2022

Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis
Chan LK, Tsesmelis M, Gerstenlauer M, Leithäuser F, Kleger A, Frick LD, Maier HJ, Wirth T. Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis.
Commun Biol. 2022 May 27;5(1):509. doi: 10.1038/s42003-022-03371-3. PMID: 35624133

CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia
Ketzer F, Abdelrasoul H, Vogel M, Marienfeld R, Müschen M, Jumaa H, Wirth T, Ushmorov A.
Oncogenesis. 2022 Jan 10;11(1):1.doi: 10.1038/s41389-021-00377-0.

2021

BOB. 1/OBF. 1 is required during B cell ontogeny for B cell differentiation and germinal center function
Betzler, A. C., Fiedler, K., Hoffmann, T. K., Fehling, H. J., Wirth, T., & Brunner, C.
Eur J Immunol. 2021 Dec 8.doi: 10.1002/eji.202149333.

Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation
Pan L, Hoffmeister P, Turkiewicz A, Huynh NND, Große-Berkenbusch A, Knippschild U, Gebhardt JCM, Baumann B, Borggrefe T, Oswald F.
Cancers (Basel). 2021 Oct 8;13(19):5027. doi: 10.3390/cancers13195027. PMID: 34638511; PMCID: PMC8508133.

IKK2/NF-κB Activation in Astrocytes Reduces amyloid β Deposition: A Process Associated with Specific Microglia Polarization
Yang, S., Magnutzki, A., Alami, N. O., Lattke, M., Hein, T. M., Scheller, J. S., Kröger, C., Oswald, F., Yilmazer-Hanke, D., & Wirth, T
Cells. 2021 Oct 6;10(10):2669.doi: 10.3390/cells10102669

Hyperstable SGK1 steps out of AKT’s shadow
Gehringer, F., & Ushmorov, A.
Blood.2021 Sep 16;138(11):917-918.doi: 10.1182/blood.2021012518

Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice
Tsesmelis, M., Tiwary, K., Steiger, K., Sperb, N., Gerstenlauer, M., Manfras, U., Maier, H. J., Hermann, P. C., Chan, L. K., & Wirth, T
Cancers (Basel).2021 Sep 10;13(18):4541.doi: 10.3390/cancers13184541.

Impaired Peyer's patch development in BOB. 1/OBF. 1‐deficient mice
Betzler, A. C., Fiedler, K., Kokai, E., Wirth, T., Hoffmann, T. K., & Brunner, C.
Eur J Immunol. 2021 Jul;51(7):1860-1863.doi: 10.1002/eji.202048578. Epub 2021 Mar 26

miR-146a regulates insulin sensitivity via NPR3
Roos J, Dahlhaus M, Funcke JB, Kustermann M, Strauss G, Halbgebauer D, Boldrin E, Holzmann K, Möller P, Trojanowski BM, Baumann B, Debatin KM, Wabitsch M, Fischer-Posovszky P.
Cell Mol Life Sci. 2021 Mar;78(6):2987-3003. doi: 10.1007/s00018-020-03699-1. Epub 2020 Nov 18. PMID: 33206203; PMCID: PMC8004521.

ω‐Imidazolyl‐alkyl derivatives as new preclinical drug candidates for treating non‐alcoholic steatohepatitis
Diesinger, T., Lautwein, A., Buko, V., Belonovskaya, E., Lukivskaya, O., Naruta, E., Kirko, S., Andreev, V., Dvorsky, R., & Buckert, D
Physiol Rep. 2021 Mar;9(6):e14795.doi: 10.14814/phy2.14795

A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma
Diesinger, T., Lautwein, A., Bergler, S., Buckert, D., Renz, C., Dvorsky, R., Buko, V., Kirko, S., Schneider, E., & Kuchenbauer, F.
Can J Gastroenterol Hepatol. 2021 Feb 2;2021:8854432.doi: 10.1155/2021/8854432. eCollection 2021

 

2020

Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS
Ouali Alami N, Tang L, Wiesner D, Commisso B, Bayer D, Weishaupt J, Dupuis L, Wong P, Baumann B, Wirth T, Boeckers TM, Yilmazer-Hanke D, Ludolph Al, Roselli F.
Life Sci Alliance 2020 Sep 8;3(11):e201900571. doi: 10.26508/lsa.201900571. Print 2020 Nov.

Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma
Sperb N, Tsesmelis M, Wirth T.
Int J Mol Sci 2020 Jul 31;21(15):5486. doi: 10.3390/ijms21155486.

Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis
Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O, Naruta E, Kirko S, Andreev V, Buckert D, Bergler S, Renz C, Schneider E, Kuchenbauer F, Kumar M, Büchele B, Simmet T, Müller-Ennoch D, Wirt T, Haehner T.
PLoS ONE 15(7): e0235990. https://doi.org/10.1371/journal.pone.0235990

Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma.
Gehringer F, Weissinger SE, Möller P, Wirth T, Ushmorov A.
Leukemia 34, 857–871 (2020). https://doi.org/10.1038/s41375-019-0628-0

Elevated β-cell stress levels promote severe diabetes development in mice with MODY4.
Trojanowski B, Salem HH, Neubauer H, Simon E, Wagner M, Dorajo R, Boehm BO, Labriola L, Wirth T, Baumann B.
J Endocrinol 2020 Feb;244(2):323-337. doi: 10.1530/JOE-19-0208.

 

2019

STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, Huber-Lang M, Relja B, Wirth T, Röszer T, Baumann B, Boeckers T, Knöll B, Roselli F.
Brain Behav Immun. 2019 Jun 15. pii: S0889-1591(19)30254-5.

Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis.
Lu M, Hartmann D, Braren R, Gupta A, Wang B, Wang Y, Mogler C, Cheng Z, Wirth T, Friess H, Kleeff J, Hüser N, Sunami Y.
BMC Cancer. 2019 Sep 5;19(1):887. doi: 10.1186/s12885-019-6110-6. PubMed PMID: 31488102; PubMed Central PMCID: PMC6728971.

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M.
Cancer Cell. 2019 Sep 16;36(3):250-267.e9. doi: 10.1016/j.ccell.2019.08.001. PubMed PMID: 31526758.

An IKK/NF-kB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation.
Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A.Cancers (Basel). 2019 Sep 21;11(10). pii: E1410. doi: 10.3390/cancers11101410. PubMed MID: 31546614; PubMed Central PMCID: PMC6827060.

FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt Lymphoma.
Gehringer F, Weissinger SE, Swier LJ, Möller P, Wirth T, Ushmorov A.
Cancers (Basel). 2019 Sep 25;11(10). pii: E1427. doi: 10.3390/cancers11101427.

Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma.
He J, Gerstenlauer M, Chan LK, Leithäuser F, Yeh MM, Wirth T, Maier HJ.
Cancer Lett. 2019 Aug 28;458:113-122. doi: 10.1016/j.canlet.2019.05.023. Epub 2019 May 22.

 

2018

FOXO in B-cell lymphopoiesis and B cell neoplasia.
Ushmorov A, Wirth T.
Semin Cancer Biol. 2018 Jun;50:132-141.

IKK2/NF-kB signaling protects neurons after traumatic brain injury.
Mettang M, Reichel SN, Lattke M, Palmer A, Abaei A, Rasche V, Huber-Lang M, Baumann B, Wirth T.
FASEB J. 2018 Apr;32(4):1916-1932. doi: 10.1096/fj.201700826R.

Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia.
Wang F, Demir S, Gehringer F, Osswald CD, Seyfried F, Enzenmüller S, Eckhoff SM, Maier T, Holzmann K, Debatin KM, Wirth T, Meyer LH, Ushmorov A.
Blood. 2018 Apr 5. pii: blood-2017-10-813576. doi: 10.1182/blood-2017-10-813576.

Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation.
Osswald CD, Xie L, Guan H, Herrmann F, Pick SM, Vogel MJ, Gehringer F, Chan FC, Steidl C, Wirth T, Ushmorov A.
Blood. 2018 Apr 5;131(14):1556-1567. doi: 10.1182/blood-2017-07-795278.

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.
Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, Röver S, Rogers-Evans M, Rothenhäusler B, Ullmer C, Fingerle J, Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, Roselli F, Baumann B.
EMBO J. 2018 Jun 6. pii: e98697. doi: 10.15252/embj.201798697.

2017

Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration. 
Lattke M, Reichel SN, Magnutzki A, Abaei A, Rasche V, Walther P, Calado DP, Ferger B, Wirth T, Baumann B.
Mol Neurodegener. 2017 Feb 13;12(1):16. doi: 10.1186/s13024-017-0157-0.

NF-κB-mediated astrocyte dysfunction initiates neurodegeneration.
Lattke M, Reichel SN, Baumann B.
Oncotarget. 2017 May 31;8(31)

Activation of oncogenic pathways in classical Hodgkin lymphoma by decitabine: A rationale for combination with small molecular weight inhibitors.
Swerev TM, Wirth T, Ushmorov A.
Int J Oncol. 2017 Feb;50(2)

FOXO in B-cell lymphopoiesis and B cell neoplasia.
Ushmorov A, Wirth T.
Semin Cancer Biol. 2017 Jul 31.  

A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.
Meyer P, Maity P, Burkovski A, Schwab J, Müssel C, Singh K, Ferreira FF, Krug L, Maier HJ, Wlaschek M, Wirth T, Kestler HA, Scharffetter-Kochanek
PLoS Comput Biol. 2017;13(12)

Epithelial NEMO/IKK? limits fibrosis and promotes regeneration during pancreatitis.
Chan LK, Gerstenlauer M, Konukiewitz B, Steiger K, Weichert W, Wirth T, Maier HJ
Gut. 2017;66(11): 1995-2007

2016

The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6. 
Stauss D, Brunner C, Berberich-Siebelt F, Höpken UE, Lipp M, Müller G;
EMBO J. 2016 Apr 15;35(8):881-98. doi: 10.15252/embj.201591459. Epub 2016 Mar 8.

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in HBV surface antigen-driven HCC by controlling the UPR. 
Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M;
2016 Jan 11. doi: 10.1002/hep.28435.

Activation of oncogenic pathways in classical Hodgkin lymphoma by decitabine: A rationale for combination with small molecular weight inhibitors
Swerev TM, Wirth T, Ushmorov A;
Int J Oncol. 2016 Dec 30. doi: 10.3892/ijo.2016.3827. PubMed PMID: 28035374.

Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis.
Chan LK, Gerstenlauer M, Konukiewitz B, Steiger K, Weichert W, Wirth T, Maier HJ;
Gut. 2016 Jul 27. pii: gutjnl-2015-311028. doi:10.1136/gutjnl-2015-311028.  PubMed PMID: 27464707.

Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis. 
Guan H, Xie L, Wirth T, Ushmorov A;
Oncotarget. 2016 Jun 14;7(24):36854-36864. doi:10.18632/oncotarget.9210. PubMed PMID: 27166193; PubMed Central PMCID: PMC5095044.

A paired comparison between glioblastoma "stem cells" and differentiated cells.
Schneider M1, Ströbele S, Nonnenmacher L, Siegelin MD, Tepper M, Stroh S, Hasslacher S, Enzenmüller S, Strauss G, Baumann B, Karpel-Massler G, Westhoff MA, Debatin KM, Halatsch ME.
Int J Cancer. 2016 Apr 1;138(7):1709-18. doi: 10.1002/ijc.29908. Epub 2015 Nov 17.

2015

Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality. Bärbel Kraut, Harald J. Maier, Enikö Kókai, Katja Fiedler, Thomas Boettger, Annett Illing, Sawa Kostin, Paul Walther, Thomas Braun, and Thomas Wirth; PLoS One. 2015 Nov 5;10(11):e0141591. doi: 10.1371; PLoS One. 2015; PubMed

NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells. Kilzheimer M, Quandt J, Langhans J, Weihrich P, Wirth T, Brunner C; Eur J Immunol. 2015 Dec;45(12):3441-53. doi: 10.1002/eji.201545475. Eur J Immunol. Epub 2015 Oct 20.

