Dr. Carola Dreier

Research

As a postdoctoral research fellow in the research group of Prof. Annika Herwig I focus on the role of thyroid hormones in torpor regulation in the Djungarian hamster (Phodopus sungorus). Therefore, in vivo biochemical, metabolic rate measurements and molecular methods are applied to further understand the brain regulative mechanisms during the energy saving mode torpor. In the future, this knowledge could be applied in surgery, life support measures or space travels.

To investigate the role of thyroid hormones in torpor regulation, I use the following methods:

in vivo:

  • radio frequency based telemetry to continuously meassure core body temperature
  • respiratory gas analysis to measure metabolic rate via indirect calorimetry
  • pharmacological manipulation of the brain.

in vitro:

  • immunohistochemical examination of the brain
  • gene expression analysis (quantitative PCR and in situ hybridization) 

 

 

Publications

Bertram S, Thiele S, Dreier C, Resa-Infante P, Preuß A, von Riel D, Mok CKP, Schwalm F, Peiris JSM, Klenk HD, Gabriel G (2017). H7N9 Influenza A Virus Exhibits Importin-α7-Mediated Replication in the Mammalian Respiratory Tract. Am J Pathol. 187(4): 831-840. doi: 10.1016/j.ajpath.2016.12.017. Epub 2017 Feb 9. 

Engels G, Hierweger AM, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker HW, Arck PC, Gabriel G (2017). Pregnancy-Related Immune Adaptation Promotes The Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. Cell Host Microbe 21(3): 321-333. doi: 10.1016/j.chom.2017.02.020.

Otte A, Marriott AC, Dreier C, Dove B, Mooren K, Klingen TR, Sauter M, Thompson KA, Bennett A, Klingel K, van Riel D, McHardy AC, Carroll MW, Gabriel G (2016) Evolution of 2009 H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and transmissibility in the ferret model. Sci Rep 24:6, 28583. doi: 10.1038/srep28583.

Dreier C (2016) Untersuchungen zur Pathogenese und Transmission eines frettchenadaptierten H7N7 Influenza A Virus. Inaugural-Dissertation Universität Hamburg. 158p. 

Conference and Meeting contributions

Dreier C, Resa-Infante P, Preuß A, van Riel D, Thiele S, Klenk HD, Gabriel G (2017). Ferrett-adapted H7N7 HPAIV Pathogenicity and Transmissibibility in Small Animal Models. Talk, 14th HKU Pasteur Virology Course, HKU-Pasteur Research Pole, Hong Kong.

Dreier C, Resa-Infante P, Preuß A, van Riel D, Thiele S, Klenk HD, Gabriel G (2017). Ferrett-adapted H7N7 HPAIV Pathogenicity and Transmissibibility in Small Animal Models. Talk, 27th Gfv Meeting, Marburg, Germany.

Otte A, Marriott AC, Dreier C, Dove B, Mooren K, Klingen TR, Sauter M, Thompson KA, Bennett A, Klingel K, van Riel D, McHardy AC, Carroll MW, Gabriel G (2016) Evolution of 2009 H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and transmissibility in the ferret model. Poster, Evaluation, Heinrich Pette Institute, Hamburg, Germany.

Dreier C, Resa-Infante P, Preuß A, van Riel D, Thiele S, Klenk HD, Gabriel G (2016). Ferrett-adapted H7N7 HPAIV Pathogenicity and Transmissibility in Small Animal Models. Poster, Evaluation, Heinrich Pette Institute, Hamburg, Germany.

Walendy-Gnirß K, Bertram S, Schiecke A, Preuß A, Dreier C, Herwig A, Gabriel G (2016). The Siberian Hamster as a New Model to Study Seasonal Impact on Influenza A Virus Pathogenicity. Poster, Scientific Retreat of the Heinrich Pette Institute , Hamburg, Germany.

Dreier C, Resa-Infante P, Bertram S, Gabriel G (2016). Role of the Importin-α1 Gene in Influenza A Virus Replication and Pathogenicity. Poster, Scientific Retreat of the Heinrich Pette Institute  Hamburg, Germany.

Dreier C, Resa-Infante P, Bertram S, Gabriel G (2016). Determinants of Highly Pathogenic H7N7 Avian Influenza Virus Pathogenicity and Transmission. Poster, 5th International Influenza Meeting, Münster, Germany.

Dreier C, Resa-Infante P, Bertram S, Gabriel G (2016). Determinants of Highly Pathogenic H7N7 Avian Influenza Virus Pathogenicity and Transmission. Poster, Options IX for the Control of Influenza, Chicago, USA.

Dreier C, Resa-Infante P, Gabriel G (2015). Viral Determinants of H7N7 HPAIV-Pathogenicity and Transmission. Talk, LCI Retreat, Jesteburg, Germany.

Dreier C, Resa-Infante P, Gabriel G (2015). Viral Determinants of H7N7 HPAIV-Pathogenicity and Transmission. Talk, Scientific Retreat of Heinrich Pette Institute, Hamburg, Germany.

Dreier C, Resa-Infante P, Gabriel G (2014). Animal models in influenza research. Talk, 3rd Young Scientist Retreat, Ammersbek, Germany.

Dreier C, Resa-Infante P, Gabriel G (2013). Role of the Importin-α1 Gene in Influenza A Virus Replication and Pathogenicity. Poster, Evaluation, Heinrich Pette Institute , Hamburg, Germany.

 

 

Contact

  • Dr. Carola Dreier
  • Room: M25/5210
  • Phone: +49 (0) 731-50- 22636
  • Fax: +49 (0) 731-50-22629