Dr. habil. Tamás Röszer
Immune surveillance and metabolism are two principles sustaining life. Dysfunctional interplay between the immune system and metabolism drives the development of metabolic diseases such as insulin resistance, metabolic syndrome and diabetes mellitus. Worryingly, these diseases are increasingly prevalent among children. Our research aim is to better understand how the neuroendocrine system governs the interaction between immune cells and metabolic tissues, particularly after birth and during the early development. We have identified a hormone - neuropeptide FF (NPFF) - that is released from hypothalamic nuclei and the pancreatic islets. NPFF improves metaboilic health by controlling the number and behavior of adipose tissue macrophages (ATMs), which are metabolically important immune cells of the adipose tissue. We have also found that ATMs develop before birth, and hence can impact on adipose tissue health in infants. More recently, we have identified breast-milk specific lipids - alkylglycerols - that are converted by ATMs into specific signaling molecules that function to maintain heat-generating ("fat-burning") beige adipose tissue in the infant. Interestingly, NPFF guides the ability of ATMs to metabolize alkylglycerols. Infants not fully breast-fed are more prone to premature loss of their beige adipose tissue, which might lead to the development of obesity and metabolic diseases in later life.
Vvideo summaries of our recent research are available on the website of The Journal of Clinical Investigation (NPFF effects on ATMs, Breast-milk lipid signaling and adipose tissue development) and on the webpage of the European Commission CORDIS. Our work is currently supported by the German Research Fund (DFG), the European Foundation for the Study of Diabetes (EFSD), a PRC Fellowhip Program and the German Academic Exchange Service (DAAD).
Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A, Harauma A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuróczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB and Röszer T (2019) Breast milk alkylglyerols sustain beige adipocytes through adipose tissue macrophages. J Clin Invest 129(6)
Röszer, T (2018) Understanding the Biology of Self-Renewing Macrophages. Cells 2018, 7(8):103
Waqas SFH, Noble A, Hoang AC, Ampem G, Popp M, Strauß S, Guille M. Röszer T (2017) Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse. J Leukoc Biol 102(3): 845-855
Waqas SFG, Hoang AC, Lin Y, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen J, Gerling IC, Nam S, Lim J, Martinez-Ibanez J, Real JT, Paschke S, Quillet R, Ayachi S, Simonin F, Schneider M, Brinkman J, Lamming DW, Seroogy CM, Röszer T (2017) Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest 127(7): 2842-2854
Menendez-Guiterrez MP, Röszer T, Fuentes L, Nunez V, Escolano A, Redondo JM, DeClerck N, Metzger D, Valledor AF, Ricote M (2015) Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest 125(2): 809-823
- Dr. habil. Tamás Röszer
- Room: M25/5404; 5406
- Phone: +49 (0) 731-50- 22695
- Fax: +49 (0) 731-50-22629
- Lab members:
- Haidong Yu, PhD student
- Anh Cuong Hoang, PhD student
- Antonia Stubenvoll, Bachelor candidate