Zusammenstellung von Bildern aus dem Sonderforschungsbereich

CRC related publications


M. Mannes, C. Q. Schmidt, B. Nilsson, K. N. Ekdahl and M. Huber-Lang, "Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis", Semin Immunopathol, vol. 43, no. 6, pp. 773-788, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34191093 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243057/pdf/281_2021_Article_872.pdf
C. Ehrnthaller, S. Braumuller, S. Kellermann, F. Gebhard, M. Perl and M. Huber-Lang, "Complement Factor C5a Inhibits Apoptosis of Neutrophils-A Mechanism in Polytrauma?", J Clin Med, vol. 10, no. 14, pp. 3157, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34300323 https://mdpi-res.com/d_attachment/jcm/jcm-10-03157/article_deploy/jcm-10-03157-v2.pdf
M. S. Huber-Lang, A. Ignatius, J. Kohl, M. Mannes and C. K. Braun, "Complement in Trauma - Traumatised Complement?", Br J Pharmacol, vol. 178, no. 14, pp. 2863-2879, 2021.
M. Mannes, A. Dopler, O. Zolk, S. J. Lang, R. Halbgebauer, B. Hochsmann, A. Skerra, C. K. Braun, M. Huber-Lang, H. Schrezenmeier and C. Q. Schmidt, "Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity", Blood, vol. 137, no. 4, pp. 443-455, 2021.
File:https://www.ncbi.nlm.nih.gov/pubmed/33507296 https://ashpublications.org/blood/article-abstract/137/4/443/474570/Complement-inhibition-at-the-level-of-C3-or-C5?redirectedFrom=fulltext
J. Scekic-Zahirovic, I. Sanjuan-Ruiz, V. Kan, S. Megat, P. De Rossi, S. Dieterle, R. Cassel, M. Jamet, P. Kessler, D. Wiesner, L. Tzeplaeff, V. Demais, S. Sahadevan, K. M. Hembach, H. P. Muller, G. Picchiarelli, N. Mishra, S. Antonucci, S. Dirrig-Grosch, J. Kassubek, V. Rasche, A. Ludolph, A. L. Boutillier, F. Roselli, M. Polymenidou, C. Lagier-Tourenne, S. Liebscher and L. Dupuis, "Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects", Nat Commun, vol. 12, no. 1, pp. 3028, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34021132 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140148/pdf/41467_2021_Article_23187.pdf
M. Singer, P. J. Young, J. G. Laffey, P. Asfar, F. S. Taccone, M. B. Skrifvars, C. S. Meyhoff and P. Radermacher, "Dangers of hyperoxia", Crit Care, vol. 25, no. 1, pp. 440, 2021.
P. Pfänder, A. K. Eiers, U. Burret and S. Vettorazzi, "Deletion of Cdk5 in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10", Int J Mol Sci, vol. 22, no. 17, pp. 9648, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34502552 https://mdpi-res.com/d_attachment/ijms/ijms-22-09648/article_deploy/ijms-22-09648-v2.pdf
B. Trautwein, T. Merz, N. Denoix, C. Szabo, E. Calzia, P. Radermacher and O. McCook, "DeltaMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage", Antioxidants (Basel), vol. 10, no. 2, pp. 233, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33546491 https://mdpi-res.com/d_attachment/antioxidants/antioxidants-10-00233/article_deploy/antioxidants-10-00233-v2.pdf
A. Mossa, J. Pagano, L. Ponzoni, A. Tozzi, E. Vezzoli, M. Sciaccaluga, C. Costa, S. Beretta, M. Francolini, M. Sala, P. Calabresi, T. M. Boeckers, C. Sala and C. Verpelli, "Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice", Molecular Psychiatry, vol. 26, pp. 1928–1944, 2021.
M. Haffner-Luntzer, V. Fischer and A. Ignatius, "Differences in Fracture Healing Between Female and Male C57BL/6J Mice", Front Physiol, vol. 12, pp. 1227, 2021.
