The Institute of Pharmaceutical Biotechnology

Institute

At our institute we combine structural biology (mainly X-ray crystallogrpahy), biophysical approaches, and biochemistry with cell biology to allow for an integrated research approach.

Research topics focus on RNA-based gene regulation in eukaryotes (Niessing), structure-guided inhibitor design (Niessing), and various areas of biotechnology, including biomaterials for medical applications and recombinant biosurfactants for a growing bioeconomy (Rosenau). For more details, please visit the groups subpages under the RESEARCH pulldown menue.

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News

Recent Publications

Horlamus F, Wittgens A, Noll P, Michler J, Müller I, Weggenmann F, Oellig C, Rosenau F, Henkel M, Hausmann R .
One‐step bioconversion of hemicellulose polymers to rhamnolipids with Cellvibrio japonicus: A proof‐of‐concept for a potential host strain in future bioeconomy.
Global Change Biology (GCB) Bioenergy. (2018)

Wittgens A, Rosenau F. On the road towards tailor-made rhamnolipids: current state and perspectives.
Appl Microbiol Biotechnol. (2018)

Bodenberger, N. et al. Lectin-Functionalized Composite Hydrogels for "Capture-and-Killing" of Carbapenem-Resistant Pseudomonas aeruginosa. Biomacromolecules (2018)

Rehage, N. et al. Binding of NUFIP2 to Roquin promotes recognition  and regulation of ICOS mRNA.
Nat. Commun
. ( 2018)

Edelmann, F. et al. Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
Nat. Struct. Mol. Biol.
(2017)

Weber, J. et al. Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
eLife
(2016)

The DFG Research Unit FOR2333 " consists of seven German-wide teams (speaker: Ulm University).
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The DFG Priority Program SPP1935 aims at understanding RNA-bound determinants of posttranscriptional gene regulation.