The Institute of Pharmaceutical Biotechnology


At our institute we combine structural biology (mainly X-ray crystallography), biophysical approaches, and biochemistry with cell biology to allow for an integrated research approach.

Research topics focus on RNA-based gene regulation in eukaryotes (Niessing), structure-guided inhibitor design (Niessing), and various areas of biotechnology, including biomaterials for medical applications and recombinant biosurfactants for a growing bioeconomy (Rosenau). For more details, please visit the groups subpages under the INSTITUTE/RESEARCH pulldown menue.


Master or PhD students, please don't hesitate to contact us directly.



Recent Publications

Proske, M., Janowski, R., Bacher, S., Kang, H.-S., Monecke, T., Koehler, T., Hutten, S., Tretter, J., Crois, A., Molitor, L., Varela-Rial, A., Fino, R., Donati, E., de Fabritiis, G., Dormann, D., Sattler, M., & Niessing, D. (2024). PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. 
ELife, 13.

Kissmann, A.K., Bolotnikov, G., Li, R., Müller, F., Xing, H., Krämer,·M., Gottschalk, K.-E., Andersson, J., Weil, T., Rosenau, F. (2024). IMPATIENT‑qPCR: monitoring SELEX success during in vitro aptamer evolution.
Applied Microbiology and Biotechnology  108:284

Zhang, Y., Xing, H., Bolotnikov, G., Krämer, M., Bozdogan, A., Kissmann, A.K., Weil, T., Spellerberg, B., Stenger, S., Rosenau, F. (2024). Robust Fluorometric Aptamer Assay for Direct and Rapid Detection of Clinical Isolates of Candida spec. 
Int. J. Mol. Sci. 2024, 25, 3444. Doi: 10.3390/ijms25063444

Witzenberger, M., Burczyk, S., Settele, D., Mayer, W., Welp, L.M., Heiss, M., Wagner, M., Monecke, T., Janowski, R., Carell, T., Urlaub, H., Hauck, S.M., Voigt, A.* and Niessing, D.* (2023).
Human TRMT2A methylates tRNA and contributes to translation fidelity.
Nucleic Acids Res. Jul 3;gkad565. Online ahead of print.

Lena Molitor*, Melina Klostermann*, Sabrina Bacher, Juliane Merl-Pham, Nadine Spranger, Sandra Burczyk, Carolin Ketteler, Ejona Rusha, Daniel Tews, Anna Pertek, Marcel Proske, Anke Busch, Sarah Reschke, Regina Feederle, Stefanie M Hauck, Helmut Blum, Micha Drukker, Pamela Fischer-Posovszky, Julian König, Kathi Zarnack#, Dierk Niessing#.
Nucleic Acids Research (2023).


Head: Prof. Dr. Dierk Niessing

Secretary: Ursula Seifert
tel: ++ 49 / 731 / 50-23161
fax: ++ 49 / 731 / 50-23169
Room N27 2.076
office hours:
Mon: 07:15-15:45
Wed: 07:15-15:54

Thu: 07:15-11:15

James-Franck-Ring N27; 89081 Ulm

Follow us on Twitter: #theNiessingLabs

How to find us (Map)

The DFG Research Unit FOR2333 " consists of seven German-wide teams (speaker: Ulm University).


The DFG Priority Program SPP1935 aims at understanding RNA-bound determinants of posttranscriptional gene regulation.