Recent publications affiliated with the DZKJ Site Ulm

Vallois D, Missiaglia E, Veloza L, Fischer A, Cavalieri D, Rattina V, Bisig B, Roh V, Wiehle L, Sarkis R, Bachy E, Bonnet C, Bruneau J, Cairoli A, De Wind R, Drieux F, Dubois R, Emile J-F, Fataccioli V, Laribi K, Ledoux-Pilon A, Lemonnier F, Llamas-Gutierrez F, Morel P, Parrens M, Poullot E, Quintanilla-Martinez L, Sandrini J, Somja J, Xerri L, Tournilhac O, Gaulard P, Siebert R and de Leval L. Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma. Leukemia. 2025 [Epub ahead of print].

Bisle E, Haange S-B, Rojas R, Behnke A, Karabatsiakis A, Gumpp A, Mack M, Mavioglu RN, Lutz-Bonengel S, Rolle-Kampczyk U, Mielcarek A, von Bergen M and Kolassa I-T. Serum metabolomics in women with major depressive disorder: Associations with mitochondrial function, inflammation, and oxidative stress. Psychiatry Res. 2025; 351:116569.

Hildebrandt X, Veli Ö, Hyoubi A, Zinngrebe J, Abdallah AT, Rodefeld J, Hoffmann A, Gardeweg L, Kaya Ö, Wagner E, Lindhorst A, Poggenberg M, Wang Y, Dimmler J, Schillings J, Koci P, Bonechi F, Capuccino LV, Kiefer C, Kelepouras K, Ghosh A, Noé F, Wolfrum C, Singer M, Liccardi G, Luedde T, Yavas A, Ghallab A, Hengstler JG, Antczak P, Gericke M, Winkels H, Blüher M, Walczak H, Annibaldi A, Fischer-Posovszky P and Peltzer N. Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. Sci Adv. 2025; 11(38):eadw2539.

Quarta S, Calabriso N, Carluccio MA, Lo Rizzo M, Wabitsch M, Verri T, Maffia M, Damiano F, Siculella L, Santarpino G and Massaro M. Anti-Inflammatory Role of Myo-Inositol in Obesity: Suppression of TNF-α-Induced Inflammation and Monocyte Adhesion in Hypertrophic Human Adipocytes. Food Sci Nutr. 2025; 13(9):e70962.

Aldehoff AS, Karkossa I, Broghammer H, Krupka S, Weiner J, Goerdeler C, Nuwayhid R, Langer S, Wabitsch M, Rolle-Kampczyk U, Klöting N, Blüher M, Heiker JT, von Bergen M and Schubert K. Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH. Environ Sci Technol. 2025; 59(31):16193-16216.

Brandt-Heunemann S, Vogel M, Kiess W, Körner A, Blüher M, Meigen C, Stein R, Wenzel E, Landgraf K, von Schnurbein J, Denzer C, Lennerz BS, Elad L, Kornmann M, Pridzun L, Rothenbacher D, Steinacker JM, Janda A, Rutters F, Elders PJM, Neuhäuser-Berthold M, Boeing H, Juul A, Ranke MB, Kratzsch J and Wabitsch M. Reference Values for Serum Leptin Levels in Children, Adolescents, and Adults With Normal Weight, Overweight, and Obesity. J Clin Endocrinol Metab. 2025 [Epub ahead of print].

Debatin K-M, Gärtner J, Klein C, Körner A, A Mall M, C Muntau A and van den Berg N. The German Center for Child and Adolescent Health - A new structure for translational research in pediatrics shaping the health of children today and future generations. Mol Cell Pediatr. 2025; 12(1):12.

Mandl M, Heuboeck E, Benedikt P, Huber F, Mamunchak O, Grossmann S, Kotnik M, Hamzic-Jahic E, Bhogal CS, Lipp A-M, Raml E, Zwerschke W, Wabitsch M, Voelkl J, Zierer A and Bernhard D. The Capability to Undergo ACSL4-Mediated Ferroptosis Is Acquired During Brown-like Adipogenesis and Affected by Hypoxia. Cells. 2025; 14(16).

