|Projektteam am Institut||Gabriele Nagel|
The metabolic syndrome (MetS) encompassing obesity, insulin resistance, hypertension and dyslipidaemia, is strongly influenced by nutritional lifestyle. The MetS has consistently been related to an increased risk of cardiovascular disease, stroke and diabetes, but little is known about the association with cancer. Obesity, a key feature of the MetS, has consistently been related to an increased risk of cancer overall and to cancer at some specific sites. However, less is known about the association of cancer to other MetS factors, in single or jointly.
The Me-Can cohort includes nearly 600 000 subjects with prospectively collected data on factors in the MetS, including body mass index, blood pressure, and blood glucose from sub-cohorts in Austria, Norway, and Sweden. The total number of incident cancers is nearly 40000. Factors in the MetS, in single and jointly, will be related to cancer incidence and cancer mortality, overall and for cancer at specific sites. Relative and absolute risk will be calculated as well as the fraction of cancer attributable to the MetS.
We expect factors in the MetS to be positively related to incident and fatal overall cancer risk and to risk of cancer at some specific sites, with a higher risk for subjects with presence of several MetS factors.
Beitrag des Instituts
1. NOR Data from Norwegian Health Surveys, Norway Tone Bjørge, Dept of Public Health and Primary Health Care
2. MPM Malmö Preventive Medicine, Sweden Jonas Manjer, Dept of Medicine, Malmö University Hospital, Surgery and Orthopaedics,
3. VHM&PP Vorarlberg Health Monitoring and Prevention Program, Austria Kilian Rapp, Institute of Epidemiology, University of Ulm, Germany
4. VIP Västerbotten Intervention Project, Sweden Pär Stattin, Dept of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University Hospital, Umeå, Sweden Co-ordinator Tanja Stocks, Dept of Perioperative Surgery, Urology and Andrology, Umeå University Hospital, Umeå, Sweden