Niessing lab

# shared first author  - * shared corresponding author



Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V.
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Nat Immunol. 2021 Nov 22. doi: 10.1038/s41590-021-01064-3.

Molitor L, Bacher S, Burczyk S, Niessing D.
The Molecular Function of PURA and Its Implications in Neurological Diseases.
Front Genet. 2021 Mar 11;12:638217.


Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A.
Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.
Nat Commun. 10(1), 2266 (2019).

Heber S., Gáspár I., Tants J.-N., Günther J., Fernandez Moya S, Janowski R., Ephrussi A., Sattler M., Niessing D.
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Nature Commun. 10(1), 1659 (2019).


Fuenzalida-Werner JP*, Janowski R, Mishra K, Weidenfeld I, Niessing D, Ntziachristos V, Stiel AC
Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation.
J Struct Biol. 2018 Oct 1. pii: S1047-8477(18)30273-9. doi: 10.1016/j.jsb.2018.09.013.

Tretter JY, Schorpp K, Luxenburger E, Trambauer J, Steiner H, Hadian K, Gires O*, Niessing D*.
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor
J. Biol. Chem. jbc.RA118.002776. doi:10.1074/jbc.RA118.002776

Hofweber M; Hutten S; Bourgeois B; Spreitzer E; Niedner-Boblenz A; Schifferer M; Ruepp MD; Simons M; Niessing D; Madl T; Dormann D.
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Cell 173(3):706-719.e13 (2018).

Rehage, N.#; Davydova, E.-O.#; Conrad, C.#; Behrens, G.; Maiser, A.; Stehklein, J.E.; Brenner, S.; Klein, J.; Jeridi, A.; Hoffmann, A.L.; Lee, E.; Dianzani, U.; Willemsen, R.; Feederle, R.; Reiche, K.; Hackermüller, J.; Leonhardt, H.; Sharma, S.*; Niessing, D.*; Heissmeyer, V.*
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Nat. Commun. 9:299 (2018)

Reijnders, M.R. ; Janowski, R. ; Alvi, M. ; ... Nellaker, C. ; Niessing, D. ; Hunt, D.T.E. ; Baralle, D.
PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature.
J. Med. Genet. 55, 104-113 (2018)

Niessing, D. ; Jansen, R.P. ; Pohlmann, T ; Feldbrügge, M.
mRNA transport in fungal top models.
Wiley Interdiscip. Rev. RNA 9, DOI: 10.1002/wrna.1453 (2018)


Edelmann, F. ; Schlundt, A. ; Heym, R.G. ; Jenner, A. ; Niedner-Boblenz, A. ; Syed, M.I. ; Paillart, J.C. ; Stehle, R. ; Janowski, R. ; Sattler, M. ; Jansen, R.P. ; Niessing, D.
Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
Nat. Struct. Mol. Biol. 24, 152-161 (2017)

Tausch, F. ; Dietrich, R. ; Schauer, K. ; Janowski, R. ; Niessing, D. ; Märtlbauer, E. ; Jessberger, N.
Evidence for complex formation of the Bacillus cereus haemolysin BL components in solution.
Toxins 9:288 (2017)

Jansen, R.P. ; Niessing, D.
mRNA-Lokalisation: Wenn RNAs auf Reise gehen …
BioSpektrum 23, 510-512 (2017)

Schlundt, A. ; Buchner, S. ; Janowski, R. ; Heydenreich, T. ; Heermann, R. ; Lassak, J. ; Geerlof, A. ; Stehle, R. ; Niessing, D. ; Jung, K. ; Sattler, M.
Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.
Sci. Rep. 7:1051 (2017)


Weber, J. ; Bao, H. ; Hartlmüller, C. ; Wang, Z. ; Windhager, A. ; Janowski, R. ; Madl, T. ; Jin, P. ; Niessing, D.
Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
eLife 5:e11297 (2016)

Janowski, R. ; Scanu, S. ; Niessing, D. ; Madl, T.
Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.
Act. Cryst. F 72, 743-749 (2016)

Vincendeau, M. ; Hadian, K. ; Messias, A.C. ; Brenke, J.K. ; Halander, J. ; Griesbach, R.A. ; Greczmiel, U. ; Bertossi, A. ; Stehle, R. ; Nagel, D. ; Demski, K. ; Velvarska, H. ; Niessing, D. ; Geerlof, A. ; Sattler, M. ; Krappmann, D.
Inhibition of canonical NF-κB signaling by a small molecule targeting NEMO-ubiquitin interaction.
Sci. Rep. 6:18934 (2016)