Neuronal redox imbalance results in altered energy homeostasis and early postnatal lethality. Maity-Kumar G, Thal DR, Baumann B, Scharffetter-Kochanek K, Wirth T; FASEB J. PubMed

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA; PLoS One PubMed

Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins. Sauter D, Hotter D, Van Driessche B, Stürzel CM, Kluge SF, Wildum S, Yu H, Baumann B, Wirth T, Plantier JC, Leoz M, Hahn BH, Van Lint C, Kirchhoff F; Cell Rep. PubMed

Tumor necrosis factor-alpha confers cardioprotection through ectopic expression of keratins K8 and K18. Papathanasiou S, Rickelt S, Soriano ME, Schips TG, Maier HJ, Davos CH, Varela A, Kaklamanis L, Mann DL, Capetanaki Y; Nature Medicine 2015 PubMed

2014

HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization. Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J 3rd, Froehling S, Scholl C, Seufferlein T.; Cancer Res. 2014 Oct 8. pii: canres.1017.2014. Full PDF

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin Lymphoma. Vogel MJ, Xie L, Guan H, Tooze RM, Maier T, Kostezka U, Maier HJ, Holzmann K, Chun Chan F, Steidl C, Reichel JB, Weitzer CD, Gehringer F, Kick AB, Cesarman E, Roshal M, Gascoyne RD, Möller P, Wirth T, Ushmorov A.; Blood. 2014 Sep 17. pii: blood-2014-07-590570. blood

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma. Xie L, Ritz O, Leithäuser F, Guan H, Färbinger J, Weitzer CD, Gehringer F, Bruederlein S, Holzmann K, Vogel MJ, Möller P, Wirth T, Ushmorov A.; Oncotarget. 2014 Jul 30;5(14):5392-402. PubMed

Targeting the intratumor heterogeneity in PMBL. Ritz O, Möller P, Ushmorov A.; Cell Cycle. 2014 Jul 15;13(15). PubMed

Long-term IKK2/NF-κB signaling in pancreatic β-cells induces immune-mediated diabetes. Salem HH, Trojanowski B, Fiedler K, Maier HJ, Schirmbeck R, Wagner M, Boehm BO, Wirth T, Baumann B.; Diabetes. 2014 Mar;63(3):960-75. doi: 10.2337/db13-1037. PubMed

MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts. Hipp NI, Christner L, Wirth T, Mueller-Klieser W, Walenta S, Schröck E, Debatin KM, Beltinger C.; Carcinogenesis. 2014 Feb;35(2):479-88. doi: 10.1093/carcin/bgt341. PubMed

2013

Deficiency of innate and acquired immunity caused by an IKBKB mutation. Pannicke U, Baumann B, Fuchs S, Henneke P, Rensing-Ehl A, Rizzi M, Janda A, Hese K, Schlesier M, Holzmann K, Borte S, Laux C, Rump EM, Rosenberg A, Zelinski T, Schrezenmeier H, Wirth T, Ehl S, Schroeder ML, Schwarz K.; N Engl J Med. 2013 Dec 26;369(26):2504-14. doi: 10.1056/NEJMoa1309199. PubMed

The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes. Stockmann M, Meyer-Ohlendorf M, Achberger K, Putz S, Demestre M, Yin H, Hendrich C, Linta L, Heinrich J, Brunner C, Proepper C, Kuh GF, Baumann B, Langer T, Schwalenstöcker B, Braunstein KE, von Arnim C, Schneuwly S, Meyer T, Wong PC, Boeckers TM, Ludolph AC, Liebau S.; J Neural Transm. 2013 May;120(5):785-98. doi: 10.1007/s00702-012-0910-z. Epub 2012 Nov 11. PubMed

MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts. Hipp NI, Christner L, Wirth T, Mueller-Klieser W, Walenta S, Schröck E, Debatin KM, Beltinger C.; Carcinogenesis. 2013 Nov 16. PubMed

Inhibition of NF-κB Signaling Ablates the Invasive Phenotype of Glioblastoma. Westhoff MA, Zhou S, Nonnenmacher L, Karpel-Massler G, Jennewein C, Schneider M, Halatsch ME, Carragher NO, Baumann B, Krause A, Simmet T, Bachem MG, Wirtz CR, Debatin KM.; Mol Cancer Res. 2013 Dec;11(12):1611-23. doi: 10.1158/1541-7786.MCR-13-0435-T. Epub 2013 Oct 21. PMID: 24145173 PubMed

Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging. Maqbool A, Lattke M, Wirth T, Baumann B.; Mol Neurodegener. 2013 Oct 12;8:40. doi: 10.1186/1750-1326-8-40. PMID: 24119288 PubMed 

TBX3 Directs Cell-Fate Decision toward Mesendoderm. Weidgang CE, Russell R, Tata PR, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Boeckers TM, Bauer K, Kartikasari AE, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein T, Zenke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S, Kleger A.; Stem Cell Reports. 2013 Aug 29;1(3):248-65. doi: 0.1016/j.stemcr.2013.08.002. PubMed

CHOP-mediated hepcidin suppression modulates hepatic iron load. Mueller K, Sunami Y, Stuetzle M, Güldiken N, Kucukoglu O, Mueller S, Kulaksiz H, Schwarz P, Strnad P.; J Pathol. 2013 Jun 8. doi: 10.1002/path.4221. PubMed

MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen. Fiedler K, Kokai E, Bresch S, Brunner C.; Am J Blood Res. 2013 May 5;3(2):124-40. Print 2013. PubMed

Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury. Weckbach S, Hohmann C, Denk S, Kellermann P, Huber-Lang MS, Baumann B, Wirth T, Gebhard F, Bachem M, Perl M.; J Trauma Acute Care Surg. 2013 Mar;74(3):792-800. doi: 10.1097/TA.0b013e31827a3655. PMID: 23425737 PubMed

Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB. Mueller K, Quandt J, Marienfeld RB, Weihrich P, Fiedler K, Claussnitzer M, Laumen H, Vaeth M, Berberich-Siebelt F, Serfling E, Wirth T, Brunner C.; Nucleic Acids Res. 2013 Feb 1;41(4):2138-54. PubMed

Decitabine represses translocated MYC oncogene in Burkitt lymphoma. Guan H, Xie L, Klapproth K, Weitzer CD, Wirth T, Ushmorov A.; J Pathol. 2013 Jan 23. doi: 10.1002/path.4164. PubMed

2012

Anti-inflammatory therapy in type 1 diabetes. Baumann B, Salem HH, Boehm BO.; Curr Diab Rep. 2012 Oct;12(5):499-509 PubMed

The role of transcription factors in the guidance of granulopoiesis. Fiedler K, Brunner C.; Am J Blood Res. 2012;2(1):57-65 PubMed

Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men. Müller M, Stockmann M, Malan D, Wolheim A, Tischendorf M, Linta L, Katz SF, Lin Q, Latz S, Brunner C, Wobus AM, Zenke M, Wartenberg M, Boeckers TM, von Wichert G, Fleischmann BK, Liebau S, Kleger A.; Stem Cell Rev. 2012 Sep;8(3):720-40. doi: 10.1007/s12015-011-9324-9. No abstract available. PMID: 22038332 PubMed

Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors. Schmidt-Strassburger U, Schips TG, Maier HJ, Kloiber K, Mannella F, Braunstein KE, Holzmann K, Ushmorov A, Liebau S, Boeckers TM, Wirth T.; FASEB J. 2012 Aug 30. [Epub ahead of print] PubMed PMID: 22935140. medline abstract

Nuclear Factor κB Activation Impairs Ependymal Ciliogenesis and Links Neuroinflammation to Hydrocephalus Formation.  Lattke M, Magnutzki A, Walther P, Wirth T, Baumann B.; J Neurosci. 2012 Aug 22;32(34):11511-23. medline abstract

Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP. Oeckl P, Lattke M, Wirth T, Baumann B, Ferger B.; Neurobiol Dis. 2012 Jun 30;48(3):481-487. [Epub ahead of print] PubMed PMID: 22750522. medline abstract

Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure. Maier HJ, Schips TG, Wietelmann A, Krüger M, Brunner C, Sauter M, Klingel K, Böttger T, Braun T, Wirth T.; Proc Natl Acad Sci U S A.; 2012 Jul 2. medline abstract

Requirement of NEMO/IKKγ for effective expansion of KRAS-induced precancerous lesions in the pancreas. Maier HJ, Wagner M, Schips TG, Salem H, Baumann B, Wirth T.; Oncogene, 2012; medline abstract

IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling. Schmeisser MJ, Baumann B, Johannsen S, Vindedal GF, Jensen V, Hvalby ØC, Sprengel R, Seither J, Maqbool A, Magnutzki A, Lattke M, Oswald F, Boeckers TM, Wirth T.; J Neurosci. 2012 Apr 18;32(16):5688-703. medline abstract

Hepatic activation of IKK/NF-κB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Sunami Y, Leithäuser F, Gul S, Fiedler K, Güldiken N, Espenlaub S, Holzmann KH, Hipp N, Sindrilaru A, Luedde T, Baumann B, Wissel S, Kreppel F, Schneider M, Scharffetter-Kochanek K, Kochanek S, Strnad P, Wirth T.; Hepatology. 2012 Mar 12. doi: 10.1002/hep.25711.  medline abstract

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Xie L, Ushmorov A, Leithäuser F, Guan H, Steidl C, Färbinger J, Pelzer C, Vogel MJ, Maier HJ, Gascoyne RD, Möller P, Wirth T.; Blood. 2012 Apr 12;119(15):3503-11. Epub 2012 Feb 17. medline abstract

Mechanisms Controlling Hematopoiesis, Hematology - Science and Practice. Fiedler, K., Brunner, C.; Dr. Charles Lawrie (Ed.), ISBN: 978-953-51-0174-1, InTech, Available from

2011

Intestinal carcinogenesis: IKK can go all the way. Sunami Y, Wirth T.; J Clin Invest. 2011 Jul; 121(7):2551-3.  medline abstract

FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model. Schips TG, Wietelmann A, Höhn K, Schimanski S, Walther P, Braun T, Wirth T, Maier HJ.; Cardiovasc Res. 2011 Sep 1; 91(4):587-97. Epub 2011 May 30. medline abstract

Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm. Giehl K, Bachem M, Beil M, Böhm BO, Ellenrieder V, Fulda S, Gress TM, Holzmann K, Kestler HA, Kornmann M, Menke A, Möller P, Oswald F, Schmid RM, Schmidt V, Schirmbeck R, Seufferlein T, von Wichert G, Wagner M, Walther P, Wirth T, Adler G.; Pancreas. 2011 May; 40(4):489-502. medline abstract

2010

Epithelial-Mesenchymal Transition in Pancreatic Carcinoma. Maier HJ , Wirth T,  Beug H; Cancers, 2010; 2, 2058-2083. full text

KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classical Hodgkin lymphoma. Guan H, Xie L, Leithäuser F, Flossbach L, Möller P, Wirth T, Ushmorov A; Blood, 2010; medline abstract

Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. Rausch V, Liu L, Kallifatidis G, Baumann B, Mattern J, Gladkich J, Wirth T, Schemmer P,  Büchler MW, Zöller M, Salnikov AV, Herr I; Cancer Res., 2010; medline abstract

The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Beilke S, Oswald F, Genze F, Wirth T, Adler G, Wagner M; Oncogene, 2010 May 17; medline abstract

NF-κB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Maier HJ, Schmidt-Strassburger U, Huber MA, Wiedemann EM, Beug H, Wirth T; Cancer Lett, 2010 Mar 27; medline abstract

Advances in the understanding of MYC-induced lymphomagenesis.  Klapproth K, Wirth T;  Br J Haematol, Epub 2010 Mar 21; medline abstract

BI 5700, a selective chemical inhibitor of IκB Kinase 2, specifically suppresses epithelial-mesenchymal transition and metastasis in mouse models of tumor progression. Huber MA, Maier HJ, Alacaptan M, Wiedemann E, Braunger J, Boehmelt G, Madwed JB, Young ERR, Marshall DR, Pehamberger H, Wirth T, Kraut N, Beug H; Genes & Cancer, 2010; 1:101-114; abstract

Dietary polyphenol quercetin targets pancreatic cancer stem cells. Zhou W, Kallifatidis G, Baumann B, Rausch V, Mattern J, Gladkich J, Giese N, Moldenhauer G, Wirth T, Büchler MW, Salnikov AV, Herr I.; Int J Oncol. 2010 Sep; 37(3):551-61. medline abstract

2009

Initiation of Dopaminergic Differentiation of Nurr1(-) Mesencephalic Precursor Cells Depends on Activation of Multiple MAP Kinase Pathways. Sabolek M., Baumann B., Heinrich M., Meyer AK., Herborg A., Liebau S., Maisel M., Hermann A., Ventz K., Schwarz J., Wirth T., Storch A.; Stem Cells. 2009 May 14. [Epub ahead of print] medline abstract

