Chronological order


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1998
 

Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.

  1 M H Siegel DRK Dresden auto 1:2 *
before 1997
weak D type 2 RHD(G385A)
6 7

  2 N I Eicher SRK Bern (CH) allo 1:128
before 1997
DNB RHD(G355S)
2 3

  3 C B Lonicer BRK München allo 1:32
1997
DNB RHD(G355S)
2 3

  4 Z-y Zhu Shanghai (China) allo 1:128
not reported
DVI type III RHD-Ce(3-6)-D (exon scanning)
4

  5 C Lonicer BRK München allo 1:1
before 1997
weak D type 15 RHD(G282D)
6 7

  6 N I Eicher SRK Bern (CH) auto 1:1 *
1987
weak D type 1 RHD(V270G)
6 7

  7 D Schönitzer Blutbank Innsbruck (A) allo 1:16
1993
DNB RHD(G355S)
2 3

  8 C Gassner Blutbank Innsbruck (A) allo 1:32
before 1997
DNB RHD(G355S)
2 3

  9 S Kilga-Nogler Blutbank Innsbruck (A) allo 1:16
1960s
DIIIc RHD-CE(3)-Dc 1
10 E Rainer Blutbank Innsbruck (A) auto 1:8 *
before 1997
regular D  RHD hemizygous (RHD deletion PCR-RFLP)
1

11 T H Müller DRK Oldenburg auto 1:4 *
before 1997
weak D type 2 RHD(G385A)
6 7

12 N I Eicher SRK Bern (CH) allo 1:16
before 1998
DIII type IV RHD (L62F,A137V,N152T)
6

13 C Green BTS Edinburgh (Scotland) allo 1:64
not reported
D cat Va (Hus.) RHD-CE(5)-D
1 5

14 B Ladewig Biotest AG Dreieich allo 1:128
before 1997
weak D type 4.2.2 RHD(T201R,F223V,I342T)
6 8

15 B Ladewig Biotest AG Dreieich auto 1:1 *
before 1997
weak D type 4.2.1 RHD(T201R,F223V,I342T)
6 8

16 M Palfi Uni Linköpping (S) & Lund (S) allo 1:32
before 1997
DFL
RHD(Y165C)
2

1999
 

Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.

17 E Becker Uni Magdeburg auto 1:2 *
1995
regular D CDe/CDe: RHD + RHD(IVS5-38del4)
2

18 I von Zabern DRK Gera allo 1:4
before 1997
DIV type IV RHD-CE(7:D350H-A354N)-D
2 13

19 C Green BTS Edinburgh (Scotland) allo 1:64
not reported
DVI type 2 RHD-Ce(4-6)-D (exon scanning)
1

20 J Perkins Hospital Blood Bank, Evanston IL (USA) allo 1:8
1971
DVI type 2 RHD-Ce(4-6)-D (exon scanning)
1

21 A Salama Charite, Berlin auto 1:64 *
1999
weak D type 1 RHD(V270G)
1

22 M Geurts Blood Service - Waikato, Hamilton (NZ) auto 1:32 *
1998
weak D type 1 RHD(V270G)
1

23 N I Eicher SRK Bern (CH) allo 1:1
before 1997
DIV type III RHD-CE(6-9)-D
9

24 N I Eicher SRK Bern (CH) allo 1:256
before 1997
DIV pending

2000

Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.

25 N I Eicher SRK Bern (CH) allo <1:1
before 1994
DVII RHD(L110P)
1

26 W A Flegel DRK Ulm allo 1:2
before 1997
DIV type III RHD-CE(6-9)-D
9

27 B Ladewig Biotest AG Dreieich allo 1:128
1992
DOL/Cde S RHD(M170T,F223V) , CdeS
2 10

28 B Zimmermann DRK Bremen allo 1:8
July 1999
DVI type II RHD-Ce(4-6)-D (exon scanning)
1

29 A Seltsam Charite Berlin allo 1:256
April 2000
DIV type IV RHD-CE(7:D350H-A354N)-D 1 13
30 A Agildere Uni Regensburg auto <1:1 *
Dec 1999
weak D type 2 RHD(G385A)
1