Prenen F, Vandermosten L, Knoops S, Pollenus E, Possemiers H, Dagneau de Richecour P, Caratti G, Cawthorne C, Vettorazzi S, Cranshoff Y, Schols D, Claes S, Deroose CM, Himmelreich U, Tuckermann J and Van den Steen PE. JAK/STAT inhibition protects glucocorticoid receptor knockout mice from lethal malaria-induced hypoglycemia and hyperinflammation. EMBO Mol Med. 2025; 17(8):2040-2070.

Zinngrebe J, Brenner ED, Schlichtig F, Stifel U, Tews D, Falk J, Schlotter D, Fitzel R, Meyer L-H, Debatin K-M and Fischer-Posovszky P. Bridging the marrow: a co-culture-platform of leukemia cells and MS5-derived stromal cells or adipocytes. Cell Death Discov. 2025; 11(1):366.

Alshammari WS, Duncan EM, Vita L, Kenawy M, Dibnah B, Wabitsch M, Gould GW and Hudson BD. Inverse agonism of the FFA4 free fatty acid receptor controls both adipogenesis and mature adipocyte function. Cell Signal. 2025; 131:111714.

Clément K, van den Akker ELT, Argente J, Beales P, Cetiner M, Dubern B, Farooqi S, Gouronc A, Kühnen P, Le Beyec J, Lebreton L, Meeker D, Müller HL, Muller J, Poitou C, Sleiman P, Vaisse C, Wabitsch M, Young J and Dollfus H. IMPROVE 2023: The 2nd International Meeting on Pathway-Related Obesity: Vision & Evidence. Clin Obes. 2025; 15(5):e70029.

Dutta D, Gouveia MH, Gorman BR, Adu-Gyamfi A, Lee C-H, Ogwang MD, Kerchan P, Reynolds SJ, Tenge CN, Were PA, Wekesa WN, Tenge RK, Masalu N, Kawira EL, Kinyera T, Otim I, Nabalende H, Dhudha H, Candia B, Abaru J, Yan W, Florez-Vargas O, Xie Y, Ho M, Ayers LW, Bhatia K, Goedert JJ, Pfeiffer RM, Manning M, Hutchinson A, Cole N, Luo W, Hicks B, Chagaluka G, Johnston WT, Mutalima N, Borgstein E, Liomba GN, Kamiza S, Mkandawire N, Molyneux EM, Mitambo C, Newton R, Siebert R, Dean M, Yeager M, Chanock SJ, Prokunina-Olsson L and Mbulaiteye SM. A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival. Leukemia. 2025; 39(9):2196-2206.

Glaser S, Wagener R, Harkins SK, Voena C, Bens S, Klapper W, Laurent C, Mathas S, Ren M, Sander S, Schnaudt-Mastrangelo C, Wößmann W, Xerri L, Ammerpohl O, Zelenetz AD, Louissaint A, Chiarle R and Siebert R. Comparative DNA Methylation Profiling of Human and Murine ALK-Positive B-Cell Neoplasms. Genes Chromosomes Cancer. 2025; 64(7):e70060.

Keltsch E, Greiner J, Wahl L, Knape I, Tews D, Denkinger M, Debatin K-M and Strauss G. Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs). Immun Ageing. 2025; 22(1):29.

Kostrzeba E, Bik-Multanowski M, Brandt-Heunemann S, Małecka-Tendera E, Mazur A, Ranke MB, Wabitsch M, Wójcik M, Zachurzok A, Marcinkiewicz K, Przestalska-Sowa A and Petriczko E. Delayed Intervention for Severe Childhood Obesity in Poland: A 7-Year Gap Between Onset and Specialized Care. J Clin Med. 2025; 14(13).

