Dr. habil. Tamás Röszer

Research

Immune surveillance and metabolism are two principles sustaining life. Dysfunctional interplay between the immune system and metabolic processes causes metabolic diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Worryingly, these diseases are becoming prevalent among children today. Our research focuses on understanding how the neuroendocrine system controls the interaction between immune cells and metabolic tissues, especially after birth and during the early development. Recently, we have identified a hormone, called neuropeptide FF (NPFF) which is released from hypothalamic nuclei and the pancreatic islets. NPFF improves metaboilic health through shaping the behaviour of the so-called adipose tissue macrophages (ATMs). ATMs are metabolically impactful immune cells. We have found that ATMs develop before birth, hence they can have impact on adipose tissue health in children. Currently, we study how changes in metabolic rate trigger neuroendocrine signals, which affect ATMs and can reduce the risk of metabolic diseases. Moreover, we aim to undertand the impact of neonate feeding on ATM behaviour, and eventually, the healthy development of adipose tissue. We employ various model organisms, including amphibia and mouse models of obesity and diabetes, and we also run clinical studies. A video summary of our recent research is available on the website of The Journal of Clinical Investigation (https://www.jci.org/posts/540 ) and on the webpage of the European Commission CORDIS (https://cordis.europa.eu/result/rcn/221338_de.html ). Our work is currently supported by the German Research Fund (DFG), the European Foundation for the Study of Diabetes (EFSD), a PRC Fellowhip Program and the German Academic Exchange Service (DAAD).

Recent publications

Waqas SFH, Noble A, Hoang AC, Ampem G, Popp M, Strauß S, Guille M. Röszer T (2017) Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse. J Leukoc Biol 102(3): 845-855

Waqas SFG, Hoang AC, Lin Y, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen J, Gerling IC, Nam S, Lim J, Martinez-Ibanez J, Real JT, Paschke S, Quillet R, Ayachi S, Simonin F, Schneider M, Brinkman J, Lamming DW, Seroogy CM, Röszer T (2017) Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest 127(7): 2842-2854

Röszer T (2017) Transcriptional control of apoptotic cell clearance by macrophage nuclear receptors. http://rdcu.be/I2KJ Apoptosis 22(2): 284-294.

Ampem G, Azegrouz H, Bacsadi L, Schmidt S, Thuróczy J, Röszer T (2016) Adipose tissue macrophages in non-rodent mammals: a comparative study. Cell Tissue Res 363(2): 461-478

Menendez-Guiterrez MP, Röszer T, Fuentes L, Nunez V, Escolano A, Redondo JM, DeClerck N, Metzger D, Valledor AF, Ricote M (2015) Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest 125(2): 809-823

 

 

Contact

  • Dr. habil Tamás Röszer
  • Room: M25/5404; 5406
  • Phone: +49 (0) 731-50- 22695
  • Fax: +49 (0) 731-50-22629


  • Lab members:
  • Grace Ampem, PhD student
  • Haidong Yu, PhD student
  • Sedat Dilbaz, Master student
  • Moritz Thumm, Bacherlor student
  • Anh Hoang, Bachelor student