Z. Li, J. Zhang, S. Halbgebauer, A. Chandrasekar, R. Rehman, A. Ludolph, T. Boeckers, M. Huber-Lang, M. Otto, F. Roselli and F. O. Heuvel, "Differential effect of ethanol intoxication on peripheral markers of cerebral injury in murine blunt traumatic brain injury", Burns Trauma, vol. 9, pp. tkab027, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34604393 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484207/pdf/tkab027.pdf
D. Bayer, S. Antonucci, H. P. Muller, R. Saad, L. Dupuis, V. Rasche, T. M. Böckers, A. C. Ludolph, J. Kassubek and F. Roselli, "Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients", Transl Neurodegener, vol. 10, no. 1, pp. 17, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34059131 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168014/pdf/40035_2021_Article_241.pdf
D. A. C. Messerer, M. Fauler, A. Horneffer, A. Schneider, O. Keis, L. M. Mauder and P. Radermacher, "Do medical students recognise the deteriorating patient by analysing their vital signs? A monocentric observational study based on the National Early Warning Score 2", BMJ Open, vol. 11, no. 2, pp. e044354, 2021.
B. Weber, I. Lackner, T. Miclau, J. Stulz, F. Gebhard, R. Pfeifer, P. Cinelli, S. Halvachizadeh, M. Teuben, H. C. Pape, M. Lipiski, N. Cesarovic and M. Kalbitz, "Early myocardial damage (EMD) and valvular dysfunction after femur fracture in pigs", Sci Rep, vol. 11, no. 1, pp. 8503, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33875675 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055677/pdf/41598_2021_Article_86151.pdf
B. Weber, I. Lackner, M. Baur, F. Gebhard, R. Pfeifer, P. Cinelli, S. Halvachizadeh, M. Teuben, H. C. Pape, A. Imhof, M. Lipiski, N. Cesarovic and M. Kalbitz, "Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs", Sci Rep, vol. 11, no. 1, pp. 1151, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33441945 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806767/pdf/41598_2020_Article_80409.pdf
R. Cintean, C. Pankratz, F. Gebhard and K. Schutze, "Early Results in Non-Displaced Femoral Neck Fractures Using the Femoral Neck System", Geriatr Orthop Surg Rehabil, vol. 12, pp. 21514593211050153, 2021.
File:https://www.ncbi.nlm.nih.gov/pubmed/34733579 https://journals.sagepub.com/doi/pdf/10.1177/21514593211050153
F. Zink, J. Vogt, U. Wachter, J. Hartert, M. Horchler, F. Hezel, T. Kapapa, T. Datzmann, A. Hoffmann, M. Wepler, E. Calzia, P. Radermacher and C. Hartmann, "Effects of Acute Subdural Hematoma-Induced Brain Injury On Energy Metabolism in Peripheral Blood Mononuclear Cells", Shock, vol. 55, no. 3, pp. 407-417, 2021.
S. Ehnert, B. Relja, K. Schmidt-Bleek, V. Fischer, A. Ignatius, C. Linnemann, H. Rinderknecht, M. Huber-Lang, M. Kalbitz, T. Histing and A. Nüssler, "Effects of immune cells on mesenchymal stem cells during fracture healing", World J Stem Cells, vol. 13, no. 11, pp. 1667-1695, 2021.
