Hormonal regulation and novel mechanism for the resolution of inflammation

Research directions:

  • Hormonal control and regulation of inflammatory processes
  • Regulators during inflammation and the resolution of inflammation

 

Inflammation is a natural reaction of the body to invading pathogens. Depending on the type of inflammatory response and pathology, it can occur as acute (sepsis, lung inflammation) or chronic inflammation. In addition, during inflammation, cells are exposed to constant mechanical stresses that influence their inflammatory status. The reduction of inflammation that in turn later supports the resolution inflammation is a crucial mechanism to revert the body back to a healthy status.

My group aims to investigate novel hormonal driven mechanisms in inflammation. With the aim to identify and target new regulators for anti-inflammatory processes, and pro-resolving mechanisms to accelerate the resolution of inflammatory processes.

[Translate to english:] AG Vettorazzi

Selected publications

M. Wepler, J.M. Preuss, T. Merz, C. Hartmann, U. Wachter, O. McCook, J. Vogt, S. Kress,M. Groeger, M. Fink, A. Scheuerle, P. Moeller, E. Calzia, U. Burret, P. Radermacher, J.P. Tuckermann, S. Vettorazzi, Impaired Glucocorticoid Receptor Dimerization Aggravates LPS Induced Circulatory and Pulmonary Dysfunction, Frontiers in Immunology 10 (2020).

P. Pfaender, M. Fidan, U. Burret, L. Lipinski, S. Vettorazzi, Cdk5 Deletion Enhances the Anti-inflammatory Potential of GC-Mediated GR Activation During Inflammation, Frontiers in Immunology 10 (2019).

M. Koenen, S. Culemann, S. Vettorazzi, G. Caratti, L. Frappart, W. Baum, G. Kroenke, U. Baschant, J.P. Tuckermann, Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis, Annals of the Rheumatic Diseases 77(11) (2018) 1610-1618.

P. Galuppo, S. Vettorazzi, J. Hoevelmann, C.-J. Scholz, J.P. Tuckermann, J. Bauersachs, D. Fraccarollo, The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling, Faseb Journal 31(11) (2017) 5122-5132.

S. Vettorazzi, C. Bode, L. Dejager, L. Frappart, E. Shelest, C. Klassen, A. Tasdogan, H.M. Reichardt, C. Libert, M. Schneider, F. Weih, N.H. Uhlenhaut, J.-P. David, M. Graeler, A. Kleiman, J.P. Tuckermann, Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1, Nature Communications 6 (2015).

weitere Publikationen von Frau Dr. Sabine Vettorazzi finden Sie in unserem Publikationsverzeichnis.

Group leader