The Institute of Pharmaceutical Biotechnology
Imagine a big city without a car driving and no mail being delivered. The resulting chaos is similar to what happens to a cell when its molecular transport systems are impaired. Our goal is to understand the molecular principles underlying cargo recognition by transport complexes, complex assembly and activation, and eventually complex disassembly after the transport. Our research tools are X-ray crystallography, quantitative biophysical approaches, biochemistry, and in vivo studies.
The DFG Research Unit FOR2333 "Macromolecular complexes in mRNA localization" consists of seven teams throughout Germany and is funded since 2016 (speaker: D. Niessing, vice-speaker: Michael Feldbrügge, Uni Düsseldorf).
Rehage, N. et al. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Nat. Commun. ( 2018)
Edelmann, F. et al. Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
Nat. Struct. Mol. Biol. (2017)
Weber, J. et al. Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
Heym, R.G. et al. In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation.
J. Cell Biol. (2013)