08.02.2026 New Publication:
Phage Display-Derived Peptides Have Neutralizing Activities Against Biofilm Formation by Candida albicans, Candidozyma auris and Candida parapsilosis
https://doi.org/10.3390/ph19020286
31.01.2026 Joint Publication with Researchers from Boehringer Ingelheim:
Antigen affinity chromatography for functional separation and efficient characterization of critical monoclonal antibody variants
https://doi.org/10.1016/j.chroma.2026.466761
22.01.2026 New Publication:
Microbiota from young mice restore the function of aged ISCs
https://doi.org/10.1016/j.stemcr.2025.102788
08.01.2026 New Publication:
Integrating Computational and Experimental Approaches for the Discovery of Multifunctional Peptides from the Marine Gastropod Pisania pusio with Antimicrobial and Anticancer Properties
https://doi.org/10.3390/md24010032
29.12.2025 New Publication:
Photoactive Hydrogels Containing Merocyanine/Spiropyran Units for Wound Dressing Applications
https://doi.org/10.1021/acs.biomac.5c01956
Research Visit at University Ulm
During a two-week research stay at the University of Ulm, we were pleased to host Dr. Gonzalo Fenoy from the Danube Private University (DPU), our partner in the PI-SENS project led by Prof. Kleber at DPU, for a series of collaborative experiments aimed at advancing our aptamer-based biosensing platforms for bacterial detection. His visit enabled close hands-on work with our team, the exchange of methodological expertise, and the definition of concrete technical milestones for the next project phase. We thank Dr. Fenoy for the productive collaboration and look forward to continuing our joint progress within PI-SENS. More information about PI-SENS is available on the official website: https://www.dpu-research-pisens.at/
10.12.2025 New Publication:
Amyloid fibrils of the Als5p-derived peptide NH2-SNGIVIVATTRTV-COOH influence the biofilm formation of Candida albicans by shape-edging microcolony morphology
https://doi.org/10.1080/21505594.2025.2597576
03.10.2025 New Publication:
Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling
https://doi.org/10.1038/s41392-025-02424-3
14.08.2025 New Publication:
FluMag-SELEX derived specific individual aptamers can fluorescently label the ageing immanent protein-crosslinker glucosepane in diabetic mouse tissues
14.09.2025 New Publication:
An Aptamer-Based gFET-Sensor for Specific Quantification of Gene Therapeutic Human Adenovirus Type 5
12.07.2025 New Publication:
The Power of Old Hats: Rediscovering Inosine-EpPCR to Create Starting Libraries for Whole-Cell-SELEX
This new study by Grigory Bolotnikov, Ann-Kathrin Kissmann, Daniel Gruber, Andreas Bellmann and Frank Rosenau (Institute of Pharmaceutical Biotechnology, Ulm University, Germany) and Roger Hasler, Christoph Kleber, Wolfgang Knoll (DPU, Krems) brings renewed attention to a long-overlooked technique — error-prone PCR using inosine — as a surprisingly powerful way to create diverse molecular aptamer libraries. These short DNA sequences can be evolved in the laboratory to bind specific targets, such as bacteria or human cells, and have wide applications in diagnostics and therapeutics. Instead of relying on expensive, pre-made DNA libraries, the decision was made to start with a very simple DNA sequence using a low-cost method involving the nucleobase analogon inosine to introduce variation. The resulting libraries were then tested against ten very different targets, including beneficial and harmful bacteria as well as human cells. After only two rounds of selection, many of the resulting aptamers showed new and specific binding abilities — proving the method works. In essence, this work shows that older, simpler scientific tools — when applied creatively — can still solve modern problems. The key takeaway is that inosine-based error-prone PCR offers a cost-effective, accessible way to kickstart aptamer development, making it easier for more researchers to enter the field. Link to the article: https://doi.org/10.3390/bios15070448.
03.07.2025 New Publication:
A combined experimental and theoretical approach to unveil the antimicrobial performance and mechanism of graphene quantum dots for disinfecting multidrug-resistant bacteria
