Research: Amyloid biotechnology
Amyloid fibrils may not only occur inside living organismus in the course of disease, but also as functional devices. Likewise there are increasing attempts to utilize amyloids for technological purposes. We previously extended this research by analyzing the applicative potential of amyloid oligomers. Moreover, we have been using biotechnologically engineered antibody fragments to investigate the mechanism and pathogenicity of different amyloid structures.
Luong TQ, Erwin N, Neumann M, Schmidt A, Loos C, Schmidt V, Fändrich M, Winter R
Hydrostatic pressure increases the catalytic activity of amyloid fibril enzymes.
Angewandte Chemie Int. Ed. 2016, 55, 12412–12416
Aumüller T, Fändrich M
Protein chemistry: Catalytic amyloid fibrils.
Nature Chemistry 2014, 6, 273-274
Kumar ST, Meinhardt J, Fuchs AK, Aumüller T, Leppert J, Büchele B, Knüpfer U, Ramachandran R, Yadav JK, Prell E, Morgado I, Ohlenschläger O, Horn U, Simmet T, Görlach M, Fändrich M
Structure and biomedical applications of amyloid oligomer nanoparticles.
ACS Nano 2014, 25, 8, 11042-11052
Prof. Dr. Marcus Fändrich
Tel: +49-(0)731/50 32750
Fax: +49-(0)731/50 32759
Room number 1.55