Zusammenstellung von Bildern aus dem Sonderforschungsbereich

CRC related publications

2016

64.
C. Heise, J. C. Schroeder, M. Schoen, S. Halbedl, D. Reim, S. Woelfle, M. R. Kreutz, M. J. Schmeisser and T. M. Boeckers, "Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus", Front Cell Neurosci, vol. 10, pp. 106, 2016.
DOI:10.3389/fncel.2016.00106
File:https://www.ncbi.nlm.nih.gov/pubmed/27199660
63.
P. Asfar, J. A. Russell, J. Tuckermann and P. Radermacher, "Selepressin in Septic Shock: A Step Toward Decatecholaminization?", Crit Care Med, vol. 44, no. 1, pp. 234-6, 2016.
DOI:10.1097/CCM.0000000000001441
File:https://www.ncbi.nlm.nih.gov/pubmed/26672929
62.
S. Halbedl, M. Schoen, M. S. Feiler, T. M. Boeckers and M. J. Schmeisser, "Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals", J Neurochem, vol. 137, no. 1, pp. 26-32, 2016.
DOI:10.1111/jnc.13523
File:https://www.ncbi.nlm.nih.gov/pubmed/26725465
61.
C. C. Wu, F. Kruse, M. D. Vasudevarao, J. P. Junker, D. C. Zebrowski, K. Fischer, E. S. Noel, D. Grun, E. Berezikov, F. B. Engel, A. Oudenaarden, G. Weidinger and J. Bakkers, "Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration", Dev Cell, vol. 36, no. 1, pp. 36-49, 2016.
DOI:10.1016/j.devcel.2015.12.010
File:https://www.ncbi.nlm.nih.gov/pubmed/26748692
60.
D. Jiang, J. Muschhammer, Y. Qi, A. Kugler, J. C. Vries, M. Saffarzadeh, A. Sindrilaru, S. V. Beken, M. Wlaschek, M. A. Kluth, C. Ganss, N. Y. Frank, M. H. Frank, K. T. Preissner and K. Scharffetter-Kochanek, "Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells", Stem Cells, vol. 34, no. 9, pp. 2393-406, 2016.
DOI:10.1002/stem.2417
File:https://www.ncbi.nlm.nih.gov/pubmed/27299700
59.
A. Kovtun, S. Bergdolt, R. Wiegner, P. Radermacher, M. Huber-Lang and A. Ignatius, "The crucial role of neutrophil granulocytes in bone fracture healing", Eur Cell Mater, vol. 32, pp. 152-62, 2016.
File:http://www.ncbi.nlm.nih.gov/pubmed/27452963
58.
S. Anastasiadou and B. Knöll, "The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration", Exp Neurol, vol. 279, pp. 243-260, 2016.
DOI:10.1016/j.expneurol.2016.03.012
File:https://www.ncbi.nlm.nih.gov/pubmed/26980486
57.
S. Falkner, S. Grade, L. Dimou, K. K. Conzelmann, T. Bonhoeffer, M. Gotz and M. Hubener, "Transplanted embryonic neurons integrate into adult neocortical circuits", Nature, vol. 539, no. 7628, pp. 248-253, 2016.
DOI:10.1038/nature20113
File:https://www.ncbi.nlm.nih.gov/pubmed/27783592
56.
T. Wang, A. Riegger, M. Lamla, S. Wiese, P. Oeckl, M. Otto, Y. Wu, S. Fischer, H. Barth, S. L. Kuan and T. Weil, "Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides", Chem Sci, vol. 7, no. 5, pp. 3234-3239, 2016.
DOI:10.1039/c6sc00005c
File:https://www.ncbi.nlm.nih.gov/pubmed/29997815
55.
I. M. Sehring, C. Jahn and G. Weidinger, "Zebrafish fin and heart: what's special about regeneration?", Curr Opin Genet Dev, vol. 40, pp. 48-56, 2016.
DOI:10.1016/j.gde.2016.05.011
File:https://www.ncbi.nlm.nih.gov/pubmed/27351724

