2018
Special section: Replication stress, a threat to the nuclear and mitochondrial genome
Wiesmüller L, Scharffetter-Kochanek K, Geiger H.
Mutat Res. 2018 Jan ↑
Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo
Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H.
Arch Toxicol. 2018 Jan ↑
2017
Balance your folate or the yin and yang of folate in hematopoiesis
Geiger H.
Haematologica. 2017 Dec ↑
RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance
Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K, Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y.
Stem Cell Reports. 2017 Dec ↑
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors
Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.
Exp Hematol. 2017 Dec ↑
The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.
Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H.
Stem Cell Rep. 2017 Nov ↑
Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F.
Leukemia. 2017 Nov ↑
HSC Niche Biology and HSC Expansion Ex Vivo.
Kumar S, Geiger H.
Trends Mol Med. 2017 Sep ↑
Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
Florian MC, Klenk J, Marka G, Soller K, Kiryakos H, Peter R, Herbolsheimer F, Rothenbacher D, Denkinger M, Geiger H.
J Gerontol A Biol Sci Med Sci. 2017 Sep ↑
Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A
Oben KZ, Alhakeem SS, McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills HF Jr, St
Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S.
Oncotarget. 2017 Aug ↑
Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells.
Senger K, Marka G, Soller K, Sakk V, Florian MC, Geiger H.
Exp Hematol. 2017 Jul ↑
Alpha-Ketoglutarate Curbs Differentiation and Induces Cell Death in Mesenchymal Stromal Precursors with Mitochondrial Dysfunction
Singh K, Krug L, Basu A, Meyer P, Treiber N, Vander Beken S, Wlaschek M, Kochanek S, Bloch W, Geiger H, Maity P, Scharffetter-Kochanek K.
Stem Cells. 2017 Jul ↑
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H.
EMBO J. 2017 May ↑
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A,
Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA,
Stegle O, Trumpp A.
Cell. 2017 May ↑
MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling
Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein
E, Kerr WG, Kuchenbauer F, Lapidot T.
Leukemia. 2017 May ↑
Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice
Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y.
Stem Cell Reports. 2017 Apr ↑
Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.
Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H.
Cell Rep. 2017 Mar ↑
Limitations and challenges of genetic barcode quantification
Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K.
Sci Rep. 2017 Mar ↑
Rejuvenation of aged hematopoietic stem cells.
Guidi N, Geiger H.
Semin Hematol. 2017 Jan ↑
Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells
Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel
C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RA.
J Exp Med. 2017 Jan ↑
2016
Aging of hematopoietic stem cells: DNA damage and mutations?
Moehrle BM, Geiger H.
Exp Hematol. 2016 Oct ↑
Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.
Akunuru S, Geiger H.
Trends Mol Med. 2016 Aug ↑
Quantitative trait gene Slit2 positively regulates murine hematopoietic stem cell numbers
Waterstrat A, Rector K, Geiger H, Liang Y.
Sci Rep. 2016 Aug ↑
The European Hematology Association Roadmap for European Hematology Research: a consensus document
Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ; EHA Roadmap for European Hematology Research.
Haematologica. 2016 Feb ↑
Depleting senescent cells to combat aging
Geiger H.
Nat Med. 2016 Jan ↑
2015
Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.
Moehrle BM, Nattamai K, Brown A, Florian MC, Ryan M, Vogel M, Bliederhaeuser C, Soller K, Prows DR, Abdollahi A, Schleimer D, Walter D, Milsom MD, Stambrook P, Porteus M, Geiger H.
Cell Rep. 2015 Dec ↑
HSC Aging and Senescent Immune Remodeling.
Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H.
Trends Immunol. 2015 Dec ↑
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A,
Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA.
Cell Stem Cell. 2015 Oct ↑
Stem Cells and Aging: What's Next?
Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y.
Cell Stem Cell. 2015 Jun ↑
2014
Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.
Geiger H, Zheng Y.
Exp Cell Res. 2014 Dec ↑
Hematopoietic stem cell aging.
Geiger H, Denkinger M, Schirmbeck R.
Curr Opin Immunol. 2014 Aug ↑
2013
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Florian MC, Nattamai KJ, Dörr K, Marka G, Uberle B, Vas V, Eckl C, Andrä I, Schiemann M, Oostendorp RA, Scharffetter-Kochanek K, Kestler HA, Zheng Y, Geiger H.
Nature. 2013 Nov ↑
Cdc42 and aging of hematopoietic stem cells.
Geiger H, Zheng Y.
Curr Opin Hematol. 2013 Jul ↑
The ageing haematopoietic stem cell compartment.
Geiger H, de Haan G, Florian MC.
Nat Rev Immunol. 2013 May ↑
2012
Contribution of an aged microenvironment to aging-associated myeloproliferative disease.
Vas V, Wandhoff C, Dörr K, Niebel A, Geiger H.
PLoS One. 2012 Feb ↑
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Florian MC, Dörr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, Filippi MD, Hasenberg A, Gunzer M, Scharffetter-Kochanek K, Zheng Y, Geiger H.
Cell Stem Cell. 2012 May ↑
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M.
Nat Med. 2012 Jul ↑
Aging of the microenvironment influences clonality in hematopoiesis.
Vas V, Senger K, Dörr K, Niebel A, Geiger H.
PLoS One. 2012 Aug ↑
2010
Concise review: polarity in stem cells, disease, and aging.
Florian MC, Geiger H.
Stem Cells. 2010 Sep ↑
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Köhler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H.
Nat Med. 2010 Oct ↑
2009
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.
Köhler A, Schmithorst V, Filippi MD, Ryan MA, Daria D, Gunzer M, Geiger H.
Blood. 2009 Jul ↑
Quantification of genomic mutations in murine hematopoietic cells.
Geiger H, David S, Nattamai KJ, Jan V.
Methods Mol Biol. 2009 ↑