Publikationen

2017

Doppler K, Jentschke HM, Schulmeyer L, Vadasz D, Janzen A, Luster M, Hoffken H, Mayer G, Brumberg J, Booij J, Musacchio T, Klebe S, Sittig-Wiegand E, Volkmann J, Sommer C, Oertel WH (2017) Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease. Acta neuropathologica.

Lasser-Katz E, Simchovitz A, Chiu WH, Oertel WH, Sharon R, Soreq H, Roeper J, Goldberg JA (2017) Mutant alpha-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease. Journal of Neuroscience 37: 47-57.

Kilpatrick BS, Eden ER, Hockey LN, Yates E, Futter CE, Patel S (2017) An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling. Cell reports 18: 1636-1645.

Surmeier DJ, Obeso JA, Halliday GM (2017) Selective neuronal vulnerability in Parkinson disease. Nature reviews Neuroscience 18: 101-113.

Surmeier DJ, Schumacker PT, Guzman JD, Ilijic E, Yang B, Zampese E (2017) Calcium and Parkinson's disease. Biochemical and biophysical research communications 483: 1013-1019.

Yang SY, Beavan M, Chau KY, Taanman JW, Schapira AH (2017) A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers. Stem cell reports.

2016

Kilpatrick BS, Magalhaes J, Beavan MS, McNeill A, Gegg ME, Cleeter MW, Bloor-Young D, Churchill GC, Duchen MR, Schapira AH, Patel S (2016) Endoplasmic reticulum and lysosomal Ca(2)(+) stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts. Cell calcium 59: 12-20.

Duda J, Potschke C, Liss B (2016) Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease. Journal of neurochemistry 139 Suppl 1: 156-178.

Gegg ME, Schapira AH (2016) Mitochondrial dysfunction associated with glucocerebrosidase deficiency. Neurobiology of disease 90: 43-50

Lazniewska J, Rzhepetskyy Y, Zhang FX, Zamponi GW, Weiss N (2016) Cooperative roles of glucose and asparagine-linked glycosylation in T-type calcium channel expression. Pflugers Arch 468: 1837-1851.

Migdalska-Richards A, Schapira AH (2016) The relationship between glucocerebrosidase mutations and Parkinson disease. Journal of neurochemistry 139 Suppl 1: 77-90.

Oertel W, Schulz JB (2016) Current and experimental treatments of Parkinson disease: A guide for neuroscientists. Journal of neurochemistry 139 Suppl 1: 325-337.

Sulzer D, Cragg SJ, Rice ME (2016) Striatal dopamine neurotransmission: regulation of release and uptake. Basal ganglia 6: 123-148.

2015

Brimblecombe KR, Gracie CJ, Platt NJ, Cragg SJ (2015) Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains. Journal of physiology 593: 929-946.

Cooper G, Lasser-Katz E, Simchovitz A, Sharon R, Soreq H, Surmeier DJ, Goldberg JA (2015) Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. Journal of neurophysiology 114: 1513-1520.

Dragicevic E, Schiemann J, Liss B (2015): Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience. 2015 Jan 22;284:798-814.

Hockey LN, Kilpatrick BS, Eden ER, Lin-Moshier Y, Brailoiu GC, Brailoiu E, Futter CE, Schapira AH, Marchant JS, Patel S (2015) Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition. Journal of cell science 128: 232-238.

Pacelli C, Giguere N, Bourque MJ, Levesque M, Slack RS, Trudeau LE (2015) Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons. Current biology : CB 25: 2349-2360.

Poetschke C, Dragicevic E, Duda J, Benkert J, Dougalis A, DeZio R, Snutch TP, Striessnig J, Liss B (2015) Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Scientific reports 5: 13688.

Zamponi GW, Striessnig J, Koschak A, Dolphin AC (2015) The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential. Pharmacological reviews 67: 821-870.

2014

Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Lujan R, Malenka R C, Striessnig J, Liss B (2014): Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain: 137(Pt 8):2287-302.

McNeill A, Magalhaes J, Shen C, Chau KY, Hughes D, Mehta A, Foltynie T, Cooper JM, Abramov AY, Gegg M, Schapira AH (2014) Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain: 137: 1481-1495.

Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker PT, Surmeier DJ (2014) Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nature neuroscience 17: 832-840

Schapira AH, Patel S (2014) Targeting mitochondria for neuroprotection in Parkinson disease. JAMA neurology 71: 537-538

ältere

Goldberg JA, Guzman JN, Estep CM, Ilijic E, Kondapalli J, Sanchez-Padilla J, Surmeier DJ (2012) Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease. Nature neuroscience 15: 1414-1421.

Ilijic E, Guzman JN, Surmeier DJ (2011) The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiology of disease 43: 364-371.

Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker PT, Surmeier DJ (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468: 696-700.