The IKK2/NF- κB-pathway suppresses MYC-induced lymphomagenesis. Klapproth K., Sander S., Marinkovic D., Baumann B., Wirth T.; Blood. 2009 Jul 23. [Epub ahead of print] medline abstract

Epstein-Barr Virus-Induced Gene-3 is Expressed in Human Atheroma Plaques. Kempe S., Heinz P., Kokai E., Devergne O., Marx N., Wirth T.; Am J Pathol. 2009 175:440-447. medline abstract

Myc Regulates Embryonic Vascular Permeability and Remodeling. Kokai E, Voss F, Fleischer F, Kempe S, Marinkovic D, Wolburg H, Leithäuser F, Schmidt V, Deutsch U, Wirth T.; Circ Res. 2009 104:1151-1159. Epub 2009 Apr 30.; medline-abstract

TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF- κB signaling pathway. Hess K., Ushmorov A., Fiedler J., Brenner RE., Wirth T.;  Bone, 2009 45:367-376. Epub 2009 May 3.; medline-abstract

Repressing the repressor - a new mode of MYC action in lymphomagenesis. Sander, S., Bullinger, L., Wirth, T.; Cell Cyle, 2009; 8:556-559  medline-abstract

Sulforaphane targets pancreatic tumor-initiating cells by NF-κB-induced anti-apoptotic signaling. Kallifatidis, G., Rausch, V., Baumann, B., Apel, A., Beckermann, B.M., Groth, A., Mattern, J., Li, Z., Kolb, A., Moldenhauer, G., Altevogt, P., Wirth, T., Werner, J., Schemmer, P., Büchler, M.W., Salnikov, A.V., Herr, I; Gut, 2009;  medline-abstract

2008

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Sander, S., Bullinger, L., Klapproth, K., Fiedler, K., Kestler, H.A., Barth, T.F.E., Möller, P., Stilgenbauer, S., Pollack, J.R., Wirth, T; Blood, 2008; 112:4202-4212  medline-abstract

ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. Ushmorov, A., Leithäuser, F., Ritz, O., Barth, T.F., Möller, P., Wirth, T; Leukemia, 2008; 22:1942-1944  medline-abstract

Phosphorylation of serine 68 in the Iκ (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-α-induced NF-κB activity. Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB; J Biol Chem, 2008; 283:76-86  medline-abstract

Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-κB family member RelB. Leidner J, Palkowitsch L, Marienfeld U, Fischer D, Marienfeld R; Biochem J, 2008; 416:117-127  pdf

N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells. Ushmorov A, Hogarty MD, Liu X, Knauss H, Debatin KM, Beltinger C; Oncogene, 2008; 27: 3424-3434;  medline-abstract

Characterization of sonic hedgehog as a novel NF-κB target gene that promotes NF-κB-mediated apoptosis resistance and tumor growth in vivo. Kasperczyk H, Baumann B, Debatin KM, Fulda S; FASEB J, 2008; 23:21-33;  medline-abstract

Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations. Sander S, Bullinger L, Leupolt E,  Benner A, Kienle D, Katzenberger T, Kalla J, Ott G, Müller-Hermelink HK, Barth TF, Möller P, Lichter P, Döhner H, Stilgenbauer S; Haematologica, 2008; 93:641-645  medline-abstract

αPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling. Missy K, Hu B, Schilling K, Harenberg A, Sakk V, Kuchenbecker K, Kutsche K, Fischer KD; Mol Cell Biol, 2008; 28:3776-3789  medline-abstract

2007

BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Brunner C, Sindrilaru A, Girkontaite I, Fischer KD, Sunderkötter C, Wirth T; EMBO J., 2007; 26:3191-202   medline-abstract

Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. Baumann B, Wagner M, Aleksic T, von Wichert G, Weber CK, Adler G, Wirth T; J Clin Invest., 2007; 117:1502-13. medline-abstract

c-MYC activation impairs the NF-κB and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma. Schlee M, Holzel M, Bernard S, Mailhammer R, Schuhmacher M, Reschke J, Eick D, Marinkovic D, Wirth T, Rosenwald A, Staudt LM, Eilers M, Baran-Marszak F, Fagard R, Feuillard J, Laux G, Bornkamm GW; Int J Cancer, 2007; 120:1387-95. medline-abstract

Cellular immune reaction in the pancreas is induced by constitutively active IκB kinase-2. Aleksic T, Baumann B, Wagner M, Adler G, Wirth T, Weber CK; Gut., 2007; 56:227-36. medline-abstract

Enriching suicide gene bearing tumor cells for an increased bystander effect. Unger MM, Wahl J, Ushmorov A, Buechele B, Simmet T, Debatin KM, Beltinger C; Cancer Gene Ther, 2007; 14:30-38.  medline-abstract

Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner. Wicovsky A, Muller N, Daryab N, Marienfeld R, Kneitz C, Kavuri S, Leverkus M, Baumann B, Wajant H; J Biol Chem, 2007; 282:2174-2183. medline-abstract

Strongly reduced alloreactivity and Long-Term Survival Times of Cardiac Allografts in Vav1- and Vav1/Vav2-Knockout Mice. Weckbecker G, Bruns C, Fischer KD, Heusser C, Li J, Metzler B, Morris R, Nuesslein-Hildesheim  B, Raulf F, Wieczorek G, Zenke G; Transplant Int., 2007; 20:353-364.  medline-abstract

The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) directly associates with Vav to promote phagocytosis of human pathogens. Schmitter T, Pils S, Sakk V, Frank R, Fischer KD, Hauck C; Immunol., 2007; 178:3797-3805.  medline-abstract

Mitogenic CD28 Signals Require the Exchange Factor Vav1 to Enhance TCR Signaling at the SLP-76-Vav-Itk Signalosome. Dennehy KM, Elias F, Na SY, Fischer KD, Hunig T, Luhder F;  J Immunol, 2007; 178:1363-1371  medline-abstract

Role of caspases in CD95L- and TRAIL-induced non-apoptotic signaling in pancreatic tumour cells. Siegmund D, Klose S, Zhou D, Baumann B, Roder C, Kalthoff H, Wajant H, Trauzold A; Cell Signal, 2007; 19:1172-1184  medline-abstract

Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, reseistance to therapy, and short survival. Stilgenbauer S, Sander S, Bullinger L, Benner A, Leupolt E, Winkler D, Krober A, Kienle D, Lichter P, Dohner H, Stilgenbauer S; Haematologica, 2007; 92:1242-1245  medline-abstract

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia. Bullinger L, Rucker FG, Kurz S, Du J, Scholl C, Sander S, Corbacioglu A, Lottaz C, Krauter J, Frohling S, Ganser A, Schlenk RF, Dohner K, Pollak JR, Dohner H; Blood, 2007; 110:1291-1300  medline-abstract

Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmaier K, Martini R, Wiendl H; Mol Cell Neurosci., 2007; 36:416-424  medline-abstract

2006

Btk expression is controlled by Oct and BOB.1/OBF.1. Brunner C, Wirth T; Nucleic Acids Res. 2006; 34: 1807-15. medline-abstract

BOB.1/OBF.1 - A Critical Regulator of B Cell Function. Brunner C, Wirth T; Current Immunology Reviews, 2006; 2: 3-12. publication

Epigenic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma. Ushmorov A, Leithäuser F, Sakk O, Weinhäusel A, Popov SW, Möller P, Wirth T; Blood, 2006; 107: 2493-500. medline-abstract

2005

IKK mediates ischemia-induced neuronal death. Herrmann O, Baumann B, de Lorenzi R, Muhammad S, Zhang W, Kleesiek J, Malfertheiner M, Kohrmann M, Potrovita I, Maegele I, Beyer C, Burke JR, Hasan MT, Bujard H, Wirth T, Pasparakis M, Schwaninger M; NatMed. 2005; 12: 1322-9. medline-abstract

NF-κB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program. Kempe S, Kestler H, Lasar A, Wirth T; Nucleic Acids Res. 2005; 33: 5308-19. medline-abstract

Bruton's Tyrosine Kinase is involved in innate and adaptive immunity. Brunner C, Müller B, Wirth T; Histol Histopathol. 2005; 20: 945-55. medline-abstract

Activation of the IκB kinase complex is sufficient for neuronal differentiation of PC12 cells. Azoitei N, Baumann B, Wirth T; Neurochem. 2005; 93: 1487-501. medline-abstract

B Cell Hyperresponsiveness and Expansion of Mature Follicular B Cells but not of Marginal Zone B Cells in NFATc2/c3 Double-Deficient Mice Samanata DN, Palmetshofer A, Marinkovic D, Wirth T, Serfling E, Nitschke L; J.Immunol. 2005; 174: 4797-802. medline-abstract

Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line. Ritz O, Leithäuser F, Hasel C, Bruderlein S, Ushmorov A, Möller P, Wirth T; J Pathol. 2005; 205: 336-48. medline-abstract

2004

The Role of Bruton's Tyrosine Kinase in innate and adaptive immunity. Brunner C, Müller B, Wirth T; Recent Res.Devel. Experimental Med., 2004.  publication

NF-kB: Critical Regulator of Inflammation and the Immune Response. Lasar A, Marienfeld R, Wirth T, Baumann B; Handbook of Experimental Pharmacology Vol. 166/Transcription Factors. eds. S.J. Triezenberg, M. Gossen, J. Kaufmann 2004; pp. 325-76. publication

Epithelial-mesenchymal transition: NF-κB takes center stage. Huber MA, Beug H, Wirth T; Cell Cycle. 2004; 3: 1477-80. medline-abstract

Identification of novel Myc target genes with a potential role in lymphomagenesis. Marinkovic D, Marinkovic T, Kokai E, Barth T, Möller P, Wirth T; Nucleic Acids Res. 2004; 32: 5368-78. medline-abstract

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. Huber MA, Azoitei N, Baumann B, Grünert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T; J Clin Invest 2004; 114: 569-81. medline-abstract

Epigenetic silencing of the immunoglobulin heavy chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression. Ushmorov A, Ritz O, Hummel M, Leithäuser F, Möller P, Stein H, Wirth T; Blood 2004; 104: 3326-34. medline-abstract

Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFκB activation and interleukin-6 release. Wenk J, Schuller J, Hinrichs C, Syrovets T, Azoitei N, Podda M, Wlaschek M, Brenneisen P, Schneider LA, Sabiwalsky A, Peters T, Sulyok S, Dissemond J, Schauen M, Krieg T, Wirth T, Simmet T, Scharffetter-Kochanek K; J Biol Chem. 2004; 279: 45634-42. medline-abstract

Reversible lymphomagenesis in conditionally c-MYC expressing mice. Marinkovic D, Marinkovic T, Mahr B, Hess J, Wirth T; Int J Cancer 2004; 110: 336-42. medline-abstract

New roles for Bcl10 in B cell development and LPS response. Fischer KD, Tedford K, Wirth T; Trends in Immunol 2004; 25: 113-6. medline-abstract

Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator. Laumen H, Brunner C, Greiner A, Wirth T; Nucleic Acids Res. 2004; 32: 1577-83. medline-abstract

Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct 2, PU.1 and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas and Hodgkin lymphomas. Loddenkemper C, Anagnostopoulos I, Hummel M, Jöhrens-Leder K, Foss HD, Jundt F, Wirth T, Dörken B, Stein H; J Pathol 2004; 202: 60-69. medline-abstract

2003

Expression of the Aldehyde Dehydrogenase 2-like Gene is Controlled by BOB.1/OBF.1 in B Lymphocytes. Brunner C, Laumen H, Kraut N, Wirth T; J Biol Chem 2003; 278: 45231-9. medline-abstract

Critical role of RelB serine 368 for dimerization and p100 stabilisation. Maier HJ, Marienfeld R, Wirth T, Baumann B; J Biol Chem 2003; 278: 39242-50. medline-abstract

Bruton´s tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in NF-κB activation by Toll-like receptor 4. Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O´Neill LAJ; J Biol Chem 2003; 278: 26258-64. medline-abstract

Caspase-mediated cleavage converts TRAF1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF- κB activation. Henkler F, Baumann B, Fotin-Mleczek M, Weingärtner M, Schwenzer R, Peters N, Graneß A, Wirth T, Scheurich P, Schmid JA, Wajant H; J Biol Chem 2003; 278: 29216-30. medline-abstract

