Institute of Protein Biochemistry

In 2012, the institute was established under the Director Prof. Dr. Marcus Fändrich. Its research as well as its teaching duties are at the interface between biology, chemistry, physics and medicine with the main focus being on protein biochemistry.

Major techniques used at our institute are the recombinant expression and purification of proteins, the biophysical characterization of protein conformations, electron and fluorescence microscopy as well as cell biology.


Announcement of the


4. Ulm Meeting on “Biophysics of Amyloid Formation”

18-20 February 2020, Ulm University, Germany

To be held in co-operation with the DFG Forschungsgruppe FOR 2969 as well as with the Helmholtz-Zentrum München, SFB 1279, SFB 1035 and the Japan Society for the Promotion of Science (JSPS)


Confirmed speakers so far:

Robert G. Griffin (Cambridge), Tuomas P.J. Knowles (Cambridge), Beat Meier (Zürich), Daniel P. Raleigh (Stony Brook), Stefan Schönland (Heidelberg), Jayant B. Udgaonkar (Pune), Erich Wanker (Berlin), Gunilla T. Westermark (Uppsala), Per Westermark (Uppsala)


Early bird registration deadline: 30 September 2019.


More information and registration:


New publication in Nature Communications. Title: “Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary
ATTR amyloidosis” Schmidt M, Wiese S, Adak V, Engler J, Agarwal S, Fristz G, Westermark P, Zacharias M, Fändrich M. Nature Comm. 10, 5008 (2019)


New publication in Nature Communications. Title: “Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s
brain tissue” Kollmer M, Close W, Funk L, Rasmussen J, Bsoul A, Schierhorn A, Schmidt M, Sigurdson CJ, Jucker M, Fändrich M. Nature Comm. 10, 4760 (2019)

See also the coverage by the Alzforum:

See also a press release from Ulm University:



It is with great sadness that the Institute learned of the death of Chris Dobson on 8 September 2019, aged 69. He was one of the most respected scientists in the field of amyloid research and a great inspiration to all of us. A tribute of St. John’s College, Cambridge, and an online book of condolence can be found here:



The German Research Council (Deutsche Forschungsgemeinschaft) will fund a nation-wide Research Unit (FOR 2969) to investigate the mechanisms of protein misfolding in systemic AL amyloidosis (speaker Marcus Fändrich). Partners of the consortium will come from Munich, Heidelberg, Erlangen and Kiel.



New publication in Nature Communications. Title: “Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis” Radamaker, L, Lin Y-H, Annamalai K, Huhn S, Hegenbart U, Schönland SO, Fritz G, Schmidt M, Fändrich M. Nature Comm. 10, 1103 (2019)



New publication in Nature Communications. Title: “Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids” Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmid M. Nature Comm. 10, 1104 (2019)



The 3rd Ulm Meeting "Biophysics of Amyloid Formation" with a keynote lecture from David Eisenberg and 100 registered participants from 22 different countries and four continents was successfully held at Ulm University.


Prof. Dr. Marcus Fändrich
Tel: +49-(0)731/50 32750
Fax: +49-(0)731/50 32759
Helmholtzstraße 8/1
Room number 1.55


Valmira Ademi
Tel: +49-(0)731/50 32751
Fax: +49-(0)731/50 32759
Helmholtzstraße 8/1
Room number 1.54

Useful links

Homepage of Ulm University
Homepage of the Faculty of Natural Sciences
Homepage of the Department of Biology