Schlundt, A. ; Niessing, D. ; Heissmeyer, V. ; Sattler, M.
RNA recognition by Roquin in posttranscriptional gene regulation.
Wiley Interdiscip. Rev. RNA 7, 455-469 (2016)

Janowski, R.#; Heinz, G.A.#; Schlundt, A.#; Wommelsdorf, N. ; Brenner, S. ; Gruber, A.R. ; Blank, M. ; Buch, T. ; Buhmann, R. ; Zavolan, M. ; Niessing, D.*; Heissmeyer, V.*; Sattler, M.*
Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Nat. Commun. 7:11032 (2016)

Morgen, M. ; Jöst, C. ; Malz, M. ; Janowski, R. ; Niessing, D. ; Klein, C.D. ; Gunkel, N. ; Miller, A.K.
Spiroepoxytriazoles are fumagillin-like irreversible inhibitors of MetAP2 with potent cellular activity
ACS Chem. Biol. 11, 1001-1011 (2016)


Edelmann, F. ; Niedner, A. ; Niessing, D.
ASH1 mRNP-core factors form stable complexes in absence of cargo RNA at physiological conditions.
RNA Biol. 12, 233-237 (2015)


Schlundt, A.# ; Heinz, G.A.# ; Janowski, R.# ; Geerlof, A. ; Stehle, R.* ; Heissmeyer, V.* ; Niessing, D.* ; Sattler, M.*
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Nat. Struct. Mol. Biol. 21, 671-678 (2014)

Edelmann, F. ; Niedner, A. ; Niessing, D.
Production of pure and functional RNA for in vitro reconstitution experiments.
Methods 65, 333-341 (2014)

Jansen, R.P. ; Niessing, D. ; Baumann, S. ; Feldbrügge, M.
mRNA transport meets membrane traffic.
Trends Genet. 30, 408-417 (2014)

Niedner, A. ; Edelmann, F ; Niessing, D.
Of social molecules: The interactive assembly of ASH1 mRNA-transport complexes in yeast.
RNA Biol. 11, 998-1009 (2014)


Heym, R.G. ; Zimmermann, D. ; Edelmann, F. ; Israel, L. ; Ökten, Z. ; Kovar, D.R. ; Niessing, D.
In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation.
J. Cell Biol. 203, 971-984 (2013)

Niedner, A. ; Müller, M. ; Moorthy, B.T. ; Jansen, R.-P. ; Niessing, D.
Role of Loc1p in assembly and reorganization of nuclear ASH1 messenger ribonucleoprotein particles in yeast.
Proc. Natl. Acad. Sci. U.S.A. 110, E5049–E5058 (2013)

Pfaff, J. ; Hennig, J. ; Herzog, F. ; Aebersold, R. ; Sattler, M. ; Niessing, D.* ; Meister, G.*
Structural features of Argonaute–GW182 protein interactions.
Proc. Natl. Acad. Sci. U.S.A. 110, 3770-3779 (2013)

Velvarska, H. ; Niessing, D.
Purification, crystallization and preliminary crystallographic analysis of the globular domain of the human type V myosin Myo5a.
Acta Crystallogr. F-Struct. Biol. Cryst. Commun. 69, 1220-1223 (2013)

Velvarska, H. ; Niessing, D.
Structural insights into the globular tails of the human type V myosins Myo5a, Myo5b, and Myo5c.
PLoS ONE 8:e82065 (2013)

Walcher, T. ; Xie, Q. ; Sun, J. ; Irmler, M. ; Beckers, J. ; Öztürk, T. ; Niessing, D. ; Stoykova, A. ; Cvekl, A. ; Ninkovic, J. ; Götz, M.-L.
Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation.
Development 140, 1123-1136 (2013)


Jansen, R.-P. ; Niessing, D.
Assembly of mRNA-protein complexes for directional mRNA transport in eukaryotes - an overview.
Curr. Protein Pept. Sci. 13, 284-293 (2012)

Aumiller, V. ; Graebsch, A. ; Kremmer, E. ; Niessing, D. ; Förstemann, K.
Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte.
RNA Biol. 9, 633-643 (2012)

Hüls, D. ; Storchova, Z. ; Niessing, D.
Post-translational modifications regulate assembly of early spindle orientation complex in yeast.
J. Biol. Chem. 287, 16238-16245 (2012)

Heym, R.G. ; Niessing, D.
Principles of mRNA transport in yeast.
Cell. Mol. Life Sci. 69, 1843-1853 (2012)

Hüls, D. ; Niessing, D.
Purification, crystallization and preliminary crystallographic analysis of Kar9p from Saccharomyces cerevisiae.
Acta Crystallogr. F-Struct. Biol. Cryst. Commun. 68, 1251-1254 (2012)

Niessing, D.
RNA-binding proteins in fungi and their role in mRNA localization.
In: Lorković, Z.J.* [Eds.]: RNA Binding Proteins. Austin, TX: Landes Biosciences, 2012.


