The Institute of Pharmaceutical Biotechnology


At our institute we combine structural biology (mainly X-ray crystallography), biophysical approaches, and biochemistry with cell biology to allow for an integrated research approach.

Research topics focus on RNA-based gene regulation in eukaryotes (Niessing), structure-guided inhibitor design (Niessing), and various areas of biotechnology, including biomaterials for medical applications and recombinant biosurfactants for a growing bioeconomy (Rosenau). For more details, please visit the groups subpages under the INSTITUTE/RESEARCH pulldown menue.



Recent Publications

Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth TFE, Strauß G, Boldrin E, Posovszky C, Schulz A, Beringer O, Rieser E, Jacobsen EM, Lorenz MR, Schwarz K, Pannicke U, Walczak H, Niessing D, Schuetz C, Fischer-Posovszky P, Debatin KM.
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
EMBO Mol Med. (2022), 14(3):e14901.

Valerie Amann, Ann-Kathrin Kissmann, Markus Krämer, Imke Krebs, Julio A. Perez-Erviti, Anselmo J. Otero-Gonzalez, Fidel Morales-Vicente, Armando Rodríguez, Ludger Ständker, Tanja Weil and Frank Rosenau
"Increased activities against biofilms of the pathogenic yeast Candida
albicans of optimized Pom-1 derivatives"
Pharmaceutics 2022, 14(2), 318;

Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V.
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Nat Immunol. 2021 Nov 22. doi: 10.1038/s41590-021-01064-3.

Heinz F. Raber, Dennis H. Kubiczek, Nicholas Bodenberger, Ann-Kathrin Kissmann, Deena D’souza, Hu Xing, Daniel Mayer, Pengfei Xu, Uwe Knippschild, Barbara Spellerberg, Tanja Weil and Frank Rosenau
FluCell-SELEX Aptamers as Specific Binding Molecules for Diagnostics of the Health Relevant Gut Bacterium Akkermansia muciniphila
International Journal of Molecular Sciences (2021) 22, no. 19: 10425.

Patrizia Favella, Ann-Kathrin Kissmann, Heinz Fabian Raber, Dennis Horst Kubiczek, Patrick Bodenberger, Nicholas Emil Bodenberger, Frank Rosenau,
Diffusion-controlled release of the theranostic protein-photosensitizer Azulitox from composite of Fmoc-Phenylalanine Fibrils encapsulated with BSA hydrogels,
Journal of Biotechnology, (2021) Volume 341, 51-62, ISSN 0168-1656,

Melaine González-García, Fidel Morales-Vicente, Erbio D. Pico, Hilda Garay, Daniel G. Rivera, Mark Grieshober, Lia Raluca Olari, Rüdiger Groß, Carina Conzelmann, Franziska Krüger, Fabian Zech, Caterina Prelli Bozzo, Janis A. Müller, Alexander Zelikin, Heinz Raber, Dennis Kubiczek, Frank Rosenau, Jan Münch, Steffen Stenger, Barbara Spellerberg, Octavio L. Franco, Armando A. Rodriguez Alfonso, Ludger Ständker and Anselmo J. Otero-Gonzalez
Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains" 
Biomolecules (2021) 11, no. 5: 745.

Heinz F. Raber, Jetmira Sejfijaj, Ann-Kathrin Kissmann, Andreas Wittgens, Melaine Gonzalez-Garcia, Annia Alba, Antonio A. Vázquez, Fidel E. Morales Vicente, Julio P. Erviti, Dennis Kubiczek, Anselmo Otero-González, Armando Rodríguez, Ludger Ständker, and Frank Rosenau.
Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against CandidaaurisC. parapsilosis and C. albicans Biofilms
Pathogens (2021). 10, no. 4: 496.

Molitor M.*, Bacher S.*, Burczyk S.*, Niessing D
The molecular function of PURA and its implications in neurological diseases.
Frontiers in Genetics (2021)

Yan Wang,  Dennis Kubiczek,  Felix Horlamus,  Heinz Fabian Raber,  Till Hennecke,  Daniel Einfalt,  Marius Henkel,  Rudolf Hausmann,  Andreas Wittgens,  Frank Rosenau
Bioconversion of lignocellulosic to high value food proteins: recombinant production of bovine and human αS1‐casein based on wheat straw lignocelluloses
Global Change Biology (GCB) Bioenergy. (2020) doi:10.1111/gcbb.12791

Heinz Fabian Raber, Thomas Heerde, Suzanne Nour El Din, Carolin Flaig, Fabienne Hilgers, Nora Bitzenhofer, Karl-Erich Jäger, Thomas Drepper, Kay-Eberhard Gottschalk, Nicholas Emil Bodenberger, Tanja Weil, Dennis Horst Kubiczek, Frank Rosenau
Azulitox?A Pseudomonas aeruginosa P28-Derived Cancer-Cell-Specific Protein Photosensitizer
Biomacromolecules (2020) doi: 10.1021/acs.biomac.0c01216.

Kubiczek D, Flaig C, Raber H, Dietz S, Kissmann AK, Heerde T, Bodenberger N, Wittgens A, González-Garcia M, Kang F, Franco OL, Staendker L, Otero-González AJ, Walther P, Gottschalk KE, Weil T, Rosenau F.
A Cerberus-Inspired Anti-Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging "Superbug" Yeast Candida auris.
Macromol Biosci. (2020) doi:10.1002/mabi.202000005. PubMed PMID: 32104975.

Bator I, Wittgens A, Rosenau F, Tiso T, Blank LM.
Comparison of Three Xylose Pathways in Pseudomonas putida KT2440 for the Synthesis of Valuable Products
Front Bioeng Biotechnol (2020). doi:10.3389/fbioe2019.00480

Heber S, Gáspár I, Tants J.-N, Günther J, Fernandez Moya S, Janowski R, Ephrussi A, Sattler M, Niessing D.
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Nature Commun. (2019), 10

Head: Prof. Dr. Dierk Niessing

Secretary: Anne Scheiffele
tel: ++ 49 / 731 / 50-23161
fax: ++ 49 / 731 / 50-23169
Room N27 2.076
(Mo, We, Thu: 8-1 PM, Tue: 1-5 PM)

James-Franck-Ring N27; 89081 Ulm

Follow us on Twitter: #theNiessingLabs

How to find us (Map)

The DFG Research Unit FOR2333 " consists of seven German-wide teams (speaker: Ulm University).


The DFG Priority Program SPP1935 aims at understanding RNA-bound determinants of posttranscriptional gene regulation.