31 S Wegener DRK Rostock auto 1:1 *
papain only
June 2000
weak D type 1 RHD(V270G)
1

32 M Kerowgan DRK Mannheim auto 1:1 *
1996
weak D type 1 RHD(V270G)
1

33 B Ekermo Uni Linköpping (S) auto 1:1 *
1999
weak D type 1 RHD(V270G)
1

34 E K Petershofen DRK Frankfurt allo 1:2
March 2000
DVII RHD(L110P)
12

35 D Teixidor DRK Frankfurt allo 1:2
not reported
DVII RHD(L110P)
1

36 E K Petershofen DRK Frankfurt allo titer not reported
1952
R 0Har RHCE-D(5)-CE
11

37 E M Quenzel DRK Hagen allo 1:32
March 2000
R 0Har RHCE-D(5)-CE
1

38 K Angert Uni Aachen allo 1:1
1992
DAU-3
RHD(V279M,T379M)
2

2001

Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.

39 E M Quenzel DRK Hagen auto 1:128
Sep 2000
weak D type 1 RHD(V270G)
1

40 W A Flegel DRK Ulm auto 1:4 Jan 2001 weak D type 2 RHD(G385A) 1
41 J Jorgensen Uni Aarhus (DK) allo 1:4
not reported
DNB RHD(G355S)
2 3

42 N I Eicher SRK Bern (CH) allo/auto 1:1
before 1997
weak D type 4.0.1
RHD(T201R,F223V)
1

43
N I Eicher
SRK Bern (CH) allo 1:8
since 1997
DIIIc
RHD-CE(3)-D
1

44
R Zimmermann
Uni Erlangen

Juli 2000

pending


45
S Frandson
San Diego Blood Bank (USA)
allo 1:16
not reported
DIIIc
RHD-CE(3)-D
1

46
E M Quenzel
DRK Hagen
auto 1:32
in 2000
weak D type 2
RHD(G385A)
1

2002


Entry
Serologist
Institute
anti-D
immunized
Trivial name
RHD work-up
Ref.

47
E M Quenzel
DRK Hagen
allo 1:256
before 1997
R0Har
RHCE-D(5)-CE
1

48 H P Geisen
Diakonie Schwäbisch Hall
auto 1:4
Nov 2001
weak D type 1
RHD(V270G)
1

49
E M Quenzel
DRK Hagen
allo 1:8
Nov 2001
DNB
RHD(G355S)
2 3

50
N I Eicher
SRK Bern (CH)
allo 1:1
Nov 2001
DVII
RHD(L110P)
1

51
N I Eicher
SRK Bern (CH)
allo/auto titer unknown
unknown
weak D type 4.0.0/RHDPsi
RHD(T201R,F223V) , RHDPsi


52
M R Combs
Duke Durham NC (USA)
auto 1:32
Jan 2002
weak D type 2
RHD(G385A)
1

53
E M Quenzel
DRK Hagen
allo 1:1000 + auto
Dec 2001
R 0Har
RHCE-D(5)-CE
1


54
M R Combs
Duke Durham NC (USA)
allo 1:8
Sept 1997
DVI type II
RHD-Ce(4-6)-D (exon scanning)
1

55
M R Combs
Duke Durham NC (USA)
allo 1:1
Oct 2001
DAU-4
RHD(E233K,T379M)
1

56
H Velhagen
DRK Berlin
allo 1:1
before 1997
DHMi
RHD(T283I)
1

57
A Opitz
Uni Würzburg
auto 1:8
before 1997
regular D
RHD homozygous (RHD deletion PCR-RFLP)
1

58
H P Geisen
Diakonie Schwäbisch Hall
allo 1:4
before 1997
DVI type 2
RHD-Ce(4-6)-D (exon scanning)
1

59
J Poole
IBGRL Bristol (England)
auto 1:1
in 2001
weak D type 1
RHD(V270G)
1

60
F F Wagner
DRK Ulm
auto 1:4
in 2001
weak D type 1
RHD(V270G)
1

61
A Himmel
DRK Bad Kreuznach
auto 1:1
2000 or 2001
weak D type 1
RHD(V270G)
1

62
W Antl
Klinikum Nürnberg
auto 1:8
 Juni 2002
weak D type 33
RHD(V174M)
1
63
K Wenz
DRK Kassel
auto 1:8
before 1997
weak D type 2
RHD(G385A)
1

64
N I Eicher
SRK Bern (CH)
allo 1:256
1997
weak D type 11
RHD(M295I) in CDe haplotype
1

65
M R Combs
Duke Durham NC (USA)
auto 1:128
Feb 2002
DIII type V
RHD(L62F,A127V,N152T,T201R,F223V)
1

66
C Gabriel
Blutzentrale Linz (A)
1:1
Sept 1999
DVI type I
RHD-cE(4-5)-D (exon scanning)
1

2003


Entry
Serologist
Institute
anti-D
immunized
Trivial name
RHD work-up
Ref.