Albers DPJ, Novikova S, Vieyto-Nuñez J, Almeida-Hernández Y, Pastorio C, Klassen F, Weiss D, von Maltitz P, Jaikishan J, Datta M, Jumaa H, Jebaraj BMC, Stilgenbauer S, Kumar M, Maity PC, Buske C, Stifel U, Zinngrebe J, Fischer-Posovszky P, Chevigné A, Kirchhoff F, Sanchez-Garcia E, Münch J and Harms M. GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration. Cell Commun Signal. 2025; 23(1):234.

Lang J, Bergner T, Zinngrebe J, Lepelley A, Vill K, Leiz S, Wlaschek M, Wagner M, Scharffetter-Kochanek K, Fischer-Posovszky P, Read C, Crow YJ, Hirschenberger M and Sparrer KMJ. Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling. EMBO Rep. 2025; 26(9):2232-2261.

Martin L, Maric D, Idriss S, Delamare M, Le Roy A, Maaziz N, Caillaud A, Si-Tayeb K, Robriquet F, Lenglet M, Erceau L, Bellanné-Chantelot C, Plo I, Aral B, Garrec C, Airaud F, Gianfermi C, Antunes V, Keppner A, Vincent SM, Desfontaine A, Modé N, Laporte F, Gaignerie A, Chariau C, Leray I, Rogue C, David L, Redon R, Bézieau S, Mansour-Hendili L, Galactéros F, Maillet T, Pasquet M, Cougoul P, Nloga A-M, Gardin C, Guitton C, Dubruille V, Giacobbi-Milet V, Leblanc T, Kaya Z, Semama D, James C, Carillo S, Ochmann M, Waage A, Mortier E, Maillasson M, Quéméner A, Cario H, Skoda RC, Zermati Y, Hoogewijs D, Marchand A, Girodon F and Gardie B. Identification of Hepatic-like EPO as a Cause of Polycythemia. N Engl J Med. 2025; 392(17):1684-1697.

Zorn S, de Groot CJ, Brandt-Heunemann S, von Schnurbein J, Abawi O, Bounds R, Ruck L, Guijo B, Martos-Moreno GÁ, Nicaise C, Courbage S, Klehr-Martinelli M, Siebert R, Dubern B, Poitou C, Clément K, Argente J, Kühnen P, Farooqi IS, Wabitsch M and van den Akker E. Early childhood height, weight, and BMI development in children with monogenic obesity: a European multicentre, retrospective, observational study. Lancet Child Adolesc Health. 2025; 9(5):297-305.

Glaser S, Wagener R, Kretzmer H, López C, Baptista MJ, Bens S, Bernhart S, Bhatia K, Borkhardt A, Elgaafary S, Hoffmann S, Hübschmann D, Hummel M, Klapper W, Kolarova J, Kreuz M, Lazzi S, Löffler M, Navarro JT, Neequaye J, Onyango N, Onyuma T, Ott G, Radlwimmer B, Rohde M, Rosenwald A, Rosolowski M, Schlesner M, Szczepanowski M, Tapia G, Wößmann W, Küppers R, Trümper L, Leoncini L, Lichter P, Del Val C, Ammerpohl O, Burkhardt B, Mbulaiteye SM, Siebert R, Consortium IM and Project MMML. Subtyping Burkitt Lymphoma by DNA Methylation. Genes Chromosomes Cancer. 2025; 64(4):e70042.

Niedermayer A, Stursberg J, Bergmann AK, Zimmermann M, Cario G, Brüggemann M, Köhler R, Steinbach D, Reimann C, Seyfried F, Meyer LH and Debatin K-M. Remission induction in refractory, drug resistant pediatric PICALM::MLLT10+ B-cell acute lymphoblastic leukemia by venetoclax. Leukemia. 2025; 39(6):1520-1525.

Peng Z, Siziba LP, Brenner H, Wernecke D, Rothenbacher D and Genuneit J. Changes in Childhood Atopic Dermatitis Incidence and Risk Factors Over Time: Results From Two German Birth Cohorts. Clin Exp Allergy. 2025; 55(6):469-480.

