Scientific publications Annika Herwig


Haugg E, Borner J, Stalder G, Kübber-Heiss A, Giroud S, Herwig A. (2023) Comparative transcriptomics of the garden dormouse hypothalamus during hibernation. FEBS Open Bio. doi: 10.1002/2211-5463.13731.

Kawach R, Diedrich V, Gruber A, Leopold K, Herwig A, Vujić Spasić M. (2023) Seasonal and fasting induced changes in iron metabolism in Djungarian hamsters. PLoS One. doi: 0.1371/journal.pone.0293971.

Cuyutupa VR, Moser D, Diedrich V, Cheng Y, Billaud JN, Haugg E, Singer D, Bereiter-Hahn J, Herwig A, Choukér A. (2023) Blood transcriptomics mirror regulatory mechanisms during hibernation-a comparative analysis of the Djungarian hamster with other mammalian species. Pflugers Arch. doi: 10.1007/s00424-023-02842-8. 

Diedrich V, Haugg E, Van Hee J, Herwig A. (2023) Role of glucose in daily torpor of Djungarian hamsters (Phodopus sungorus): challenge of continuous in vivo blood glucose measurements. Am J Physiol Regul Integr Comp Physiol. doi: 10.1152/ajpregu.00040.2023. 

Kissmann AK, Rosenau F, Herwig A, Diedrich V. (2023) Short Photoperiod-Dependent Enrichment of Akkermansia spec. as the Major Change in the Intestinal Microbiome of Djungarian Hamsters (Phodopus sungorus). Int J Mol Sci. doi: 10.3390/ijms24076605


Hoang AC, Sasi-Szabó L, Pál T, Szabó T, Diedrich V, Herwig A, Landgraf K, Körner A, Röszer T. (2022) Mitochondrial RNA stimulates beige adipocyte development in young mice. Nat Metab. doi: 10.1038/s42255-022-00683-w.

Haugg E, Borner J, Diedrich V, Herwig A. (2022) Comparative transcriptomics of the Djungarian hamster hypothalamus during short photoperiod acclimation and spontaneous torpor. FEBS Open Bio. doi: 10.1002/2211-5463.13350. 


Haugg E, Herwig A, Diedrich V.  (2021) Body Temperature and Activity Adaptation of Short Photoperiod-Exposed Djungarian Hamsters (Phodopus sungorus): Timing, Traits, and Torpor. Front Physiol. doi: 10.3389/fphys.2021.626779.

Piscitiello E, Herwig A, Haugg E, Schröder B, Breves G, Steinlechner S, Diedrich V. (2021) Acclimation of intestinal morphology and function in Djungarian hamsters (Phodopus sungorus) related to seasonal and acute energy balance. J Exp Biol, doi: 10.1242/jeb.232876.


Diedrich V, Haugg E, Dreier C, Herwig A.  (2020) What can seasonal models teach us about energy balance? J Endocrinol, doi: 10.1530/JOE-19-0502


Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A, Harauma A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuróczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB, Röszer T. (2019) Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. J Clin Invest, doi: 10.1172/JCI125646


Bank JHH, Wilson D, Rijntjes E, Barrett P, Herwig A. (2017) Alternation between short- and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters (Phodopus sungorus). J Neuroendocrinol,  doi: 10.1111/jne.12487.

Bank JHH, Cubuk C, Wilson D, Rijntjes E, Kemmlng J, Markowsky H, Barret P, Herwig A. (2017) Gene expression analysis during daily torpor in Djungarian hamsters (Phodopus sungorus) and hypothalamic T3 microdialysis suggest low central T3 concentrations as requirement for torpor expression. J Comp Physiol B, doi: 10.1007/s00360-017-1086.

Cubuk C, Kemmling J, Fabrizius A, Herwig A. (2017) Transcriptome anaylsis of hyothalamic gene expression during daily torpor in Djungarian hamster (Phodopus sungorus). Frotn Neuroendocrinol, Front Neurosci, doi: 10.3389/fnins.2017.00122

Cubuk C, Markowsky H, Herwig A. (2017) Hypothalamic control systems show differential gene expression during spontaneous daily torpor and fasting-induced torpor in the Djungarian hamster (Phodopus sungorus). Plos1, doi: 10.1371/journal.pone.0186299



Jastroch M, Giroud S, Barrett P, Geiser F, Heldmaier G, Herwig A. (2016) Seasonal control of mammalian energy balance: recent advances in the understanding of daily torpor and hibernation. Review. J Neuroendocrinol, doi: 10.1111/jne.12437.

Petri I, Diedrich V, Wilson D, Fernández-Calleja J, Herwig A, Steinlechner S, Barret P (2016) Orchestration of gene expression across the seasons: Hypothalamic gene expression in natural photoperiod throughout the year in the Siberian hamster. Scientific Reports, 6: 29869, doi: 10.1038/srep29689.

Cubuk C, Bank JH, Herwig A (2016) The Chemistry of Cold: Mechanisms of Torpor Regulation in the Siberian Hamster. Physiology (Bethesda) 31: 51-59.


Bank JH, Kemmling J, Rijntjes E, Wirth EK, Herwig A (2015) Tyroid hormone status affects expression of daily torpor and gene transcription in Djungarian hamsters (Phodopus sungorus). Hormones and Behavior 75: 120-129.


