2018

Special section: Replication stress, a threat to the nuclear and mitochondrial genome
Wiesmüller L, Scharffetter-Kochanek K, Geiger H.
Mutat Res. 2018 Jan

Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo
Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H.
Arch Toxicol. 2018 Jan

2017

Balance your folate or the yin and yang of folate in hematopoiesis
Geiger H.
Haematologica. 2017 Dec

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance
Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K, Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y.
Stem Cell Reports. 2017 Dec

Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors
Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.
Exp Hematol. 2017 Dec

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.
Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H.
Stem Cell Rep. 2017 Nov

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F.
Leukemia. 2017 Nov

HSC Niche Biology and HSC Expansion Ex Vivo.
Kumar S, Geiger H.
Trends Mol Med. 2017 Sep 

Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
Florian MC, Klenk J, Marka G, Soller K, Kiryakos H, Peter R, Herbolsheimer F, Rothenbacher D, Denkinger M, Geiger H.  
J Gerontol A Biol Sci Med Sci. 2017 Sep 

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A
Oben KZ, Alhakeem SS, McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills HF Jr, St
Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S.
Oncotarget. 2017 Aug

Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells.
Senger K, Marka G, Soller K, Sakk V, Florian MC, Geiger H.
Exp Hematol. 2017 Jul  

Alpha-Ketoglutarate Curbs Differentiation and Induces Cell Death in Mesenchymal Stromal Precursors with Mitochondrial Dysfunction
Singh K, Krug L, Basu A, Meyer P, Treiber N, Vander Beken S, Wlaschek M, Kochanek S, Bloch W, Geiger H, Maity P, Scharffetter-Kochanek K.
Stem Cells. 2017 Jul

Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H.       
EMBO J. 2017 May 

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A,
Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA,
Stegle O, Trumpp A.
Cell. 2017 May

MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling
Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein
E, Kerr WG, Kuchenbauer F, Lapidot T.
Leukemia. 2017 May

Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice
Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y. 
Stem Cell Reports. 2017 Apr

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.
Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H.  
Cell Rep. 2017 Mar 

Limitations and challenges of genetic barcode quantification
Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K.
Sci Rep. 2017 Mar

Rejuvenation of aged hematopoietic stem cells.
Guidi N, Geiger H.  
Semin Hematol. 2017 Jan 

Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells
Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel
C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RA.
J Exp Med. 2017 Jan

2016

Aging of hematopoietic stem cells: DNA damage and mutations?
Moehrle BM, Geiger H.  
Exp Hematol. 2016 Oct 

Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.
Akunuru S, Geiger H.  
Trends Mol Med. 2016 Aug 

Quantitative trait gene Slit2 positively regulates murine hematopoietic stem cell numbers
Waterstrat A, Rector K, Geiger H, Liang Y.
Sci Rep. 2016 Aug

The European Hematology Association Roadmap for European Hematology Research: a consensus document
Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ; EHA Roadmap for European Hematology Research.
Haematologica. 2016 Feb

Depleting senescent cells to combat aging
Geiger H.
Nat Med. 2016 Jan

2015

Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.
Moehrle BM, Nattamai K, Brown A, Florian MC, Ryan M, Vogel M, Bliederhaeuser C, Soller K, Prows DR, Abdollahi A, Schleimer D, Walter D, Milsom MD, Stambrook P, Porteus M, Geiger H.  
Cell Rep. 2015 Dec 

HSC Aging and Senescent Immune Remodeling.
Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H.  
Trends Immunol. 2015 Dec 

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A,
Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA.
Cell Stem Cell. 2015 Oct

Stem Cells and Aging: What's Next?
Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y.
Cell Stem Cell. 2015 Jun

2014

Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.
Geiger H, Zheng Y.  
Exp Cell Res. 2014 Dec 

Hematopoietic stem cell aging.
Geiger H, Denkinger M, Schirmbeck R.  
Curr Opin Immunol. 2014 Aug 

2013

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Florian MC, Nattamai KJ, Dörr K, Marka G, Uberle B, Vas V, Eckl C, Andrä I, Schiemann M, Oostendorp RA, Scharffetter-Kochanek K, Kestler HA, Zheng Y, Geiger H.  
Nature. 2013 Nov 

Cdc42 and aging of hematopoietic stem cells.
Geiger H, Zheng Y.  
Curr Opin Hematol. 2013 Jul 

The ageing haematopoietic stem cell compartment.
Geiger H, de Haan G, Florian MC.  
Nat Rev Immunol. 2013 May 

2012

Contribution of an aged microenvironment to aging-associated myeloproliferative disease.
Vas V, Wandhoff C, Dörr K, Niebel A, Geiger H.  
PLoS One. 2012 Feb 

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Florian MC, Dörr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, Filippi MD, Hasenberg A, Gunzer M, Scharffetter-Kochanek K, Zheng Y, Geiger H.  
Cell Stem Cell. 2012 May 

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M.  
Nat Med. 2012 Jul 

Aging of the microenvironment influences clonality in hematopoiesis.
Vas V, Senger K, Dörr K, Niebel A, Geiger H.  
PLoS One. 2012 Aug 

2010

Concise review: polarity in stem cells, disease, and aging.
Florian MC, Geiger H.  
Stem Cells. 2010 Sep 

Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Köhler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H.  
Nat Med. 2010 Oct 

2009

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.
Köhler A, Schmithorst V, Filippi MD, Ryan MA, Daria D, Gunzer M, Geiger H.  
Blood. 2009 Jul 

Quantification of genomic mutations in murine hematopoietic cells.
Geiger H, David S, Nattamai KJ, Jan V.  
Methods Mol Biol. 2009  ↑