B-cell-specific transgenic expression of Bc12 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. Brunner C, Marinkovic D, Klein J, Samardzic T, Mitschke L, Wirth T; J Exp Med 2003; 197: 1205-11. medline-abstract

The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. Amano H, Amano E, Moll T, Marinkovic D, Ibnou-Zekri N, Martinez-Soria E, Semac I, Wirth T, Nitschke L, Izui S; J Immunol. 2003; 170: 2293-301. medline-abstract

2002

Rocaglamide derivates are potent inhibitors of NF-κB activation in T-cells. Baumann B, Bohnenstengel F, Siegmund D, Wajant H, Weber C, Herr I, Debatin KM, Proksch P, Wirth T; J Biol Chem 2002; 277: 44791-800. medline-abstract

BOB.1/OBF.1 deficiency results in reduction of the marginal zone B cell compartment. Samardzic T, Marinkovic D, Nielsen PJ, Nitschke L, Wirth T; Mol Cell Biol 2002; 22: 8320-31. medline-abstract

Lack of correlation between NF-κB activation and induction of programmed cell death in PC12 pheochromocytoma cells treated with 6-hydroxydopamine or the cannabinoid receptor 1-agonist CP55,940. Erlandsson N, Baumann B, Rössler OG, Kaufmann K, Giehl KM, Wirth T, Thiel G; Biochem Pharmacol 2002; 64 487-95. medline-abstract

CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Samardzic T, Gerlach J, Müller K, Marinkovic D, Hess J, Nitschke L, Wirth T; Eur J Immunol. 2002; 32: 2481-9.  medline-abstract

Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-κB and extracellular signal-regulated protein kinase activation. Bartholomä P, Erlandsson N, Kaufmann K, Rössler OG, Baumann B, Wirth T, Giehl KM, Thiel G; Biochem Pharmacol. 2002; 63: 1507-1516. medline-abstract

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. Jundt F, Kley K, Anagnostopoulos I, Schulze-Probsting K, Greiner A, Mathas S, Scheidereit C, Wirth T, Stein H, Dorken B.; Blood. 2002; 99: 3060-2. medline-abstract

Reduction of marginal zone B cells in CD22-deficient mice. Samardzic T, Marinkovic D, Danzer CP, Gerlach J, Nitschke L, Wirth T; Eur J Immunol. 2002; 32: 561-7. medline-abstract

The IKK-2/I κBα /NF-κB pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in IκBα-deficient mice. Huber MA, Denk A, Peter RU, Weber L, Kraut N, Wirth T; J Biol Chem. 2002; 277: 1268-75. medline-abstract

2001

Regulation of BOB.1/OBF.1 stability by SIAH. Boehm J, He Y, Greiner A, Staudt L, Wirth T; EMBO J. 2001; 20: 4153-62. medline-abstract

Activation of NF-κ B via the I κ B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. Denk A, Goebeler M, Schmid S, Berberich I, Ritz O, Lindemann D, Ludwig S, Wirth T; J Biol Chem. 2001; 276: 28451-8. medline-abstract

Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor. Hess J, Werner A, Wirth T, Melchers F, Jack HM, Winkler TH; Proc Natl Acad Sci U S A. 2001; 98:1745-50. medline-abstract

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells. Theil J, Laumen H, Marafioti T, Hummel M, Lenz G, Wirth T, Stein H.; Blood. 2001; 97: 3191-6. medline-abstract

The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development. Hess J, Nielsen PJ, Fischer KD, Bujard H, Wirth T; Mol Cell Biol. 2001; 21: 1531-9. medline-abstract

Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Weber CK, Liptay S, Wirth T, Adler G, Schmid RM; Blood. 2001; 97: 496-501. medline-abstract

2000

Suppression of NF- κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β. Weber CK, Liptay S, Wirth T, Adler G, Schmid RM; Gastroenterology. 2000; 119: 1209-18. medline-abstract

Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Greiner A, Muller KB, Hess J, Pfeffer K, Muller-Hermelink HK, Wirth T; Am J Pathol 2000; 156: 501-7. medline-abstract

The BOB.1 / OBF.1 co-activator is essential for octamer-dependent transcription in B cells. Laumen H, Nielsen PJ, Wirth T; Eur J Immunol 2000; 30: 458-69. medline-abstract

Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Marafioti T, Hummel M, Foss HD, Laumen H, Korbjuhn P, Anagnostopoulos I, Lammert H, Demel G, Theil J, Wirth T, Stein H; Blood 2000; 95: 1443-50. medline-abstract

Raf induces NF- κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Baumann B, Weber CK, Troppmair J, Whiteside S, Israel A, Rapp UR, Wirth T; Proc Natl Acad Sci U S A 2000; 97: 4615-20. medline-abstract

NF-κB transcription factors: critical regulators of hematopoiesis and neuronal survival. Denk A, Wirth T, Baumann B; Cytokine and Growth Fact Rev 2000: 303-320. medline-abstract

1999

NF-κB is activated and promotes cell death in focal cerebral ischemia. Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M; Nat Med 1999; 5: 554-9. medline-abstract

In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system. Pitzer C, Schindowski K, Pomer S, Wirth T, Zoller M; Cancer Gene Ther 1999; 6: 139-46. medline-abstract

Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1. Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J; J Biol Chem 1999; 274: 12910-6. medline-abstract

 

1998

Inhibition of nuclear factor κB activation attenuates apoptosis resistance in lymphoid cells. Jeremias I, Kupatt C, Baumann B, Herr I, Wirth T, Debatin KM; Blood 1998; 91: 4624-31. medline-abstract

The mutant plasmacytoma cell line S107 allows the identification of distinct pathways leading to NF-κB activation. Baumann B, Kistler B, Kirillov A, Bergman Y, Wirth T; J Biol Chem 1998; 273: 11448-55. medline-abstract

Induction of nuclear factor-κB during primary B cell differentiation. Kistler B, Rolink A, Marienfeld R, Neumann M, Wirth T; J Immunol 1998; 160: 2308-17. medline-abstract

 

Molecular genetics of the germinal center reaction. Hess J, Laumen H, Müller K, Wirth T; J Cell Physiol 1998: 525-34. medline-abstract

Application of differential cDNA-screening techniques to the identifying of unique gene expression in tumours and lymphocytes. Hess J, Laumen H, Wirth T; Curr Opi Immunol 1998: 125-30. medline-abstract