Herwig A, Campbell G, Mayer CD, Boelen A, Anderson RA, Ross AW, Mercer JG, Barrett PA (2014) Tyroid Hormone Challenge in Hypothyroid Rats identifies T3 Regulated Genes in the Hypothalamus and in Models with Altered Energy Balance and Glucose Homeostasis. Tyroid.2014 Sep 2 (Epub ahead of print) dor: 10.1089/thy2014.0169

de Vrij, EL, Vogelaar PC, Goris M, Houertjes MC, Herwig A, Dugbartey GJ, Boerma AS, Strijkstra AM, Bouma HR, Henning RH (2014) Platelet Dynamics during Natural and Pharmacologically Induced Torpor and Forced Hypothermia. Plos One.10,9(4) e93218. doi: 101371/journal.pone.0093218.


Bouma HR, Dugbartey GJ, Boerema AS, Talaei F, Herwig A, Goris M, van Buiten A, Strijkstra AM , Carey HV, Henning RH, Kroese FG. (2013)  Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination. J Leukoc Biol Jun 13 [Epub ahead of print].

Herwig A, de Vries EM, Bolborea M, Wilson D, Mercer JG, Ebling FJ, Morgan PJ, Barrett P (2013) Hypothalamic ventricular ependymal thyroid hormone deiodinases are an important element of circannual timing in the Siberian hamster (Phodopus sungorus). PLoS One ,doi: 10.1371/journal.pone.0062003.

Helwig M, Herwig A, Barrett P, Mercer J, Klingenspor M. (2013)  Photoperiod-dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol 25:190-197.


Herwig A, Petri I, Barrett P (2012) Hypothalamic gene expression rapidly changes in response to photoperiod in juvenile Siberian hamsters (Phodopus sungorus). J Neuroendocrinol 2012; 24:991-998


Nilaweera K*, Herwig A*, Bolborea M, Campbell G, Mayer CD, Morgan PJ, Ebling FJP, Barrett P. (2011)  Photoperiodic regulation of glycogen metabolism, glycolysis and glutamine synthesis in tanycytes of the Siberian hamster suggests novel roles of tanycytes in hypothalamic function. Glia  59:1695-1705.
* These authors contributed equally to this work

Davidson S, Lear M, Shanley L, Hing B, Baizan-Edge, Herwig A, Starkey A, Barrett P, MacKenzie A. (2011)  Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala; implications for obesity, depression and alcoholism. Neuropsychopharmacology 36:2211-2221

Bouma HR, Kroese FGM, Kok JW, Talaei F, Boerema AS, Herwig A, Draghiciu O, van Buiten A, Epema AH, van Dam A, Strijkstra AM, Henning RH(2011) Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate. PNAS 108:2052-2057



Herwig A, Wilson D, Logie TJ, Morgan PJ, Mercer JG and Barrett P (2009) Photoperiod and acute energy deficits interact on components of the thyroid hormone system in hypothalamic tanycytes of the Siberian hamster. Am J Physiol Regul Integr Comp Physiol 296: R1307-R1315.

Cottrell EC, Cripps RL, Duncan JS, Barrett P, Mercer JG, Herwig A, Ozanne SE (2009) Developmental changes in hypothalamic leptin receptor: relationship with the postnatal l eptin surge and energy balance neuropeptides in the postnatal rat. Am J Physiol Regul Integr Comp Physiol 296:R631-639


Herwig A, Ross AW, Morgan PJ and Barrett P (2008) Hypothalamic thyroid hormone energy balance regulation. Review. Obesity Facts 1:71-79.

Herwig A, Revel FG, Saboureau M, Steinlechner S and Pévet P (2008)  Daily torpor, hibernation and the circadian clock. Hypometabolism in Mammals. Hibernation, Torpor and Cryobiology 1:125-133.


Herwig A, Saboureau M, Pévet P and Steinlechner S (2007) Daily torpor affects the molecular machinery of the circadian clock in Djungarian hamsters (Phodopus sungorus). Eur J Neurosci 26:2739-2746.

Herwig A, Ivanova EA, Lydon H, Barrett P, Steinlechner S and Loudon AS (2007) Histamine H3 receptor and orexin A expression during daily torpor in the Djungarian hamster (Phodopus sungorus). Neuroendocrinol 19:1001-1007.

Revel FG*, Herwig A*, Garidou ML, Dardente H, Menet JS, Masson-Pévet M, Simonneaux V, Saboureau M and Pévet P (2007) The circadian clock of European hamsters (Cricetus critcetus) stops ticking during hibernation. Proc Natl Acad Sci U S A. 104(34):13816-20.
* These authors contributed equally to this work


Herwig A, Revel F, Saboureau M, Pévet P, Steinlechner S (2006)  Daily torpor alters multiple gene expression in the suprachiasmatic nucleus and pineal gland of the Djungarian hamster (Phodopus sungorus). Chronobiol Int 23(1-2):269-76.

Herwig A, Pévet P, Bothorel B, Steinlechner S, Saboureau M (2006) Trans-pineal microdialysis in the Djungarian hamster (Phodopus sungorus): a tool to study seasonal changes of circadian clock activities. J Pineal Res. 40(2):177-83.