2015

54.
T. Schatton, J. Yang, S. Kleffel, M. Uehara, S. R. Barthel, C. Schlapbach, Q. Zhan, S. Dudeney, H. Mueller, N. Lee, J. C. Vries, B. Meier, S. Vander Beken, M. A. Kluth, C. Ganss, A. H. Sharpe, A. M. Waaga-Gasser, M. H. Sayegh, R. Abdi, K. Scharffetter-Kochanek, G. F. Murphy, T. S. Kupper, N. Y. Frank and M. H. Frank, "ABCB5 Identifies Immunoregulatory Dermal Cells", Cell Rep, vol. 12, no. 10, pp. 1564-74, 2015.
DOI:10.1016/j.celrep.2015.08.010
File:https://www.ncbi.nlm.nih.gov/pubmed/26321644
53.
S. Sirko, M. Irmler, S. Gascon, S. Bek, S. Schneider, L. Dimou, J. Obermann, D. De Souza Paiva, F. Poirier, J. Beckers, S. M. Hauck, Y. A. Barde and M. Gotz, "Astrocyte reactivity after brain injury-: The role of galectins 1 and 3", Glia, vol. 63, no. 12, pp. 2340-61, 2015.
DOI:10.1002/glia.22898
File:https://www.ncbi.nlm.nih.gov/pubmed/26250529
52.
K. Wagner, M. Gröger, O. McCook, A. Scheuerle, P. Asfar, M. Huber-Lang, A. Ignatius, B. Jung, M. Duechs, P. Möller, M. Georgieff, E. Calzia, P. Radermacher and F. Wagner, "Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100 % O2", PLoS One, vol. 10, no. 7, pp. e0132810, 2015.
DOI:10.1371/journal.pone.0132810
File:http://www.ncbi.nlm.nih.gov/pubmed/26225825
51.
D. Langgartner, A. M. Fuchsl, N. Uschold-Schmidt, D. A. Slattery and S. O. Reber, "Chronic subordinate colony housing paradigm: a mouse model to characterize the consequences of insufficient glucocorticoid signaling", Front Psychiatry, vol. 6, pp. 18, 2015.
DOI:10.3389/fpsyt.2015.00018
File:https://www.ncbi.nlm.nih.gov/pubmed/25755645
50.
H. Barth, S. Fischer, A. Moglich and C. Förtsch, "Clostridial C3 Toxins Target Monocytes/Macrophages and Modulate Their Functions", Front Immunol, vol. 6, pp. 339, 2015.
DOI:10.3389/fimmu.2015.00339
File:https://www.ncbi.nlm.nih.gov/pubmed/26175735
49.
P. Asfar and P. Radermacher, "Drug-Induced "Suspended Animation": Can a Dream Become True?", Crit Care Med, vol. 43, no. 7, pp. 1528-30, 2015.
DOI:10.1097/CCM.0000000000000985
File:https://www.ncbi.nlm.nih.gov/pubmed/26079228
48.
S. Denk, R. Wiegner, F. M. Hones, D. A. Messerer, P. Radermacher, M. Weiss, M. Kalbitz, C. Ehrnthaller, S. Braumuller, O. McCook, F. Gebhard, S. Weckbach and M. Huber-Lang, "Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma", Mediators Inflamm, vol. 2015, pp. 463950, 2015.
DOI:10.1155/2015/463950
File:https://www.ncbi.nlm.nih.gov/pubmed/26556956
47.
J. Kemmler, R. Bindl, O. McCook, F. Wagner, M. Gröger, K. Wagner, A. Scheuerle, P. Radermacher and A. Ignatius, "Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma", PLoS One, vol. 10, no. 7, pp. e0131194, 2015.
DOI:10.1371/journal.pone.0131194
File:http://www.ncbi.nlm.nih.gov/pubmed/26147725
46.
P. Xu, P. Fischer-Posovszky, J. Bischof, P. Radermacher, M. Wabitsch, D. Henne-Bruns, A. M. Wolf, A. Hillenbrand and U. Knippschild, "Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin", Mol Cell Endocrinol, vol. 406, no. C, pp. 87-101, 2015.
DOI:10.1016/j.mce.2015.02.010
File:https://www.ncbi.nlm.nih.gov/pubmed/25724478
45.
J. Theiss-Suennemann, K. Jorss, J. J. Messmann, S. D. Reichardt, E. Montes-Cobos, F. Luhder, A. W. H, R. Dressel, H. J. Grone, G. Strauss and H. M. Reichardt, "Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells", J Pathol, vol. 235, no. 4, pp. 646-55, 2015.
DOI:10.1002/path.4475
File:https://www.ncbi.nlm.nih.gov/pubmed/25358639
44.