DOI:DOI: 10.4252/wjsc.v13.i11.1667
S. Preau, D. Vodovar, B. Jung, S. Lancel, L. Zafrani, A. Flatres, M. Oualha, G. Voiriot, Y. Jouan, J. Joffre, F. Huel, N. De Prost, S. Silva, E. Azabou and P. Radermacher, "Energetic dysfunction in sepsis: a narrative review", Ann Intensive Care, vol. 11, no. 1, pp. 104, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34216304 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254847/pdf/13613_2021_Article_893.pdf
S. A. Appiah, C. L. Foxx, D. Langgartner, A. Palmer, C. A. Zambrano, S. Braumuller, E. J. Schaefer, U. Wachter, B. L. Elam, P. Radermacher, C. E. Stamper, J. D. Heinze, S. N. Salazar, A. K. Luthens, A. L. Arnold, S. O. Reber, M. Huber-Lang, C. A. Lowry and R. Halbgebauer, "Evaluation of the gut microbiome in association with biological signatures of inflammation in murine polytrauma and shock", Sci Rep, vol. 11, no. 1, pp. 6665, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33758228 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988149/pdf/41598_2021_Article_85897.pdf
A. Kerstan, E. Niebergall-Roth, J. Esterlechner, H. M. Schroder, M. Gasser, A. M. Waaga-Gasser, M. Goebeler, K. Rak, P. Schrufer, S. Endres, P. Hagenbusch, K. Kraft, K. Dieter, S. Ballikaya, N. Stemler, S. Sadeghi, N. Tappenbeck, G. F. Murphy, D. P. Orgill, N. Y. Frank, C. Ganss, K. Scharffetter-Kochanek, M. H. Frank and M. A. Kluth, "Ex vivo-expanded highly pure ABCB5(+) mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data", Cytotherapy, vol. 23, no. 2, pp. 165-175, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33011075 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310651/pdf/nihms-1714686.pdf
M. Haffner-Luntzer, "Experimental agents to improve fracture healing: utilizing the WNT signaling pathway", Injury, vol. 52, pp. S44-S48, 2021.
O. McCook, N. Denoix, P. Radermacher, C. Waller and T. Merz, "H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease", J Clin Med, vol. 10, no. 16, pp. 3484, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34441780 https://mdpi-res.com/d_attachment/jcm/jcm-10-03484/article_deploy/jcm-10-03484-v2.pdf
T. Datzmann, T. Merz, O. McCook, C. Szabo and P. Radermacher, "H2S as a Therapeutic Adjuvant Against COVID-19: Why and How?", Shock, vol. 56, no. 5, pp. 865-867, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33443365 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518209/pdf/shk-56-865.pdf
L. Debler, A. Palmer, S. Braumuller, B. Klohs, T. E. Mollnes, K. Holzmann, M. Huber-Lang and R. Halbgebauer, "Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury", Mediators Inflamm, vol. 2021, pp. 6654318, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33574730 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857921/pdf/MI2021-6654318.pdf
C. Ehrnthaller, A. Schultze, G. Wakileh, T. Neff, S. Häfner, P. Radermacher and M. Huber-Lang, "Hemorrhagic shock induces renal complement activation", Eur J Trauma Emerg Surg, vol. 47, no. 2, pp. 373-380, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/31309238 https://link.springer.com/content/pdf/10.1007/s00068-019-01187-1.pdf
A. Bühler, B. M. Gahr, D. D. Park, A. Bertozzi, A. Boos, M. Dalvoy, A. Pott, F. Oswald, R. A. Kovall, B. Kühn, G. Weidinger, W. Rottbauer and S. Just, "Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish", PLoS Genet, vol. 17, no. 11, pp. e1009890, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34723970 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584950/pdf/pgen.1009890.pdf
A. Magnutzki, N. O. Alami, M. Lattke, T. M. Hein, J. S. Scheller, C. Kroger, F. Oswald, D. Yilmazer-Hanke, T. Wirth and B. Baumann, "IKK2/NF-kappaB Activation in Astrocytes Reduces amyloid beta Deposition: A Process Associated with Specific Microglia Polarization", Cells, vol. 10, no. 10, pp. 2669, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34685649 https://mdpi-res.com/d_attachment/cells/cells-10-02669/article_deploy/cells-10-02669-v3.pdf
D. A. C. Messerer, R. Halbgebauer, B. Nilsson, H. Pavenstadt, P. Radermacher and M. Huber-Lang, "Immunopathophysiology of trauma-related acute kidney injury", Nat Rev Nephrol, vol. 17, no. 2, pp. 91-111, 2021.