Müller, M. ; Heym, R.G. ; Meyer, A. ; Kramer, K. ; Schmid, M. ; Cramer, P. ; Urlaub, H. ; Jansen, R.P. ; Niessing, D.
A cytoplasmic complex mediates specific mRNA recognition and localization in yeast.
PLoS Biol. 9:e1000611 (2011)


Graebsch, A. ; Roche, S. ; Niessing, D.
Ein Baustein des Fragilen X-assozierten Tremor/Ataxie-Syndroms.
BioSpektrum 16, 635-637 (2010)

Graebsch, A. ; Roche, S. ; Kostrewa, D. ; Söding, J. ; Niessing, D.
Of bits and bugs - on the use of bioinformatics and a bacterial crystal structure to solve a eukaryotic repeat-protein structure.
PLoS ONE 5:e13402 (2010)

Heuck, A. ; Fetka, I. ; Brewer, D.N. ; Hüls, D. ; Munson, M. ; Jansen, R.P. ; Niessing, D.
The structure of the Myo4p globular tail and its function in ASH1 mRNA localization.
J. Cell Biol. 189, 497-510 (2010)


Graebsch, A. ; Roche, S. ; Niessing, D.
X-ray structure of pur-α reveals a whirly-like fold and an unusual nucleic-acid binding surface.
Proc. Natl. Acad. Sci. U.S.A. 106, 18521-18526 (2009)

Müller, M. ; Richter, K. ; Heuck, A. ; Kremmer, E. ; Buchner, J. ; Jansen, R.P. ; Niessing, D.
Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization.
RNA 15, 2002-2012 (2009)

Buschmann, H. ; Hauptmann, M. ; Niessing, D. ; Lloyd, C.W. ; Schäffner, A.
Helical growth of the Arabidopsis mutant tortifolia2 does not depend on cell division patterns but involves handed twisting of isolated cells.
Plant Cell 21, 2090-2106 (2009)

2008 and before

Du, T.G. ; Jellbauer, S. ; Müller, M. ; Schmid, M. ; Niessing, D. ; Jansen, R.P.
Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA.
EMBO Rep. 9, 781-787 (2008)

Heuck, A. ; Du, T.G. ; Jellbauer, S. ; Richter, K. ; Kruse, C. ; Jaklin, S. ; Müller, M. ; Buchner, J. ; Jansen, R.P. ; Niessing, D.
Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes.
Proc. Natl. Acad. Sci. U.S.A. 105, 19778-19783 (2007)

Müller, M. ; Heuck, A. ; Niessing, D.
Directional mRNA transport in eukaryotes: Lessons from yeast.
Cell. Mol. Life Sci. 64, 171-180 (2007)

Niessing, D.
Should i stay or should i go?
BioSpektrum 12, 789-790 (2006)

Cramer, P. ; Sträßer, K. ; Niessing, D. ; Meister, G. ; Jansen, R.-P.
RNA als Koordinator und Regulator der Genexpression.
BioSpektrum 11, 523-525 (2005)

Niessing D. Hüttelmaier S, Zenklusen D, Singer RH, Burley SK.
She2p is a novel RNA binding protein with a basic helical hairpin motif.
Cell. 2004 Nov 12;119(4):491-502.

Leung T, Bischof J, Söll I, Niessing D, Zhang D, Ma J, Jäckle H, Driever W.
bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish.
Development. 2003 Aug;130(16):3639-49. 

Niessing D, Blanke S, Jäckle H. Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.
Genes Dev. 2002 Oct 1;16(19):2576-82.

Niessing D, Driever W, Sprenger F, Taubert H, Jäckle H, Rivera-Pomar R.
Homeodomain position 54 specifies transcriptional versus translational control by Bicoid.
Mol Cell. 2000 Feb;5(2):395-401.

Niessing D, Dostatni N, Jäckle H, Rivera-Pomar R.
Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo.
EMBO J. 1999 Apr 1;18(7):1966-73.

Rivera-Pomar R, Niessing D, Schmidt-Ott U, Gehring WJ, Jäckle H.
RNA binding and translational suppression by bicoid.
Nature. 1996 Feb 22;379(6567):746-9.