S. Vettorazzi, C. Bode, L. Dejager, L. Frappart, E. Shelest, C. Klassen, A. Tasdogan, H. M. Reichardt, C. Libert, M. Schneider, F. Weih, N. Henriette Uhlenhaut, J. P. David, M. Graler and A. Kleiman, "Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1", Nat Commun, vol. 6, pp. 7796, 2015.
DOI:10.1038/ncomms8796
File:https://www.ncbi.nlm.nih.gov/pubmed/26183376
43.
S. Häfner, F. Beloncle, A. Koch, P. Radermacher and P. Asfar, "Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update", Ann Intensive Care, vol. 5, no. 1, pp. 42, 2015.
DOI:10.1186/s13613-015-0084-6
File:https://www.ncbi.nlm.nih.gov/pubmed/26585328
42.
J. J. Messmann, T. Reisser, F. Leithauser, M. B. Lutz, K. M. Debatin and G. Strauss, "In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity", Blood, vol. 126, no. 9, pp. 1138-48, 2015.
DOI:10.1182/blood-2015-01-624163
File:https://www.ncbi.nlm.nih.gov/pubmed/26185131
41.
A. M. Vogl, M. M. Brockmann, S. A. Giusti, G. Maccarrone, C. A. Vercelli, C. A. Bauder, J. S. Richter, F. Roselli, A. S. Hafner, N. Dedic, C. T. Wotjak, D. M. Vogt-Weisenhorn, D. Choquet, C. W. Turck, V. Stein, J. M. Deussing and D. Refojo, "Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition", Nat Neurosci, vol. 18, no. 2, pp. 239-51, 2015.
DOI:10.1038/nn.3912
File:https://www.ncbi.nlm.nih.gov/pubmed/25581363
40.
S. Anastasiadou, S. Liebenehm, D. Sinske, C. Reckendorf, B. Moepps, A. Nordheim and B. Knöll, "Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model", Glia, vol. 63, no. 6, pp. 958-76, 2015.
DOI:10.1002/glia.22794
File:https://www.ncbi.nlm.nih.gov/pubmed/25639799
39.
S. Häfner, K. Wagner, M. Wepler, J. Matallo, M. Gröger, O. McCook, A. Scheuerle, M. Huber-Lang, M. Frick, S. Weber, B. Jung, E. Calzia, M. Georgieff, P. Möller, P. Dietl, P. Radermacher and F. Wagner, "Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma", Shock, vol. 43, no. 2, pp. 140-7, 2015.
DOI:10.1097/SHK.0000000000000277
File:https://www.ncbi.nlm.nih.gov/pubmed/25526372
38.
M. Kalbitz, J. J. Grailer, F. Fattahi, L. Jajou, T. J. Herron, K. F. Campbell, F. S. Zetoune, M. Bosmann, J. V. Sarma, M. Huber-Lang, F. Gebhard, R. Loaiza, H. H. Valdivia, J. Jalife, M. W. Russell and P. A. Ward, "Role of extracellular histones in the cardiomyopathy of sepsis", FASEB J, vol. 29, no. 5, pp. 2185-93, 2015.
DOI:10.1096/fj.14-268730
File:https://www.ncbi.nlm.nih.gov/pubmed/25681459
37.
M. Schoen, J. M. Reichel, M. Demestre, S. Putz, D. Deshpande, C. Proepper, S. Liebau, M. J. Schmeisser, A. C. Ludolph, J. Michaelis and T. M. Boeckers, "Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons", Front Cell Neurosci, vol. 9, pp. 496, 2015.
DOI:10.3389/fncel.2015.00496
File:https://www.ncbi.nlm.nih.gov/pubmed/26834559
36.
K. Singh, P. Maity, L. Krug, P. Meyer, N. Treiber, T. Lucas, A. Basu, S. Kochanek, M. Wlaschek, H. Geiger and K. Scharffetter-Kochanek, "Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN", EMBO Mol Med, vol. 7, no. 1, pp. 59-77, 2015.
DOI:10.15252/emmm.201404082
File:https://www.ncbi.nlm.nih.gov/pubmed/25520316
35.
P. Asfar, M. Singer and P. Radermacher, "Understanding the benefits and harms of oxygen therapy", Intensive Care Med, vol. 41, no. 6, pp. 1118-21, 2015.
DOI:10.1007/s00134-015-3670-z
File:https://www.ncbi.nlm.nih.gov/pubmed/25634474
34.
D. Wehner, C. Jahn and G. Weidinger, "Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration", J Vis Exp, no. 100, pp. e52756, 2015.
DOI:10.3791/52756
File:https://www.ncbi.nlm.nih.gov/pubmed/26168286

