Tissue homeostasis: Development, aging and regeneration
Research at the Institute of Biochemistry and Molecular Biology is focussed on the question how tissues and organs are formed during embryogenesis and maintained during regeneration and aging. These processes are regulated by extracellular growth factors, intracellular signal transduction pathways and gene regulatory networks. We are focussing in our work on heart, kidney, bone, and the nervous system. To tackle these questions, we use different model organisms such as Mus musculus, Xenopus laevis, Danio rerio, Drosophila melanogaster or murine embryonic stem cells. We also use systems biology approaches to gain deeper insights into these processes.
Publication highlights of research group leaders
Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk Vadim, Kraus J, Kestler H, Kühl M*, Rudolph KL* (2015) Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage, Embo J, in press, * corresponding authors
Cizelsky W*, Tata A*, Kühl M+, Kühl SJ+ (2014) The Wnt/JNK target gene alcam is required for embryonic kidney development, Development, 141, 2064-74, *equal authors, +corresponding authors
Özan G,Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P and Weidinger G (2013) Lypd6 enhances Wnt/b-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains, Dev Cell, 26, 331-45
Burkhalter MD, Fralish GB, Premont RT, Caron MG and Philipp M (2013) Grk5l controls heart development by limiting mTOR signaling during symmetry breaking, Cell Reports, 4, 625-32
Bugner V, Tecza A, Gessert S, Kühl M (2011) Peter Pan functions independent of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis, Development, 138, 2369-78
Mann T, Bodmer R, Pandur P (2009) The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis, Development, 136, 317-26
Maurus D, Heligon C, Bürger-Schwärzler A, Brändli A, Kühl M (2005) Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis, Embo J, 24, 1181-1181
Pandur P, Läsche M, Eisenberg L, Kühl M (2002) Wnt-11 stimulation of a non-canonical Wnt-pathway is required for cardiogenesis, Nature 418, 636-641
Institute of Biochemistry and Molecular Biology
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