Institute

At our institute we combine structural biology (mainly X-ray crystallography), biophysical approaches, and biochemistry with cell biology to allow for an integrated research approach.

Research topics focus on RNA-based gene regulation in eukaryotes (Niessing), structure-guided inhibitor design (Niessing), and various areas of biotechnology, including biomaterials for medical applications and recombinant biosurfactants for a growing bioeconomy (Rosenau). For more details, please visit the groups subpages under the RESEARCH pulldown menue.

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News

Recent Publications

Kubiczek D, Flaig C, Raber H, Dietz S, Kissmann AK, Heerde T, Bodenberger N, Wittgens A, González-Garcia M, Kang F, Franco OL, Staendker L, Otero-González AJ, Walther P, Gottschalk KE, Weil T, Rosenau F.
A Cerberus-Inspired Anti-Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging "Superbug" Yeast Candida auris.
Macromol Biosci. (2020) doi:10.1002/mabi.202000005. PubMed PMID: 32104975.

Bator I, Wittgens A, Rosenau F, Tiso T, Blank LM.
Comparison of Three Xylose Pathways in Pseudomonas putida KT2440 for the Synthesis of Valuable Products
Front Bioeng Biotechnol (2020). doi:10.3389/fbioe2019.00480

Vicente FEM, González-Garcia M, Diaz Pico E, Moreno-Castillo E, Garay HE, Rosi PE, Jimenez AM, Campos-Delgado JA, Rivera DG, Chinea G, Pietro RCLR, Stenger S, Spellerberg B, Kubiczek D, Bodenberger N, Dietz S, Rosenau F, Paixão MW, Ständker L, Otero-González AJ.
Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity.
ACS Omega. (2019) 4(21):19081-19095. doi: 10.1021/acsomega.9b02201. eCollection 2019 Nov 19. PubMed PMID: 31763531; PubMed Central PMCID: PMC6868880.

Arnold S, Henkel M, Wanger J, Wittgens A, Rosenau F, Hausmann R.
Heterologous rhamnolipid biosynthesis by P. putida KT2440 on bio-oil derived small organic acids and fractions
AMB Expr. 9:80. doi: 10.1186/s13568-019-0804-7

Heber S, Gáspár I, Tants J.-N, Günther J, Fernandez Moya S, Janowski R, Ephrussi A, Sattler M, Niessing D.
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Nature Commun. (2019).

Wang Y, Horlamus F, Henkel M, Kovacic F, Schläfle S, Hausmann R, Wittgens A, Rosenau F.
Growth of engineered Pseudomonas putida KT2440 on glucose, xylose, and arabinose: Hemicellulose hydrolysates and their major sugars as sustainable carbon sources.
Global Change Biology (GCB) Bioenergy. (2018)

Horlamus F, Wittgens A, Noll P, Michler J, Müller I, Weggenmann F, Oellig C, Rosenau F, Henkel M, Hausmann R .
One‐step bioconversion of hemicellulose polymers to rhamnolipids with Cellvibrio japonicus: A proof‐of‐concept for a potential host strain in future bioeconomy.
Global Change Biology (GCB) Bioenergy. (2018)

Wittgens A, Rosenau F. On the road towards tailor-made rhamnolipids: current state and perspectives.
Appl Microbiol Biotechnol. (2018)

Bodenberger, N. et al. Lectin-Functionalized Composite Hydrogels for "Capture-and-Killing" of Carbapenem-Resistant Pseudomonas aeruginosa.
Biomacromolecules (2018)

Rehage, N. et al. Binding of NUFIP2 to Roquin promotes recognition  and regulation of ICOS mRNA.
Nat. Commun. (2018)

Edelmann, F. et al. Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
Nat. Struct. Mol. Biol. (2017)