Congratulations, Judith and Kostas!
Judith Schlett and Konstantinos Tsesmelis sucessfully defend their PhD thesis. Judith worked on the role of NF-kB in oligodendrocytes and Kostas PhD project dealed with the consequences of increased oxidative stress in astrocytes.
Militadis Tsesmelis defends his PhD-Thesis!
During his PhD, he discovered that NEMO, an essential protein for the activation of the NF-κB pathway, supports metastasis of pancreatic cancer cells to the liver through the activation of the epithelial-mesenchymal transition (EMT) program. Parts of his work have been published in the MDPI Journal Cancers. We are happy to keep Miltos as a Post Doc in our group!
Congratulations, Dr. Franz Ketzer!
Franz successfully defends his Ph.D. thesis. He discovered an essential role of Cyclin D3 in the proliferation and survival program of B-cell acute lymphoblastic leukemia. Parts of his thesis have been published in the Nature Journal Oncogenesis. Franz will continue his career as Post Doc in the Lab of Marcus Müschen at Yale School of Medicine!
The new SFB 1506- Aging at Interfaces is starting!
PD Dr. Bernd Baumann and Prof. Dr. Franz Oswald are PIs of project A05 "Notch/NF-kB crosstalk at the aging synapse: Role of inflammaging on cognitive decline"! Congratulations!
Ulrike successfully defends her master´s thesis "Rapid degradation of endogenous FOXO1 in B-cell acute lymphoblastic leukemia for identification of direct regulatory targets" and graduated from the Master Programme Molecular Medicine. After doing her bachelor´s thesis and master´s thesis in the field of leukemia, she is now switching sides, but luckily staying with us at the institute of physiological chemistry. She will start her PhD project about pancreatic cancer in April!
Congratulations to the Ushmorov group and especially to Franz Ketzer as the first author. They published the article “CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia” in the Nature Journal Oncogenesis. They identified the direct transcriptional regulation of CCND3 by FOXO1 and demonstrated why CCND3 depletion might be superior to inhibition of its associated kinases CDK4/6 in B-ALL.
Great News. Congratulations to PD Dr. Bernd Baumann and his group! In this publication they show, that NF-kB activation in astrocytes can have a positive effect on microglia polarization and therefore ameliorate the burden of Aß deposition.
Congratulations to Miltiadis! He published parts of his PhD project! Within the publication "Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice" they show that in the absence of NEMO, KPC mice exhibit extended survival, which is accompanied by a strong reduction in the development of liver metastasis and ascites.
Dr. Franziska Gehringer and Dr. Alexey Ushmorov publish a “Blood”commentary to the article “SGK1 mutations in DLBCL generate hyperstable protein neoisoforms that promote AKT independence” entitled "Hyperstable SGK1 steps out of AKT’s shadow".
Congratulations, Dr. Trojanowski! Bernadette worked within her PhD project on the mechanisms of IKK/NF-kB dependent diabetes development and regeneration!
We are happy that our group was able to publish a new review article about pancreatic cancer and tumor microenvironment!
Congrats to Nadine and Miltiadis!
Welcome to the group, Tabea Hein!
Tabea will work within the Trauma SFB 1149 on the role of NF-kB in Microglia after Traumatic Brain Injury!
Franziska Gehringer defends her PhD thesis with distinction! In the group of Dr. Alexey Ushmorov she investigated how important the regulation of the PTEN-PI3K-AKT axis and FOXO1 for maintainence of Burkitt lymphoma is! Congratulations Dr. Gehringer!
Christine Rüppel graduates as M.Sc. Molecular Medicine. During her Master Thesis in the Group of Dr. Alexey Ushmorov, supervised by Franziska Gehringer, she worked on the role of FOXO transcrption factors in B cell lymphomas! Congratulations!