1997

RelB is a key player for both κ B-dependent transcription and demethylation in B cells. Kistler B, Baumann B, Bergman Y, Wirth T; Immunobiology 1997; 198: 24-34. medline-abstract

Identification of target genes of the lymphoid-specific transcription factor Oct2. Pfisterer P, Hess J, Wirth T; Immunobiology 1997; 198: 217-26. medline-abstract

Glutamate-dependent activation of NF- κB during mouse cerebellum development. Guerrini L, Molteni A, Wirth T, Kistler B, Blasi F; J Neurosci 1997; 17: 6057-63. medline-abstract

Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T; Science 1997; 277: 221-5. medline-abstract

 

1996

CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2. Pfisterer P, Konig H, Hess J, Lipowsky G, Haendler B, Schleuning WD, Wirth T; Mol Cell Biol 1996; 16: 6160-8. medline-abstract

CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB. Neumann M, Wohlleben G, Chuvpilo S, Kistler B, Wirth T, Serfling E, Schimpl A; J Immunol 1996; 157: 4862-9. medline-abstract

A role for nuclear NF-κB in B-cell-specific demethylation of the Igκ locus. Kirillov A, Kistler B, Mostoslavsky R, Cedar H, Wirth T, Bergman Y; Nat Genet 1996; 13: 435-41. medline-abstract

Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids. Reich L, Sharir H, Ber R, Wirth T, Bergman Y, Laskov R; Somat Cell Mol Genet 1996; 22: 1-20. medline-abstract

 

1995

High mobility group protein 2 functionally interacts with the domains of octamer transcription factors. Zwilling S, Konig H, Wirth T; EMBO J 1995; 14:1198-208. medline-abstract

Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Konig H, Pfisterer P, Corcoran LM, Wirth T; Genes Dev 1995; 9:1598-607.medline-abstract

Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. Pfisterer P, Zwilling S, Hess J, Wirth T; J Biol Chem 1995; 270: 29870-80.medline-abstract

Lymphoid- and myeloid-specific activity of the PU.1 promoter is determined by the combinatorial action of octamer and ets transcription factors. Kistler B, Pfisterer P, Wirth T; Oncogene 1995; 11: 1095-106. medline-abstract

 

HMG2 functionally interacts with the POU-domain of octamer transcription factors. Zwilling S, König H, Wirth T; Embo J 1995: 1198-1208. medline-abstract

Molecular principles of Oct2-mediated gene activationin B cells. Wirth T, Pfisterer P, Annweiler A, Zwilling S, König H; Immunobiology 1995. 161-170. medline-abstract

1994

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells. Lernbecher T, Kistler B, Wirth T; Embo J 1994: 4060-4069. medline-abstract

Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms. Annweiler A, Zwilling S, Wirth T; Nucl Acids Res 1994: 4250-8. medline-abstract

The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. Zwillling S, Annweiler A, Wirth T; Nucl Acids Res 1994: 1655-62. medline-abstract

Differential transactivation potential of Oct1 and Oct2 is determined by additional B-cell-specific activities. Pfisterer P, Annweiler A, Ullmer C, Corcoran LM, Wirth T; Embo J 1994: 1654-63. medline-abstract

1993

Distinct members of the NF-κB/Rel transcription factor family are responsible for tissue-specific and inducible gene activation. Lernbecher T, Müller U, Wirth T; Nature 1993: 767-770. medline-abstract

TGF-β and cyclosporin A inhibit the inducible activity of the IL-2 gene in T-cells through a non-canonical octamer binding site. Lernbecher T, Müller U, Wirth T; Mol Cell Biol 1993: 1155-1162, medline-abstract

Analysis of transcriptional stimulation by recombinant Oct proteins in a cell-free system. Annweiler A, Zwilling S, Hipskind RA, Wirth T; J Biol Chem 1993: 2525-2534, medline-abstract

1992

Functional analysis of defined mutations in the immunglobulin heavy-chain enhancer in transgenic mice. Annweiler A, Müller U, Wirth T; Nucl Acids Res 1992: 1503-1509, medline-abstract

Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity. Annweiler A, Müller-Immerglück M, Wirth T; Mol Cell Biol 1992: 3107-3116, medline-abstract

1991

Anti-IgM antibodies down modulate mu-enhancer activity and OTF2 levels in LPS-stimulated mouse splenic B-cells. Chen U, Scheuermann R, Wirth T, Gerster T, Roeder RG, Harshman K, Berger C; Nucl Acids Res 1991: 5981-5989, medline-abstract

A strategy for efficient in vitro translation of cDNAs using the rabbit β-globin leader sequence. Annweiler A, Hipskind RA, Wirth T; Nucl Acids Res 1991: 3750, medline-abstract

Multiple Oct2 isoforms are generated by alternative splicing. Wirth T, Priess A, Annweiler A, Zwilling S, Oeler B; Nucl Acids res 1991: 43-51, medline-abstract

1983-1988

1988

Nuclear factor NF-κB can functionally interact with its cognate binding site to provide lymphoid-specific promoter function. Wirth T, Baltimore D; Embo J 1988: 3109-3113, medline-abstract

1987

An octamer oligonucleotide placed upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Wirth T, Staudt L, Baltimore D; Nature 1987: 174-178, medline-abstract

1986

A lymphoid specific protein binding to the octamer motif of immunoglobulin genes. Staudt LM, Singh H, Sen R, Wirth T, Sharp PA, Baltimore D; Nature 1986: 640-643, medline-abstract

1985

Structure and genomic organization of a new family of murine retrovirus - related DNA sequences (MuRRS). Schmidt M, Wirth T, Kröger B, Horak I; Nucl Acids Res 1985: 3461-3470, medline-abstract

1984

Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS). Schmidt M, Glöggler K, Wirth T, Horak I; Proc. Natl. Acad. Sci USA 1984: 6696-6730, medline-abstract

Evidence for mobility of a new family of mouse middle repetitive DNA elements (LTR-IS). Wirth T, Schmidt M, Baumruker T, Horak I; Nucl Acids Res 1984: 3603-3610, medline-abstract

1983

Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats. Wirth T, Glöggler K, Baumruker T, Schmidt M, Horak I; Proc. NAtl. Acad Sci USA 1983: 3327-3330, medline-abstract