Osteoporosis and diabetes are common diseases with a high prevalence in the ageing population. Chronic low-grade inflammation accelerates insulin resistance, and chronic high-grade inflammation such as arthritis also has profound effects on bone integrity.
Our lab aims to unravel the endocrine control of immune and stromal cell interactions during these pathologies and investigate how the resolution of inflammation can be fine-tuned to alleviate disease and enable tissue integrity repair.
We also discovered that the stress hormone-activated glucocorticoid receptor (GR) not only controls inflammation via transcriptional effects, but also influences inflammation resolution through non-genomic effects that influence cellular immune metabolism and attenuate oncogenic RAS signalling.
Finally, the Integrated 3R Center Ulm (iR3 Center), for which Jan Tuckermann is the spokesperson, is concerned with combining replacement methods and modelling approaches with refined animal experiments (only when absolutely necessary).
Research interests:
Cell type-specific transcriptional and non-transcriptional regulation by the glucocorticoid receptor in inflammation, immunometabolism (intrinsic and extrinsic immunometabolism (diabetes); and bone integrity during aging and physical trauma
Stress-hormonal control of cell differentiation and function in physiology
Endocrine control of stress and resilience.
Publications
Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids.
Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G. Nature. 2024 May;629(8010):184-192. doi: 10.1038/s41586-024-07282-7. Epub 2024 Apr 10. PMID: 38600378
Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance.
Caratti G, Stifel U, Caratti B, Jamil AJM, Chung KJ, Kiehntopf M, Gräler MH, Blüher M, Rauch A, Tuckermann JP. Nat Commun. 2023 Apr 20;14(1):2271. doi: 10.1038/s41467-023-37831-z. PMID: 37080971. Free PMC article.
Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids.
Caratti G, Desgeorges T, Juban G, Stifel U, Fessard A, Koenen M, Caratti B, Théret M, Skurk C, Chazaud B, Tuckermann JP, Mounier R. EMBO Rep. 2023 Feb 6;24(2):e55363. doi: 10.15252/embr.2022
Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing.
Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J. Bone Res. 2022 Apr 6;10(1):33. doi: 10.1038/s41413-022-00195-z. PMID: 35383146; PMCID: PMC898372
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumour growth.
Caratti B, Fidan M, Caratti G, Breitenecker K, Engler M, Kazemitash N, Traut R, Wittig R, Casanova E, Ahmadian MR, Tuckermann JP, Moll HP, Cirstea IC. Sci Signal. 2022 Mar 22;15(726):eabm4452. doi: 10.1126/scisignal.abm4452. Epub 2022 Mar 22. PMID: 35316097