67
S Glinz
Pistoia (I)
auto 1:8
before 1997
regular D 
RHD hemizygous (RHD deletion PCR-RFLP)
1

68
C Lonicer
BRK München
allo <1:1
before 1997
R0Har
RHCE-D(5)-CE
1

69
A Himmel
DRK Bad Kreuznach
allo 1:2
1960
DVI type I
RHD-cE(4-5)-D (exon scanning)
1

70
M Heuberger
DRK Kassel
auto 1:2
after 1999
weak D type 1
RHD(V270G)
1

71
A Habibi
DRK Kassel
allo 1:32
before 1997
DVI type III
RHD-Ce(3-6)-D (exon scanning)
1

72
W Antl
Klinikum Nürnberg
allo 1:4
unknown
DVI type I
RHD-cE(4-5)-D (exon scanning)
1

73
I von Zabern
DRK Bad Kreuznach
auto 1:4
May 2003
weak D type 1
RHD(V270G)
1

74
H Hustinx
SRK Bern (CH)
allo 1:4+auto
after 1999
DVII
RHD(L110P)
1

75
C Gabriel
Blutzentrale Linz (A)
auto 1:1
unknown
regular D
RHD homozygous (RHD deletion PCR-RFLP)
1

76
P Pavel
Uni Halle
auto 1:512
after 1998
regular D
RHD homozygous (RHD deletion PCR-RFLP)
1

77
E Strobel
Städt. Krankenhaus München-Schwabing
allo 1:4
June 2002
R0Har
RHCE-D(5)-CE
1

78
W. Röhrl
Städt. Krankenhaus München-Perlach
allo 1:32000
Sept 2003
DVI type II
RHD-Ce(4-6)-D (exon scanning)
1

79
J Lüdecke
BRK Nürnberg
auto <1:1
Dec 2002
weak D type 1
RHD(V270G)
1

80
M Heuberger
DRK Kassel
allo 1:1
before 1997
DIV type IV
RHD-CE(7:D350H-A354N)-D
13

81
M R Combs
Duke Durham NC (USA)
auto 1:8
Nov 2003
regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
2004


Entry
Serologist
Institute
anti-D
immunized
Trivial name
RHD work-up
Ref.

82
U Prockat
DRK-Kliniken Berlin
1:4
before 1997
DDE
RHD(D40E) 2
83
R Kempf
BG-Kliniken Bochum
auto 1:1
Jan 2004
regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
84
E Holzberg
Gemeinschaftspraxis Weiden
allo 1:16
in 2001

pending


85
W Endres
Katharinenhospital Stuttgart
allo 1:128
before 1997
DIV type IV
RHD-CE(7:D350H-A354N)-D
13

86
C Gabriel Blutzentrale Linz (A) allo 1:1
Aug 1998
DVI type II RHD-Ce(4-6)-D (exon scanning) 1
87
A Seltsam
Uni Hannover
allo 1:2
before 1997 DIVb
RHD-CE(7-9)-D 1
88
F Etzel
Praxisgemeinschaft Bonn
allo 1:16
in 2003
R 0Har RHCE-D(5)-CE 1
89
W A Flegel
IKT Ulm
allo 1:8
before 1997 DNB RHD(G355S) 1
90
B Just
DRK West Hagen
allo 1:1
Jan 2002
DNB
RHD(G355S) 1
91
E M Quenzel Kliniken Schwerin
auto 1:2
unknown regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
92
N Grunnet
Uni Aarhus (DK) auto 1:32
July 2004
weak D type 5
RHD(A149D) 1
93
T Weiland
Medilys Blutdepot Hamburg
allo/auto titer 1:1
after 1997
weak D type 4.0.0/RHDPsi 
RHD(T201R,F223V) , RHDPsi