File:https://www.ncbi.nlm.nih.gov/pubmed/32958893 https://www.nature.com/articles/s41581-020-00344-9
P. Kolb, A. Schundner, M. Frick and K. E. Gottschalk, "In Vitro Measurements of Cellular Forces and their Importance in the Lung-From the Sub- to the Multicellular Scale", Life (Basel), vol. 11, no. 7, pp. 691, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34357063 https://mdpi-res.com/d_attachment/life/life-11-00691/article_deploy/life-11-00691.pdf
K. Luntzer, I. Lackner, B. Weber, Y. Mödinger, A. Ignatius, F. Gebhard, S. Y. Mihaljevic, M. Haffner-Luntzer and M. Kalbitz, "Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption", Int J Mol Sci, vol. 22, no. 5, pp. 2759, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33803323 https://mdpi-res.com/d_attachment/ijms/ijms-22-02759/article_deploy/ijms-22-02759.pdf
C. Cherifi, A. Latourte, S. Vettorazzi, J. Tuckermann, S. Provot, H. K. Ea, A. Ledoux, J. Casas, O. Cuvillier, P. Richette, A. Ostertag, E. Hay and M. Cohen-Solal, "Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis", Osteoarthritis Cartilage, vol. 29, no. 9, pp. 1335-1345, 2021.
Y. Hachemi, A. E. Rapp, S. Lee, A. Dorn, B. T. Krüger, K. Kaiser, A. Ignatius and J. Tuckermann, "Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing", Front Immunol, vol. 11, pp. 628287, 2021.
S. Bernhard, S. Hug, A. E. P. Stratmann, M. Erber, L. Vidoni, C. L. Knapp, B. D. Thomass, M. Fauler, B. Nilsson, K. Nilsson Ekdahl, K. Fohr, C. K. Braun, L. Wohlgemuth, M. Huber-Lang and D. A. C. Messerer, "Interleukin 8 Elicits Rapid Physiological Changes in Neutrophils That Are Altered by Inflammatory Conditions", J Innate Immun, vol. 13, no. 4, pp. 225-241, 2021.
File:https://www.ncbi.nlm.nih.gov/pubmed/33857948 https://www.karger.com/Article/Pdf/514885
D. A. C. Messerer, H. Schmidt, M. Frick and M. Huber-Lang, "Ion and Water Transport in Neutrophil Granulocytes and Its Impairment during Sepsis", Int J Mol Sci, vol. 22, no. 4, pp. 1699, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33567720 https://mdpi-res.com/d_attachment/ijms/ijms-22-01699/article_deploy/ijms-22-01699-v2.pdf
A. Bertozzi, C. C. Wu, P. D. Nguyen, M. D. Vasudevarao, M. A. Mulaw, C. D. Koopman, T. P. Boer, J. Bakkers and G. Weidinger, "Is zebrafish heart regeneration "complete"? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts", Dev Biol, vol. 471, pp. 106-118, 2021.
S. Lee, P. Liu and M. Ahmad, "Leukemia inhibitory factor treatment attenuates the detrimental effects of glucocorticoids on bone in mice", Bone, vol. 145, pp. 115843, 2021.
O. McCook, A. Scheuerle, N. Denoix, T. Kapapa, P. Radermacher and T. Merz, "Localization of the hydrogen sulfide and oxytocin systems at the depth of the sulci in a porcine model of acute subdural hematoma", Neural Regen Res, vol. 16, no. 12, pp. 2376-2382, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33907009 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374554/pdf/NRR-16-2376.pdf
T. Merz, S. Kress, M. Gröger, P. Radermacher and O. McCook, "Mouse Intensive Care Unit (MICU)", Methods Mol Biol, vol. 2321, pp. 121-135, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34048012 https://link.springer.com/content/pdf/10.1007%2F978-1-0716-1488-4_11.pdf
A. Streitberg, S. Jakel, J. E. Bernhardi, C. Straube, F. Buggenthin, C. Marr and L. Dimou, "NG2-Glia Transiently Overcome Their Homeostatic Network and Contribute to Wound Closure After Brain Injury", Frontiers in Cell and Developmental Biology, vol. 9, pp. 15, 2021.
