-018-32364-8. PMID: 30232406 Free PMC article.

Thy-1 (CD90) promotes bone formation and protects against obesity.

Picke AK, Campbell GM, Blüher M, Krügel U, Schmidt FN, Tsourdi E, Winzer M, Rauner M, Vukicevic V, Busse B, Salbach-Hirsch J, Tuckermann JP, Simon JC, Anderegg U, Hofbauer LC, Saalbach A. Sci Transl Med. 2018 Aug 8;10(453):eaao6806. doi: 10.1126/scitranslmed.aao6806. PMID: 30089635

New horizons for osteoanabolic treatment?

Ignatius A, Tuckermann J. Nat Rev Endocrinol. 2018 Sep;14(9):508-509. doi: 10.1038/s41574-018-0069-2. PMID: 30050157 No abstract available.

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

Javaheri T, Kazemi Z, Jan Pencik, Pham HTT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DNT, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R. Cell Death Dis. 2018 Jul 23;9(8):800. doi: 10.1038/s41419-018-0773-9. PMID: 30038364 Free PMC article.

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis.

Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U, Tuckermann JP. Ann Rheum Dis. 2018 Nov;77(11):1610-1618. doi: 10.1136/annrheumdis-2017-212762. Epub 2018 Jul 11. PMID: 29997111 Free PMC article.

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover.

Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G. J Bone Miner Res. 2018 Nov;33(11):2035-2047. doi: 10.1002/jbmr.3533. Epub 2018 Jul 24. PMID: 29949664 Free article.

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.

Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6. doi: 10.1016/j.ccell.2018.05.003. PMID: 29894692 Free PMC article.

Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.

Hildebrandt S, Baschant U, Thiele S, Tuckermann J, Hofbauer LC, Rauner M. Sci Rep. 2018 Jun 7;8(1):8711. doi: 10.1038/s41598-018-26300-z. PMID: 29880826 Free PMC article.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C. J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25. PMID: 29746256 Free PMC article.

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice.

Müller C, Zidek LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF. Elife. 2018 Jun 4;7:e34985. doi: 10.7554/eLife.34985. PMID: 29708496 Free PMC article.

[Osteoimmunology-IMMUNOBONE : Regulation of bone by inflammation].

Rauner M, Buttgereit F, Distler J, Garbe AI, Herrmann M, Hofbauer L, Hoffmann M, Jessberger R, Kornak U, Krönke G, Mundlos S, Spies C, Tuckermann J, Zwerina J. Z Rheumatol. 2018 May;77(Suppl 1):12-15. doi: 10.1007/s00393-018-0455-0. PMID: 29691689 Review. German. No abstract available.

[Mutual influence of immune system and bones].

Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A. Z Rheumatol. 2018 May;77(Suppl 1):8-11. doi: 10.1007/s00393-018-0454-1. PMID: 29675686 Review. German. No abstract available.

The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay.

Baake T, Jörß K, Suennemann J, Roßmann L, Bohnenberger H, Tuckermann JP, Reichardt HM, Fischer HJ, Reichardt SD. Oncotarget. 2018 Mar 2;9(21):15437-15450. doi: 10.18632/oncotarget.24602. eCollection 2018 Mar 20. PMID: 29643984 Free PMC article.

Molecular mechanisms of glucocorticoids on skeleton and bone regeneration after fracture.

Hachemi Y, Rapp AE, Picke AK, Weidinger G, Ignatius A, Tuckermann J. J Mol Endocrinol. 2018 Jul;61(1):R75-R90. doi: 10.1530/JME-18-0024. Epub 2018 Mar 27. PMID: 29588427 Free PMC article. Review.

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.

Bartelt A, Behler-Janbeck F, Beil FT, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J, Niemeier A. Bone Res. 2018 Feb 26;6:4. doi: 10.1038/s41413-017-0006-3. eCollection 2018. PMID: 29507818 Free PMC article.

100

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation.

Linder M, Hecking M, Glitzner E, Zwerina K, Holcmann M, Bakiri L, Ruocco MG, Tuckermann J, Schett G, Wagner EF, Sibilia M. Cell Death Differ. 2018 Jun;25(6):1094-1106. doi: 10.1038/s41418-017-0054-7. Epub 2018 Feb 14. PMID: 29445126 Free PMC article.