2005


Entry Serologist Institute anti-D immunized Trivial name RHD work-up Ref.
94
A Mildner
Klinikum Reutlingen
allo 1:8
1996
DIV type III RHD-CE(6-9)-D 9
95
E M Quenzel Kliniken Schwerin auto 1:2
unknown
weak D type 3/regular D
RHD(S3C), RHD; homozygous (RHD deletion PCR-RFLP)
1
96
A Habibi
DRK Kassel auto 1:2
May 2005
weak D type 1
RHD(V270G) 1
97
B Just
DRK West Hagen allo 1:32
Oct 2002
R 0Har RHCE-D(5)-CE 1









2006

Entry Serologist Institute anti-D immunized Trivial name RHD work-up Ref.
98
I Menke-Möllers
Wisplinghoff & Kollegen Köln
allo 1:4
Dec 2005
R 0Har RHCE-D(5)-CE 1
99
Quibell P
Prince George BC (CDN)
auto 1:2
Apr 2005
weak D type 2 RHD(G385A) 1
100
I von Zabern IKT Ulm anti-LWa 1:2 1999
DFV (without anti-D)
RHD(F223V) aka D667; LWa negative
2
101
H Hustinx SRK Bern (CH) allo 1:64
1998
DV type 7
RHD-CE(5:F223V-G263R)-D

102
I von Zabern IKT Ulm auto 1:2 Nov 2004
weak D type 1 RHD(V270G) 1
103
H Hustinx SRK Bern (CH) allo/auto titer 1:1 2003
weak D type 4.2.2/RHDPsi RHD(T201R,F223V,I342T) , RHDPsi    


104
H Hustinx SRK Bern (CH) allo <1:1
July 2006
DNB RHD(G355S) 1
105
B Just DRK West Hagen allo 1:8 June 2006
DIV type IV RHD-CE(7:D350H-A354N)-D 13









2007
106
B Just DRK West Hagen allo 1:2 unknown R 0Har RHCE-D(5)-CE 1
107
M Waldner
Ospedala S. Chiara, Trento (I)
auto 1:4
March 2006
weak D type 1 RHD(V270G) 1
108
P Pavel
Uni Halle-Wittenberg
auto 1:4
before 1997 regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
109
W A Flegel
IKT Ulm auto 1:16
Oct 2007
weak D type 1 RHD(V270G) 1
110
K P Strathmann
DRK West Breitscheid, Ratingen
allo 1:4
March 2007
DMI RHD(M170I)










2008
111
S Enkel
ZKT Tübingen
allo/auto 1:32
2007
DNU
RHD(G353R) in CDe haplotype 1
112
M K Moulds
LifeShare Shreveport (USA)
allo 1:16
unknown partial D pending 1
113
K P Strathmann DRK West Breitscheid, Ratingen allo/auto 1:4
Jan 2008 DVII
RHD(L110P) 1
114
A Stenzel
DRK West Breitscheid, Ratingen allo 1:16
2006 R 0Har RHCE-D(5)-CE 1
115
G Denomme
Toronto ON (CDN)
auto 1:4
Dec 2007
weak D type 1 RHD(V270G) 1
116
M Heuberger
DRK Kassel auto 1:128
Nov 2007
weak D type 2 RHD(G385A) 1
117
K P Strathmann DRK West Breitscheid, Ratingen auto 1:4 May 2008
regular D CDe/cde: RHD(IVS5-38del4) + RHD deletion 2
118
J Burkhart
BRK München
allo 1:16
2006
DIVa-2

RHD(L62F, N152T, D350H)

1

119
P Pirzer
Klinikum St. Marien, Amberg
allo 1:8
Mar 1988
DIV type 5 RHD-CE(7-9)-D
1

120
J-M Minon
C.H.R. de la Citadelle, Liege (B)
allo 1:64
2008
weak D type 4.2.3/RHDPsi RHD(T201R,F223V,I342T) , RHDPsi 1
121
K P Strathmann DRK West Breitscheid, Ratingen auto 1:1
Oct 2008 weak D type 2 RHD(G385A) 1
122
A-M Hittmann
DRK West Breitscheid, Ratingen allo/auto 1:1
July 2008 weak D type 4.2 subtype & serology pending
1
123
G Denomme Toronto ON (CDN) auto 1:2
Sept 2008
weak D type 1 RHD(V270G) 1









