News

March 2022

Congratulations, Dr. Franz Ketzer!

Franz successfully defends his Ph.D. thesis. He discovered an essential role of Cyclin D3 in the proliferation and survival program of B-cell acute lymphoblastic leukemia. Parts of his thesis have been published in the Nature Journal Oncogenesis.

January 2022

The new SFB 1506- Aging at Interfaces is starting!
PD Dr. Bernd Baumann and Prof. Dr. Franz Oswald are PIs of project A05 "Notch/NF-kB crosstalk at the aging synapse: Role of inflammaging on cognitive decline"! Congratulations!

 

Ulrike successfully defends her master´s thesis "Rapid degradation of endogenous FOXO1 in B-cell acute lymphoblastic leukemia for identification of direct regulatory targets" and graduated from the Master Programme Molecular Medicine. After doing her bachelor´s thesis and master´s thesis in the field of leukemia, she is now switching sides, but luckily staying with us at the institute of physiological chemistry. She will start her PhD project about pancreatic cancer in April!

December 2021

Congratulations to the Ushmorov group and especially to Franz Ketzer as the first author. They published the article “CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia” in the Nature Journal Oncogenesis. They identified the direct transcriptional regulation of CCND3 by FOXO1 and demonstrated why CCND3 depletion might be superior to inhibition of its associated kinases CDK4/6 in B-ALL.

CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia

October 2021

Great News. Congratulations to PD Dr. Bernd Baumann and his group! In this publication they show, that NF-kB activation in astrocytes can have a positive effect on microglia polarization and therefore ameliorate the burden of Aß deposition.

IKK2/NF-kB Activation in Astrocytes Reduces Amyloid ß Deposition: A Process Associated with Specific Microglia Polarization

September 2021

Congratulations to Miltiadis! He published parts of his PhD project! Within the publication "Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice" they show that in the absence of NEMO, KPC mice exhibit extended survival, which is accompanied by a strong reduction in the development of liver metastasis and ascites.

Dr. Franziska Gehringer and Dr. Alexey Ushmorov publish a “Blood”commentary to the article “SGK1 mutations in DLBCL generate hyperstable protein neoisoforms that promote AKT independence” entitled "Hyperstable SGK1 steps out of AKT’s shadow".

November 2020

ltr: Prof. Dr. Thomas Wirth, Dr. Bernadette Trojanowski, PD Dr. Bernd Baumann

Congratulations, Dr. Trojanowski! Bernadette worked within her PhD project on the mechanisms of IKK/NF-kB dependent diabetes development and regeneration!

July 2020

We are happy that our group was able to publish a new review article about pancreatic cancer and tumor microenvironment!

Congrats to Nadine and Miltiadis!

Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma

April 2020

Welcome to the group, Tabea Hein!
Tabea will work within the Trauma SFB 1149 on the role of NF-kB in Microglia after Traumatic Brain Injury!

March 2020

Franziska Gehringer defends her PhD thesis with distinction! In the group of Dr. Alexey Ushmorov she investigated how important the regulation of the PTEN-PI3K-AKT axis and FOXO1 for maintainence of Burkitt lymphoma is! Congratulations Dr. Gehringer!

ltr: Prof. Dr. Thomas Wirth, Dr. Franziska Gehringer, Dr. Alexey Ushmorov
ltr: Franziska Gehringer, Christine Rüppel, Dr. Alexey Ushmorov

Christine Rüppel graduates as M.Sc. Molecular Medicine. During her Master Thesis in the Group of Dr. Alexey Ushmorov, supervised by Franziska Gehringer, she worked on the role of FOXO transcrption factors in B cell lymphomas! Congratulations!