Bone is a dynamic endocrine organ that constantly remodels itself to maintain homeostasis and responds to injury through a highly coordinated regeneration process. Disruptions to these processes - whether in everyday bone remodelling or fracture healing - can lead to loss of function, chronic pain and reduced quality of life. Understanding the underlying regulatory mechanisms is therefore crucial for progress in bone health.
Our research focuses on von Fällen the role of glucocorticoid receptor signalling in skeletal stem and progenitor cells during both bone regeneration and homeostasis. In addition, we investigate the microenvironment of the stem cell niche in bone and develop alternative in vitro models for bone research. Our integrative approach opens new perspectives and creates the basis for the identification of novel therapeutic targets to improve bone homeostasis and fracture healing.
Research interests:
Endocrine regulation in skeletal stem cells and osteoprogenitors for bone homeostasis and regeneration
Microenvironment in the bone stem cell niche
Alternative in vitro models for bone research
Publications
Loss of Notch signalling in skeletal stem cells enhances bone formation with aging.
Remark LH, Leclerc K, Ramsukh M, Lin Z, Lee S, Dharmalingam B, Gillinov L, Nayak VV, El Parente P, Sambon M, et al. Bone Res. 2023;11:50. doi: 10.1038/s41413-023-00283-8
Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing.
Lee S, Remark LH, Josephson AM, Leclerc K, Lopez EM, Kirby DJ, Mehta D, Litwa HP, Wong MZ, Shin SY, et al. Npj Regen. Med. 2021;6:29. doi: 10.1038/s41536-021-00139-x
Leukemia inhibitory factor treatment attenuates the detrimental effects of glucocorticoids on bone in mice.
Lee S, Liu P, Ahmad M, Tuckermann JP. Bone. 2021;145:115843. doi: 10.1016/j.bone.2021.115843
Propranolol reverses impaired fracture healing response observed with selective serotonin reuptake inhibitor treatment.
Lee S, Remark LH, Buchalter DB, Josephson AM, Wong MZ, Litwa HP, Ihejirika R, Leclerc K, Markus D, Yim NL, et al. J Bone Miner Res. 2020;35:932-941. doi: 10.1002/jbmr.3950
Deletion of menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.
Lee S, Liu P, Teinturier R, Jakob J, Tschaffon M, Tasdogan A, Wittig R, Hoeller S, Baumhoer D, Frappart L, et al. Oncogene. 2018;37:616-626. doi: 10.1038/onc.2017.364
