2020
TLR4-dependent shaping of the wound site by MSCs accelerates wound healing
Munir S, Basu A, Maity P, Krug L, Haas P, Jiang D, Strauss G, Wlaschek M, Geiger H, Singh K, Scharffetter-Kochanek K
EMBO Rep. 2020 Mar
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
Kared H, Tan SW, Lau MC, Chevrier M, Tan C, How W, Wong G, Strickland M, Malleret B, Amoah A, Pilipow K, Zanon V, Govern NM, Lum J, Chen JM, Lee B,
Florian MC, Geiger H, Ginhoux F, Ruiz-Mateos E, Fulop T, Rajasuriar R, Kamarulzaman A, Ng TP, Lugli E, Larbi A.
Nat Commun. 2020 Feb
2019
HPRT and Purine Salvaging Are Critical for Hematopoietic Stem Cell Function
Vogel M, Moehrle B, Brown A, Eiwen K, Sakk V, Geiger H.
Stem Cells. 2019 Dec
Haematopoietic stem cells in perisinusoidal niches are protected from ageing
Saçma M, Pospiech J, Bogeska R, de Back W, Mallm JP, Sakk V, Soller K, Marka G, Vollmer A, Karns R, Cabezas-Wallscheid N, Trumpp A, Méndez-Ferrer S, Milsom MD, Mulaw MA, Geiger H, Florian MC.
Nat Cell Biol. 2019 Nov
Lazy Sundays: role of day of the week and reactivity on objectively measured physical activity in older people
Klenk J, Peter RS, Rapp K, Dallmeier D, Rothenbacher D, Denkinger M, Büchele G; ActiFE Study Group, Becker T, Böhm B, Scharffetter-Kochanek K, Stingl J,
Koenig W, Riepe M, Peter R, Geiger H, Ludolph A, von Arnim C, Nagel G, Weinmayr G, Steinacker JM, Laszlo R.
Eur Rev Aging Phys Act. 2019 Oct 27
KRas(G12D) expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals
Hochstetler CL, Feng Y, Sacma M, Davis AK, Rao M, Kuan CY, You LR, Geiger H, Zheng Y.
Exp Hematol. 2019 Oct
Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)
Agrawal M, Schwarz P, Giaimo BD, Bedzhov I, Corbacioglu A, Weber D, Gaidzik VI, Jahn N, Rücker FG, Schroeder T, Kindler T, Wattad M, Götze K, Lübbert M, Salwender H, Ringhoffer M, Lange E, Koller E, Thol F, Heuser M, Ganser A, Bullinger L, Paschka P, Döhner H, Geiger H, Borggrefe T, Döhner K, Oswald F.
Leukemia. 2019 Aug
Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach
Klose M, Florian MC, Gerbaulet A, Geiger H, Glauche I.
Stem Cells. 2019 Jul
Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance
Zhang C, Fondufe-Mittendorf YN, Wang C, Chen J, Cheng Q, Zhou D, Zheng Y, Geiger H, Liang Y.
Haematologica. 2019 Jun
The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function
Brown A, Schuetz D, Han Y, Daria D, Nattamai KJ, Eiwen K, Sakk V, Pospiech J, Saller T, van Zant G, Wagner W, Geiger H.
Haematologica. 2019 May
2018
Impaired immune surveillance accelerates accumulation of senescent cells and aging
Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V.
Nat Commun. 2018 Dec
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells
Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC.
Genome Biol. 2018 Nov
Chromosome integrity checkpoints in stem and progenitorcells: transitions upon differentiation, pathogenesis, and aging
Brown A, Geiger H.
Cell Mol Life Sci. 2018 Oct
Aging alters the epigenetic asymmetry of HSC division
Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H.
PLoS Biol. 2018 Sep
A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells
Du W, Liu W, Mizukawa B, Shang X, Sipple J, Wunderlich M, Geiger H, Davies S, Mulloy J, Pang Q, Zheng Y.
Leukemia. 2018 Sep
Epigenetic age-predictor for mice based on three CpG sites
Han Y, Eipel M, Franzen J, Sakk V, Dethmers-Ausema B, Yndriago L, Izeta A, de Haan G, Geiger H, Wagner W.
Elife. 2018 Aug
Aged murine hematopoietic stem cells drive aging-associated immune remodeling
Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R.
Blood. 2018 Aug
Special section: Replication stress, a threat to the nuclear and mitochondrial genome
Wiesmüller L, Scharffetter-Kochanek K, Geiger H.
Mutat Res. 2018 Jan
Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo
Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H.
Arch Toxicol. 2018 Jan
2017
Balance your folate or the yin and yang of folate in hematopoiesis
Geiger H.
Haematologica. 2017 Dec
RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance
Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K, Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y.
Stem Cell Reports. 2017 Dec
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors
Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.
Exp Hematol. 2017 Dec
The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.
Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H.
Stem Cell Rep. 2017 Nov
Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F.