2009
124
H-D Barth
DRK NSTOB Gera
auto 1:4
Juli 2008
weak D type 33
RHD(V174M) 1





































foreign laboratory




published by the consortium



Gerne untersuchen wir Ihre Proben Anmeldung zur Untersuchung: Voraussetzungen
Versandbogen (deutsch)







Your entries are welcome How to submit samples? 
It's easy!
Report form (English)






References
  • 1. No plans to publish.  
  • 2. Manuscipt in preparation or published: Click on RHD allele for link to reference.
  • 3. Wagner, F.F., Gassner, C., Eicher, N.I., Lonicer, C.B., Flegel, W.A.: Characterization of D category IV type IV, DFW, and DNB (abstract). Transfusion 38;1998:63S and Wagner, F.F., Eicher, N.I., Jorgensen J.R., Lonicer, C.B., Flegel, W.A.: DNB: a partial D with anti-D frequent in Central Europe. Blood 100:2002:2253
  • 4. Flegel, W.A., Wagner, F.F., Müller, T.H., Gassner, C.: Rh phenotype prediction by DNA typing and its application to practice. Transfus Med 8;1998:281 View full text online  
  • 5. The RHD allele D cat Va (Hus.) was originally described in: Rouillac, C., Colin, Y., Hughes-Jones, N.C., Beolet, M., D'Ambrosio, A.-M., Cartron, J.-P., Le Van Kim, C.: Transcript analysis of D category phenotypes predicts hybrid Rh D-CE-D proteins associated with alteration of D epitopes. Blood 85;1995:2937-2944  
  • 6. Wagner, F.F., Frohmajer, A., Ladewig, B., Eicher, N.I., Lonicer, C.B., Müller, T.H., Siegel, M.H., Flegel, W.A.: Weak D alleles express distinct phenotypes. Blood 95;2000:2699-2708  
  • 7. Wagner, F.F., Gassner, C., Müller, T.H., Schönitzer, D., Schunter, F., Flegel, W.A.: Molecular basis of weak D phenotypes. Blood 93;1999:385 View full text online
  • 8. Weak D type 4.2.1 and type 4.2.2 resemble the partial D DAR but carry one and two, respectively, additional silent mutations. DAR was described in: Hemker MB, Ligthart PC, Berger L, van Rhenen DJ, van der Schoot CE, Maaskant-van Wijk PA: DAR, a new RhD variant involving exons 4, 5, and 7, often in linkage with ceAR, a new Rhce variant frequently found in African blacks. Blood 94;1999:4337-4342  
  • 9. The RHD allele D cat IV type III was originally described in reference 6 (immunohematology) and reference 7 (molecular biology).
  • 10. Avent, N.D., Poole, J., Singleton, B., Chabert, T., Romeiras, M.C., Rodrigues, M.J., Watt, J., Bruce, H.: Studies of two partial Ds: DMH and DOL. Transfus. Med. 9(suppl) 33, 1999 (Abstract) 
  • 11. Petershofen, E.K., Teixidor, D., Rabold, U., Heuberger, G., Sireis, W., Seifried, E.: Alloanti-D antibody production in a Rh33 R O HAR patient. A case report. Vox Sang. 78(supp 1) P033, 2000 (Abstract) 
  • 12. Petershofen, E.K., Teixidor, D., Doescher, A., Rabold, U., Hundhausen, T., Spika, A., Schmidt-Matilla, E.W., Schunter, F., Seifried, E.: Induction of alloanti-D antibodies after transfsuion of RBC in a patient with Rhesus-D category VII. Transfus. Clin. Biol. 8(suupl 1) 172s (P421), 2001 (Abstract) 
  • 13. Wagner, F.F., Gassner, C., Eicher, N.I., Lonicer, C., Flegel, W.A.: Characterization of D category IV type IV, DFW, and DNB. Transfusion 38:63S, 1998. (Abstract)




     

     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     

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  • * Evaluation of the case reports revealed positive antibody elution with or without auto-antibodies in serum.


  • all titers in LISS/antiglobulin/gel technique; n.d. - not determined   

     


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