The Institute of Pharmaceutical Biotechnology


At our institute we combine structural biology (mainly X-ray crystallography), biophysical approaches, and biochemistry with cell biology to allow for an integrated research approach.

Research topics focus on RNA-based gene regulation in eukaryotes (Niessing), structure-guided inhibitor design (Niessing), and various areas of biotechnology, including biomaterials for medical applications and recombinant biosurfactants for a growing bioeconomy (Rosenau). For more details, please visit the groups subpages under the RESEARCH pulldown menue.



Recent Publications

Arnold S, Henkel M, Wanger J, Wittgens A, Rosenau F, Hausmann R.
Heterologous rhamnolipid biosynthesis by P. putida KT2440 on bio-oil derived small organic acids and fractions
AMB Expr. 9:80. doi: 10.1186/s13568-019-0804-7

Heber S, Gáspár I, Tants J.-N, Günther J, Fernandez Moya S, Janowski R, Ephrussi A, Sattler M, Niessing D.
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Nature Commun. (2019).

Wang Y, Horlamus F, Henkel M, Kovacic F, Schläfle S, Hausmann R, Wittgens A, Rosenau F.
Growth of engineered Pseudomonas putida KT2440 on glucose, xylose, and arabinose: Hemicellulose hydrolysates and their major sugars as sustainable carbon sources.
Global Change Biology (GCB) Bioenergy. (2018)

Horlamus F, Wittgens A, Noll P, Michler J, Müller I, Weggenmann F, Oellig C, Rosenau F, Henkel M, Hausmann R .
One‐step bioconversion of hemicellulose polymers to rhamnolipids with Cellvibrio japonicus: A proof‐of‐concept for a potential host strain in future bioeconomy.
Global Change Biology (GCB) Bioenergy. (2018)

Wittgens A, Rosenau F. On the road towards tailor-made rhamnolipids: current state and perspectives.
Appl Microbiol Biotechnol.(2018)

Bodenberger, N. et al. Lectin-Functionalized Composite Hydrogels for "Capture-and-Killing" of Carbapenem-Resistant Pseudomonas aeruginosa.
Biomacromolecules (2018)

Rehage, N. et al. Binding of NUFIP2 to Roquin promotes recognition  and regulation of ICOS mRNA.
Nat. Commun. (2018)

Edelmann, F. et al. Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
Nat. Struct. Mol. Biol. (2017)

The DFG Research Unit FOR2333 " consists of seven German-wide teams (speaker: Ulm University).


The DFG Priority Program SPP1935 aims at understanding RNA-bound determinants of posttranscriptional gene regulation.