Vinnai BÁ, Arianti R, Fischer-Posovszky P, Wabitsch M, Fésüs L and Kristóf E. The importance of thiamine availability in the thermogenic competency of human adipocytes. Mol Cell Endocrinol. 2025; 599:112483.

Bundschu K, Aleksandrova-Yankulovska S, Denzer C, Dornbrach T, Eberhart S, Glisic L, Barata AG, Gündel H, Hönig K, Janni W, Khinda K, Rafensteiner L, Siebert R, Steger F, Stilgenbauer S, Wabitsch M, Wiesmüller L, Wilhelm M, Wojak B and Hancke K. Future perspectives of fertility protection. J Reprod Immunol. 2025; 168:104455.

Clemens V, Wernecke D, Fegert JM, Genuneit J, Rothenbacher D and Braig S. Maternal child maltreatment and trajectories of offspring behavioural and emotional difficulties from age 4 to 7 years - results from a prospective birth cohort study. Eur Child Adolesc Psychiatry. 2025; 34(3):1039-1050.

Schirmer M, Zorn S, von Schnurbein J and Wabitsch M. Innovative Care for Children and Adolescents with Severe and/or Genetic Obesity. Horm Res Paediatr. 2025:1-12 [Epub ahead of print].

Schmidt ENC, Evert BO, Pregler BEF, Melhem A, Hsieh M-C, Raspe M, Strobel H, Roos J, Pietsch T, Schuss P, Fischer-Posovszky P, Westhoff M-A, Hölzel M, Herrlinger U, Vatter H, Waha A, Schneider M and Potthoff A-L. Tonabersat enhances temozolomide-mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition. Mol Oncol. 2025; 19(3):878-898.

Hecker D, Song X, Baumgarten N, Diagel A, Katsaouni N, Li L, Li S, Maji RK, Behjati Ardakani F, Ma L, Tews D, Wabitsch M, Björkegren JLM, Schunkert H, Chen Z and Schulz MH. Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci. bioRxiv. 2025 [Epub ahead of print].

Argente J, Farooqi IS, Chowen JA, Kühnen P, López M, Morselli E, Gan H-W, Spoudeas HA, Wabitsch M and Tena-Sempere M. Hypothalamic obesity: from basic mechanisms to clinical perspectives. Lancet Diabetes Endocrinol. 2025; 13(1):57-68.

Heymsfield SB, Clément K, Dubern B, Goldstone AP, Haqq AM, Kühnen P, Richards J, Roth CL, Akker ELTvd, Wabitsch M and Yanovski JA. Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway-Associated Disease: A Roundtable Summary. Curr Obes Rep. 2025; 14(1):13.

Peng Z, Siziba LP, Mank M, Stahl B, Gonsalves J, Wernecke D, Rothenbacher D and Genuneit J. Profiles of 71 Human Milk Oligosaccharides and Novel Sub-Clusters of Type I Milk: Results from the Ulm SPATZ Health Study. Nutrients. 2025; 17(2):280.

Berretta S, Andreazza AC, Ben-Shachar D, Gilbert-Jaramillo J, Glausier JR, Hahn M, Kolassa I-T, Nehir Mavioglu R, Molina AJA, Picard M, Sarnyai Z, McCullumsmith RE, Steiner J and Do KQ. Metabolic Abnormalities in Psychiatric Disorders A Transdiagnostic, Whole-Body Approach: A Transdiagnostic, Whole-Body Approach 2025, In Metabolic Neuropsychiatry [Book Chapter]: 155-191.

Brown RJ, Akinci B, Al Yaarubi S, Bismuth E, Cappa M, Deeb A, Kamrath C, Musso C, Patni N, Prodam F, Williams R and Wabitsch M. The clinical approach to child and adolescent patients with lipodystrophy: a series of international case discussions. Front Endocrinol. 2025; 16:1597053.

