The Institute of Pharmaceutical Biotechnology

Institute

At our institute we combine structural biology (mainly X-ray crystallography), biophysical approaches, and biochemistry with cell biology to allow for an integrated research approach.

Research topics focus on RNA-based gene regulation in eukaryotes (Niessing), structure-guided inhibitor design (Niessing), and various areas of biotechnology, including biomaterials for medical applications and recombinant biosurfactants for a growing bioeconomy (Rosenau). For more details, please visit the groups subpages under the RESEARCH pulldown menue.

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Watch our video with lab impressions from our research on PURA syndrome

News

Recent Publications

Molitor M.*, Bacher S.*, Burczyk S.*, Niessing D
The molecular function of PURA and its implications in neurological diseases.
Frontiers in Genetics (2021) doi.org/10.3389/fgene.2021.638217

Yan Wang,  Dennis Kubiczek,  Felix Horlamus,  Heinz Fabian Raber,  Till Hennecke,  Daniel Einfalt,  Marius Henkel,  Rudolf Hausmann,  Andreas Wittgens,  Frank Rosenau
Bioconversion of lignocellulosic to high value food proteins: recombinant production of bovine and human αS1‐casein based on wheat straw lignocelluloses
Global Change Biology (GCB) Bioenergy. (2020) doi:10.1111/gcbb.12791

Heinz Fabian Raber, Thomas Heerde, Suzanne Nour El Din, Carolin Flaig, Fabienne Hilgers, Nora Bitzenhofer, Karl-Erich Jäger, Thomas Drepper, Kay-Eberhard Gottschalk, Nicholas Emil Bodenberger, Tanja Weil, Dennis Horst Kubiczek, Frank Rosenau
Azulitox?A Pseudomonas aeruginosa P28-Derived Cancer-Cell-Specific Protein Photosensitizer
Biomacromolecules (2020) doi: 10.1021/acs.biomac.0c01216.

Kubiczek D, Flaig C, Raber H, Dietz S, Kissmann AK, Heerde T, Bodenberger N, Wittgens A, González-Garcia M, Kang F, Franco OL, Staendker L, Otero-González AJ, Walther P, Gottschalk KE, Weil T, Rosenau F.
A Cerberus-Inspired Anti-Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging "Superbug" Yeast Candida auris.
Macromol Biosci. (2020) doi:10.1002/mabi.202000005. PubMed PMID: 32104975.

Bator I, Wittgens A, Rosenau F, Tiso T, Blank LM.
Comparison of Three Xylose Pathways in Pseudomonas putida KT2440 for the Synthesis of Valuable Products
Front Bioeng Biotechnol (2020). doi:10.3389/fbioe2019.00480

Heber S, Gáspár I, Tants J.-N, Günther J, Fernandez Moya S, Janowski R, Ephrussi A, Sattler M, Niessing D.
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Nature Commun. (2019).

Vicente FEM, González-Garcia M, Diaz Pico E, Moreno-Castillo E, Garay HE, Rosi PE, Jimenez AM, Campos-Delgado JA, Rivera DG, Chinea G, Pietro RCLR, Stenger S, Spellerberg B, Kubiczek D, Bodenberger N, Dietz S, Rosenau F, Paixão MW, Ständker L, Otero-González AJ.
Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity.
ACS Omega. (2019) 4(21):19081-19095. doi: 10.1021/acsomega.9b02201. eCollection 2019 Nov 19. PubMed PMID: 31763531; PubMed Central PMCID: PMC6868880.

Rehage, N. et al. Binding of NUFIP2 to Roquin promotes recognition  and regulation of ICOS mRNA.
Nat. Commun. (2018)

The DFG Research Unit FOR2333 " consists of seven German-wide teams (speaker: Ulm University).
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The DFG Priority Program SPP1935 aims at understanding RNA-bound determinants of posttranscriptional gene regulation.