2014

33.
J. Witte, W. Kahler, T. Wunderlich, P. Radermacher, C. Wohlrab and A. Koch, "Dose-time dependency of hyperbaric hyperoxia-induced DNA strand breaks in human immune cells visualized with the comet assay", Undersea Hyperb Med, vol. 41, no. 3, pp. 171-81, 2014.
File:https://www.ncbi.nlm.nih.gov/pubmed/24984312
32.
J. A. Vogt, U. Wachter, K. Wagner, E. Calzia, M. Gröger, S. Weber, M. Georgieff, P. Asfar, E. Fontaine, P. Radermacher, X. M. Leverve and F. Wagner, "Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock", Intensive Care Med Exp, vol. 2, no. 1, pp. 19, 2014.
DOI:10.1186/2197-425X-2-19
File:https://www.ncbi.nlm.nih.gov/pubmed/26266919
31.
O. McCook, P. Radermacher, C. Volani, P. Asfar, A. Ignatius, J. Kemmler, P. Möller, C. Szabo, M. Whiteman, M. E. Wood, R. Wang, M. Georgieff and U. Wachter, "H2S during circulatory shock: Some unresolved questions", Nitric Oxide, vol. 41, pp. 48-61, 2014.
DOI:10.1016/j.niox.2014.03.163
File:http://www.ncbi.nlm.nih.gov/pubmed/24650697
30.
K. Geurtzen, F. Knopf, D. Wehner, L. F. Huitema, S. Schulte-Merker and G. Weidinger, "Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull", Development, vol. 141, no. 11, pp. 2225-34, 2014.
DOI:10.1242/dev.105817
File:https://www.ncbi.nlm.nih.gov/pubmed/24821985
29.
M. Haffner-Luntzer, A. Heilmann, A. E. Rapp, S. Beie, T. Schinke, M. Amling, A. Ignatius and A. Liedert, "Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice", PLoS One, vol. 9, no. 12, pp. e116282, 2014.
DOI:10.1371/journal.pone.0116282
File:https://www.ncbi.nlm.nih.gov/pubmed/25551381
28.
J. L. Eisenbacher, H. Schrezenmeier, B. Jahrsdorfer, C. Kaltenmeier, M. T. Rojewski, T. Yildiz, T. Beyer, A. Erle, D. S. Wiegmann, S. Grassl, R. Hang, S. Korper, M. Wiesneth, M. T. Lotze and R. Lotfi, "S100A4 and uric acid promote mesenchymal stromal cell induction of IL-10+/IDO+ lymphocytes", J Immunol, vol. 192, no. 12, pp. 6102-10, 2014.
DOI:10.4049/jimmunol.1303144
File:https://www.ncbi.nlm.nih.gov/pubmed/24795458
27.
C. Lehnert, M. Weiswange, I. Jeremias, C. Bayer, M. Grunert, K. M. Debatin and G. Strauss, "TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation", J Immunol, vol. 193, no. 8, pp. 4021-31, 2014.
DOI:10.4049/jimmunol.1303242
File:https://www.ncbi.nlm.nih.gov/pubmed/25217163
26.
Y. Qi, D. Jiang, A. Sindrilaru, A. Stegemann, S. Schatz, N. Treiber, M. Rojewski, H. Schrezenmeier, S. Vander Beken, M. Wlaschek, M. Bohm, A. Seitz, N. Scholz, L. Dürselen, J. Brinckmann, A. Ignatius and K. Scharffetter-Kochanek, "TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds", J Invest Dermatol, vol. 134, no. 2, pp. 526-537, 2014.
DOI:10.1038/jid.2013.328
File:https://www.ncbi.nlm.nih.gov/pubmed/23921952
25.
D. Wehner, W. Cizelsky, M. D. Vasudevaro, G. Ozhan, C. Haase, B. Kagermeier-Schenk, A. Roder, R. I. Dorsky, E. Moro, F. Argenton, M. Kuhl and G. Weidinger, "Wnt/beta-catenin signaling defines organizing centers that orchestrate growth and differentiation of the regenerating zebrafish caudal fin", Cell Rep, vol. 6, no. 3, pp. 467-81, 2014.
DOI:10.1016/j.celrep.2013.12.036
File:https://www.ncbi.nlm.nih.gov/pubmed/24485658