B. Wildemann, A. Ignatius, F. Leung, L. A. Taitsman, R. M. Smith, R. Pesantez, M. J. Stoddart, R. G. Richards and J. B. Jupiter, "Non-union bone fractures", Nat Rev Dis Primers, vol. 7, no. 1, pp. 57, 2021.
F. Gärtner, A. Gihring, A. Roth, J. Bischof, P. Xu, L. Elad, M. Wabitsch, T. Burster and U. Knippschild, "Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex", Frontiers in Immunology, vol. 12, 2021.
P. Maity, K. Singh, L. Krug, A. Koroma, A. Hainzl, W. Bloch, S. Kochanek, M. Wlaschek, M. Schorpp-Kistner, P. Angel, A. Ignatius, H. Geiger and K. Scharffetter-Kochanek, "Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging", Cell Rep, vol. 36, no. 9, pp. 109634, 2021.
K. Ernst, A. K. Mittler, V. Winkelmann, C. Kling, N. Eberhardt, A. Anastasia, M. Sonnabend, R. Lochbaum, J. Wirsching, M. Sakari, A. T. Pulliainen, C. Skerry, N. H. Carbonetti, M. Frick and H. Barth, "Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo", Sci Rep, vol. 11, no. 1, pp. 5429, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33686161 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940712/pdf/41598_2021_Article_84817.pdf
Z. Najafova, P. Liu, F. Wegwitz, M. Ahmad, L. Tamon, R. L. Kosinsky, W. Xie, S. A. Johnsen and J. Tuckermann, "RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk", Cell Death Differ, vol. 28, no. 2, pp. 700-714, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/32901120 https://www.nature.com/articles/s41418-020-00614-w.pdf
S. Chakraborty, V. E. Winkelmann, S. Braumuller, A. Palmer, A. Schultze, B. Klohs, A. Ignatius, A. Vater, M. Fauler, M. Frick and M. Huber-Lang, "Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock", Sci Rep, vol. 11, no. 1, pp. 2158, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/33495506 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835219/pdf/41598_2020_Article_79607.pdf
E. Daini, S. Hagmeyer, C. A. De Benedictis, J. S. Cristovao, M. Bodria, A. M. Ross, A. Raab, T. M. Boeckers, J. Feldmann, C. M. Gomes, M. Zoli, A. Vilella and A. M. Grabrucker, "S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis", Translational Psychiatry, vol. 11, no. 1, pp. 13, 2021.
H. P. Muller, D. Lule, F. Roselli, A. Behler, A. C. Ludolph and J. Kassubek, "Segmental involvement of the corpus callosum in C9orf72-associated ALS: a tract of interest-based DTI study", Ther Adv Chronic Dis, vol. 12, pp. 20406223211002969, 2021.
File:https://www.ncbi.nlm.nih.gov/pubmed/33815737 https://journals.sagepub.com/doi/pdf/10.1177/20406223211002969
K. Schuetze, A. Eickhoff, C. Dehner, A. Blidon, F. Gebhard and P. H. Richter, "Short-term outcome of fragility fractures of the pelvis in the elderly treated with screw osteosynthesis and external fixator", Eur J Trauma Emerg Surg, 2021.
A. E. P. Stratmann, L. Wohlgemuth, M. E. Erber, S. Bernhard, S. Hug, M. Fauler, L. Vidoni, A. O. K. Mohamed, B. D. Thomass, F. Munnich, L. Stukan, K. J. Fohr, M. Mannes, M. S. Huber-Lang and D. A. C. Messerer, "Simultaneous Measurement of Changes in Neutrophil Granulocyte Membrane Potential, Intracellular pH, and Cell Size by Multiparametric Flow Cytometry", Biomedicines, vol. 9, no. 11, pp. 1504, 2021.
File:pdfhttps://www.ncbi.nlm.nih.gov/pubmed/34829733 https://mdpi-res.com/d_attachment/biomedicines/biomedicines-09-01504/article_deploy/biomedicines-09-01504-v4.pdf