Perry BI, Brand BA, de Boer JN, Swann P, Pillinger T, Pielke L, Varadarajan S, Campbell I and Kolassa I-T. Metabolism across the Lifespan Implications for Body and Mind 2025, In Metabolic Neuropsychiatry [Book Chapter]: 223-244.

Schmidt H, Menrath I, Wiegand S, Reinehr T, Kiess W, Hebebrand J, von Schnurbein J, Holl RW, Holle R, Scherag A, Wabitsch M and Brandt-Heunemann S. Youths with Extreme Obesity: A High-Risk Group for Pain and Mental Health Impairments. Obes Facts. 2025; 18(1):21-30.

Sprissler J, Pannicke U, Rump E-M, Schrezenmeier H, Casadei N, Pogoda M, Kuhlburger L, Oquendo MB, Czemmel S, Debatin K-M, Erlacher M, Schwarz K and Felgentreff K. RAG recombinase expression discriminates the development of natural killer cells. Front Immunol. 2025; 16:1607664.

Wernecke D, Peter RS, Braig S, Genuneit J and Rothenbacher D. Maternal employment patterns after childbirth and child mental health with 4-6 years of age. Front Psychol. 2025; 16:1580373.

Wernecke D, Peter RS, Braig S, Zarco M, Genuneit J and Rothenbacher D. Longitudinal associations between the COVID-19 pandemic and sleep characteristics in children and parents. Front Public Health. 2025; 13:1604195.

van den Berg N, Tomczyk S, Kölch M, Schmidt S, Heckmann M and Wabitsch M. Versorgung und Prävention bei Adipositas bei Kindern und Jugendlichen – Ansätze der Community Medicine Adipositas. 2024 June; 18(02):51-55.

Eigemann J, Janda A, Schuetz C, Lee-Kirsch MA, Schulz A, Hoenig M, Furlan I, Jacobsen E-M, Zinngrebe J, Peters S, Drewes C, Siebert R, Rump E-M, Führer M, Lorenz M, Pannicke U, Kölsch U, Debatin K-M, von Bernuth H, Schwarz K and Felgentreff K. Non-Skewed X-inactivation Results in NF-κB Essential Modulator (NEMO) Δ-exon 5-autoinflammatory Syndrome (NEMO-NDAS) in a Female with Incontinentia Pigmenti. J Clin Immunol. 2024 September; 45(1):1.

Fischer-Posovszky P and Zinngrebe J. Brown adipose tissue fights the battle against leukaemia. Nat Rev Endocrinol. 2024 December; 20(12):699-700.

Gärtner J, Berner R, Debatin K-M, Klein C, Körner A, Mall MA, Muntau AC and van den Berg N. Deutsches Zentrum für Kinder- und Jugendgesundheit: Interdisziplinäre Forschung für eine gesunde Zukunft von Kindern und Jugendlichen Monatsschr Kinderheilkd. 2024 June; 172(8):704-710.

Giannopoulou EZ, Brandt S, Zorn S, Denzer C, von Schnurbein J, Fukami M, Kaiser A, Schmidt M and Wabitsch M. Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome. Front Endocrinol. 2024 ; 15:1487884.

Yu GZ, Krentz NAJ, Bentley L, Zhao M, Paphiti K, Sun H, Honecker J, Nygård M, Dashti H, Bai Y, Reid M, Thaman S, Wabitsch M, Rajesh V, Yang J, Mattis KK, Abaitua F, Casero R, Hauner H, Knowles JW, Wu JY, Mandrup S, Claussnitzer M, Svensson KJ, Cox RD and Gloyn AL. Loss of RREB1 reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes. bioRxiv. 2024 July [Epub ahead of print].

Zorn S, Schirmer M, von Schnurbein J, Brandt S, Göpel E, Stein R, Wiegand S, Körner A, Kühnen P and Wabitsch M. Versorgungskonzepte für Kinder und Jugendliche mit extremer und/oder genetischer Adipositas Adipositas. 2024 June; 18(02):71-80.