2013

24.
A. Sindrilaru and K. Scharffetter-Kochanek, "Disclosure of the Culprits: Macrophages-Versatile Regulators of Wound Healing", Adv Wound Care (New Rochelle), vol. 2, no. 7, pp. 357-368, 2013.
DOI:10.1089/wound.2012.0407
File:https://www.ncbi.nlm.nih.gov/pubmed/24587973
23.
S. Bardehle, M. Kruger, F. Buggenthin, J. Schwausch, J. Ninkovic, H. Clevers, H. J. Snippert, F. J. Theis, M. Meyer-Luehmann, I. Bechmann, L. Dimou and M. Gotz, "Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation", Nat Neurosci, vol. 16, no. 5, pp. 580-6, 2013.
DOI:10.1038/nn.3371
File:https://www.ncbi.nlm.nih.gov/pubmed/23542688
22.
F. Seichter, A. Wilk, K. Wörle, S. S. Kim, J. A. Vogt, U. Wachter, P. Radermacher and B. Mizaikoff, "Multivariate determination of 13CO2/12CO2 ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors", Anal Bioanal Chem, vol. 405, no. 14, pp. 4945-51, 2013.
DOI:10.1007/s00216-013-6824-2
File:https://www.ncbi.nlm.nih.gov/pubmed/23503745
21.
S. Saxena, F. Roselli, K. Singh, K. Leptien, J. P. Julien, F. Gros-Louis and P. Caroni, "Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival", Neuron, vol. 80, no. 1, pp. 80-96, 2013.
DOI:10.1016/j.neuron.2013.07.027
File:https://www.ncbi.nlm.nih.gov/pubmed/24094105
20.
B. Grotek, D. Wehner and G. Weidinger, "Notch signaling coordinates cellular proliferation with differentiation during zebrafish fin regeneration", Development, vol. 140, no. 7, pp. 1412-23, 2013.
DOI:10.1242/dev.087452
File:https://www.ncbi.nlm.nih.gov/pubmed/23462472
19.
S. Sirko, G. Behrendt, P. A. Johansson, P. Tripathi, M. Costa, S. Bek, C. Heinrich, S. Tiedt, D. Colak, M. Dichgans, I. R. Fischer, N. Plesnila, M. Staufenbiel, C. Haass, M. Snapyan, A. Saghatelyan, L. H. Tsai, A. Fischer, K. Grobe, L. Dimou and M. Gotz, "Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]", Cell Stem Cell, vol. 12, no. 4, pp. 426-39, 2013.
DOI:10.1016/j.stem.2013.01.019
File:https://www.ncbi.nlm.nih.gov/pubmed/23561443
18.
N. Hartmann, J. J. Messmann, F. Leithauser, M. Weiswange, M. Kluge, H. Fricke, K. M. Debatin and G. Strauss, "Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions", Blood, vol. 121, no. 3, pp. 556-65, 2013.
DOI:10.1182/blood-2012-04-423392
File:https://www.ncbi.nlm.nih.gov/pubmed/23203823
17.
A. Maqbool, M. Lattke, T. Wirth and B. Baumann, "Sustained, neuron-specific IKK/NF-kappaB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging", Mol Neurodegener, vol. 8, pp. 40, 2013.
DOI:10.1186/1750-1326-8-40
File:https://www.ncbi.nlm.nih.gov/pubmed/24119288
16.
D. Jiang, Y. Qi, N. G. Walker, A. Sindrilaru, A. Hainzl, M. Wlaschek, S. MacNeil and K. Scharffetter-Kochanek, "The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing", Biomaterials, vol. 34, no. 10, pp. 2501-15, 2013.
DOI:10.1016/j.biomaterials.2012.12.014
File:https://www.ncbi.nlm.nih.gov/pubmed/23317813
15.
S. Stern, S. Haverkamp, D. Sinske, A. Tedeschi, U. Naumann, S. Di Giovanni, S. Kochanek, A. Nordheim and B. Knöll, "The transcription factor serum response factor stimulates axon regeneration through cytoplasmic localization and cofilin interaction", J Neurosci, vol. 33, no. 48, pp. 18836-48, 2013.
DOI:10.1523/JNEUROSCI.3029-13.2013
File:https://www.ncbi.nlm.nih.gov/pubmed/24285890