Leukemia. 2017 Nov
HSC Niche Biology and HSC Expansion Ex Vivo.
Kumar S, Geiger H.
Trends Mol Med. 2017 Sep
Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
Florian MC, Klenk J, Marka G, Soller K, Kiryakos H, Peter R, Herbolsheimer F, Rothenbacher D, Denkinger M, Geiger H.
J Gerontol A Biol Sci Med Sci. 2017 Sep
Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A
Oben KZ, Alhakeem SS, McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills HF Jr, St
Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S.
Oncotarget. 2017 Aug
Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells.
Senger K, Marka G, Soller K, Sakk V, Florian MC, Geiger H.
Exp Hematol. 2017 Jul
Alpha-Ketoglutarate Curbs Differentiation and Induces Cell Death in Mesenchymal Stromal Precursors with Mitochondrial Dysfunction
Singh K, Krug L, Basu A, Meyer P, Treiber N, Vander Beken S, Wlaschek M, Kochanek S, Bloch W, Geiger H, Maity P, Scharffetter-Kochanek K.
Stem Cells. 2017 Jul
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H.
EMBO J. 2017 May
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A,
Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA,
Stegle O, Trumpp A.
Cell. 2017 May
MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling
Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein
E, Kerr WG, Kuchenbauer F, Lapidot T.
Leukemia. 2017 May
Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice
Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y.
Stem Cell Reports. 2017 Apr
Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.
Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H.
Cell Rep. 2017 Mar
Limitations and challenges of genetic barcode quantification
Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K.
Sci Rep. 2017 Mar
Rejuvenation of aged hematopoietic stem cells.
Guidi N, Geiger H.
Semin Hematol. 2017 Jan
Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells
Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel
C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RA.
J Exp Med. 2017 Jan
2016
Aging of hematopoietic stem cells: DNA damage and mutations?
Moehrle BM, Geiger H.
Exp Hematol. 2016 Oct
Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.
Akunuru S, Geiger H.
Trends Mol Med. 2016 Aug
Quantitative trait gene Slit2 positively regulates murine hematopoietic stem cell numbers
Waterstrat A, Rector K, Geiger H, Liang Y.
Sci Rep. 2016 Aug
The European Hematology Association Roadmap for European Hematology Research: a consensus document
Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ; EHA Roadmap for European Hematology Research.
Haematologica. 2016 Feb
Depleting senescent cells to combat aging
Geiger H.
Nat Med. 2016 Jan
2015
Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.
Moehrle BM, Nattamai K, Brown A, Florian MC, Ryan M, Vogel M, Bliederhaeuser C, Soller K, Prows DR, Abdollahi A, Schleimer D, Walter D, Milsom MD, Stambrook P, Porteus M, Geiger H.
Cell Rep. 2015 Dec
HSC Aging and Senescent Immune Remodeling.
Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H.
Trends Immunol. 2015 Dec
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A,
Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA.
Cell Stem Cell. 2015 Oct
Stem Cells and Aging: What's Next?
Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y.
Cell Stem Cell. 2015 Jun
2014
Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.
Geiger H, Zheng Y.
Exp Cell Res. 2014 Dec
Hematopoietic stem cell aging.
Geiger H, Denkinger M, Schirmbeck R.
Curr Opin Immunol. 2014 Aug
2013
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Florian MC, Nattamai KJ, Dörr K, Marka G, Uberle B, Vas V, Eckl C, Andrä I, Schiemann M, Oostendorp RA, Scharffetter-Kochanek K, Kestler HA, Zheng Y, Geiger H.
Nature. 2013 Nov
Cdc42 and aging of hematopoietic stem cells.
Geiger H, Zheng Y.
Curr Opin Hematol. 2013 Jul
The ageing haematopoietic stem cell compartment.
Geiger H, de Haan G, Florian MC.
Nat Rev Immunol. 2013 May
2012
Contribution of an aged microenvironment to aging-associated myeloproliferative disease.
Vas V, Wandhoff C, Dörr K, Niebel A, Geiger H.
PLoS One. 2012 Feb
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Florian MC, Dörr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, Filippi MD, Hasenberg A, Gunzer M, Scharffetter-Kochanek K, Zheng Y, Geiger H.
Cell Stem Cell. 2012 May
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M.
Nat Med. 2012 Jul
Aging of the microenvironment influences clonality in hematopoiesis.
Vas V, Senger K, Dörr K, Niebel A, Geiger H.
PLoS One. 2012 Aug
2010
Concise review: polarity in stem cells, disease, and aging.
Florian MC, Geiger H.
Stem Cells. 2010 Sep
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Köhler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H.
Nat Med. 2010 Oct
2009
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.
Köhler A, Schmithorst V, Filippi MD, Ryan MA, Daria D, Gunzer M, Geiger H.
Blood. 2009 Jul
Quantification of genomic mutations in murine hematopoietic cells.
Geiger H, David S, Nattamai KJ, Jan V.
Methods Mol Biol. 2009