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Institute of Biochemistry and Molecular Biology

Albert-Einstein-Allee 11

89081 Ulm

Tissue homeostasis: Development, aging and regeneration

Research at the Institute of Biochemistry and Molecular Biology is focussed on the question how tissues and organs are formed during embryogenesis and maintained during regeneration and aging. These processes are regulated by extracellular growth factors, intracellular signal transduction pathways and gene regulatory networks. We are focussing in our work on heart, kidney, bone, and the nervous system. To tackle these questions, we use different models such as Xenopus laevis, Danio rerio and Drosophila melanogaster and cell culture. We also use systems biology approaches to gain deeper insights into these processes.

Secretary

Stefanie Scherer

Carolin Moll

Tel.: ++49-731-500 23281

Fax: ++49-731-500 23277

Office hours

Monday-Thursday 8 a.m.-5 p.m.

Friday 1-5 p.m.

Location

M24 Level 3

Webmaster

Susanne Kühl

Publication highlights of research group leaders

Avila AI, Illing A, Becker F, Maerz LD, Morita Y, Philipp M, Burkhalter MD (2016) Xpg limits the expression of haematopoietic stem cells and progenitor cells after ionising radiation, Nuc. Acids Res., 44:4703-20

Chi-Chung Wu, Fabian Kruse, Mohankrishna Dalvoy Vasudevarao, Jan Philipp Junker, David C. Zebrowski, Kristin Fischer, Emily S. Noël, Dominic Grün, Eugene Berezikov, Felix B. Engel, Alexander van Oudenaarden, Gilbert Weidinger* and Jeroen Bakkers* (2016). Spatially-resolved genome-wide transcriptional profiling identifies BMP signaling as essential regulator of zebrafish cardiomyocyte regeneration. Dev. Cell. 36, 36-49. *corresponding authors

Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk Vadim, Kraus J, Kestler H, Kühl M*, Rudolph KL* (2015) Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage, Embo J, in press, * corresponding authors

Cizelsky W*, Tata A*, Kühl M+, Kühl SJ+ (2014) The Wnt/JNK target gene alcam is required for embryonic kidney development, Development, 141, 2064-74, *equal authors, +corresponding authors

Özan G,Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P and Weidinger G (2013) Lypd6 enhances Wnt/b-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains, Dev Cell, 26, 331-45

Burkhalter MD, Fralish GB, Premont RT, Caron MG and Philipp M (2013) Grk5l controls heart development by limiting mTOR signaling during symmetry breaking, Cell Reports, 4, 625-32

Bugner V, Tecza A, Gessert S, Kühl M (2011) Peter Pan functions independent of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis, Development, 138, 2369-78

Mann T, Bodmer R, Pandur P (2009) The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis, Development, 136, 317-26

Maurus D, Heligon C, Bürger-Schwärzler A, Brändli A, Kühl M (2005) Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis, Embo J, 24, 1181-1181

Pandur P, Läsche M, Eisenberg L, Kühl M (2002) Wnt-11 stimulation of a non-canonical Wnt-pathway is required for cardiogenesis, Nature 418, 636-641