The research group of Dr. Michael Schön focuses on a range of topics in neuroscience and biomedical research.
For questions, please write to: michael.schoen(at)uni-ulm.de

Main research areas include:
1) Autism Spectrum Disorders, with a particular focus on Phelan-McDermid Syndrome —including investigations into its underlying causes, support for affected families, and research using models of the disorder.
Link to first European based medical guidelines: ern-ithaca.eu/guidelines/ern-ithaca-guidelines/phelan-mcdermid-guideline/
Introduction of the guidelines and to Phelan-McDermid Syndrome: www.sciencedirect.com/science/article/pii/S1769721223000605
Characterization of a Phelan-McDermind Syndrome mouse model: www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2022.1051175/full
2) Molecular structure of synapses.
Medical thesis and publication on the ALS protein FUS at synapses: 
SHANK expression in the human and mouse brain: bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01712-0
3) Development of advanced immunohistochemical staining techniques for human brain tissue using the CLARITY tissue-clearing method.
human CLARITY (hCLARITY) as a technique to improve immunohistochemistry in long term fixated human neural tissue: bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01582-6
4) Neurodegenerative disease research based on human brain tissue, in collaboration with Prof. Dr. Heiko Braak and Prof. Dr. Kelly Del Tredici.
Anatomy and progress of phospho-tau accumulation in the human archicortex: 
journals.sagepub.com/doi/10.3233/JAD-240483
link.springer.com/article/10.1007/s00401-025-02862-x
5) Epidemiological and immunity studies during the COVID-19 pandemic among students and faculty. Effects of SARS-CoV-2 infection in neurons.
COVID infection study in Ulm medical school: www.medrxiv.org/content/10.1101/2021.05.04.21256382v3
Role of IFITM proteins in SARS-CoV-2 infection: www.nature.com/articles/s41467-021-24817-y

Former or currently not actively researched topics:
6) Anatomy and phylogeny of the entorhinal cortex, in collaboration with Prof. Dr. Heiko Braak and Prof. Dr. Kelly Del Tredici.
Phylogeny of pre-alpha layer neuronal islands in the primate line: onlinelibrary.wiley.com/doi/full/10.1002/cne.25233
7) Brain lateralization in humans with situs inversus.
Indications of brain lateralization in body donors with situs inversus: www.pulsus.com/scholarly-articles/situs-inversus--macroscopic-workup-and-analysis-of-cerebral-lateralization-using-manual-and-imaging-techniques.pdf
8) Tumor diagnostics in long-term fixed human body donors.
Molecular and immunohistochemical accessibility in tumors of long-term fixated body donors: www.sciencedirect.com/science/article/pii/S0014480024000182

A scientific-medical compendium on the COVID-19 pandemic (last update in October 2021), authored by Dr. Michael Schön, is available for download:
Download the document here: www.uni-ulm.de/fileadmin/website_uni_ulm/med.inst.030/Downloads/Wissenschaftliche_Informationen_zur_Pandemie.pdf
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